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New insights into the role of cortisol and the glucocorticoid receptor in severe depression
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“Visceral, neuroendocrine, and autonomic disturbances also characterize MDD, and they often lead to altered weight, appetite, and sleep (34).”
From Localization of Dysfunction in Major Depressive Disorder: Prefrontal Cortex and Amygdala (2011) · cites this paper as [34]
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“This reduction, which appears to be greatest in patients with the longest duration of illness (Sheline et al 1999) may be, in part, mediated by hypercortisolism.”
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Metadata
- Authors
- Gold, P. W., Drevets, W. C., Charney, D. S., & Drevets, W. C.
- Affiliations
- National Institutes of Health (US)
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2002-09
- Volume
- 52
- Issue
- 5
- Pages
- 381-385
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W1992668905
- Cited by
- 219
- References
- 44
- Citations by year
- 2026: 2 · 2025: 2 · 2023: 2 · 2022: 2 · 2021: 5 · 2020: 2 · 2019: 3 · 2018: 2 · 2017: 7 · 2016: 3 · 2015: 7 · 2014: 5 · 2013: 12 · 2012: 8
- FWCI
- 7.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- cortisol, glucocorticoid receptor, severe depression, psychotic depression, mifepristone, hypercortisolism, stress response, hypothalamic-pituitary-adrenal axis, mood disorders
- MeSH terms
- Amygdala, Antidepressive Agents, Depressive Disorder, Hippocampus, Humans, Hydrocortisone, Hypothalamus, Receptors, Glucocorticoid, Mifepristone, Prefrontal Cortex
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