Effect of a 5-HT2C serotonin agonist, dexnorfenfluramine, on amyloid precursor protein metabolism in guinea pigs

Release of Alzheimer Amyloid Precursor Derivatives Stimulated by Activation of Muscarinic Acetylcholine Receptors

Nitsch, R. M., Slack, B. E., Wurtman, R. J., & Growdon, J. H. (1992) · Science · doi:10.1126/science.1411529 · Cited by 898 · see citing works

Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the β-amyloid precursor protein

Mattson, M. P., Cheng, B., Culwell, A. R., Esch, F. S., Lieberburg, I. M., & Rydel, R. E. (1993) · Neuron · doi:10.1016/0896-6273(93)90315-i · Cited by 795 · see citing works

Activation of protein kinase C inhibits cellular production of the amyloid beta-protein.

Hung, A. Y., Haass, C., Nitsch, R. M., Qiu, W. Q., Citron, M., Wurtman, R. J., Growdon, J. H., & Selkoe, D. J. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)49409-x · Cited by 399 · see citing works

Memory-enhancing effects of secreted forms of the β-amyloid precursor protein in normal and amnestic mice

Méziane, H., Dodart, J., Mathis, C., Little, S. H., Clemens, J. A., Paul, S. M., & Ungerer, A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.21.12683 · Cited by 355 · see citing works

Conservation of the sequence of the Alzheimer's disease amyloid peptide in dog, polar bear and five other mammals by cross-species polymerase chain reaction analysis

Johnstone, E. M., Chaney, M. O., Norris, F. H., Pascual, R. V., & Little, S. H. (1991) · Molecular Brain Research · doi:10.1016/0169-328x(91)90088-f · Cited by 312 · see citing works

5-HT1c receptor is a prominent serotonin receptor subtype in the central nervous system.

Molineaux, S. M., Jessell, T. M., Axel, R., & Julius, D. J. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.17.6793 · Cited by 261 · see citing works

Increase of synaptic density and memory retention by a peptide representing the trophic domain of the amyloid beta/A4 protein precursor.

Roch, J., Masliah, E., Roch‐Levecq, A., Sundsmo, M. P., Otero, D. A., Veinbergs, I., & Saitoh, T. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.16.7450 · Cited by 255 · see citing works

Serotonin 5-HT2a and 5-HT2c Receptors Stimulate Amyloid Precursor Protein Ectodomain Secretion

Nitsch, R. M., Deng, M., Growdon, J. H., & Wurtman, R. J. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.8.4188 · Cited by 219 · see citing works

Neurochemical mechanism of action of drugs which modify feeding via the serotoninergic system

Garattini, S. K., Mennini, T., Bendotti, C., Invernizzi, R. W., & SAMANIN, R. (1986) · Appetite · doi:10.1016/s0195-6663(86)80050-2 · Cited by 192 · see citing works

Cell-surface beta-amyloid precursor protein stimulates neurite outgrowth of hippocampal neurons in an isoform-dependent manner

Qiu, W. W. Q., Ferreira, A., Miller, C., Koo, E., & Selkoe, D. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-03-02157.1995 · Cited by 190 · see citing works

Two distinct serotonin receptors: regional variations in receptor binding in mammalian brain

Peroutka, S. J., & Snyder, S. H. (1981) · Brain Research · doi:10.1016/0006-8993(81)90562-x · Cited by 176 · see citing works

Serotonin-releasing effects of substituted piperazines in vitro

Pettibone, D. J., & Williams, M. J. (1984) · Biochemical Pharmacology · doi:10.1016/0006-2952(84)90424-6 · Cited by 102 · see citing works

Prostaglandin E2Stimulates Amyloid Precursor Protein Gene Expression: Inhibition by Immunosuppressants

Lee, R. K. K., Knapp, S., & Wurtman, R. J. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-03-00940.1999 · Cited by 85 · see citing works

Comparative studies on the anorectic activity of d-fenfluramine in mice, rats, and guinea pigs

Mennini, T., Bizzi, A., Caccia, S., Codegoni, A., Fracasso, C., Frittoli, E., Guiso, G., Padura, I. M., Taddei, C., Uslenghi, A., et al. (1991) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/bf00169550 · Cited by 79 · see citing works

Reduction of cerebrospinal fluid amyloid β after systemic administration of M1 muscarinic agonists

Beach, T. G., Walker, D. G., Potter, P. E., Sue, L. I., & Fisher, A. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02484-2 · Cited by 66 · see citing works

Serotonin 5‐HT2C Receptor Stimulates Cyclic GMP Formation in Choroid Plexus

Kaufman, M. J., Hartig, P. R., & Hoffman, B. J. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.64010199.x · Cited by 61 · see citing works

Stimulation of amyloid precursor protein synthesis by adrenergic receptors coupled to cAMP formation

Lee, R. K. K., Araki, W., & Wurtman, R. J. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.10.5422 · Cited by 51 · see citing works

Amyloid precursor protein in guinea pigs — complete cDNA sequence and alternative splicing

Beck, M., Müller, D., & Bigl, V. (1997) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/s0167-4781(96)00232-1 · Cited by 35 · see citing works

Alzheimer's disease: the tacrine legacy

Kelly, J. S. (1999) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(99)01344-9 · Cited by 28 · see citing works

Neural control of dieting

Spedding, M., Ouvry, C., Millan, M. J., Duhault, J., Dacquet, C., & Wurtman, R. J. (1996) · Nature · doi:10.1038/380488a0 · Cited by 22 · see citing works

Guinea-pig primary cell cultures provide a model to study expression and amyloidogenic processing of endogenous amyloid precursor protein

Beck, M., Brückner, M. K., Holzer, M., Kaap, S., Pannicke, T., Arendt, T., & Bigl, V. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00390-5 · Cited by 21 · see citing works

A safe and simple technique for obtaining cerebrospinal fluid from rabbits.

Rk, K., & Jf, P. (1979) · PubMed · Cited by 14 · see citing works

Untitled work

(2000) · doi:10.1002/1531-8249(200012)48:6

Serotonin signaling is associated with lower amyloid-β levels and plaques in transgenic mice and humans

Cirrito, J. R., Disabato, B. M., Restivo, J. L., Verges, D. K., Goebel, W. D., Sathyan, A., Hayreh, D., D'Angelo, G., Benzinger, T., Yoon, H., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1107411108 · Cited by 370 · see citing works

The role of G protein-coupled receptors in the pathology of Alzheimer's disease

Thathiah, A., & De Strooper, B. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn2977 · Cited by 288 · see citing works

The serotonergic system and cognitive function

Štrac, D. Š., Pivac, N., & Mück‐Šeler, D. (2016) · Translational Neuroscience · doi:10.1515/tnsci-2016-0007 · Cited by 282 · see citing works

The serotonergic system in ageing and Alzheimer's disease

Rodriguez, J. J., Noristani, H. N., & Verkhratsky, A. (2012) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2012.06.010 · Cited by 266 · see citing works

An Antidepressant Decreases CSF Aβ Production in Healthy Individuals and in Transgenic AD Mice

Sheline, Y., West, T., Yarasheski, K., Swarm, R., Jasielec, M. S., Fisher, J. R., Ficker, W. D., Yan, P., Xiong, C., Frederiksen, C., et al. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3008169 · Cited by 238 · see citing works

The role of serotonin in memory: interactions with neurotransmitters and downstream signaling

Seyedabadi, M., Fakhfouri, G., Ramezani, V., Mehr, S. E., & Rahimian, R. (2014) · Experimental Brain Research · doi:10.1007/s00221-013-3818-4 · Cited by 137 · see citing works

Enhanced Prospects for Drug Delivery and Brain Targeting by the Choroid Plexus–CSF Route

Johanson, C. E., Duncan, J. A., Stopa, E. G., & Baird, A. (2005) · Pharmaceutical Research · doi:10.1007/s11095-005-6039-0 · Cited by 128 · see citing works

Serotonergic system, cognition, and BPSD in Alzheimer’s disease

Chakraborty, S., Lennon, J. C., Malkaram, S. A., Zeng, Y., Fisher, D. W., & Dong, H. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.03.050 · Cited by 123 · see citing works

The Relationship Between Cerebrospinal Fluid Biomarkers and Depression in Elderly Women

Gudmundsson, P., Skoog, I. G., Wærn, M., Blennow, K., Palsson, S. P., Rosengren, L., & Gustafson, D. (2007) · American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e3180547091 · Cited by 112 · see citing works

G Protein-Coupled Receptors (GPCRs) in Alzheimer’s Disease: A Focus on BACE1 Related GPCRs

Zhao, J., Deng, Y., Jiang, Z., & Qing, H. (2016) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2016.00058 · Cited by 108 · see citing works

Characterization of serotonin 5‐HT2Creceptor signaling to extracellular signal‐regulated kinases 1 and 2

Werry, T. D., Gregory, K. J., Sexton, P. M., & Christopoulos, A. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03161.x · Cited by 89 · see citing works

Drug Repositioning Approaches for the Discovery of New Therapeutics for Alzheimer's Disease

Kim, T. (2014) · Neurotherapeutics · doi:10.1007/s13311-014-0325-7 · Cited by 82 · see citing works

Amyloid Hypothesis: Is There a Role for Antiamyloid Treatment in Late-Life Depression?

Mahgoub, N., & Alexopoulos, G. S. (2016) · The American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2015.12.003 · Cited by 81 · see citing works

Redundant Gs-coupled serotonin receptors regulate amyloid-β metabolism in vivo

Fisher, J. R., Wallace, C. E., Tripoli, D. L., Sheline, Y. I., & Cirrito, J. R. (2016) · Molecular Neurodegeneration · doi:10.1186/s13024-016-0112-5 · Cited by 79 · see citing works

SAR of psilocybin analogs: Discovery of a selective 5-HT2C agonist

Sard, H., Kumaran, G., Morency, C., Roth, B. L., Compton-Toth, B. A., He, P., & Shuster, L. (2005) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2005.06.104 · Cited by 77 · see citing works

5-Hydroxytryptamine 2C (5-HT2C) Receptor Agonists as Potential Antiobesity Agents

Nilsson, B. M. (2006) · Journal of Medicinal Chemistry · doi:10.1021/jm058240i · Cited by 75 · see citing works

Antidepressants are a rational complementary therapy for the treatment of Alzheimer's disease

Aboukhatwa, M. A., Dosanjh, L. E., & Luo, Y. (2010) · Molecular Neurodegeneration · doi:10.1186/1750-1326-5-10 · Cited by 69 · see citing works

Drug Discovery Targeted to the Alzheimer's APP mRNA 5'-Untranslated Region: The Action of Paroxetine and Dimercaptopropanol

Payton, S. M., Cahill, C. M., Randall, J., Gullans, S. R., & Rogers, J. T. (2003) · Journal of Molecular Neuroscience · doi:10.1385/jmn:20:3:267 · Cited by 61 · see citing works

Is there a CSF biomarker profile related to depression in elderly women?

Gudmundsson, P., Skoog, I. G., Wærn, M., Blennow, K., Zetterberg, H., Rosengren, L., & Gustafson, D. (2010) · Psychiatry Research · doi:10.1016/j.psychres.2008.11.012 · Cited by 55 · see citing works

Antidepressant drugs for beta amyloid-induced depression: A new standpoint?

Schiavone, S., Tucci, P., Mhillaj, E., Bové, M., Trabace, L., & Morgese, M. G. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.05.004 · Cited by 51 · see citing works

Pharmacological Treatment of Depression in Alzheimer’s Disease: A Challenging Task

Cassano, T., Calcagnini, S., Carbone, A., Bukke, V. N., Orkisz, S., Villani, R., Romano, A., Avolio, C., & Gaetani, S. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01067 · Cited by 43 · see citing works

The role of synaptic activity in the regulation of amyloid beta levels in Alzheimer's disease

Cheng, X., Wu, J., Geng, M., & Xiong, J. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.11.021 · Cited by 48 · see citing works

FDA-Preapproved Drugs Targeted to the Translational Regulation and Processing of the Amyloid Precursor Protein

Morse, L. J., Payton, S. M., Cuny, G. D., & Rogers, J. T. (2004) · Journal of Molecular Neuroscience · doi:10.1385/jmn:24:1:129 · Cited by 47 · see citing works

Effect of escitalopram dose and treatment duration on CSF Aβ levels in healthy older adults

Sheline, Y. I., Snider, B. J., Beer, J. C., Seok, D., Fagan, A., Suckow, R., Lee, J.-M., Waligórska, T., Korecka, M., Aselcioglu, I., et al. (2020) · Neurology · doi:10.1212/wnl.0000000000010725 · Cited by 41 · see citing works

Potential cognitive enhancing and disease modification effects of SSRIs for Alzheimer’s disease

Chow, T. W., Pollock, B. G., & Milgram, N. W. (2007) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.a937 · Cited by 45 · see citing works

Treatment of dementia with neurotransmission modulation

Doggrell, S. A., & Evans, S. (2003) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.12.10.1633 · Cited by 43 · see citing works

Imipramine and citalopram facilitate amyloid precursor protein secretion in vitro

PAKASKI, M., BJELIK, A., HUGYECZ, M., KASA, P., JANKA, Z., & KALMAN, J. (2005) · Neurochemistry International · doi:10.1016/j.neuint.2005.03.004 · Cited by 43 · see citing works

Aging, cortical injury and Alzheimer's disease-like pathology in the guinea pig brain

Bates, K. A., Vink, R., Martins, R. N., & Harvey, A. R. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.11.020 · Cited by 31 · see citing works

5-HT2C receptor modulators: a patent survey

Lee, J., Jung, M. E., & Lee, J. (2010) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.2010.518956 · Cited by 29 · see citing works

Alzheimer’s Disease Etiology Hypotheses and Therapeutic Strategies: A Perspective

Scarano, N., Musumeci, F., Casini, B., Brullo, C., D’Ursi, P., Fossa, P., Schenone, S., & Cichero, E. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26146980 · Cited by 30 · see citing works

Understanding How Physical Exercise Improves Alzheimer’s Disease: Cholinergic and Monoaminergic Systems

Zong, B., Yu, F., Zhang, X., Zhao, W., Sun, P., Li, S., & Li, L. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.869507 · Cited by 29 · see citing works

Determination of guinea-pig cortical γ-secretase activity ex vivo following the systemic administration of a γ-secretase inhibitor

Grimwood, S., Hogg, J. E., Jay, M. T., Lad, A. M., Lee, V. S., Murray, F., Peachey, J., Townend, T., Vithlani, M., Beher, D., et al. (2005) · Neuropharmacology · doi:10.1016/j.neuropharm.2005.01.016 · Cited by 25 · see citing works

New 5-HT2C receptor agonists

Bishop, M. J., & Nilsson, B. M. (2003) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.13.11.1691 · Cited by 22 · see citing works

Trait anxiety, a personality risk factor associated with Alzheimer’s Disease

Li, S., Wang, C., Wang, W., & Tan, J. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110124 · Cited by 19 · see citing works

Targeting the serotonergic system in the treatment of neurodegenerative diseases—emerging therapies and unmet challenges

Brüge, A., Ponimaskin, E. G., & Labus, J. (2025) · Pharmacological Reviews · doi:10.1016/j.pharmr.2025.100071 · Cited by 12 · see citing works

Serotonin Receptor Gene Polymorphisms Are Associated with Cerebrospinal Fluid, Genetic, and Neuropsychological Biomarkers of Alzheimer’s Disease

Leko, M. B., Perković, M. N., Španić, E., Štrac, D. Š., Pleić, N., Vogrinc, Ž., Gunjača, I., Bežovan, D., Erjavec, G. N., Klepac, N., et al. (2022) · Biomedicines · doi:10.3390/biomedicines10123118 · Cited by 11 · see citing works

Serotoninergic antidepressants positively affect platelet ADAM10 expression in patients with Alzheimer's disease

Bianco, O. A. F. M., Manzine, P. R., Nascimento, C. M. C., Vale, F. A. C., Pavarini, S. C. I., & Cominetti, M. R. (2015) · International Psychogeriatrics · doi:10.1017/s1041610215001842 · Cited by 11 · see citing works

The Combined Effects of Amyloidosis and Serotonin Deficiency by Tryptophan Hydroxylase-2 Knockout Impacts Viability of the APP/PS1 Mouse Model of Alzheimer’s Disease

von Linstow, C. V., Waider, J., Bergh, M. S.-S., Anzalone, M., Madsen, C. N., Nicolau, A., Wirenfeldt, M., Lesch, K., & Finsen, B. (2021) · Journal of Alzheimer's Disease · doi:10.3233/jad-210581 · Cited by 12 · see citing works

Curcumin effect on non-amyloidogenic pathway for preventing Alzheimer’s disease

(2019) · Biointerface Research in Applied Chemistry · doi:10.33263/briac94.085089 · Cited by 8 · see citing works

Neurotransmitters and Immunity: Molecular Mechanisms, Biological Functions, Diseases, and Potential Therapeutic Targets

Li, G., Li, F., Tang, Y., Guo, S., Yao, Y., Yuan, F., Zhang, B., Jiang, Y. Y., Wang, J., Wu, D., et al. (2025) · MedComm · doi:10.1002/mco2.70556 · Cited by 6 · see citing works

Activation of 5-HT2C Receptor Promotes the Expression of Neprilysin in U251 Human Glioma Cells

Tian, X.-L., Yu, L., Li, W.-Q., Hu, Y. H., Yin, M., & Wang, Z. (2014) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-014-0138-6 · Cited by 6 · see citing works

Computer-Aided Drug Design Approaches to Study Key Therapeutic Targets in Alzheimer’s Disease

Lemos, A., Melo, R., Moreira, I. S., & Cordeiro, M. N. D. S. (2017) · Neuromethods · doi:10.1007/978-1-4939-7404-7_3 · Cited by 4 · see citing works

GPCR, a rider of Alzheimer’s disease

Liu, X., & Zhao, J. (2011) · Frontiers in Biology · doi:10.1007/s11515-011-1129-3 · Cited by 2 · see citing works

Establishment and characterization of RNA-edited serotonin 2C receptor isoform cell models and alteration of amyloid precursor protein ectodomain secretion in HEK293 APPSwe cells

Guo, L., Zhang, J., Yan, Q.-X., & Yin, M. (2011) · Human Cell · doi:10.1007/s13577-011-0014-3 · Cited by 2 · see citing works

Neurotoxic Oxidative Metabolite of Serotonin

Volicer, L., Wrona, M. Z., Matson, W. R., & Dryhurst, G. (2007) · Humana Press eBooks · doi:10.1007/978-1-59259-888-5_8 · Cited by 2 · see citing works

The potential use of natural killer cells to treat Alzheimer's disease: Can nutrition play a role?

Dong, A., Huang, Y., Chen, H., Liu, R., Wu, W., Gao, H., Wang, C., Yu, J., & Wang, L. (2024) · eFood · doi:10.1002/efd2.145 · Cited by 1 · see citing works

Alzheimer Disease—Link With Major Depressive Disorder and Efficacy of Antidepressants in Modifying its Trajectory

Fakih, N., & Fakhoury, M. (2024) · Journal of Psychiatric Practice · doi:10.1097/pra.0000000000000779 · Cited by 1 · see citing works

Yeast as a Model for Studying Aβ Aggregation, Toxicity and Clearance

Bharadwaj, P. (2011) · Australasian Journal of Paramedicine · Cited by 1 · see citing works

Regulation of biochemical pathways involved in neurodegeneration

Pooler, A. M. (2005) · DSpace@MIT (Massachusetts Institute of Technology)

Activation of 5-HT 2C Receptor Promotes the Expression of Neprilysin in U251 Human Glioma Cells

Wang, Y. H. Y.-J. (2015)

Serotonin, Kognition, Demenz

Förstl, H. (2005) · Steinkopff eBooks · doi:10.1007/3-7985-1537-9_5

BindingDB Entry 50016618: SAR of psilocybin analogs: discovery of a selective 5-HT 2C agonist.

BindingDB (2009) · UC San Diego · doi:10.7270/q2pz58b5

Serotonergic Signaling Pathways that Suppress Amyloid Beta in Mouse Models of AD

Fisher, J. R. (2014) · Open Scholarship Institutional Repository (Washington University in St. Louis) · doi:10.7936/k74f1nr2

[5-HT2C receptor subtype modulate production of secretory beta-amyloid protein precursor in incubated rat hippocampal slices].

Zhang, G., Gao, D.-L., Cao, L.-G., & Yin, M. (2004) · PubMed

Activation of 5-HT 2C Receptor Promotes the Expression of Neprilysin in U251 Human Glioma Cells

Wang, Y. H. Y.-J. (2015)

Serotonin 5-HT2a and 5-HT2c Receptors Stimulate Amyloid Precursor Protein Ectodomain Secretion

Nitsch, R. M., Deng, M., Growdon, J. H., & Wurtman, R. J. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.8.4188 · Cited by 219 · see citing works

5‐HT4 receptor agonists increase sAPPα levels in the cortex and hippocampus of male C57BL/6j mice

Cachard-Chastel, M., Lezoualc’h, F., Dewachter, I., Deloménie, C., Croes, S., Devijver, H., Langlois, M., LEUVEN, F. V., Sicsic, S., & Gardier, A. M. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707178 · Cited by 70 · see citing works

O2‐04‐04: SPECIFIC SEROTONIN RECEPTOR SUBTYPES RESPONSIBLE FOR DECREASED CSF AB PRODUCTION

Cirrito, J. R., Sheline, Y. I., Fisher, J., Lee, J., & West, T. (2014) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2014.04.176 · Cited by 1 · see citing works