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Tryptophan Hydroxylation: Measurement in Pineal Gland, Brainstem, and Carcinoid Tumor
Abstract
Development of a rapid and sensitive radioassay has permitted study of the conversion of tryptophan to 5-hydroxytryptophan in mammalian tissues. Of normal tissues examined, beef and rat pineal gland contained the highest activity. This is the first direct demonstration of tryptophan hydroxylase in this hydroxyindole-rich tissue. Rat and rabbit brainstem and human carcinoid tumor also had quantities of enzyme that could be measured easily. The reaction requires a reduced pteridine and oxygen and is inhibited by para-chlorophenylalanine.
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Cited by
Indole Metabolism in the Pineal Gland: A Circadian Rhythm in N -Acetyltransferase
Klein, D. C., & Weller, J. L. (1970) · Science · doi:10.1126/science.169.3950.1093 · Cited by 746
Simonneaux, V., & Ribelayga, C. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.2.2 · Cited by 740
The serotonin system in autism spectrum disorder: From biomarker to animal models
Muller, C. L., Anacker, A. M. J., & Veenstra-VanderWeele, J. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2015.11.010 · Cited by 531
Serotonin neurons, neuroplasticity, and homeostasis of neural tissue
Azmitia, E. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00022-6 · Cited by 184
Metadata
- Authors
- Lovenberg, W., Jequier, E., & Sjoerdsma, A.
- Venue
- Science
- Published
- 1967-01-13
- Volume
- 155
- Issue
- 3759
- Pages
- 217-219
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1964119248
- Cited by
- 471
- References
- 0
- FWCI
- 10.88
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lovenberg, W., Jequier, E., & Sjoerdsma, A. (1967). Tryptophan Hydroxylation: Measurement in Pineal Gland, Brainstem, and Carcinoid Tumor. Science. https://doi.org/10.1126/science.155.3759.217
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
