Effects of cardiopulmonary bypass on leukocyte and endothelial adhesion molecules
Abstract
During the inflammatory response, triggered by cardiopulmonary bypass, interaction between activated leukocytes, platelets, and endothelial cells is mediated through the expression of three main groups of adhesion molecules: the selectins, the integrins, and the immunoglobulin superfamily. The selectins, which mediate the initial rolling of the leukocyte on the endothelium, are divided in three subgroups: L-selectin is expressed on all three leukocyte types, P-selectin is expressed on platelets and endothelial cells, and E-selectin is only expressed on endothelial cells. Integrins can be found on most cell types, consist of an alpha and a beta subunit and mediate firm adhesion of the leukocyte and migration into the tissues. They are classified into subgroups according to the type of their beta subunit. Immunoglobulins such as ICAM-1 and VCAM-1 are expressed mainly on endothelium and act as ligands for certain integrins. This review article summarizes the existing, and rapidly expanding, literature concerning the effects of cardiopulmonary bypass on the expression of leukocyte and endothelial adhesion molecules. Deeper understanding of the, behavior and the role of adhesion molecules during cardiopulmonary bypass may facilitate effective intervention in the inflammatory response process and suppression of its adverse effects.
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Exposure of blood elements to the foreign surface of the bypass circuit induces a systemic inflammatory response, leading to capillary leak, edema formation, and myocardial diastolic and systolic dysfunction.
“The exposure of the patient’s blood elements to the foreign surface of the bypass circuit induces a systemic inflammatory response, leading to capillary leak, edema formation, and myocardial diastolic and systolic dysfunction [3-6].”
From Management of the Low Cardiac Output Syndrome Following Surgery for Congenital Heart Disease (2016) · cites this paper as [3]
The systemic and regional inflammatory response with cardiopulmonary bypass and reperfusion injury increases total body oxygen demand while impairing oxygenation, cardiac output, and systemic oxygen delivery.
“The systemic and regional inflammatory response that occurs with cardiopulmonary bypass and reperfusion injury increases total body oxygen demand while impairing oxygenation, cardiac output and systemic oxygen delivery [3-6].”
From Management of the Low Cardiac Output Syndrome Following Surgery for Congenital Heart Disease (2016) · cites this paper as [3]
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Ridker, P. M., Hennekens, C. H., Roitman-Johnson, B., Stampfer, M. J., & Allen, J. (1998) · The Lancet · doi:10.1016/s0140-6736(97)09032-6 · Cited by 1,229 · see citing works
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Gorbet, M. B., & Sefton, M. V. (2004) · Biomaterials · doi:10.1016/j.biomaterials.2004.01.023 · Cited by 1,347 · see citing works
Management of the Low Cardiac Output Syndrome Following Surgery for Congenital Heart Disease
K. Chandler, H., & Kirsch, R. (2016) · Current Cardiology Reviews · doi:10.2174/1573403x12666151119164647 · Cited by 74 · see citing works
“The systemic and regional inflammatory response that occurs with cardiopulmonary bypass and reperfusion injury increases total body oxygen demand while impairing oxygenation, cardiac output and systemic oxygen delivery [3-6].”
BackgroundFung, Y. L., Silliman, C. C., Minchinton, R. M., Wood, P., & Fraser, J. F. (2008) · Shock · doi:10.1097/shk.0b013e318173e717 · Cited by 17 · see citing works
- Authors
- Asimakopoulos, G., & Taylor, K. M.
- Affiliations
- Hammersmith Hospital (GB)
- Corresponding author
- Taylor, Kenneth M
- Venue
- The Annals of Thoracic Surgery
- Publisher
- Elsevier BV
- Published
- 1998-12
- Volume
- 66
- Issue
- 6
- Pages
- 2135-2144
- ISSN
- 0003-4975 (ISSN-L)
- OpenAlex
- W2058700103
- Cited by
- 173
- References
- 1
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 1 · 2020: 3 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 5 · 2015: 4 · 2014: 5 · 2013: 6 · 2012: 11
- FWCI
- 2.98
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Annals of Thoracic Surgery (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Cardiac and Coronary Surgery Techniques
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Health Sciences › Medicine › Biochemistry › Blood transfusion and management
- Keywords
- cardiopulmonary bypass, adhesion molecules, leukocyte-endothelium interaction, selectins, integrins, immunoglobulin superfamily, L-selectin, P-selectin, E-selectin, ICAM-1, VCAM-1, inflammation, endothelial cells, platelets, leukocyte adhesion
- MeSH terms
- Animals, Cardiopulmonary Bypass, Humans, Inflammation, Cell Adhesion Molecules, Systemic Inflammatory Response Syndrome, Inflammation Mediators
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