The DOI matches its Crossref record; 78 of the 78 references it cites were found in a registry or an index.
Opposite metabolic changes in the habenula and ventral tegmental area of a genetic model of helpless behavior
Abstract
Congenitally helpless rats have been selectively bred to display an immediate helpless response to stress in order to model hereditary brain differences that contribute to depression vulnerability. Differences in regional brain metabolism between congenitally helpless and non-helpless rats were investigated using quantitative cytochrome oxidase histochemistry. The results indicated that congenitally helpless rats had 64-71% elevated metabolism in the habenula and a 25% elevation in the related interpeduncular nucleus. In contrast, helpless rats had 28% reduced metabolism in the ventral tegmental area (VTA) and 14-16% reductions in the basal ganglia and basolateral and central amygdala. The opposite metabolic changes in the habenula and ventral tegmental area may be especially important for determining the congenitally helpless rat's global pattern of brain activity, which resembles the metabolic activity pattern produced by dopamine antagonism.
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“The LHb is implicated in negative mood states in both animal and human research.”
From Deep brain stimulation for depression. (2022) · cites this paper as [41]
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Psychopharmacology: The third generation of progress
O’Connell, R. A. (1988) · Comprehensive Psychiatry · doi:10.1016/0010-440x(88)90057-0 · Cited by 3,020
Psychopharmacology: The Third Generation of Progress.
(1988) · Annals of Internal Medicine · doi:10.7326/0003-4819-108-3-509_2 · Cited by 2,021
Limbic-cortical dysregulation: a proposed model of depression
(1997) · The Journal of Neuropsychiatry and Clinical Neurosciences · doi:10.1176/jnp.9.3.471 · Cited by 1,585
The amygdala: Neurobiological aspects of emotion, memory, and mental dysfunction.
Aggleton, J. P. (1992) · Wiley-Liss eBooks · Cited by 1,536
Neuroimaging studies of mood disorders
Drevets, W. C. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01020-9 · Cited by 1,334
The amygdala: Neurobiological aspects of emotion, memory and mental dysfunction
Scheel-Krüger, J. (1993) · Journal of Chemical Neuroanatomy · doi:10.1016/0891-0618(93)90037-5 · Cited by 1,281
Cytochrome oxidase: an endogenous metabolic marker for neuronal activity
Wong-Riley, M. T. T. (1989) · Trends in Neurosciences · doi:10.1016/0166-2236(89)90165-3 · Cited by 1,238
Drevets, W. C. (2001) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00203-8 · Cited by 1,146
Associative processes in addiction and reward. The role of amygdala-ventral striatal subsystems
EVERITT, B. J., PARKINSON, J. A., OLMSTEAD, M. C., ARROYO, M., ROBLEDO, P., & ROBBINS, T. W. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb09280.x · Cited by 708
Swerdlow, N. R., & Koob, G. F. (1987) · Behavioral and Brain Sciences · doi:10.1017/s0140525x00047488 · Cited by 674
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Gass, N., Cleppien, D., Zheng, L., Schwarz, A. J., Meyer-Lindenberg, A., Vollmayr, B., Weber-Fahr, W., & Sartorius, A. (2014) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2013.12.004 · Cited by 36
Metadata
- Authors
- Shumake, J., Edwards, E., & Gonzalez-Lima, F.
- Affiliations
- The University of Texas at Austin (US)
- University of Maryland, Baltimore (US)
- Corresponding author
- Gonzalez-Lima, F.
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 2003-02
- Volume
- 963
- Issue
- 1-2
- Pages
- 274-281
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W1999881677
- Cited by
- 232
- References
- 78
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 11 · 2023: 2 · 2022: 10 · 2021: 9 · 2020: 14 · 2019: 18 · 2018: 21 · 2017: 20 · 2016: 13 · 2015: 11 · 2014: 18 · 2013: 16 · 2012: 6
- FWCI
- 2.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (T32MH18837, T32MH018837)
- National Institute of Neurological Disorders and Stroke (R01NS037755, R01 NS-37755)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Keywords
- brain regional metabolism, habenula, ventral tegmental area, interpeduncular nucleus, amygdala, basal ganglia, depression vulnerability, stress response, dopamine antagonism, cytochrome oxidase histochemistry
- MeSH terms
- Animals, Basal Ganglia, Behavior, Animal, Electron Transport Complex IV, Histocytochemistry, Male, Phenotype, Stress, Psychological, Rats, Sprague-Dawley, Ventral Tegmental Area, Habenula, Rats
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