Brand, Martin D.

Topology of superoxide production from different sites in the mitochondrial electron transport chain

St-Pierre, J., Buckingham, J. A., Roebuck, S. J., & Brand, M. D. (2002) · Journal of Biological Chemistry

Mitochondrial Function and PathologyRedox biology and oxidative stress

Cited by 1,545

Superoxide activates mitochondrial uncoupling proteins

Echtay, K. S., Roussel, D., St-Pierre, J., Jekabsons, M. B., Cadenas, S., Stuart, J. A., Harper, J. A., Roebuck, S. J., Morrison, A., Pickering, S., et al. (2002) · Nature

Mitochondrial Function and PathologyATP Synthase and ATPases Research

Cited by 1,382

The sites and topology of mitochondrial superoxide production

Brand, M. D. (2010) · Experimental Gerontology

Mitochondrial Function and PathologyRedox biology and oxidative stress

Cited by 1,217

Mitochondrial generation of superoxide and hydrogen peroxide as the source of mitochondrial redox signaling

Brand, M. D. (2016) · Free Radical Biology and Medicine

Mitochondrial Function and PathologyRedox biology and oxidative stress

Cited by 1,063

Mitochondrial superoxide: production, biological effects, and activation of uncoupling proteins

Brand, M. D., Affourtit, C., Esteves, T. C., Green, K., Lambert, A. J., Miwa, S., Pakay, J. L., & Parker, N. (2004) · Free Radical Biology and Medicine

Mitochondrial Function and PathologyRedox biology and oxidative stress

Cited by 1,032

Mitofusin-2 Determines Mitochondrial Network Architecture and Mitochondrial Metabolism

Bach, D., Pich, S., Soriano, F. X., Vega, N., Baumgartner, B., Oriola, J., Daugaard, J. R., Lloberas, J., Camps, M., Zierath, J. R., et al. (2003) · Journal of Biological Chemistry

Mitochondrial Function and PathologyAutophagy in Disease and Therapy

Cited by 832

Mitochondrial proton and electron leaks

Jastroch, M., Divakaruni, A. S., Mookerjee, S., Treberg, J. R., & Brand, M. D. (2010) · Essays in Biochemistry

Mitochondrial Function and PathologyATP Synthase and ATPases Research

Cited by 829

Uncoupling to survive? The role of mitochondrial inefficiency in ageing

Brand, M. D. (2000) · Experimental Gerontology

Mitochondrial Function and PathologyGenetics, Aging, and Longevity in Model Organisms

Cited by 789

Physiological functions of the mitochondrial uncoupling proteins UCP2 and UCP3

Brand, M. D., & Esteves, T. C. (2005) · Cell Metabolism

Mitochondrial Function and PathologyAdipose Tissue and Metabolism

Cited by 785

Uncoupled and surviving: individual mice with high metabolism have greater mitochondrial uncoupling and live longer

Speakman, J. R., Talbot, D. A., Selman, C., Snart, S., McLaren, J. S., Redman, P., Krol, E., Jackson, D. M., Johnson, M. S., & Brand, M. D. (2004) · Aging Cell

Genetics, Aging, and Longevity in Model OrganismsMitochondrial Function and Pathology

Cited by 761

Mitochondrial Complex II Can Generate Reactive Oxygen Species at High Rates in Both the Forward and Reverse Reactions

Quinlan, C. L., Orr, A. L., Perevoshchikova, I. V., Treberg, J. R., Ackrell, B. A., & Brand, M. D. (2012) · Journal of Biological Chemistry

Mitochondrial Function and PathologyRedox biology and oxidative stress

Cited by 670

Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean

Clapham, J. C., Arch, J. R. S., Chapman, H., Haynes, A., Lister, C., Moore, G. B. T., Piercy, V., Carter, S. A., Lehner, I., Smith, S. A., et al. (2000) · Nature

Adipose Tissue and MetabolismMetabolism, Diabetes, and Cancer

Cited by 604

Prevention of mitochondrial oxidative damage as a therapeutic strategy in diabetes

Green, K., Brand, M. D., & Murphy, M. P. (2004) · Diabetes

Mitochondrial Function and PathologyPancreatic function and diabetes

Cited by 490

Inhibitors of the quinone-binding site allow rapid superoxide production from mitochondrial nadh:Ubiquinone oxidoreductase (complex i)

Lambert, A. J., & Brand, M. D. (2004) · Journal of Biological Chemistry

Mitochondrial Function and PathologyCoenzyme Q10 studies and effects

Cited by 480

Superoxide production by NADH:ubiquinone oxidoreductase (complex I) depends on the pH gradient across the mitochondrial inner membrane

LAMBERT, A. J., & BRAND, M. D. (2004) · Biochemical Journal

Mitochondrial Function and PathologyCoenzyme Q10 studies and effects

Cited by 470

The causes and functions of mitochondrial proton leak

Brand, M. D., Chien, L.-F., Ainscow, E. K., Rolfe, D. F. S., & Porter, R. K. (1994) · Biochimica et Biophysica Acta (BBA) - Bioenergetics

Mitochondrial Function and PathologyATP Synthase and ATPases Research

Cited by 466

The basal proton conductance of mitochondria depends on adenine nucleotide translocase content

Brand, M. D., Pakay, J. L., Ocloo, A., Kokoszka, J., Wallace, D. C., Brookes, P. S., & Cornwall, E. J. (2005) · Biochemical Journal

Mitochondrial Function and PathologyATP Synthase and ATPases Research

Cited by 410

The efficiency and plasticity of mitochondrial energy transduction.

Brand, M. D. (2005) · Biochemical Society Transactions

Mitochondrial Function and PathologyATP Synthase and ATPases Research

Cited by 406

Superoxide Activates Mitochondrial Uncoupling Protein 2 from the Matrix Side

Echtay, K. S., Murphy, M. P., Smith, R. A. J., Talbot, D. A., & Brand, M. D. (2002) · Journal of Biological Chemistry

Mitochondrial Function and PathologyRedox biology and oxidative stress

Cited by 388

Sites of superoxide and hydrogen peroxide production by muscle mitochondria assessed ex vivo under conditions mimicking rest and exercise

Goncalves, R. L. S., Quinlan, C. L., Perevoshchikova, I. V., Hey-Mogensen, M., & Brand, M. D. (2015) · Journal of Biological Chemistry

Mitochondrial Function and PathologyRedox biology and oxidative stress

Cited by 329

The 2-oxoacid dehydrogenase complexes in mitochondria can produce superoxide/hydrogen peroxide at much higher rates than complex I

Quinlan, C. L., Goncalves, R. L. S., Hey-Mogensen, M., Yadava, N., Bunik, V. I., & Brand, M. D. (2014) · Journal of Biological Chemistry

Mitochondrial Function and PathologyBiochemical Acid Research Studies

Cited by 310

Mitochondrial uncoupling as a target for drug development for the treatment of obesity.

Harper, J. A., Dickinson, K., & Brand, M. D. (2001) · Obesity Reviews

Adipose Tissue and MetabolismMitochondrial Function and Pathology

Cited by 250

The on-off switches of the mitochondrial uncoupling proteins

Azzu, V., & Brand, M. D. (2010) · Trends in Biochemical Sciences

Mitochondrial Function and PathologyAdipose Tissue and Metabolism

Cited by 239

Suppressors of Superoxide-H 2 O 2 Production at Site I Q of Mitochondrial Complex I Protect against Stem Cell Hyperplasia and Ischemia-Reperfusion Injury

Brand, M. D., Goncalves, R. L. S., Orr, A. L., Vargas, L., Gerencser, A. A., Borch Jensen, M., Wang, Y. T., Melov, S., Turk, C. N., Matzen, J. T., et al. (2016) · Cell Metabolism

Mitochondrial Function and PathologyRedox biology and oxidative stress

Cited by 228