Post stroke depression: epidemiology, pathophysiology, and biological treatment
Abstract
Depression is a common occurrence after stroke and is associated with excess disability, cognitive impairment, and mortality. The authors undertook a systematic review of the English language literature to review several aspects of this illness, including the prevalence of this disorder, the debate on its etiology, and the current understanding of the biological treatment of poststroke depression. Methodological problems encountered in the study of poststroke depression are highlighted throughout the manuscript. The authors conclude that the available evidence supports poststroke depression as being multifactorial in origin and consistent with the biopsychosocial model of mental illness.
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In people with cardiovascular diseases and stroke survivors, MDD is associated with a significant decrease in quality of life.
“In people with cardiovascular diseases and stroke survivors, MDD is associated with increased health care costs and unplanned rehospitalizations23,25, an increased risk of atrial fibrillation and chest pain2, and a significant decrease in quality of life45,46.”
From Comorbidity between major depressive disorder and physical diseases: a comprehensive review of epidemiology, mechanisms and management (2023) · cites this paper as [46]
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Determinants of Quality of Life in the Acute Stage Following Stroke
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Is poststroke depression a vascular depression?
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Pair housing reverses post-stroke depressive behavior in mice
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Atherosclerosis and Incident Depression in Late Life
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Diagnosis and Treatment of Major Depressive Disorder
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- Authors
- Whyte, E. M., & Mulsant, B. H.
- Affiliations
- University of Pittsburgh (US)
- Corresponding author
- Mulsant, Benoit H
- ORCID
- Mulsant, Benoit H
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2002-08
- Volume
- 52
- Issue
- 3
- Pages
- 253-264
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2070191749
- Cited by
- 488
- References
- 126
- Citations by year
- 2026: 8 · 2025: 19 · 2024: 14 · 2023: 11 · 2022: 21 · 2021: 19 · 2020: 20 · 2019: 25 · 2018: 19 · 2017: 21 · 2016: 41 · 2015: 34 · 2014: 27 · 2013: 32 · 2012: 16
- FWCI
- 2.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Public Health Service (MH01613, T32 MH19986)
- Topics
- Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Keywords
- post-stroke depression, stroke, depression prevalence, etiology, pathophysiology, biological treatment, biopsychosocial model, cognitive impairment, disability, mortality
- MeSH terms
- Aged, Antidepressive Agents, Depressive Disorder, Major, Major Depressive Disorder, Humans, Time Factors, Stroke
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