Cited by 169Mitochondrial Function and PathologyATP Synthase and ATPases ResearchAdipose Tissue and Metabolism

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Mitochondrial proton leak and the uncoupling protein 1 homologues

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Stuart, J.A, Cadenas, S, Jekabsons, M.B, Roussel, D, Brand, M.D·2001·Biochimica et Biophysica Acta (BBA) - Bioenergetics

DOI 10.1016/s0005-2728(00)00243-7

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Abstract

Mitochondrial proton leak is the largest single contributor to the standard metabolic rate (SMR) of a rat, accounting for about 20% of SMR. Yet the mechanisms by which proton leak occurs are incompletely understood. The available evidence suggests that both phospholipids and proteins in the mitochondrial inner membrane are important determinants of proton conductance. The uncoupling protein 1 homologues (e.g. UCP2, UCP3) may play a role in mediating proton leak, but it is unlikely they account for all of the observed proton conductance. Experimental data regarding the functions of these proteins include important ambiguities and contradictions which must be addressed before their function can be confirmed. The physiological role of the proton leak, and of the uncoupling protein 1 homologues, remains similarly unclear.

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Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia
Fleury, C., Neverova, M., Collins, S., Raimbault, S., Champigny, O., Lévi-Meyrueis, C., Bouillaud, F., Seldin, M. F., Surwit, R. S., Ricquier, D., et al. (1997) · Nature Genetics · doi:10.1038/ng0397-269 · Cited by 1,630
Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese
Enerbäck, S., Jacobsson, A., Simpson, E. M., Guerra, C., Yamashita, H., Harper, M.-E., & Kozak, L. P. (1997) · Nature · doi:10.1038/387090a0 · Cited by 1,379
Uncoupling protein‐3: a new member of the mitochondrial carrier family with tissue‐specific expression
Boss, O., Samec, S., Paoloni‐Giacobino, A., Rossier, C., Dulloo, A. G., Seydoux, J., Muzzin, P., & Giacobino, J. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)00384-0 · Cited by 1,041
Uncoupling: new approaches to an old problem of bioenergetics
Skulachev, V. P. (1998) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(97)00091-1 · Cited by 893
Phospholipid vesicle formation and transmembrane protein incorporation using octyl glucoside
Mimms, L. T., Zampighi, G. A., Nozaki, Y., Tanford, C., & Reynolds, J. A. (1981) · Biochemistry · doi:10.1021/bi00507a028 · Cited by 679
Energy metabolism in uncoupling protein 3 gene knockout mice
Vidal-Puig, A. J., Grujic, D., Zhang, C.-Y., Hagen, T., Boss, O., Ido, Y., Szczepanik, A., Wade, J., Mootha, V., Cortright, R., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m910179199 · Cited by 677
Synthetic Amphiphilic Peptide Models for Protein Ion Channels
Lear, J. D., Wasserman, Z. R., & DeGrado, W. F. (1988) · Science · doi:10.1126/science.2453923 · Cited by 607
Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean
Clapham, J. C., Arch, J. R. S., Chapman, H., Haynes, A., Lister, C., Moore, G. B. T., Piercy, V., Carter, S. A., Lehner, I., Smith, S. A., et al. (2000) · Nature · doi:10.1038/35019082 · Cited by 604
Self-citation
Permeation of protons, potassium ions, and small polar molecules through phospholipid bilayers as a function of membrane thickness
Paula, S., Volkov, A. G., Van Hoek, A. N., Haines, T. H., & Deamer, D. W. (1996) · Biophysical Journal · doi:10.1016/s0006-3495(96)79575-9 · Cited by 578
Reactive oxygen species, mitochondria, apoptosis and aging
Papa, S., & Skulachev, V. P. (1997) · Springer eBooks · doi:10.1007/978-1-4615-6111-8_47 · Cited by 467

Show all 74 references

Research works printed but not linked: 5

B. Cannon, A. Matthias, V. Golozoubova, K.B.E. Ohlson, U. Andersson, A. Jacobsson, J. Nedergaard, Unifying and distinguishing features of brown and white adipose tissues: UCP1 versus other UCPs, in: G. Ailhaud, B. Guy-Grands (Eds.), Progress in Obesity Research, John Libbey and Company, 1999, pp. 13–26.
Ricquier, 2000, The UCP family: where are we?, Int. J. Obes., 24, S10
Stuart, 2000, An uncoupling artifact can accompany uncoupling protein-1 expression in yeast mitochondria, Int. J. Obes., 24, S187
Cadenas, 2000, Human uncoupling protein-3 overexpression increases mitochondrial proton leak, Int. J. Obes., 24, S187
M.B. Jekabsons, B.A. Horwitz, Nucleotide effects on liver and muscle mitochondrial nonphosphorylating respiration and membrane potential, Biochim. Biophys. Acta, in press.

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Authors: Stuart, J. A., Cadenas, S., Jekabsons, M. B., Roussel, D., & Brand, M. D.
Affiliations: University of Cambridge (GB)
MRC Mitochondrial Biology Unit (GB)
Corresponding author: Brand, M.D
ORCID: Stuart, J.A
Cadenas, S
Jekabsons, M.B
Roussel, D
Brand, M.D
Venue: Biochimica et Biophysica Acta (BBA) - Bioenergetics
Publisher: Elsevier BV
Published: 2001-03
Volume: 1504
Issue: 1
Pages: 144-158
ISSN: 0005-2728 (ISSN-L)
DOI: 10.1016/s0005-2728(00)00243-7
OpenAlex: W2051826214
Cited by: 169
References: 74
Citations by year: 2026: 3 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 4 · 2021: 3 · 2020: 7 · 2019: 4 · 2018: 6 · 2017: 3 · 2016: 2 · 2015: 4 · 2014: 2 · 2013: 5 · 2012: 5
FWCI: 1.51
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 4522 d)
Locations: Biochimica et Biophysica Acta (BBA) - Bioenergetics (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › ATP Synthase and ATPases Research
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Keywords: mitochondrial proton leak, UCP2, UCP3, inner mitochondrial membrane, proton conductance, standard metabolic rate, mitochondrial membrane phospholipids, mitochondrial membrane proteins
MeSH terms: Uncoupling Protein 2, Uncoupling Protein 3, Uncoupling Protein 1, Amino Acid Sequence, Animals, Basal Metabolism, Carrier Proteins, Diffusion, Humans, Intracellular Membranes, Ion Channels, Membrane Proteins, Mitochondria, Molecular Sequence Data, Proteins, Protons, RNA, Messenger, Sequence Alignment, Sequence Homology, Models, Animal, Mitochondrial Proteins, Membrane Transport Proteins, Animals, Genetically Modified

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Mitochondrial proton leak and the uncoupling protein 1 homologues

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