Cited by 229Neurogenesis and neuroplasticity mechanismsStress Responses and CortisolMemory and Neural Mechanisms

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Reduced cell proliferation in the dentate gyrusis not correlated with the development of learned helplessness

Vollmayr, Barbara, Simonis, Claudia, Weber, Silja, Gass, Peter, Henn, Fritz·2003·Biological Psychiatry

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Abstract

Background A plethora of indirect findings suggests that mood disorders may be caused by or result in structural changes in the brain, namely decreased hippocampal cell proliferation. Methods To test for these hypotheses, we used a rat model of depression, learned helplessness. Moderate unpredictable and inescapable foot shocks induced learned helplessness only in a portion of the rats. Rats that showed helpless behavior were compared to those behaving normally after inescapable shock. Proliferating cells in the dentate gyrus were labeled with BrdU (bromodeoxyuridine). Results Helpless behavior appeared before the decrease of dentate gyrus cell proliferation was maximal. Cell proliferation was decreased to the same extent in animals that developed helplessness as those that were not helpless. Furthermore, immobilization stress, which reduced the rate of cell proliferation, did not induce learned helplessness. Conclusion These results are in line with reports that the rate of dentate gyrus cell proliferation is acutely down-regulated by stress, but the development of helpless behavior does not correlate with this process. Further studies will have to clarify if during learned helpless behavior neurogenesis is impaired by altered differentiation or survival of cells.

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Nestler, E. J., Barrot, M., DiLeone, R. J., Eisch, A. J., Gold, S. J., & Monteggia, L. M. (2002) · Neuron · doi:10.1016/s0896-6273(02)00653-0 · Cited by 3,217
Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation
Kuhn, H., Dickinson-Anson, H., & Gage, F. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-06-02027.1996 · Cited by 3,139
Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus
Malberg, J. E., Eisch, A. J., Nestler, E. J., & Duman, R. S. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-24-09104.2000 · Cited by 3,111
Functional neurogenesis in the adult hippocampus
van Praag, H., Schinder, A. F., Christie, B. R., Toni, N., Palmer, T. D., & Gage, F. H. (2002) · Nature · doi:10.1038/4151030a · Cited by 2,853
Neurogenesis in the adult is involved in the formation of trace memories
Shors, T. J., Miesegaes, G. R., Beylin, A. V., Zhao, M., Rydel, T. A., & Gould, E. (2001) · Nature · doi:10.1038/35066584 · Cited by 2,014
Transduction of psychosocial stress into the neurobiology of recurrent affective disorder
(1992) · American Journal of Psychiatry · doi:10.1176/ajp.149.8.999 · Cited by 1,848
"A Controlled Study"
Davis, H. S. (1966) · JAMA · doi:10.1001/jama.1966.03100200106038 · Cited by 1,719
Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression
Shirayama, Y., Chen, A. C.-H., Nakagawa, S., Russell, D. S., & Duman, R. S. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-08-03251.2002 · Cited by 1,654
Adult neurogenesis produces a large pool of new granule cells in the dentate gyrus
Cameron, H. A., & Mckay, R. D. G. (2001) · Journal of Comparative Neurology · doi:10.1002/cne.1040 · Cited by 1,585
Neurogenesis in the Adult Rat: Electron Microscopic Analysis of Light Radioautographs
Kaplan, M., & Hinds, J. W. (1977) · Science · doi:10.1126/science.887941 · Cited by 1,511

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Authors: Vollmayr, B., Simonis, C., Weber, S., Gass, P., & Henn, F.
Affiliations: Central Institute of Mental Health (DE)
Corresponding author: Henn, Fritz
ORCID: Gass, Peter
Venue: Biological Psychiatry
Publisher: Elsevier BV
Published: 2003-11
Volume: 54
Issue: 10
Pages: 1035-1040
ISSN: 0006-3223 (ISSN-L)
DOI: 10.1016/s0006-3223(03)00527-4
OpenAlex: W1981957263
Cited by: 229
References: 44
Citations by year: 2026: 2 · 2025: 3 · 2024: 1 · 2023: 2 · 2022: 10 · 2021: 7 · 2020: 5 · 2019: 2 · 2018: 2 · 2017: 3 · 2016: 8 · 2015: 3 · 2014: 5 · 2013: 10 · 2012: 13
FWCI: 4.13
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (acceptedVersion)
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: learned helplessness, dentate gyrus, hippocampal cell proliferation, neurogenesis, depression, mood disorders, restraint stress, inescapable footshock, BrdU labeling, rat model of depression
MeSH terms: Analysis of Variance, Animals, Behavior, Animal, Bromodeoxyuridine, Cell Count, Cell Division, Electroshock, Helplessness, Learned, Immobilization, Immunohistochemistry, Male, Radiation-Sensitizing Agents, Time Factors, Rats, Sprague-Dawley, Dentate Gyrus, Rats

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Reduced cell proliferation in the dentate gyrusis not correlated with the development of learned helplessness

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