The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Possible association of a polymorphism of the tryptophan hydroxylase gene with suicidal behavior in depressed patients
Abstract
OBJECTIVE: This study was designed to test the hypothesis that serotonin-system-related genes may be correlated with suicide risk. METHOD: Fifty-one unrelated Caucasian inpatients with major depression, with or without a history of suicidal acts, were genotyped for a biallelic polymorphism at the tryptophan hydroxylase locus. RESULTS: The less common tryptophan hydroxylase U allele occurred with greater frequency in the patients who had attempted suicide. A logistic regression analysis confirmed an association between tryptophan hydroxylase genotype and lifetime history of suicide attempts. CONCLUSIONS: Serotonergic-system-related genes may influence the risk of suicide in persons with major depression.
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Citations
Cites
Assessment of suicidal intention: The Scale for Suicide Ideation.
Beck, A. T., Kovacs, M., & Weissman, A. (1979) · Journal of Consulting and Clinical Psychology · doi:10.1037//0022-006x.47.2.343 · Cited by 3,419
Attempted Suicide Characteristics and Cerebrospinal Fluid Amine Metabolites in Depressed Inpatients
Mann, J. (1996) · Neuropsychopharmacology · doi:10.1016/s0893-133x(96)00102-9 · Cited by 178
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Cited by
Nock, M. K., Borges, G., Bromet, E. J., Cha, C. B., Kessler, R. C., & Lee, S. (2008) · Epidemiologic Reviews · doi:10.1093/epirev/mxn002 · Cited by 2,897
Mann, J. J., Huang, Y.-Y., Underwood, M. D., Kassir, S. A., Oppenheim, S., Kelly, T. M., Dwork, A. J., & Arango, V. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.8.729 · Cited by 613
The neurobiology and genetics of suicide and attempted suicide: A focus on the serotonergic system
Mann, J. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00228-1 · Cited by 394
Bondy, B., Buettner, A., & Zill, P. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001803 · Cited by 319
Genetics of the serotonergic system in suicidal behavior
Arango, V., Huang, Y.-Y., Underwood, M. D., & Mann, J. J. (2003) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(03)00048-7 · Cited by 239
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Metadata
- Venue
- American Journal of Psychiatry
- Published
- 1997-10-01
- Volume
- 154
- Issue
- 10
- Pages
- 1451-1453
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W2410025091
- Cited by
- 177
- References
- 2
- FWCI
- 19.77
- Type
- journal article
- Language
- en
- Open access
- closed
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- Possible association of a polymorphism of the tryptophan hydroxylase gene with suicidal behavior in depressed patients. (1997). American Journal of Psychiatry. https://doi.org/10.1176/ajp.154.10.1451
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
