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Lewy Bodies Contain Altered α-Synuclein in Brains of Many Familial Alzheimer's Disease Patients with Mutations in Presenilin and Amyloid Precursor Protein Genes
Open accessAbstract
Missense mutations in the alpha-synuclein gene cause familial Parkinson's disease (PD), and alpha-synuclein is a major component of Lewy bodies (LBs) in sporadic PD, dementia with LBs (DLB), and the LB variant of Alzheimer's disease (AD). To determine whether alpha-synuclein is a component of LBs in familial AD (FAD) patients with known mutations in presenilin (n = 65) or amyloid precursor protein (n = 9) genes, studies were conducted with antibodies to alpha-, beta-, and gamma-synuclein. LBs were detected with alpha- but not beta- or gamma-synuclein antibodies in 22% of FAD brains, and alpha-synuclein-positive LBs were most numerous in amygdala where some LBs co-localized with tau-positive neurofibrillary tangles. As 12 (63%) of 19 FAD amygdala samples contained alpha-synuclein-positive LBs, these inclusions may be more common in FAD brains than previously reported. Furthermore, alpha-synuclein antibodies decorated LB filaments by immunoelectron microscopy, and Western blots revealed that the solubility of alpha-synuclein was reduced compared with control brains. The presence of alpha-synuclein-positive LBs was not associated with any specific FAD mutation. These studies suggest that insoluble alpha-synuclein aggregates into filaments that form LBs in many FAD patients, and we speculate that these inclusions may compromise the function and/or viability of affected neurons in the FAD brain.
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“two studies have shown that individuals with PSEN1 mutations have increased, yet heterogeneous limbic LRP [22, 25].”
From α-synuclein in the pathophysiology of Alzheimer’s disease (2019) · cites this paper as [22]
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“co-morbid αSyn pathology has been reported in more than half of all autopsy-confirmed AD cases [22–24]”
From α-synuclein in the pathophysiology of Alzheimer’s disease (2019) · cites this paper as [22]
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“co-morbid αSyn pathology has been reported in more than half of all autopsy-confirmed AD cases [22–24]”
From α-synuclein in the pathophysiology of Alzheimer’s disease (2019) · cites this paper as [22]
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Cites
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984) · Neurology · doi:10.1212/wnl.34.7.939 · Cited by 27,915
Spillantini, M. G., Schmidt, M. L., Lee, V. M.-Y., Trojanowski, J. Q., Jakes, R., & Goedert, M. (1997) · Nature · doi:10.1038/42166 · Cited by 8,382
Self-citationMutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease
Polymeropoulos, M. H., Lavedan, C., Leroy, E., Ide, S. E., Dehejia, A., Dutra, A., Pike, B., Root, H., Rubenstein, J., Boyer, R., et al. (1997) · Science · doi:10.1126/science.276.5321.2045 · Cited by 8,240
McKeith, I. G., Galasko, D., Kosaka, K., Perry, E. K., Dickson, D. W., Hansen, L. A., Salmon, D. P., Lowe, J., Mirra, S. S., Byrne, E. J., et al. (1996) · Neurology · doi:10.1212/wnl.47.5.1113 · Cited by 3,960
AlaSOPro mutation in the gene encoding α-synuclein in Parkinson's disease
Krüger, R., Kuhn, W., Müller, T., Woitalla, D., Graeber, M., Kösel, S., Przuntek, H., Epplen, J. T., Schols, L., & Riess, O. (1998) · Nature Genetics · doi:10.1038/ng0298-106 · Cited by 3,836
Shi, S., Key, M. E., & Kalra, K. L. (1991) · Journal of Histochemistry & Cytochemistry · doi:10.1177/39.6.1709656 · Cited by 2,543
Staging of alzheimer's disease-related neurofibrillary changes
Braak, H., & Braak, E. (1995) · Neurobiology of Aging · doi:10.1016/0197-4580(95)00021-6 · Cited by 2,357
Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein
De Strooper, B., Saftig, P., Craessaerts, K., Vanderstichele, H., Guhde, G., Annaert, W., Von Figura, K., & Van Leuven, F. (1998) · Nature · doi:10.1038/34910 · Cited by 1,818
(1998) · Europe PMC (PubMed Central) · Cited by 1,594
Self-citationHYMAN, B. T., & TROJANOWSKI, J. Q. (1997) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199710000-00002 · Cited by 1,542
Self-citation
Research works printed but not linked: 1
- Foncin, 1985, Demence presenile d'Alzheimer transmise'dans une famille etendue, Rev Neurol (Paris), 141, 194
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Guo, X., Xiang, J., Ye, K., & Zhang, Z. (2025) · Cells · doi:10.3390/cells14120907 · Cited by 11
Zhan, X., Li, W., Hatterer, E., Courade, J., Piché, K., Klementieva, O. L., & Li, J. (2025) · Journal of the American Chemical Society · doi:10.1021/jacs.5c02811 · Cited by 12
Shwab, E. K., Pathak, G. A., Harvey, J., Belloy, M. E., Fischer, C. E., Lutz, M. W., Scholz, S. W., Cook, N., Reid, D. M., Chen, J., et al. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70549 · Cited by 12
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Thakur, A., Rana, M., Vanjani, S., Liou, K.-C., Taliyan, R., Nepali, K., & Yang, C. (2026) · Medicinal Research Reviews · doi:10.1002/med.70047 · Cited by 10
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Jackson, W. S., Bauer, S., Kaczmarczyk, L., & Magadi, S. S. (2024) · Biology · doi:10.3390/biology13020067 · Cited by 8
Emmer, K. L., Covy, J. P., & Giasson, B. I. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.12.005 · Cited by 7
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Sopher, B. L., Koszdin, K. L., McClain, M. E., Myrick, S. B., Martinez, R. A., Smith, A. C., & Spada, A. R. L. (2001) · Cytogenetic and Genome Research · doi:10.1159/000056962 · Cited by 7
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Iseki, E., Marui, W., Yamamoto, R., Togo, T., Katsuse, O., Kato, M., Iwatsubo, T., Kosaka, K., & Arai, H. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2005.01.056 · Cited by 6
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Masliah, E., Hansen, L. A., Rockenstein, E. M., & Hashimoto, M. (2002) · Drug Development Research · doi:10.1002/ddr.10082 · Cited by 4
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Lippa, C. F., & Knopman, D. S. (2007) · Neurology · doi:10.1212/01.wnl.0000287144.13726.3e · Cited by 4
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Hansen, L. A., & Masliah, E. (2001) · Elsevier eBooks · doi:10.1016/b978-012351830-9/50016-0 · Cited by 4
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Racine, C. A. (2009) · Cambridge University Press eBooks · doi:10.1017/cbo9780511581410.002 · Cited by 3
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Libard, S., Giedraitis, V., Kilander, L., Ingelsson, M., & Alafuzoff, I. I. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-220655 · Cited by 3
Rierola, M., Trushina, N. I., Monteiro-Abreu, N., Conze, C., Holtmannspötter, M., Kurre, R., Holzer, M., Arendt, T., Heinisch, J. J., Brandt, R., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.06.09.495530 · Cited by 4
Park, Y., Lee, H. W., Ye, B. S., Kim, S. Y., & Yu, Y. M. (2025) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2025.101218 · Cited by 2
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Cholesterol dysregulation in APOE4 astrocytes promotes α-synuclein pathology in miBrains
Mesentier-Louro, L. A., Goldman, C., Gaese, S., Buonfiglioli, A., Kyriakis, D., Harlock, A., Ndayisaba, A., Sartori, E. R., Uchitelev, A., Fullard, J. F., et al. (2026) · Cell stem cell · doi:10.1016/j.stem.2026.08.001 · Cited by 6
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Hardy, J., & Gwinn, K. A. (2008) · Handbook of clinical neurology · doi:10.1016/s0072-9752(07)01217-1 · Cited by 2
Progress in Familial Parkinson's Disease.
Mizuno, Y., Hattori, N., Asakawa, S., Shimura, H., Mori, H., & Shimizu, N. (2000) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.28.143 · Cited by 2
West, A. B., Gray, M., & Standaert, D. G. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-383834-6.00123-3 · Cited by 2
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Lippa, C. F. (2006) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/1533317506292372 · Cited by 2
Self-citationAtypical Parkinsonian Disorders
Duyckaerts, C. J. (2005) · Humana Press eBooks · doi:10.1385/1-59259-834-x:111 · Cited by 2
Gawor, K., Tomé, S. O., Vandenberghe, R. R., Damme, P. V., Vandenbulcke, M., Otto, M., Arnim, C. A. F. V., Ghebremedhin, E., Ronisz, A., Ospitalieri, S., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.06.21.599515 · Cited by 2
Kim, S., Jeon, S., Cho, K., Kang, S., Bang, S., Ye, B. S., & Lee, J.-M. (2026) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2026.1780858 · Cited by 1
Aguilar, L. F., Zaikos, T. D., Rivera, I., Wright, S. T., Lou, J., Gawronski, B., Gonzalez, L., Berry, J. V., Rouanet, J. P., Edwards, N. C., et al. (2026) · Acta Neuropathologica · doi:10.1007/s00401-026-03028-z · Cited by 1
Offerdahl, J. E. V., & Mor, D. E. (2026) · Frontiers in Neuroscience · doi:10.3389/fnins.2026.1846384 · Cited by 1
Pathogenesis of neurodegenerative diseases via templated recruitment
Guo, J. (2013) · ScholarlyCommons (University of Pennsylvania) · Cited by 1
Proceso inflamatorio en la enfermedad de Alzheimer. Papel de las citoquinas
Rubio-Perez, J. M., & Morillas-Ruiz, J. M. (2014) · doi:10.3926/oms.47 · Cited by 2
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Otero, J. L., & Scheitler, L. F. (2008) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 1
Kovács, G. G., Ferrer, I., & Alafuzoff, I. I. (2014) · Cambridge University Press eBooks · doi:10.1017/cbo9781107588660.018 · Cited by 1
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Lippa, C. F. (2001) · Springer eBooks · doi:10.1007/978-4-431-67897-7_30 · Cited by 1
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Paisán‐Ruiz, C., Parkkinen, L., & Révész, T. (2011) · doi:10.1002/9781444341256.ch23 · Cited by 1
Hashimoto, M., Sekiyama, K., Sekigawa, A., & Fujita, M. (2011) · Wiley eBooks · doi:10.1002/9781118063903.ch4 · Cited by 1
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Goedert, M., & Spillantini, M. G. (2005) · Humana Press eBooks · doi:10.1385/1-59259-834-x:077 · Cited by 1
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DeCuypere, M. G. (2010) · doi:10.21007/etd.cghs.2010.0067 · Cited by 1
Lippa, C. F., & Possin, K. L. (2016) · Wiley eBooks · doi:10.1002/9781118797662.ch6 · Cited by 1
Self-citationApetri, M. M. (2006) · OhioLink ETD Center (Ohio Library and Information Network) · Cited by 1
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Hardy, J. (2003) · Humana Press eBooks · doi:10.1007/978-1-59259-326-2_19 · Cited by 1
Neuropathology, Genetics and Biomarkers of SynucleinopathiesPreprint
Koga, S., Sekiya, H., Kondru, N., Ross, O., & Dickson, D. W. (2021) · Research Square · doi:10.21203/rs.3.rs-911958/v1
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Huey, E. D., Hardy, J., & Small, S. A. (2015) · doi:10.1002/9781118753378.ch24 · Cited by 1
Duda, J. E., Lee, V. M. ‐., & Trojanowski, J. Q. (2001) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-8225-5_15 · Cited by 1
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Galasko, D. R. (2005) · Research and perspectives in Alzheimer's disease · doi:10.1007/3-540-26522-8_5 · Cited by 1
Molecular Biology of Lewy Body Formation
Spillantini, M. G., & Tofaris, G. K. (2002) · Advances in behavioral biology · doi:10.1007/978-0-306-47593-1_83
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Malkus, K. A. (2011) · Scholarly Commons (University of Pennsylvania)
Galasko, D. R. (2003) · doi:10.1002/9780470752340.ch21
Biomarkers and Surrogate Markers in Drug Development
Cutler, N. R., Sramek, J. J., Murphy, M. F., Riordan, H., Bieck, P. R., & Carta, A. (2010) · Wiley eBooks · doi:10.1002/9781444318579.ch4
Hardy, J. (2011) · Wiley eBooks · doi:10.1002/9781444341256.ch6
Oinas, M. (2009) · Työväentutkimus Vuosikirja
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Rey, N. L., Angot, É., Dunning, C. J. R., Steiner, J. A., & Brundin, P. (2013) · Research and perspectives in Alzheimer's disease · doi:10.1007/978-3-642-35491-5_8
Mehring, B., Lin, J. C. Y., Wilson, D., & Lippa, C. F. (2000) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/153331750001500507
Self-citationGarcía, E. M. (2001) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
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Pienaar, I. S. (2008) · SUNScholar (Stellenbosch University)
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Self-citation
Metadata
- Authors
- Lippa, C. F., Fujiwara, H., Mann, D. M. A., Giasson, B., Baba, M., Schmidt, M. L., Nee, L. E., O'Connell, B., Pollen, D. A., St. George-Hyslop, P., Ghetti, B., Nochlin, D., Bird, T. D., Cairns, N. J., Lee, V. M.-Y., Iwatsubo, T., & Trojanowski, J. Q.
- Affiliations
- The University of Tokyo (JP)
- University of Manchester (GB)
- University of Pennsylvania (US)
- National Institute of Neurological Disorders and Stroke (US)
- University of Massachusetts Chan Medical School (US)
- Indiana University Hospital (US)
- University of Washington (US)
- Corresponding author
- Lippa, Carol F.
- ORCID
- Venue
- The American Journal of Pathology
- Publisher
- Elsevier BV
- Published
- 1998-11
- Volume
- 153
- Issue
- 5
- Pages
- 1365-1370
- ISSN
- 0002-9440 (ISSN-L)
- PMC
- PMC1853391
- OpenAlex
- W2066155243
- Cited by
- 533
- References
- 35
- Citations by year
- 2026: 10 · 2025: 17 · 2024: 23 · 2023: 16 · 2022: 19 · 2021: 21 · 2020: 19 · 2019: 17 · 2018: 16 · 2017: 9 · 2016: 11 · 2015: 13 · 2014: 25 · 2013: 13 · 2012: 11
- FWCI
- 17.79
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- American Journal Of Pathology (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (7r29ag013623-06)
- National Institute on Aging (P30AG010133, AG09215, U01AG006781, AG13623, P30AG010124, P01AG009215, AG-10124, P50AG005136)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Lewy bodies, alpha-synuclein, familial Alzheimer's disease, presenilin mutations, amyloid precursor protein mutations, amygdala, alpha-synuclein aggregation, protein insolubility, immunoelectron microscopy
- MeSH terms
- Adult, Aged, Alzheimer Disease, Brain, Female, Humans, Immunohistochemistry, Male, Membrane Proteins, Middle Aged, Mutation, Nerve Tissue Proteins, Blotting, Western, Microscopy, Immunoelectron, Amyloid beta-Protein Precursor, Lewy Bodies, Synucleins, alpha-Synuclein, gamma-Synuclein, Presenilin-1
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