Bioelectrorheological model of the cell. 3. Viscoelastic shear deformation of the membrane
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An analytical electromechanical model of a spherical cell exposed to an alternating electric field was used to calculate shear stress generated in the cellular membrane. Shape deformation of Neurospora crassa (slime) spheroplasts was measured. Statistical analysis permitted empirical evaluation of creep of the cellular membrane within the range of infinitesimal stress. Final results were discussed in terms of various rheological models.
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The bioelectrorheological model demonstrates the relationship between AEFs, shape deformations, and membrane destabilization, which can contribute to electroporation and other electric field-induced cell phenomena including electrofusion and electro-destruction.
“The bioelectrorheological model of the cell was proposed and has been expanded upon through a series of manuscripts by Pawlowski et al. [40,53,54,55,56,57] (Figure 3B). This model demonstrates the relationship between AEFs, shape deformations, and membrane destabilization, which can contribute to electroporation and other electric field-induced cell phenomena including electrofusion and electro-d”
From Permeabilizing Cell Membranes with Electric Fields (2021) · cites this paper as [57]
Application of AEFs causes shear stress or extensile mechanical stress to act on the cell membrane, disrupting its integrity and stability.
“The application of AEFs causes different types of stress to act on the cell membrane, thereby disrupting its integrity and stability. Based on electrical and geometric parameters of the system, cells either experience shear stress or extensile mechanical stress.”
From Permeabilizing Cell Membranes with Electric Fields (2021) · cites this paper as [57]
The bioelectrorheological model provides a possible explanation for the causes of electroporation by demonstrating the combined effects of heat energy and extensile stress leading to reversible cell membrane destabilization, which can directly result in electroporation.
“Although the electric field strengths studied by Pawlowski and colleagues [40,53,54,55,56,57] were two orders of magnitude greater than that of TTFields, the bioelectrorheological model provides a possible explanation to the causes of electroporation by demonstrating the combined effects of heat energy and extensile stress leading to reversible cell membrane destabilization, which can directly”
From Permeabilizing Cell Membranes with Electric Fields (2021) · cites this paper as [57]
Both DC and AC electroporation are believed to cause a dielectric breakdown of the cell; the oscillating nature of AC electroporation is thought to provoke structural fatigue of the membrane, comparable to the extensile stress proposed in the bioelectrorheological model.
“Both types of electroporation are believed to cause a dielectric breakdown of the cell. However, the oscillating nature of AC electroporation is thought to provoke structural fatigue of the membrane [61], comparable to the extensile stress proposed in the bioelectrorheological model [40,53,54,55,56,57].”
From Permeabilizing Cell Membranes with Electric Fields (2021) · cites this paper as [57]
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Bioelectrorheological model of the cell 1. Analysis of stresses and deformations
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Self-citationBioelectrorheological model of the cell. 2. Analysis of creep and its experimental verification
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Research works printed but not linked: 1
- Scarborough, G. A. 1978. The Neurospora plasma membrane: a new experimental system for investigating eukaryote surface membrane structure and function. In Methods in Cell Biology, Vol. 20. D. M. Prescott, editor. Academic Press, San Diego. 117-133.
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Permeabilizing Cell Membranes with Electric Fields
Aguilar, A. A., Ho, M. C., Chang, E., Carlson, K. W., Natarajan, A., Marciano, T., Bomzon, Z., & Patel, C. B. (2021) · Cancers · doi:10.3390/cancers13092283 · Cited by 76 · see citing works
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Self-citationPawłowski, P., & Fikus, M. (1993) · Biophysical Journal · doi:10.1016/s0006-3495(93)81055-5 · Cited by 11 · see citing works
Self-citationPawlowski, P., Szutowicz, I., Rózycki, S., Zieliński, J., & Fikus, M. (1996) · Biophysical Journal · doi:10.1016/s0006-3495(96)79647-9 · Cited by 6 · see citing works
Self-citation
- Authors
- Poznański, J., Pawłowski, P., & Fikus, M.
- Affiliations
- Institute of Biochemistry and Biophysics, Polish Academy of Sciences (PL)
- Venue
- Biophysical Journal
- Publisher
- Elsevier BV
- Published
- 1992-03
- Volume
- 61
- Issue
- 3
- Pages
- 612-620
- ISSN
- 0006-3495 (ISSN-L)
- PMC
- PMC1260279
- OpenAlex
- W2043733130
- Cited by
- 21
- References
- 23
- Citations by year
- 2023: 2 · 2021: 1 · 2020: 1 · 2018: 1 · 2015: 1 · 2013: 1
- FWCI
- 0.74
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Biophysical Journal (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Physical Sciences › Chemical Engineering › Fluid Flow and Transfer Processes › Rheology and Fluid Dynamics Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Electromagnetic Fields and Biological Effects
- Keywords
- plasma membrane, viscoelasticity, shear deformation, AC electric field, electromechanical model, spherical cells, rheological models
- MeSH terms
- Cell Membrane, Elasticity, Mathematics, Models, Biological, Neurospora crassa, Spheroplasts, Viscosity
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