Treatment of pharmacotherapy-refractory posttraumatic stress disorder among Cambodian refugees: a pilot study of combination treatment with cognitive-behavior therapy vs sertraline alone
Abstract
Cambodian refugees with posttraumatic stress disorder (PTSD) represent a cohort in severe need of treatment, but little information is available to guide treatment choices. We selected a sample of pharmacotherapy-refractory individuals to test the efficacy of combination treatment with sertraline and cognitive-behavior therapy (CBT) for treating PTSD. Participants in this pilot study were ten Khmer-speaking women who had been at a mean age of 22-26 years during the Pol Pot period (1975-1979). These patients were randomly assigned to either sertraline alone or combined treatment. We found that combined treatment offered additional benefit in the range of medium to large effect sizes for PTSD and associated symptoms. Our findings indicate that substantial gains can be achieved by adding CBT to pharmacotherapy for PTSD, and that a program of CBT emphasizing information, exposure, and cognitive-restructuring can be successfully modified for Khmer-speaking refugees.
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The four studies identified by that Cochrane review were all conducted on fairly small patient groups, and only one very small study (n = 10) included refugees.
“These studies were all conducted on fairly small patient groups (the largest group had 65 participants for randomisation), and only one very small study (n = 10) included refugees [11].”
From Treatment of trauma-affected refugees with venlafaxine versus sertraline combined with psychotherapy - a randomised study (2016) · cites this paper as [11]
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- Authors
- Otto, M. W., Hinton, D., Korbly, N. B., Chea, A., Ba, P., Gershuny, B. S., & Pollack, M. H.
- Affiliations
- Harvard University (US)
- North Suffolk Mental Health Association (US)
- Corresponding author
- Otto, Michael W.
- Venue
- Behaviour Research and Therapy
- Publisher
- Elsevier BV
- Published
- 2003-11
- Volume
- 41
- Issue
- 11
- Pages
- 1271-1276
- ISSN
- 0005-7967 (ISSN-L)
- OpenAlex
- W2095335279
- Cited by
- 194
- References
- 18
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 3 · 2022: 5 · 2021: 6 · 2020: 10 · 2019: 7 · 2018: 10 · 2017: 11 · 2016: 10 · 2015: 9 · 2014: 15 · 2013: 9 · 2012: 7
- FWCI
- 12.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behaviour Research and Therapy (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Van Ameringen Foundation
- Pfizer Pharmaceuticals
- Topics
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Social Sciences › Psychology › Clinical Psychology › Migration, Health and Trauma
- Social Sciences › Psychology › Clinical Psychology › Psychoanalysis and Psychopathology Research
- Keywords
- post-traumatic stress disorder, sertraline, cognitive behavioral therapy, combination therapy, Cambodian refugees, trauma exposure, cognitive restructuring, culturally tailored interventions
- MeSH terms
- Adult, Antidepressive Agents, Cambodia, Combined Modality Therapy, Female, Humans, Middle Aged, Pilot Projects, Refugees, Stress Disorders, Post-Traumatic, United States, Cognitive Behavioral Therapy, Sertraline
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