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Cited by 419

The DOI matches its Crossref record; 71 of the 71 references it cites were found in a registry or an index.

The physiological approach: functional architecture of working memory and disordered cognition in schizophrenia

Open access
Goldman-Rakic, Patricia S·1999·Biological Psychiatry
DOI 10.1016/s0006-3223(99)00130-4
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Abstract

The method of single-cell recording in awake behaving monkeys as they perform behavioral tasks is perhaps the most powerful approach to understanding the neural basis of behavior. In contrast to cellular analyses in vitro, e.g., in slice preparations, the in vivo approach allows direct correlation of cellular activity and specific processes as they are isolated by behavioral paradigms. As brain mechanisms are studied under natural conditions, inferences about the dynamic basis of information processing are direct. Limitations of this approach include the inability to unequivocally identify the cell under investigation, though location by cytoarchitectonic area and cortical depth is possible. Neurophysiological studies have not only given a dynamic view of neural processing "on line" but have allowed investigators to examine fundamental issues about normal brain function and dementia. Here I illustrate some of these issues and the power of single cell physiology to address them. Before doing so, it should be patently obvious that recording one cell at a time is a technical necessity and in no way should be taken to imply that any behavior is dependent on a single cell. Rather the neuron investigated is a representative of a cohort of cells acting in aggregate.

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Metadata

Authors
Goldman-Rakic, P. S.
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
1999-09
Volume
46
Issue
5
Pages
650-661
ISSN
0006-3223 (ISSN-L)
DOI
10.1016/s0006-3223(99)00130-4
OpenAlex
W2065476905
Cited by
419
References
71
FWCI
8.55
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: The physiological approach: functional architecture of working memory and disordered cognition in schizophrenia. https://app.cochat.ai/papers/10.1016/s0006-3223(99)00130-4
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Goldman-Rakic, P. S. (1999). The physiological approach: functional architecture of working memory and disordered cognition in schizophrenia. Biological Psychiatry. https://doi.org/10.1016/s0006-3223(99)00130-4

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.