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A unique central tryptophan hydroxylase isoform

Walther, Diego J., Bader, Michael·2003·Biochemical Pharmacology
DOI 10.1016/s0006-2952(03)00556-2
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Research works printed but not linked: 93

  1. Ramamoorthy, 1993, Antidepressant- and cocaine-sensitive human serotonin transporter: molecular cloning, expression, and chromosomal localization, Proc. Natl. Acad. Sci. U.S.A., 90, 2542, 10.1073/pnas.90.6.2542 · DOI · Paper page
  2. Cases, 1995, Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAOA, Science, 268, 1763, 10.1126/science.7792602 · DOI · Paper page
  3. Tecott, 1995, Eating disorder and epilepsy in mice lacking 5-HT2c serotonin receptors, Nature, 374, 542, 10.1038/374542a0 · DOI · Paper page
  4. Rocha, 1998, Increased vulnerability to cocaine in mice lacking the serotonin-1B receptor, Nature, 393, 175, 10.1038/30259 · DOI · Paper page
  5. Parks, 1998, Increased anxiety of mice lacking the serotonin1A receptor, Proc. Natl. Acad. Sci. U.S.A., 95, 10734, 10.1073/pnas.95.18.10734 · DOI · Paper page
  6. Gainetdinov, 1999, Role of serotonin in the paradoxical calming effect of psychostimulants on hyperactivity, Science, 283, 397, 10.1126/science.283.5400.397 · DOI · Paper page
  7. Grahame-Smith, 1964, Tryptophan hydroxylation in brain, Biochem. Biophys. Res. Commun., 16, 586, 10.1016/0006-291X(64)90197-4 · DOI · Paper page
  8. Lovenberg, 1967, Tryptophan hydroxylation: measurement in pineal gland, brainstem, and carcinoid tumor, Science, 155, 217, 10.1126/science.155.3759.217 · DOI · Paper page
  9. Jequier, 1969, Further studies on tryptophan hydroxylase in rat brainstem and beef pineal, Biochem. Pharmacol., 18, 1071, 10.1016/0006-2952(69)90111-7 · doi:10.1016/0006-2952(69)90111-7
  10. Dahlström, 1964, Evidence for the existence of monoamine-containing neurons in the central nervous system. I. Demonstration of monoamines in the cell bodies of brain stem neurons, Acta Physiol. Scand. Suppl., 232, 1
  11. Reuss, 1996, Components and connections of the circadian timing system in mammals, Cell Tissue Res., 285, 353, 10.1007/s004410050652 · DOI
  12. Sallanon, 1982, Presence of melatonin in various cat brainstem nuclei determined by radioimmunoassay, Acta Endocrinol. (Copenh), 101, 161, 10.1530/acta.0.1010161 · doi:10.1530/acta.0.1010161
  13. Miguez, 1997, Melatonin effects on serotonin synthesis and metabolism in the striatum, nucleus accumbens, and dorsal and median raphe nuclei of rats, Neurochem. Res., 22, 87, 10.1023/A:1027337606929 · doi:10.1023/a:1027337606929
  14. Coon, 1996, The human serotonin N-acetyltransferase (EC 2.3.1.87) gene (AANAT): structure, chromosomal localization, and tissue expression, Genomics, 34, 76, 10.1006/geno.1996.0243 · DOI
  15. Fiorica-Howells, 2000, Serotonin and the 5-HT(2B) receptor in the development of enteric neurons, J. Neurosci., 20, 294, 10.1523/JNEUROSCI.20-01-00294.2000 · DOI
  16. Walther, 1999, Serotonin synthesis in murine embryonic stem cells, Brain Res. Mol. Brain Res., 68, 55, 10.1016/S0169-328X(99)00046-7 · DOI
  17. Finocchiaro, 1988, Serotonin and melatonin synthesis in peripheral blood mononuclear cells: stimulation by interferon-gamma as part of an immunomodulatory pathway, J. Interferon Res., 8, 705, 10.1089/jir.1988.8.705 · DOI
  18. Weber, 1965, A study of 5-hydroxytryptamine formation from l-tryptophan in the brain and other tissues, Biochem. Pharmacol., 14, 1141, 10.1016/0006-2952(65)90044-4 · DOI
  19. Champier, 1997, Evidence for tryptophan hydroxylase and hydroxy-indol-O-methyl-transferase mRNAs in human blood platelets, Life Sci., 60, 2191, 10.1016/S0024-3205(97)00234-8 · DOI
  20. Rapport, 1948, Crystalline serotonin, Science, 108, 329, 10.1126/science.108.2804.329 · DOI · Paper page
  21. Chester, 1990, 5-Hydroxytryptamine receptor profile in healthy and diseased human epicardial coronary arteries, Cardiovasc. Res., 24, 932, 10.1093/cvr/24.11.932 · doi:10.1093/cvr/24.11.932
  22. Hixson, 1977, Contractile responses to tryptamine analogues in isolated smooth muscle, Arch. Int. Pharmacodyn. Ther., 229, 4
  23. Holland, 1976, Serotonin deficiency and prolonged bleeding in beige mice, Proc. Soc. Exp. Biol. Med., 151, 32, 10.3181/00379727-151-39137 · DOI
  24. Geba, 1996, Delayed-type hypersensitivity in mast cell-deficient mice: dependence on platelets for expression of contact sensitivity, J. Immunol., 157, 557, 10.4049/jimmunol.157.2.557 · doi:10.4049/jimmunol.157.2.557
  25. Hufton, 1995, Structure and function of the aromatic amino acid hydroxylases, Biochem. J., 311, 353, 10.1042/bj3110353 · DOI · Paper page
  26. Fitzpatrick, 1999, Tetrahydropterin-dependent amino acid hydroxylases, Annu. Rev. Biochem., 68, 355, 10.1146/annurev.biochem.68.1.355 · DOI · Paper page
  27. Kobe, 1999, Structural basis of autoregulation of phenylalanine hydroxylase, Nat. Struct. Biol., 6, 442, 10.1038/8247 · DOI
  28. Cash, 1998, Why tryptophan hydroxylase is difficult to purify: a reactive oxygen-derived species-mediated phenomenon that may be implicated in human pathology, Gen. Pharmacol., 30, 569, 10.1016/S0306-3623(97)00308-X · DOI
  29. Mockus, 1998, Advances in the molecular characterization of tryptophan hydroxylase, J. Mol. Neurosci., 10, 163, 10.1007/BF02761772 · DOI
  30. Grenett, 1987, Full-length cDNA for rabbit tryptophan hydroxylase: functional domains and evolution of aromatic amino acid hydroxylases, Proc. Natl. Acad. Sci. U.S.A., 84, 5530, 10.1073/pnas.84.16.5530 · DOI · Paper page
  31. Stoll, 1990, Characterization and chromosomal mapping of a cDNA encoding tryptophan hydroxylase from a mouse mastocytoma cell line, Genomics, 7, 88, 10.1016/0888-7543(90)90522-V · DOI
  32. Darmon, 1988, Sequence of two mRNAs encoding active rat tryptophan hydroxylase, J. Neurochem., 51, 312, 10.1111/j.1471-4159.1988.tb04871.x · DOI
  33. Boularand, 1990, Complete coding sequence of human tryptophan hydroxylase, Nucleic Acids Res., 18, 4257, 10.1093/nar/18.14.4257 · DOI
  34. Stoll, 1991, Isolation and structural characterization of the murine tryptophan hydroxylase gene, J. Neurosci. Res., 28, 457, 10.1002/jnr.490280402 · DOI
  35. Ledley, 1987, Assignment of human tryptophan hydroxylase locus to chromosome 11: gene duplication and translocation in evolution of aromatic amino acid hydroxylases, Somat. Cell Mol. Genet., 13, 575, 10.1007/BF01534499 · DOI
  36. Craig, 1991, Localization of human tryptophan hydroxylase (TPH) to chromosome 11p15.3-p14 by in situ hybridization, Cytogenet. Cell Genet., 56, 157, 10.1159/000133075 · DOI
  37. Nielsen, 1992, Genetic mapping of the human tryptophan hydroxylase gene on chromosome 11, using an intronic conformational polymorphism, Am. J. Hum Genet., 51, 1366
  38. Kim, 1991, Molecular cloning and characterization of cDNA encoding tryptophan hydroxylase from rat central serotonergic neurons, Brain Res. Mol. Brain Res., 9, 277, 10.1016/0169-328X(91)90073-7 · DOI
  39. Walther, 2003, Synthesis of serotonin by a second tryptophan hydroxylase isoform, Science, 299, 76, 10.1126/science.1078197 · DOI · Paper page
  40. Cash, 1985, Tryptophan 5-hydroxylase. Rapid purification from whole brain and production of a specific antiserum, Eur. J. Biochem., 149, 239, 10.1111/j.1432-1033.1985.tb08918.x · doi:10.1111/j.1432-1033.1985.tb08918.x
  41. Koe, 1971, Tryptophan hydroxylase inhibitors, Fed. Proc., 30, 886
  42. Nakata, 1982, Tryptophan 5-monooxygenase from mouse mastocytoma P815. A simple purification and general properties, Eur. J. Biochem., 124, 595, 10.1111/j.1432-1033.1982.tb06636.x · DOI
  43. Nakata, 1982, Purification and properties of tryptophan 5-monooxygenase from rat brain-stem, Eur. J. Biochem., 122, 41, 10.1111/j.1432-1033.1982.tb05845.x · DOI
  44. Kuhn, 1980, Comparisons of tryptophan hydroxylase from a malignant murine mast cell tumor and rat mesencephalic tegmentum, Arch. Biochem. Biophys., 199, 355, 10.1016/0003-9861(80)90291-X · doi:10.1016/0003-9861(80)90291-x
  45. Yang, 1994, High-level expression and deletion mutagenesis of human tryptophan hydroxylase, Proc. Natl. Acad. Sci. U.S.A., 91, 6659, 10.1073/pnas.91.14.6659 · DOI
  46. Hasegawa, 1987, Demonstration of non-neural tryptophan 5-mono-oxygenase in mouse intestinal mucosa, Biochem. J., 248, 501, 10.1042/bj2480501 · doi:10.1042/bj2480501
  47. Chung, 2001, Immunochemical characterization of brain and pineal tryptophan hydroxylase, J. Korean Med. Sci., 16, 489, 10.3346/jkms.2001.16.4.489 · DOI
  48. Haycock, 2002, A monoclonal antibody to tryptophan hydroxylase: applications and identification of the epitope, J. Neurosci. Methods, 114, 205, 10.1016/S0165-0270(01)00530-1 · doi:10.1016/s0165-0270(01)00530-1
  49. Dumas, 1989, Differential control of tryptophan hydroxylase expression in raphe and in pineal gland: evidence for a role of translation efficiency, J. Neurosci. Res., 24, 537, 10.1002/jnr.490240412 · DOI
  50. Hart, 1991, Post-transcriptional control of tryptophan hydroxylase gene expression in rat brain stem and pineal gland, Mol. Cell Neurosci., 2, 71, 10.1016/1044-7431(91)90041-L · doi:10.1016/1044-7431(91)90041-l
  51. Austin, 1999, Regional distribution and cellular expression of tryptophan hydroxylase messenger RNA in postmortem human brainstem and pineal gland, J. Neurochem., 72, 2065, 10.1046/j.1471-4159.1999.0722065.x · DOI
  52. Huh, 1994, A 6.1 kb 5′ upstream region of the mouse tryptophan hydroxylase gene directs expression of E. coli lacZ to major serotonergic brain regions and pineal gland in transgenic mice, Mol. Brain Res., 24, 145, 10.1016/0169-328X(94)90126-0 · DOI
  53. Son, 1996, Immortalization of neuroendocrine pinealocytes from transgenic mice by targeted tumorigenesis using the tryptophan hydroxylase promoter, Mol. Brain Res., 37, 32, 10.1016/0169-328X(95)00271-S · DOI
  54. Juillard, 1980, Pools of serotonin in the pineal gland of the mouse: the mammalian pinealocyte as a component of the diffuse neuroendocrine system, Cell Tissue Res., 213, 273, 10.1007/BF00234787 · doi:10.1007/bf00234787
  55. Iida, 2002, Proteasome-driven turnover of tryptophan hydroxylase is triggered by phosphorylation in RBL2H3 cells, a serotonin producing mast cell line, Eur. J. Biochem., 269, 4780, 10.1046/j.1432-1033.2002.03188.x · DOI
  56. Zhou, 1995, Targeted disruption of the tyrosine hydroxylase gene reveals that catecholamines are required for mouse fetal development, Nature, 374, 640, 10.1038/374640a0 · DOI · Paper page
  57. Aldegunde, 1985, Effects of pinealectomy on regional brain serotonin metabolism, Int. J. Neurosci., 26, 9, 10.3109/00207458508985598 · DOI
  58. Jiang, 2000, Identification of substrate orienting and phosphorylation sites within tryptophan hydroxylase using homology-based molecular modeling, J. Mol. Biol., 302, 1005, 10.1006/jmbi.2000.4097 · DOI
  59. McKinney, 2001, Conformation of the substrate and pterin cofactor bound to human tryptophan hydroxylase. Important role of Phe313 in substrate specificity, Biochemistry, 40, 15591, 10.1021/bi015722x · doi:10.1021/bi015722x
  60. Martinez, 2001, A structural approach into human tryptophan hydroxylase and its implications for the regulation of serotonin biosynthesis, Curr. Med. Chem., 8, 1077, 10.2174/0929867013372616 · DOI
  61. Daubner, 2002, Role of tryptophan hydroxylase phe313 in determining substrate specificity, Biochem. Biophys. Res. Commun., 292, 639, 10.1006/bbrc.2002.6719 · DOI
  62. Wang, 2002, Three-dimensional structure of human tryptophan hydroxylase and its implications for the biosynthesis of the neurotransmitters serotonin and melatonin, Biochemistry, 41, 12569, 10.1021/bi026561f · DOI · Paper page
  63. Boadle-Biber, 1980, Activation of tryptophan hydroxylase from slices of rat brain stem incubates with N6, 02′-dibutyryl adenosine-3′:5′-cyclic monophosphate, Biochem. Pharmacol., 29, 669, 10.1016/0006-2952(80)90398-6 · doi:10.1016/0006-2952(80)90398-6
  64. Ehret, 1989, Formal demonstration of the phosphorylation of rat brain tryptophan hydroxylase by Ca2+/calmodulin-dependent protein kinase, J. Neurochem., 52, 1886, 10.1111/j.1471-4159.1989.tb07272.x · DOI
  65. Johansen, 1996, Phosphorylation and activation of tryptophan hydroxylase by exogenous protein kinase A, J. Neurochem., 66, 817, 10.1046/j.1471-4159.1996.66020817.x · DOI
  66. Kuhn, 1997, Phosphorylation and activation of brain tryptophan hydroxylase: identification of serine-58 as a substrate site for protein kinase A, J. Neurochem., 68, 2220, 10.1046/j.1471-4159.1997.68052220.x · doi:10.1046/j.1471-4159.1997.68052220.x
  67. Kumer, 1997, Amino-terminal analysis of tryptophan hydroxylase: protein kinase phosphorylation occurs at serine-58, J. Neurochem., 69, 1738, 10.1046/j.1471-4159.1997.69041738.x · DOI
  68. Yohrling, 2000, Intersubunit binding domains within tyrosine hydroxylase and tryptophan hydroxylase, J. Neurosci. Res., 61, 313, 10.1002/1097-4547(20000801)61:3<313::AID-JNR9>3.0.CO;2-9 · DOI
  69. Yamauchi, 1981, A new activator protein that activates tryptophan 5-monooxygenase and tyrosine 3-monooxygenase in the presence of Ca2+/calmodulin-dependent protein kinase. Purification and characterization, J. Biol. Chem., 256, 5404, 10.1016/S0021-9258(19)69215-X · DOI · Paper page
  70. Ichimura, 1988, Molecular cloning of cDNA coding for brain-specific 14-3-3 protein, a protein kinase-dependent activator of tyrosine and tryptophan hydroxylases, Proc. Natl. Acad. Sci. U.S.A., 85, 7084, 10.1073/pnas.85.19.7084 · DOI · Paper page
  71. Makita, 1990, Involvement of activator protein in the activation of tryptophan hydroxylase by cAMP-dependent protein kinase, FEBS Lett., 268, 185, 10.1016/0014-5793(90)81004-8 · DOI
  72. Furukawa, 1993, Demonstration of the phosphorylation-dependent interaction of tryptophan hydroxylase with the 14-3-3 protein, Biochem. Biophys. Res. Commun., 194, 144, 10.1006/bbrc.1993.1796 · DOI
  73. Banik, 1997, Interaction of phosphorylated tryptophan hydroxylase with 14-3-3 proteins, J. Biol. Chem., 272, 26219, 10.1074/jbc.272.42.26219 · DOI
  74. Kowlessur, 1999, Cloning and expression of recombinant human pineal tryptophan hydroxylase in Escherichia coli: purification and characterization of the cloned enzyme, Biochim. Biophys. Acta, 1434, 317, 10.1016/S0167-4838(99)00184-3 · doi:10.1016/s0167-4838(99)00184-3
  75. Stenfors, 2002, Evidence for involvement of protein kinases in the regulation of serotonin synthesis and turnover in the mouse brain in vivo, J. Neural. Transmembr., 109, 1353, 10.1007/s00702-002-0732-5 · doi:10.1007/s00702-002-0732-5
  76. Chen, 1994, Abnormal fear response and aggressive behavior in mutant mice deficient for alpha-calcium-calmodulin kinase II, Science, 266, 291, 10.1126/science.7939668 · DOI · Paper page
  77. Meek, 1972, Tryptophan 5-hydroxylase: approximation of half-life and rate of axonal transport, J. Neurochem., 19, 1519, 10.1111/j.1471-4159.1972.tb05096.x · doi:10.1111/j.1471-4159.1972.tb05096.x
  78. Sitaram, 1978, Diurnal rhythm and turnover of tryptophan hydroxylase in the pineal gland of the rat, J. Neurochem., 31, 1021, 10.1111/j.1471-4159.1978.tb00142.x · DOI
  79. Mockus, 1997, Carboxyl terminal deletion analysis of tryptophan hydroxylase, Biochim. Biophys. Acta, 1342, 132, 10.1016/S0167-4838(97)00069-1 · doi:10.1016/s0167-4838(97)00069-1
  80. Yohrling, 1999, Identification of amino-terminal sequences contributing to tryptophan hydroxylase tetramer formation, J. Mol. Neurosci., 12, 23, 10.1385/JMN:12:1:23 · doi:10.1385/jmn:12:1:23
  81. Moran, 1998, Expression and characterization of the catalytic core of tryptophan hydroxylase, J. Biol. Chem., 273, 12259, 10.1074/jbc.273.20.12259 · DOI
  82. Bailly, 1993, Platelet serotonin levels in alcoholic patients: changes related to physiological and pathological factors, Psychiatry Res., 47, 57, 10.1016/0165-1781(93)90055-L · doi:10.1016/0165-1781(93)90055-l
  83. Moffitt, 1998, Whole blood serotonin relates to violence in an epidemiological study, Biol. Psychiatry, 43, 446, 10.1016/S0006-3223(97)00340-5 · DOI
  84. Nielsen, 1994, Suicidality and 5-hydroxyindoleacetic acid concentration associated with a tryptophan hydroxylase polymorphism, Arch. Gen. Psychiatry, 51, 34, 10.1001/archpsyc.1994.03950010034005 · DOI · Paper page
  85. Mann, 1997, Possible association of a polymorphism of the tryptophan hydroxylase gene with suicidal behavior in depressed patients, Am. J. Psychiatry, 154, 1451, 10.1176/ajp.154.10.1451 · DOI · Paper page
  86. Lalovic, 2002, Meta-analysis of the association between tryptophan hydroxylase and suicidal behavior, Am. J. Med. Genet., 114, 533, 10.1002/ajmg.10518 · DOI
  87. Rietschel, 2000, Association study of the tryptophan hydroxylase gene and bipolar affective disorder using family-based internal controls, Am. J. Med. Genet., 96, 310, 10.1002/1096-8628(20000612)96:3<310::AID-AJMG15>3.0.CO;2-H · doi:10.1002/1096-8628(20000612)96:3<310::aid-ajmg15>3.0.co;2-h
  88. Souery, 2001, Tryptophan hydroxylase polymorphism and suicidality in unipolar and bipolar affective disorders: a multicenter association study, Biol. Psychiatry, 49, 405, 10.1016/S0006-3223(00)01043-X · DOI
  89. Tang, 2001, Lack of association between the tryptophan hydroxylase gene A218C polymorphism and attention-deficit hyperactivity disorder in Chinese Han population, Am. J. Med. Genet., 105, 485, 10.1002/ajmg.1471 · DOI
  90. Morissette, 1999, Genome-wide search for linkage of bipolar affective disorders in a very large pedigree derived from a homogeneous population in Quebec points to a locus of major effect on chromosome 12q23-q24, Am. J. Med. Genet., 88, 567, 10.1002/(SICI)1096-8628(19991015)88:5<567::AID-AJMG24>3.0.CO;2-8 · DOI
  91. Vandel, 2001, SSRI-induced bleeding: two case reports, Therapie, 56, 445
  92. Layton, 2001, Is there an association between selective serotonin reuptake inhibitors and risk of abnormal bleeding? Results from a cohort study based on prescription event monitoring in England, Eur. J. Clin. Pharmacol., 57, 167, 10.1007/s002280100263 · DOI
  93. Dalton, 2003, Use of selective serotonin reuptake inhibitors and risk of upper gastrointestinal tract bleeding: a population-based cohort study, Arch. Int. Med., 163, 59, 10.1001/archinte.163.1.59 · DOI · Paper page

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Metadata

Authors
Walther, D. J., & Bader, M.
Venue
Biochemical Pharmacology
Publisher
Elsevier BV
Published
2003-11
Volume
66
Issue
9
Pages
1673-1680
ISSN
0006-2952 (ISSN-L)
DOI
10.1016/s0006-2952(03)00556-2
OpenAlex
W2035663126
Cited by
751
References
0
FWCI
7.89
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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