Cited by 488Stroke Rehabilitation and RecoveryTreatment of Major DepressionTranscranial Magnetic Stimulation Studies

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Post stroke depression: epidemiology, pathophysiology, and biological treatment

Whyte, Ellen M, Mulsant, Benoit H·2002·Biological Psychiatry

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Abstract

Depression is a common occurrence after stroke and is associated with excess disability, cognitive impairment, and mortality. The authors undertook a systematic review of the English language literature to review several aspects of this illness, including the prevalence of this disorder, the debate on its etiology, and the current understanding of the biological treatment of poststroke depression. Methodological problems encountered in the study of poststroke depression are highlighted throughout the manuscript. The authors conclude that the available evidence supports poststroke depression as being multifactorial in origin and consistent with the biopsychosocial model of mental illness.

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Authors: Whyte, E. M., & Mulsant, B. H.
Affiliations: University of Pittsburgh (US)
Corresponding author: Mulsant, Benoit H
ORCID: Mulsant, Benoit H
Venue: Biological Psychiatry
Publisher: Elsevier BV
Published: 2002-08
Volume: 52
Issue: 3
Pages: 253-264
ISSN: 0006-3223 (ISSN-L)
DOI: 10.1016/s0006-3223(02)01424-5
OpenAlex: W2070191749
Cited by: 488
References: 126
Citations by year: 2026: 8 · 2025: 19 · 2024: 14 · 2023: 11 · 2022: 21 · 2021: 19 · 2020: 20 · 2019: 25 · 2018: 19 · 2017: 21 · 2016: 41 · 2015: 34 · 2014: 27 · 2013: 32 · 2012: 16
FWCI: 2.65
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
Funders: U.S. Public Health Service (MH01613, T32 MH19986)
Topics: Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
Keywords: post-stroke depression, stroke, depression prevalence, etiology, pathophysiology, biological treatment, biopsychosocial model, cognitive impairment, disability, mortality
MeSH terms: Aged, Antidepressive Agents, Depressive Disorder, Major, Major Depressive Disorder, Humans, Time Factors, Stroke

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Post stroke depression: epidemiology, pathophysiology, and biological treatment

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