The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.
Hormone profiles in humans experiencing military survival training
Abstract
Background Clinical models of the human response to intense, acute stress have been limited to laboratory settings or cross sectional characterizations. As a result, data about the sensitivity of the human neuroendocrine activation to realistic stressors of varying magnitudes are limited. The U.S. Army survival course offers a unique opportunity to examine, in a controlled manner, the human response to acute, realistic, military stress.Methods Salivary data were collected in 109 subjects at baseline during four stress exposure time points and at recovery. Serum data was collected at baseline and recovery in 72 subjects and at baseline and during stress exposure in a subgroup of subjects (n = 21).Results Cortisol significantly increased during the captivity experience and was greatest after subjects' exposure to interrogations. Cortisol remained significantly elevated at recovery. Testosterone was significantly reduced within 12 hours of captivity. Reductions of both total and free T4 and of total and free T3 were observed, as were increases in thyrotropin.Conclusions The stress of military survival training produced dramatic alterations in cortisol, percent free cortisol, testosterone, and thyroid indices. Different types of stressors had varying effects on the neuroendocrine indices. The degree of neuroendocrine changes observed may have significant implications for subsequent responses to stress.
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“blood and saliva testosterone levels decrease following stress15”
From Neurobiology of resilience (2012) · cites this paper as [15]
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“Saliva cortisol is an accepted measure of plasma cortisol, and has been used to assess the impact of psychological and physical stress on humans in laboratory and military field studies (Kahn et al., 1988; Opstad, 1994; Morgan et al., 2000a; Lieberman et al., 2005).”
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“Briefly, testosterone concentrations would be predicted to decrease whereas cortisol concentrations would be expected to increase in stressful conditions of simulated combat and other stress-inducing exposures [54].”
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Morgan, C. A., Fichtenholtz, H. M., & Russell, B. A. H. (2015) · Lecture notes in computer science · doi:10.1007/978-3-319-20816-9_8
“Numerous studies from have established that military Survival School training represents a valid, reliable venue for assessing the impact of acute stress in humans (Morgan et al. 2000, 2006).”
BackgroundSelf-citation
Metadata
- Authors
- Morgan, C. A., Wang, S., Mason, J., Southwick, S. M., Fox, P., Hazlett, G., Charney, D. S., & Greenfield, G.
- Affiliations
- Yale University (US)
- United States Department of the Army (US)
- United States Army (US)
- Corresponding author
- Morgan, Charles A
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2000-05
- Volume
- 47
- Issue
- 10
- Pages
- 891-901
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2024255098
- Cited by
- 206
- References
- 61
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 8 · 2023: 5 · 2022: 11 · 2021: 4 · 2020: 9 · 2019: 8 · 2018: 7 · 2017: 7 · 2016: 9 · 2015: 9 · 2014: 15 · 2013: 13 · 2012: 15
- FWCI
- 1.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Keywords
- acute stress, cortisol, testosterone, free cortisol, thyroid hormones, thyroid-stimulating hormone, salivary biomarkers, serum biomarkers, captivity stress, neuroendocrine response, stress recovery
- MeSH terms
- Adult, Humans, Hydrocortisone, Male, Military Personnel, Saliva, Stress, Physiological, Stress Disorders, Post-Traumatic, Survival, Testosterone, Thyroid Gland, Thyroid Hormones
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