A critical role for NMDA receptors in parvalbumin interneurons for gamma rhythm induction and behavior
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Synchronous recruitment of fast-spiking (FS) parvalbumin (PV) interneurons generates gamma oscillations, rhythms that emerge during performance of cognitive tasks. Administration of N-methyl-D-aspartate (NMDA) receptor antagonists alters gamma rhythms, and can induce cognitive as well as psychosis-like symptoms in humans. The disruption of NMDA receptor (NMDAR) signaling specifically in FS PV interneurons is therefore hypothesized to give rise to neural network dysfunction that could underlie these symptoms. To address the connection between NMDAR activity, FS PV interneurons, gamma oscillations and behavior, we generated mice lacking NMDAR neurotransmission only in PV cells (PV-Cre/NR1f/f mice). Here, we show that mutant mice exhibit enhanced baseline cortical gamma rhythms, impaired gamma rhythm induction after optogenetic drive of PV interneurons and reduced sensitivity to the effects of NMDAR antagonists on gamma oscillations and stereotypies. Mutant mice show largely normal behaviors except for selective cognitive impairments, including deficits in habituation, working memory and associative learning. Our results provide evidence for the critical role of NMDAR in PV interneurons for expression of normal gamma rhythms and specific cognitive behaviors.
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NMDA receptors in PV-INs regulate gamma rhythms and cognitive behaviors.
“Importantly, NMDA receptors in PV-INs are regulating gamma rhythms and cognitive behaviors [121].”
From Parvalbumin interneuron vulnerability and brain disorders (2021) · cites this paper as [121]
Optic stimulation of PV interneurons in mice with reduced NR1 expression reveals diminished spike synchronization as well as increased spike latency and variance in spike timing.
“Optic stimulation of PV interneurons revealed diminished spike synchronization as well as increased spike latency and variance in spike timing.”
From Neuronal Dynamics and Neuropsychiatric Disorders: Toward a Translational Paradigm for Dysfunctional Large-Scale Networks (2012) · cites this paper as Carlén et al., 2012
Mice with a reduced expression of NMDA NR1 subunits on PV interneurons are characterized by increased spontaneous 36-44 Hz activity in somatosensory cortex compared to control animals while showing reduced gamma-band activity during sensory stimulation.
“Mice with a reduced expression of NR1 subunits were characterized by increased spontaneous 36–44 Hz activity in somatosensory cortex compared to control animals while showing reduced gamma-band activity during sensory stimulation which was accompanied by dysfunctions in habituation, working memory, and associative learning.”
From Neuronal Dynamics and Neuropsychiatric Disorders: Toward a Translational Paradigm for Dysfunctional Large-Scale Networks (2012) · cites this paper as Carlén et al., 2012
Mice with reduced NR1 expression on PV interneurons show dysfunctions in habituation, working memory, and associative learning.
“Mice with a reduced expression of NR1 subunits were characterized by increased spontaneous 36–44 Hz activity in somatosensory cortex compared to control animals while showing reduced gamma-band activity during sensory stimulation which was accompanied by dysfunctions in habituation, working memory, and associative learning.”
From Neuronal Dynamics and Neuropsychiatric Disorders: Toward a Translational Paradigm for Dysfunctional Large-Scale Networks (2012) · cites this paper as Carlén et al., 2012
Pharmacological and genetic manipulations leading to downregulation of NMDA-receptor activity consistently increase gamma-band activity during rest.
“Pharmacological and genetic manipulations leading to a downregulation of NMDA-receptor activity have consistently demonstrated an increase of gamma-band activity during rest”
From Neuronal Dynamics and Neuropsychiatric Disorders: Toward a Translational Paradigm for Dysfunctional Large-Scale Networks (2012) · cites this paper as Carlén et al., 2012
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Cites
Morris, R. G. M., Anderson, E., Lynch, G. S., & Baudry, M. (1986) · Nature · doi:10.1038/319774a0 · Cited by 3,640 · see citing works
Krystal, J. H. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950030035004 · Cited by 3,330 · see citing works
Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus
Srinivas, S., Watanabe, T., Lin, C.-S., William, C. M., Tanabe, Y., Jessell, T. M., & Costantini, F. (2001) · BMC Developmental Biology · doi:10.1186/1471-213x-1-4 · Cited by 3,121 · see citing works
Recent advances in the phencyclidine model of schizophrenia
(1991) · American Journal of Psychiatry · doi:10.1176/ajp.148.10.1301 · Cited by 2,904 · see citing works
Parvalbumin neurons and gamma rhythms enhance cortical circuit performance
Sohal, V. S., Zhang, F., Yizhar, O., & Deisseroth, K. (2009) · Nature · doi:10.1038/nature07991 · Cited by 2,606 · see citing works
Self-citationDriving fast-spiking cells induces gamma rhythm and controls sensory responses
Cardin, J. A., Carlén, M., Meletis, K., Knoblich, U., Zhang, F., Deisseroth, K., Tsai, L.-H., & Moore, C. I. (2009) · Nature · doi:10.1038/nature08002 · Cited by 2,603 · see citing works
Self-citationCortical inhibitory neurons and schizophrenia
Lewis, D. A., Hashimoto, T., & Volk, D. W. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1648 · Cited by 2,297 · see citing works
Synaptic mechanisms of synchronized gamma oscillations in inhibitory interneuron networks
Bartos, M., Vida, I., & Jonas, P. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2044 · Cited by 2,070 · see citing works
The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory.
Tsien, J. Z., Huerta, P. T., & Tonegawa, S. (1996) · Cell · doi:10.1016/s0092-8674(00)81827-9 · Cited by 1,782 · see citing works
Neuronal gamma-band synchronization as a fundamental process in cortical computation
Fries, P. (2009) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.051508.135603 · Cited by 1,713 · see citing works
Neuregulin 1 and Susceptibility to Schizophrenia
Stefánsson, H., Pétursson, H., Sigurðsson, E., Steinthórsdóttir, V., Bjornsdottir, S., Sigmundsson, T., Ghosh, S., Brynjolfsson, J., Gunnarsdottir, S., Ivarsson, O., et al. (2002) · The American Journal of Human Genetics · doi:10.1086/342734 · Cited by 1,671 · see citing works
Cellular bases of hippocampal EEG in the behaving rat
Buzsáki, G., Leung Lai-Wo, S., & Vanderwolf, C. H. (1983) · Brain Research Reviews · doi:10.1016/0165-0173(83)90037-1 · Cited by 1,397 · see citing works
Sensorimotor Gating and Schizophrenia
Braff, D. L. (1990) · Archives of General Psychiatry · doi:10.1001/archpsyc.1990.01810140081011 · Cited by 1,312 · see citing works
Homayoun, H., & Moghaddam, B. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.2213-07.2007 · Cited by 1,231 · see citing works
Neuropsychological Function in Schizophrenia
Saykin, A. J. (1991) · Archives of General Psychiatry · doi:10.1001/archpsyc.1991.01810310036007 · Cited by 1,160 · see citing works
NMDA receptor trafficking in synaptic plasticity and neuropsychiatric disorders
Lau, C. G., & Zukin, R. S. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2153 · Cited by 1,159 · see citing works
Requirement for Hippocampal CA3 NMDA Receptors in Associative Memory Recall
Nakazawa, K., Quirk, M. C., Chitwood, R. A., Watanabe, M., Yeckel, M. F., Sun, L. D., Kato, A., Carr, C. A., Johnston, D., Wilson, M. A., et al. (2002) · Science · doi:10.1126/science.1071795 · Cited by 1,090 · see citing works
Mice with Reduced NMDA Receptor Expression Display Behaviors Related to Schizophrenia
Mohn, A. R., Gainetdinov, R. R., Caron, M. G., & Koller, B. H. (1999) · Cell · doi:10.1016/s0092-8674(00)81972-8 · Cited by 1,075 · see citing works
A Developmental Switch in the Response of DRG Neurons to ETS Transcription Factor Signaling
Hippenmeyer, S., Pecho‐Vrieseling, E., Sigrist, M., Portmann, T., Laengle, C., Ladle, D. R., & Arber, S. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030159 · Cited by 1,059 · see citing works
Fries, P., Nikolić, D., & Singer, W. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.05.005 · Cited by 1,044 · see citing works
Postnatal NMDA receptor ablation in corticolimbic interneurons confers schizophrenia-like phenotypes
Belforte, J. E., Zsiros, V., Sklar, E. R., Jiang, Z., Yu, G., Li, Y., Quinlan, E. M., & Nakazawa, K. (2010) · Nature Neuroscience · doi:10.1038/nn.2447 · Cited by 752 · see citing works
A mechanism for generation of long-range synchronous fast oscillations in the cortex
Traub, R. D., Whittington, M. A., Stanford, I. M., & Jefferys, J. G. R. (1996) · Nature · doi:10.1038/383621a0 · Cited by 701 · see citing works
Gamma frequency-range abnormalities to auditory stimulation in schizophrenia
Kwon, J. S., O'Donnell, B. F., Wallenstein, G. V., Greene, R. W., Hirayasu, Y., Nestor, P. G., Hasselmo, M. E., Potts, G. F., Shenton, M. E., & McCarley, R. W. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.11.1001 · Cited by 654 · see citing works
Uhlhaas, P. J., Haenschel, C., Nikolic, D., & Singer, W. (2008) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn062 · Cited by 629 · see citing works
Transformations towards the normal distribution of broad band spectral parameters of the EEG
Gasser, T., Bächer, P., & Möcks, J. (1982) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(82)90112-2 · Cited by 584 · see citing works
Impairments in frontal cortical γ synchrony and cognitive control in schizophrenia
CHO, R. Y., Konecky, R. O., & Carter, C. S. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609440103 · Cited by 576 · see citing works
Neurophysiological Endophenotypes of Schizophrenia: The Viability of Selected Candidate Measures
Turetsky, B. I., Calkins, M. E., Light, G. A., D, A. O. M., Radant, A. D., & Swerdlow, N. R. (2006) · Schizophrenia Bulletin · doi:10.1093/schbul/sbl060 · Cited by 568 · see citing works
Altered neuregulin 1–erbB4 signaling contributes to NMDA> receptor hypofunction in schizophrenia
Hahn, C.-G., Wang, H.-Y., Cho, D.-S., Talbot, K., Gur, R. E., Berrettini, W. H., Bakshi, K. P., Kamins, J., Borgmann‐Winter, K. E., Siegel, S. J., et al. (2006) · Nature Medicine · doi:10.1038/nm1418 · Cited by 564 · see citing works
Working memory in schizophrenia: a meta-analysis
Forbes, N. F., Carrick, L. A., McIntosh, A. M., & Lawrie, S. M. (2009) · Psychological Medicine · doi:10.1017/s0033291708004558 · Cited by 550 · see citing works
Fuchs, E. C., Zivkovic, A. R., Cunningham, M. O., Middleton, S., LeBeau, F. E. N., Bannerman, D. M., Rozov, A., Whittington, M. A., Traub, R. D., Rawlins, J. N. P., et al. (2007) · Neuron · doi:10.1016/j.neuron.2007.01.031 · Cited by 532 · see citing works
Converging Evidence of NMDA Receptor Hypofunction in the Pathophysiology of Schizophrenia
Coyle, J. T., Tsai, G. E., & GOFF, D. C. (2003) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1300.020 · Cited by 443 · see citing works
A role for NMDA-receptor channels in working memory
Lisman, J. E., Fellous, J., & Wang, X. (1998) · Nature Neuroscience · doi:10.1038/1086 · Cited by 438 · see citing works
Goldman‐Rakic, P. S. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00130-4 · Cited by 416 · see citing works
Hung, A. Y., Futai, K., Sala, C., Valtschanoff, J. G., Ryu, J., Woodworth, M. A., Kidd, F. L., Sung, C. C., Miyakawa, T., Bear, M. F., et al. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.3032-07.2008 · Cited by 350 · see citing works
Self-citationA role for inhibition in shaping the temporal flow of information in prefrontal cortex
Constantinidis, C., Williams, G. V., & Goldman-Rakic, P. S. (2002) · Nature Neuroscience · doi:10.1038/nn799 · Cited by 348 · see citing works
A model of hippocampal memory encoding and retrieval: GABAergic control of synaptic plasticity
Paulsen, O., & Moser, E. I. (1998) · Trends in Neurosciences · doi:10.1016/s0166-2236(97)01205-8 · Cited by 338 · see citing works
Pinault, D. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.10.006 · Cited by 315 · see citing works
First in vivo evidence of an NMDA receptor deficit in medication-free schizophrenic patients
Pilowsky, L. S., Bressan, R. A., Stone, J. M., Erlandsson, K., Mulligan, R. S., Krystal, J. H., & Ell, P. J. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001751 · Cited by 278 · see citing works
Javitt, D. C., Doneshka, P., Zylberman, I., Ritter, W., & Vaughan, H. G. (1993) · Biological Psychiatry · doi:10.1016/0006-3223(93)90005-x · Cited by 236 · see citing works
Working memory related gamma oscillations in schizophrenia patients
Başar‐Eroğlu, C., Brand, A., Hildebrandt, H., Kedzior, K. K., Mathes, B., & Schmiedt‐Fehr, C. (2006) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2006.07.007 · Cited by 228 · see citing works
Hakami, T. M., Jones, N. C., Tolmacheva, E. A., Gaudias, J., Chaumont, J., Salzberg, M. R., O'Brien, T. J., & Pinault, D. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006755 · Cited by 222 · see citing works
Aultman, J. M., & Moghaddam, B. (2000) · Psychopharmacology · doi:10.1007/s002130000590 · Cited by 217 · see citing works
Swadlow, H. A. (1989) · Journal of Neurophysiology · doi:10.1152/jn.1989.62.1.288 · Cited by 208 · see citing works
The development of parvalbumin-immunoreactivity in the neocortex of the mouse
del Rio, J., de Lecea, L., Ferrer, I., & Soriano, E. (1994) · Developmental Brain Research · doi:10.1016/0165-3806(94)90311-5 · Cited by 205 · see citing works
Vierling-Claassen, D., Siekmeier, P. J., Stufflebeam, S. M., & Kopell, N. (2008) · Journal of Neurophysiology · doi:10.1152/jn.00870.2007 · Cited by 191 · see citing works
Self-citationCunningham, M. O., Hunt, J., Middleton, S. J., LeBeau, F. E. N., Gillies, M. J., Davies, C. H., Maycox, P. R., Whittington, M. A., & Racca, C. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.5054-05.2006 · Cited by 187 · see citing works
Nitz, D. A., & McNaughton, B. L. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00614.2003 · Cited by 184 · see citing works
Jones, R. S. G., & Buhl, E. (1993) · Neuroscience Letters · doi:10.1016/0304-3940(93)90341-h · Cited by 174 · see citing works
Word and Tone Working Memory Deficits in Schizophrenia
Wexler, B. E., Stevens, A. A., Bowers, A. A., Sernyak, M. J., & Goldman‐Rakic, P. S. (1998) · Archives of General Psychiatry · doi:10.1001/archpsyc.55.12.1093 · Cited by 173 · see citing works
Ehrlichman, R. S., Gandal, M. J., Maxwell, C. R., Lazarewicz, M. T., Finkel, L. H., Contreras, D., Turetsky, B. I., & Siegel, S. J. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.10.031 · Cited by 171 · see citing works
Neuropsychological function in schizophrenia
Nyman, H. (2002) · European Psychiatry · doi:10.1016/s0924-9338(02)80803-3 · Cited by 166 · see citing works
Neuregulin-1 Modulates Hippocampal Gamma Oscillations: Implications for Schizophrenia
Fisahn, A., Neddens, J., Yan, L., & Buonanno, A. (2008) · Cerebral Cortex · doi:10.1093/cercor/bhn107 · Cited by 162 · see citing works
Lamsa, K., Heeroma, J. H., & Kullmann, D. M. (2005) · Nature Neuroscience · doi:10.1038/nn1486 · Cited by 158 · see citing works
A somatotopic map of vibrissa motion direction within a barrel column
Andermann, M. L., & Moore, C. I. (2006) · Nature Neuroscience · doi:10.1038/nn1671 · Cited by 156 · see citing works
Self-citationLabrie, V., Lipina, T. V., & Roder, J. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1196-6 · Cited by 141 · see citing works
Neural Correlates of Vibrissa Resonance
Andermann, M. L., Ritt, J. T., Neimark, M. A., & Moore, C. I. (2004) · Neuron · doi:10.1016/s0896-6273(04)00198-9 · Cited by 128 · see citing works
Self-citationEffects of NMDA Receptor Antagonists: Implications for the Pathophysiology of Schizophrenia
Krystal, J. H., Anand, A., & Moghaddam, B. (2002) · Archives of General Psychiatry · doi:10.1001/archpsyc.59.7.663 · Cited by 128 · see citing works
Neddens, J., & Buonanno, A. (2009) · Hippocampus · doi:10.1002/hipo.20675 · Cited by 121 · see citing works
Ryu, J., Futai, K., Feliú-Mójer, M. I., Weinberg, R. J., & Sheng, M. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1944-08.2008 · Cited by 85 · see citing works
Self-citationCardin, J. A., Palmer, L. A., & Contreras, D. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0374-05.2005 · Cited by 84 · see citing works
Self-citationCognition in Mouse Models of Schizophrenia Susceptibility Genes
Arguello, P. A., & Gogos, J. A. (2009) · Schizophrenia Bulletin · doi:10.1093/schbul/sbp153 · Cited by 84 · see citing works
Ma, J., & Leung, L.-W. S. (2000) · Behavioural Brain Research · doi:10.1016/s0166-4328(00)00138-8 · Cited by 81 · see citing works
Joho, R. H., Ho, C. S., & Marks, G. A. (1999) · Journal of Neurophysiology · doi:10.1152/jn.1999.82.4.1855 · Cited by 77 · see citing works
Klamer, D., P�lsson, E., Revesz, A., Engel, J. A., & Svensson, L. (2004) · Psychopharmacology · doi:10.1007/s00213-004-1901-z · Cited by 57 · see citing works
Tonkiss, J., & Rawlins, J. N. P. (1991) · Experimental Brain Research · doi:10.1007/bf00229412 · Cited by 53 · see citing works
Kehrer, C., Dugladze, T., Maziashvili, N., Wójtowicz, A., Schmitz, D., Heinemann, U., & Gloveli, T. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.10.015 · Cited by 30 · see citing works
Sagratella, S., Pèzzola, A., Popoli, P., et al. (1992) · Psychopharmacology · doi:10.1007/bf02245874 · Cited by 23 · see citing works
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Sorted by citations
Interneuron dysfunction in psychiatric disorders
Marín, O. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3155 · Cited by 1,190 · see citing works
Hippocampal GABAergic Inhibitory Interneurons
Pelkey, K. A., Chittajallu, R., Craig, M. T., Tricoire, L., Wester, J. C., & McBain, C. J. (2017) · Physiological Reviews · doi:10.1152/physrev.00007.2017 · Cited by 889 · see citing works
EEG and MEG: Relevance to Neuroscience
Lopes da Silva, F. (2013) · Neuron · doi:10.1016/j.neuron.2013.10.017 · Cited by 900 · see citing works
Mather, M., Clewett, D., Sakaki, M., & Harley, C. W. (2016) · Behavioral and Brain Sciences · doi:10.1017/s0140525x15000667 · Cited by 695 · see citing works
Uhlhaas, P. J., & Singer, W. (2012) · Neuron · doi:10.1016/j.neuron.2012.09.004 · Cited by 512 · see citing works
Gonzalez-Burgos, G., & Lewis, D. A. (2012) · Schizophrenia Bulletin · doi:10.1093/schbul/sbs010 · Cited by 478 · see citing works
Encoding of fear learning and memory in distributed neuronal circuits
Herry, C., & Johansen, J. P. (2014) · Nature Neuroscience · doi:10.1038/nn.3869 · Cited by 474 · see citing works
Lener, M. S., Niciu, M. J., Ballard, E. D., Park, M., Park, L. T., Nugent, A. C., & Zarate, C. A. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.05.005 · Cited by 468 · see citing works
Cho, K. K. A., Hoch, R., Lee, A. T., Patel, T., Rubenstein, J. L. R., & Sohal, V. S. (2015) · Neuron · doi:10.1016/j.neuron.2015.02.019 · Cited by 329 · see citing works
An excitatory synapse hypothesis of depression
Thompson, S. M., Kallarackal, A. J., Kvarta, M. D., Van Dyke, A. M., LeGates, T. A., & Cai, X. (2015) · Trends in Neurosciences · doi:10.1016/j.tins.2015.03.003 · Cited by 265 · see citing works
Steullet, P., Cabungcal, J. H., Monin, A., Dwir, D., O'Donnell, P., Cuenod, M., & Do, K. Q. (2016) · Schizophrenia Research · doi:10.1016/j.schres.2014.06.021 · Cited by 262 · see citing works
Ketamine has distinct electrophysiological and behavioral effects in depressed and healthy subjects
Nugent, A. C., Ballard, E. D., Gould, T. D., Park, L. T., Moaddel, R., Brutsche, N. E., & Zarate, C. A. (2019) · Molecular Psychiatry · doi:10.1038/s41380-018-0028-2 · Cited by 250 · see citing works
Tasks for inhibitory interneurons in intact brain circuits
Roux, L., & Buzsáki, G. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.09.011 · Cited by 218 · see citing works
Parvalbumin interneuron vulnerability and brain disorders
Ruden, J. B., Dugan, L. L., & Konradi, C. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-020-0778-9 · Cited by 194 · see citing works
Gandal, M. J., Sisti, J., Klook, K., Ortinski, P. I., Leitman, V, Liang, Y., Thieu, T., Anderson, R., Pierce, R. C., Jonak, G., et al. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.69 · Cited by 204 · see citing works
Miller, O. H., Moran, J. T., & Hall, B. J. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.07.028 · Cited by 200 · see citing works
Optogenetic dissection of medial prefrontal cortex circuitry
Riga, D., Matos, M. R., Glas, A., Smit, A. B., Spijker, S., & Van den Oever, M. C. (2014) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2014.00230 · Cited by 208 · see citing works
Altered Cortical Ensembles in Mouse Models of Schizophrenia
Hamm, J. P., Peterka, D. S., Gogos, J. A., & Yuste, R. (2017) · Neuron · doi:10.1016/j.neuron.2017.03.019 · Cited by 175 · see citing works
Ketamine disinhibits dendrites and enhances calcium signals in prefrontal dendritic spines
Ali, F., Gerhard, D. M., Sweasy, K., Pothula, S., Pittenger, C., Duman, R. S., & Kwan, A. C. (2020) · Nature Communications · doi:10.1038/s41467-019-13809-8 · Cited by 196 · see citing works
Sinclair, D., Oranje, B., Razak, K. A., Siegel, S. J., & Schmid, S. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.05.029 · Cited by 198 · see citing works
“These electrophysiological abnormalities were accompanied by impaired habituation and subtle spatial working memory deficits (Carlén et al., 2012).”
InfluentialPham, T. H., & Gardier, A. M. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.02.017 · Cited by 186 · see citing works
Abbas, A. I., Sundiang, M. J. M., Henoch, B., Morton, M. P., Bolkan, S. S., Park, A. J., Harris, A. Z., Kellendonk, C., & Gordon, J. A. (2018) · Neuron · doi:10.1016/j.neuron.2018.09.029 · Cited by 183 · see citing works
Translation-relevant EEG phenotypes in a mouse model of Fragile X Syndrome.
Lovelace, J. W., Ethell, I. M., Binder, D. K., & Razak, K. A. (2018) · Neurobiology of Disease · doi:10.1016/j.nbd.2018.03.012 · Cited by 154 · see citing works
Dysconnectivity, large-scale networks and neuronal dynamics in schizophrenia
Uhlhaas, P. J. (2013) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2012.11.004 · Cited by 178 · see citing works
Downregulation of Parvalbumin at Cortical GABA Synapses Reduces Network Gamma Oscillatory Activity
Volman, V., Behrens, M. M., & Sejnowski, T. J. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.3041-11.2011 · Cited by 164 · see citing works
Kocsis, B. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.10.002 · Cited by 159 · see citing works
Baseline gamma power during auditory steady-state stimulation in schizophrenia
M. Spencer, K. (2012) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2011.00190 · Cited by 155 · see citing works
Do, K. Q., Cuenod, M., & Hensch, T. K. (2015) · Schizophrenia Bulletin · doi:10.1093/schbul/sbv065 · Cited by 158 · see citing works
GABAergic Control of Depression-Related Brain States
Luscher, B., & Fuchs, T. (2015) · Advances in Pharmacology · doi:10.1016/bs.apha.2014.11.003 · Cited by 149 · see citing works
Liu, Y., Ouyang, P., Zheng, Y., Mi, L., Zhao, J., Ning, Y., & Guo, W. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.664535 · Cited by 129 · see citing works
Ketamine amplifies induced gamma frequency oscillations in the human cerebral cortex
Shaw, A. D., Saxena, N., E. Jackson, L., Hall, J. E., Singh, K. D., & Muthukumaraswamy, S. D. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.04.012 · Cited by 122 · see citing works
Spatial and temporal boundaries of NMDA receptor hypofunction leading to schizophrenia
Nakazawa, K., Jeevakumar, V., & Nakao, K. (2017) · npj Schizophrenia · doi:10.1038/s41537-016-0003-3 · Cited by 110 · see citing works
Cohen, S. M., Ma, H., Kuchibhotla, K. V., Watson, B. O., Buzsáki, G., Froemke, R. C., & Tsien, R. W. (2016) · Neuron · doi:10.1016/j.neuron.2016.03.001 · Cited by 100 · see citing works
Neurosteroid Actions in Memory and Neurologic/Neuropsychiatric Disorders
Ratner, M. H., Kumaresan, V., & Farb, D. H. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00169 · Cited by 96 · see citing works
Barnes, S. A., Pinto-Duarte, A., Kappe, A., Zembrzycki, A., Metzler, A., Mukamel, E. A., Lucero, J., Wang, X., Sejnowski, T. J., Markou, A., et al. (2015) · Molecular Psychiatry · doi:10.1038/mp.2015.113 · Cited by 92 · see citing works
Pozzi, L., Dorocic, I. P., Wang, X., Carlén, M., & Meletis, K. (2014) · PLoS ONE · doi:10.1371/journal.pone.0083879 · Cited by 74 · see citing works
Self-citationMao, W., Watanabe, T., Cho, S., Frost, J. L., Truong, T., Zhao, X., & Futai, K. (2015) · European Journal of Neuroscience · doi:10.1111/ejn.12877 · Cited by 59 · see citing works
Self-citationKadriu, B., Musazzi, L., Johnston, J. N., Kalynchuk, L. E., Caruncho, H. J., Popoli, M., & Zarate, C. A. (2021) · Drug Discovery Today · doi:10.1016/j.drudis.2021.07.027 · Cited by 62 · see citing works
Rosch, R. E., Auksztulewicz, R., Leung, P. D., Friston, K. J., & Baldeweg, T. (2019) · Biological Psychiatry: Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2018.07.003 · Cited by 56 · see citing works
Rupert, D. D., & Shea, S. D. (2022) · Frontiers in Neural Circuits · doi:10.3389/fncir.2022.886629 · Cited by 58 · see citing works
Steullet, P., Cabungcal, J.-H., Cuénod, M., & Do, K. Q. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00244 · Cited by 49 · see citing works
Ferando, I., & Mody, I. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.09.010 · Cited by 49 · see citing works
Shaw, A. D., Knight, L., Freeman, T. C. A., Williams, G. M., Moran, R. J., Friston, K. J., Walters, J. T. R., & Singh, K. D. (2019) · Schizophrenia Bulletin · doi:10.1093/schbul/sbz066 · Cited by 54 · see citing works
Mechanisms Underlying Circuit Dysfunction in Neurodevelopmental Disorders
Exposito-Alonso, D., & Rico, B. (2022) · Annual Review of Genetics · doi:10.1146/annurev-genet-072820-023642 · Cited by 49 · see citing works
Zick, J. L., Blackman, R. K., Crowe, D. A., Amirikian, B., DeNicola, A. L., Netoff, T. I., & Chafee, M. V. (2018) · Neuron · doi:10.1016/j.neuron.2018.05.010 · Cited by 50 · see citing works
Abnormal interneuron development in disrupted-in-schizophrenia-1 L100P mutant mice
Lee, F. H., Zai, C. C., Cordes, S. P., Roder, J. C., & Wong, A. H. (2013) · Molecular Brain · doi:10.1186/1756-6606-6-20 · Cited by 49 · see citing works
McNally, J. M., McCarley, R. W., & Brown, R. E. (2013) · Current Psychiatry Reports · doi:10.1007/s11920-012-0346-z · Cited by 47 · see citing works
Wang, X., Pinto-Duarte, A., Sejnowski, T. J., & Behrens, M. M. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.4907 · Cited by 46 · see citing works
Harms, L., Fulham, W. R., Todd, J., Meehan, C., Schall, U., Hodgson, D. M., & Michie, P. T. (2018) · Schizophrenia Research · doi:10.1016/j.schres.2017.03.042 · Cited by 40 · see citing works
Electrophysiological intermediate biomarkers for oxidative stress in schizophrenia
Ballesteros, A., Summerfelt, A., Du, X., Jiang, P., Chiappelli, J., Tagamets, M., O’Donnell, P., Kochunov, P., & Hong, L. E. (2013) · Clinical Neurophysiology · doi:10.1016/j.clinph.2013.05.021 · Cited by 34 · see citing works
Prefrontal cortical GABAergic and NMDA glutamatergic regulation of delayed responding
Auger, M. L., & Floresco, S. B. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.09.022 · Cited by 28 · see citing works
Jones, N. C., Hudson, M., Foreman, J., Rind, G., Hill, R., Manning, E. E., & van den Buuse, M. (2018) · European Journal of Neuroscience · doi:10.1111/ejn.13722 · Cited by 20 · see citing works
- Authors
- Carlén, M., Meletis, K., Siegle, J. H., Cardin, J. A., Futai, K., Vierling-Claassen, D., Rühlmann, C., Jones, S. R., Deisseroth, K., Sheng, M., Moore, C. I., & Tsai, L.-H.
- Affiliations
- Massachusetts Institute of Technology (US)
- Karolinska Institutet (SE)
- McGovern Institute for Brain Research (US)
- Harvard University (US)
- Stanford University (US)
- Broad Institute (US)
- Corresponding author
- Carlén, M
- Moore, C I
- Tsai, L-H
- Venue
- Molecular Psychiatry
- Published
- 2011-04-05
- Volume
- 17
- Issue
- 5
- Pages
- 537-548
- ISSN
- 1359-4184 (ISSN-L)
- 1476-5578
- PMC
- PMC3335079
- OpenAlex
- W2152511855
- Cited by
- 669
- References
- 67
- Citations by year
- 2026: 33 · 2025: 49 · 2024: 46 · 2023: 34 · 2022: 36 · 2021: 56 · 2020: 50 · 2019: 45 · 2018: 52 · 2017: 38 · 2016: 42 · 2015: 62 · 2014: 48 · 2013: 43 · 2012: 25
- FWCI
- 16.69
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-nd
- www.springer.com/tdm (unspecified)
- Locations
- Molecular Psychiatry (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- HAL (submittedVersion, other-oa)
- Trinity's Access to Research Output (TARA) (Trinity College Dublin) (submittedVersion)
- Funders
- National Alliance for Research on Schizophrenia and Depression
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- NMDA receptor, parvalbumin interneurons, gamma oscillations, fast-spiking interneurons, NMDA receptor antagonists, cognitive impairment, working memory, associative learning, habituation, stereotypy, psychosis-like symptoms, cortical oscillations, optogenetic stimulation
- MeSH terms
- Animals, Association Learning, Conditioning, Psychological, Interneurons, Male, Memory, Short-Term, Mice, Transgenic, Parvalbumins, Photic Stimulation, Picrotoxin, Stereotyped Behavior, Receptors, N-Methyl-D-Aspartate, GABA Antagonists, Maze Learning, Excitatory Postsynaptic Potentials, Mice, Sensory Gating, Brain Waves, GABAergic Neurons
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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