Cited by 435Wound Healing and TreatmentsChemokine receptors and signalingInflammation biomarkers and pathways

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Chemokines IL-8, GROα, MCP-1, IP-10, and Mig Are Sequentially and Differentially Expressed During Phase-Specific Infiltration of Leukocyte Subsets in Human Wound Healing

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Engelhardt, Eva, Toksoy, Atiye, Goebeler, Matthias, Debus, Sebastian, Bröcker, Eva-Bettina, Gillitzer, Reinhard·1998·The American Journal of Pathology

DOI 10.1016/s0002-9440(10)65699-4PMC PMC1866330

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Abstract

Healing of cutaneous wounds requires a complex integrated network of repair mechanisms, including the action of newly recruited leukocytes. Using a skin repair model in adult humans, we investigated the role chemokines play in sequential infiltration of leukocyte subsets during wound healing. At day 1 after injury, the C-X-C chemokines IL-8 and growth-related oncogene alpha are maximally expressed in the superficial wound bed and are spatially and temporally associated with neutrophil infiltration. IL-8 and growth-related oncogene alpha profiles also correlate with keratinocyte migration and subsequently subside after wound closure at day 4. Macrophage infiltration reaches the highest levels at day 2 and is paralleled by monocyte chemoattractant protein-1 mRNA expression in both the basal layer of the proliferative epidermis at the wound margins and mononuclear cells in the wound area. Other monocyte-attracting chemokines such as monocyte chemoattractant protein-3, macrophage inflammatory protein-1alpha and -1beta, RANTES, and 1309 are undetectable. At day 4, perivascular focal lymphocyte accumulation correlates with strong focal expression of the C-X-C chemokines Mig and IP-10. Our results suggest that a dynamic set of chemokines contributes to the spatially and temporally different infiltration of leukocyte subsets and thus integrates the inflammatory and reparative processes during wound repair.

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Wound Healing--Aiming for Perfect Skin Regeneration
Martin, P. B. (1997) · Science · doi:10.1126/science.276.5309.75 · Cited by 4,842
Pathophysiology of acute wound healing
Li, J., Chen, J., & Kirsner, R. S. (2007) · Clinics in Dermatology · doi:10.1016/j.clindermatol.2006.09.007 · Cited by 4,042
Interleukin-8 and related chemotactic cytokines--CXC and CC chemokines.
Baggiolini, M., Dewald, B., & Moser, B. (1994) · PubMed · Cited by 2,232
Interleukin-8 as a macrophage-derived mediator of angiogenesis
Koch, A. E., Polverini, P. J., Kunkel, S. L., Harlow, L. A., DiPietro, L. A., Elner, V. M., Elner, S. G., & Strieter, R. M. (1992) · Science · doi:10.1126/science.1281554 · Cited by 2,135
Properties Of The Novel Proinflammatory Supergene Intercrine Cytokine Family
Oppenheim, J. J., Zachariae, C. O. C., Mukaida, N., & Matsushima, K. (1991) · Annual Review of Immunology · doi:10.1146/annurev.iy.09.040191.003153 · Cited by 1,878
lnterleukin-8 and Related Chemotactic Cytokines—CXC and CC Chemokines
Baggiolini, M., Dewald, B., & Moser, B. (1993) · Advances in immunology · doi:10.1016/s0065-2776(08)60509-x · Cited by 1,672
The Molecular and Cellular Biology of Wound Repair
Clark, R. A. F., & Henson, P. M. (1988) · Springer eBooks · doi:10.1007/978-1-4615-1795-5 · Cited by 1,522
Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes
Loetscher, M., Gerber, B., Loetscher, P., Jones, S. A., Piali, L., Clark-Lewis, I., Baggiolini, M., & Moser, B. (1996) · Journal of Experimental Medicine · doi:10.1084/jem.184.3.963 · Cited by 1,333
The Functional Role of the ELR Motif in CXC Chemokine-mediated Angiogenesis
Strieter, R. M., Polverini, P. J., Kunkel, S. L., Arenberg, D. A., Burdick, M. D., Kasper, J., Dzuiba, J., Van Damme, J., Walz, A., Marriott, D., et al. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.45.27348 · Cited by 1,222
The Neutrophil-Activating Protein (NAP-1) Is Also Chemotactic for T Lymphocytes
Grønhøj, C., Anderson, A. O., Appella, E., Oppenheim, J. J., & Matsushima, K. (1989) · Science · doi:10.1126/science.2648569 · Cited by 1,037

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Authors: Engelhardt, E., Toksoy, A., Goebeler, M., Debus, S., Bröcker, E.-B., & Gillitzer, R.
Affiliations: University of Würzburg (DE)
Corresponding author: Gillitzer, Reinhard
ORCID: Engelhardt, Eva
Goebeler, Matthias
Venue: The American Journal of Pathology
Publisher: Elsevier BV
Published: 1998-12
Volume: 153
Issue: 6
Pages: 1849-1860
ISSN: 0002-9440 (ISSN-L)
DOI: 10.1016/s0002-9440(10)65699-4
PMC: PMC1866330
OpenAlex: W2010087085
Cited by: 435
References: 64
Citations by year: 2026: 8 · 2025: 12 · 2024: 12 · 2023: 15 · 2022: 9 · 2021: 17 · 2020: 15 · 2019: 12 · 2018: 18 · 2017: 25 · 2016: 10 · 2015: 15 · 2014: 20 · 2013: 13 · 2012: 23
FWCI: 17.08
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: American Journal Of Pathology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Surgery › Wound Healing and Treatments
Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
Keywords: chemokines, wound healing, skin wound healing, leukocyte infiltration, neutrophil infiltration, macrophage infiltration, keratinocyte migration, interleukin-8, CXCL1, MCP-1, CXCL10, CXC chemokines, skin inflammation, lymphocyte accumulation, spatiotemporal gene expression
MeSH terms: Adult, Cell Division, Chemotactic Factors, Female, Growth Substances, Humans, Immunohistochemistry, Leukocytes, Male, Middle Aged, RNA, Messenger, Time Factors, Wound Healing, Keratinocytes, Interleukin-8, In Situ Hybridization, Neovascularization, Physiologic, Chemokines, Chemokine CCL2, Chemokines, CXC, Intercellular Signaling Peptides and Proteins, Chemokine CXCL10, Chemokine CXCL1, Chemokine CXCL9

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Chemokines IL-8, GROα, MCP-1, IP-10, and Mig Are Sequentially and Differentially Expressed During Phase-Specific Infiltration of Leukocyte Subsets in Human Wound Healing

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