Cited by 169Mitochondrial Function and PathologyATP Synthase and ATPases ResearchAdipose Tissue and Metabolism

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Mitochondrial proton leak and the uncoupling protein 1 homologues

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Stuart, J.A, Cadenas, S, Jekabsons, M.B, Roussel, D, Brand, M.D·2001·Biochimica et Biophysica Acta (BBA) - Bioenergetics

DOI 10.1016/s0005-2728(00)00243-7

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Abstract

Mitochondrial proton leak is the largest single contributor to the standard metabolic rate (SMR) of a rat, accounting for about 20% of SMR. Yet the mechanisms by which proton leak occurs are incompletely understood. The available evidence suggests that both phospholipids and proteins in the mitochondrial inner membrane are important determinants of proton conductance. The uncoupling protein 1 homologues (e.g. UCP2, UCP3) may play a role in mediating proton leak, but it is unlikely they account for all of the observed proton conductance. Experimental data regarding the functions of these proteins include important ambiguities and contradictions which must be addressed before their function can be confirmed. The physiological role of the proton leak, and of the uncoupling protein 1 homologues, remains similarly unclear.

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Authors: Stuart, J. A., Cadenas, S., Jekabsons, M. B., Roussel, D., & Brand, M. D.
Affiliations: University of Cambridge (GB)
MRC Mitochondrial Biology Unit (GB)
Corresponding author: Brand, M.D
ORCID: Stuart, J.A
Cadenas, S
Jekabsons, M.B
Roussel, D
Brand, M.D
Venue: Biochimica et Biophysica Acta (BBA) - Bioenergetics
Publisher: Elsevier BV
Published: 2001-03
Volume: 1504
Issue: 1
Pages: 144-158
ISSN: 0005-2728 (ISSN-L)
DOI: 10.1016/s0005-2728(00)00243-7
OpenAlex: W2051826214
Cited by: 169
References: 74
Citations by year: 2026: 3 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 4 · 2021: 3 · 2020: 7 · 2019: 4 · 2018: 6 · 2017: 3 · 2016: 2 · 2015: 4 · 2014: 2 · 2013: 5 · 2012: 5
FWCI: 1.51
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 4522 d)
Locations: Biochimica et Biophysica Acta (BBA) - Bioenergetics (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › ATP Synthase and ATPases Research
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Keywords: mitochondrial proton leak, UCP2, UCP3, inner mitochondrial membrane, proton conductance, standard metabolic rate, mitochondrial membrane phospholipids, mitochondrial membrane proteins
MeSH terms: Uncoupling Protein 2, Uncoupling Protein 3, Uncoupling Protein 1, Amino Acid Sequence, Animals, Basal Metabolism, Carrier Proteins, Diffusion, Humans, Intracellular Membranes, Ion Channels, Membrane Proteins, Mitochondria, Molecular Sequence Data, Proteins, Protons, RNA, Messenger, Sequence Alignment, Sequence Homology, Models, Animal, Mitochondrial Proteins, Membrane Transport Proteins, Animals, Genetically Modified

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Mitochondrial proton leak and the uncoupling protein 1 homologues

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