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New insights into the role of cortisol and the glucocorticoid receptor in severe depression
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“Visceral, neuroendocrine, and autonomic disturbances also characterize MDD, and they often lead to altered weight, appetite, and sleep (34).”
From Localization of Dysfunction in Major Depressive Disorder: Prefrontal Cortex and Amygdala (2011) · cites this paper as [34]
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“This reduction, which appears to be greatest in patients with the longest duration of illness (Sheline et al 1999) may be, in part, mediated by hypercortisolism.”
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Metadata
- Authors
- Gold, P. W., Drevets, W. C., Charney, D. S., & Drevets, W. C.
- Affiliations
- National Institutes of Health (US)
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2002-09
- Volume
- 52
- Issue
- 5
- Pages
- 381-385
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W1992668905
- Cited by
- 219
- References
- 44
- Citations by year
- 2026: 2 · 2025: 2 · 2023: 2 · 2022: 2 · 2021: 5 · 2020: 2 · 2019: 3 · 2018: 2 · 2017: 7 · 2016: 3 · 2015: 7 · 2014: 5 · 2013: 12 · 2012: 8
- FWCI
- 7.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- cortisol, glucocorticoid receptor, severe depression, psychotic depression, mifepristone, hypercortisolism, stress response, hypothalamic-pituitary-adrenal axis, mood disorders
- MeSH terms
- Amygdala, Antidepressive Agents, Depressive Disorder, Hippocampus, Humans, Hydrocortisone, Hypothalamus, Receptors, Glucocorticoid, Mifepristone, Prefrontal Cortex
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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