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Cited by 151Cytokine Signaling Pathways and InteractionsProstate Cancer Treatment and ResearchTGF-β signaling in diseases

The DOI matches its Crossref record; 41 of the 48 references it cites were found in a registry or an index.

Increased Expression of the Interleukin-11 Receptor and Evidence of STAT3 Activation in Prostate Carcinoma

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Campbell, Cara L., Jiang, Zhong, Savarese, Diane M.F., Savarese, Todd M.·2001·The American Journal of Pathology
DOI 10.1016/s0002-9440(10)63940-5PMC PMC1850253
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Abstract

Previous investigations have shown that interleukin-6, a member of the JAK-STAT activating family of cytokines, plays an important role in prostate carcinoma. Here we demonstrate the co-expression of another member of this cytokine family, interleukin-11 (IL-11), and components of its receptor (interleukin-11 receptor; IL-11R), ie, IL-11Ralpha (involved in ligand recognition), and gp130 (involved in signal transduction) in cultured normal and malignant prostate-derived epithelial cell lines. In the DU-145 prostate carcinoma cell line, rhIL-11 stimulates a transient and dose-dependent increase in the tyrosine 705-phosphorylated, active form of STAT3 (STAT3 P-Tyr705), involved in the downstream signaling of IL-11R and other members of the gp130-dependent receptors. The ability of IL-11 to activate STAT3 in prostate-derived cells may be mechanistically important, given recent data suggesting that constitutively activated STAT3 may be associated with the malignant phenotype. In 51 human primary tissues derived from normal prostate, benign prostatic hyperplasia, and prostate carcinomas, IL-11Ralpha and gp130 were commonly expressed, with a statistically significant elevation in the expression of IL-11Ralpha in prostate carcinoma. Also, the tyrosine-phosphorylated, activated form of STAT3 was observed more prominently in the nuclei of cells residing in malignant glands compared to those in nonmalignant samples. Thus, the IL-11 receptor system is up-regulated in prostate carcinoma, and may be one part of a cytokine network that maintains STAT3 in its activated form in these tissues.

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Crossref · 10.1016/s0002-9440(10)63940-5

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  1. Campbell, 1999, Coexpression of IL-11 and IL-11 receptor in primary neoplasms (ovarian) and cultured cell lines, Proc Am Assoc Cancer Res, 40, 177

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Metadata

Authors
Campbell, C. L., Jiang, Z., Savarese, D. M. F., & Savarese, T. M.
Affiliations
University of Massachusetts Chan Medical School (US)
Corresponding author
Savarese, Todd M.
Venue
The American Journal of Pathology
Publisher
Elsevier BV
Published
2001-01
Volume
158
Issue
1
Pages
25-32
ISSN
0002-9440 (ISSN-L)
DOI
10.1016/s0002-9440(10)63940-5
PMC
PMC1850253
OpenAlex
W2009228236
Cited by
151
References
48
Citations by year
2026: 2 · 2024: 2 · 2023: 1 · 2022: 7 · 2021: 4 · 2020: 3 · 2019: 2 · 2018: 6 · 2017: 3 · 2016: 7 · 2015: 7 · 2014: 7 · 2013: 8 · 2012: 8
FWCI
5.61
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • American Journal Of Pathology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • The Journal of the American Medical Association (JAMA) Network (American Medical Association) (submittedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Prostate Cancer Treatment and Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
Keywords
interleukin-11, gp130, STAT3 activation, prostate cancer, JAK/STAT signaling, cytokine receptor expression, benign prostatic hyperplasia, DU145 cells, tyrosine phosphorylation
MeSH terms
Adenocarcinoma, Cell Line, DNA-Binding Proteins, Humans, Hyperplasia, Immunohistochemistry, Male, Phosphorylation, Prostate, Prostatic Neoplasms, RNA, Messenger, Tumor Cells, Cultured, Tyrosine, Blotting, Western, Trans-Activators, Gene Expression Regulation, Neoplastic, Interleukin-11, Receptors, Interleukin, STAT3 Transcription Factor, Receptors, Interleukin-11, Interleukin-11 Receptor alpha Subunit

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