The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Stresses at the Cell-to-Substrate Interface during Locomotion of Fibroblasts
Open accessAbstract
Recent technological improvements in the elastic substrate method make it possible to produce spatially resolved measurements of the tractions exerted by single motile cells. In this study we have applied these developments to produce maps of the tractions exerted by 3T3 fibroblasts during steady locomotion. The resulting images have a spatial resolution of approximately 5 micrometers and a maximum intensity of approximately 10(2) kdyn/cm2 (10(4) pN/micrometers2). We find that the propulsive thrust for fibroblast locomotion, approximately 0.2 dyn, is imparted to the substratum within 15 micrometers of the leading edge. These observations demonstrate that the lamellipodium of the fibroblast is able to generate intense traction stress. The cell body and posterior seem to be mechanically passive structures pulled forward entirely by this action.
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Cites
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Cell Migration: A Physically Integrated Molecular Process
Lauffenburger, D. A., & Horwitz, A. F. (1996) · Cell · doi:10.1016/s0092-8674(00)81280-5 · Cited by 3,915
Role of cell shape in growth control
Folkman, J., & Moscona, A. (1978) · Nature · doi:10.1038/273345a0 · Cited by 2,422
Non-sarcomeric mode of myosin II organization in the fibroblast lamellum.
Verkhovsky, A. B., & Borisy, G. G. (1993) · The Journal of cell biology · doi:10.1083/jcb.123.3.637 · Cited by 141
Cited by
Cell Movement Is Guided by the Rigidity of the Substrate
Lo, C.-M., Wang, H.-B., Dembo, M., & Wang, Y.-L. (2000) · Biophysical Journal · doi:10.1016/s0006-3495(00)76279-5 · Cited by 3,289
Self-citationDeconstructing the third dimension – how 3D culture microenvironments alter cellular cues
Baker, B. M., & Chen, C. S. (2012) · Journal of Cell Science · doi:10.1242/jcs.079509 · Cited by 1,760
Alpha-Smooth Muscle Actin Expression Upregulates Fibroblast Contractile Activity
Hinz, B., Celetta, G., Tomasek, J. J., Gabbiani, G., & Chaponnier, C. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.9.2730 · Cited by 1,288
Adhesion-Dependent Cell Mechanosensitivity
Bershadsky, A. D., Balaban, N. Q., & Geiger, B. (2003) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.19.111301.153011 · Cited by 874
Stiffening hydrogels to probe short- and long-term cellular responses to dynamic mechanics
Guvendiren, M., & Burdick, J. A. (2012) · Nature Communications · doi:10.1038/ncomms1792 · Cited by 707
Metadata
- Authors
- Dembo, M., & Wang, Y.-L.
- Venue
- Biophysical Journal
- Publisher
- Elsevier BV
- Published
- 1999-04
- Volume
- 76
- Issue
- 4
- Pages
- 2307-2316
- ISSN
- 0006-3495 (ISSN-L)
- OpenAlex
- W2111412288
- Cited by
- 1,287
- References
- 4
- FWCI
- 5.45
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Dembo, M., & Wang, Y.-L. (1999). Stresses at the Cell-to-Substrate Interface during Locomotion of Fibroblasts. Biophysical Journal. https://doi.org/10.1016/s0006-3495(99)77386-8
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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