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Increased Expression of the Interleukin-11 Receptor and Evidence of STAT3 Activation in Prostate Carcinoma
Open accessAbstract
Previous investigations have shown that interleukin-6, a member of the JAK-STAT activating family of cytokines, plays an important role in prostate carcinoma. Here we demonstrate the co-expression of another member of this cytokine family, interleukin-11 (IL-11), and components of its receptor (interleukin-11 receptor; IL-11R), ie, IL-11Ralpha (involved in ligand recognition), and gp130 (involved in signal transduction) in cultured normal and malignant prostate-derived epithelial cell lines. In the DU-145 prostate carcinoma cell line, rhIL-11 stimulates a transient and dose-dependent increase in the tyrosine 705-phosphorylated, active form of STAT3 (STAT3 P-Tyr705), involved in the downstream signaling of IL-11R and other members of the gp130-dependent receptors. The ability of IL-11 to activate STAT3 in prostate-derived cells may be mechanistically important, given recent data suggesting that constitutively activated STAT3 may be associated with the malignant phenotype. In 51 human primary tissues derived from normal prostate, benign prostatic hyperplasia, and prostate carcinomas, IL-11Ralpha and gp130 were commonly expressed, with a statistically significant elevation in the expression of IL-11Ralpha in prostate carcinoma. Also, the tyrosine-phosphorylated, activated form of STAT3 was observed more prominently in the nuclei of cells residing in malignant glands compared to those in nonmalignant samples. Thus, the IL-11 receptor system is up-regulated in prostate carcinoma, and may be one part of a cytokine network that maintains STAT3 in its activated form in these tissues.
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“Interleukin-11 (IL-11), a member of a family of pleiotropic cytokines [120], specifically binds to IL-11 receptor α-chain (IL-11Rα) and active the signaling pathways involved in adipogenesis, osteoclastogenesis, neurogenesis, and megakaryocyte maturation and platelet production [121].”
From Advances on immunotherapy for osteosarcoma (2024) · cites this paper as [120]
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“Zhang et al. conducted the third-generation CAR-T cells targeting B7-H3 and proved the killing effects for tumor cells in vitro and in vivo using the patientderived xenografts (PDXs) model of osteosarcoma [116–125].”
From Advances on immunotherapy for osteosarcoma (2024) · cites this paper as [120]
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Metadata
- Authors
- Campbell, C. L., Jiang, Z., Savarese, D. M. F., & Savarese, T. M.
- Affiliations
- University of Massachusetts Chan Medical School (US)
- Corresponding author
- Savarese, Todd M.
- Venue
- The American Journal of Pathology
- Publisher
- Elsevier BV
- Published
- 2001-01
- Volume
- 158
- Issue
- 1
- Pages
- 25-32
- ISSN
- 0002-9440 (ISSN-L)
- PMC
- PMC1850253
- OpenAlex
- W2009228236
- Cited by
- 151
- References
- 48
- Citations by year
- 2026: 2 · 2024: 2 · 2023: 1 · 2022: 7 · 2021: 4 · 2020: 3 · 2019: 2 · 2018: 6 · 2017: 3 · 2016: 7 · 2015: 7 · 2014: 7 · 2013: 8 · 2012: 8
- FWCI
- 5.61
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- American Journal Of Pathology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- The Journal of the American Medical Association (JAMA) Network (American Medical Association) (submittedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Prostate Cancer Treatment and Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Keywords
- interleukin-11, gp130, STAT3 activation, prostate cancer, JAK/STAT signaling, cytokine receptor expression, benign prostatic hyperplasia, DU145 cells, tyrosine phosphorylation
- MeSH terms
- Adenocarcinoma, Cell Line, DNA-Binding Proteins, Humans, Hyperplasia, Immunohistochemistry, Male, Phosphorylation, Prostate, Prostatic Neoplasms, RNA, Messenger, Tumor Cells, Cultured, Tyrosine, Blotting, Western, Trans-Activators, Gene Expression Regulation, Neoplastic, Interleukin-11, Receptors, Interleukin, STAT3 Transcription Factor, Receptors, Interleukin-11, Interleukin-11 Receptor alpha Subunit
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