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Opposite metabolic changes in the habenula and ventral tegmental area of a genetic model of helpless behavior
Abstract
Congenitally helpless rats have been selectively bred to display an immediate helpless response to stress in order to model hereditary brain differences that contribute to depression vulnerability. Differences in regional brain metabolism between congenitally helpless and non-helpless rats were investigated using quantitative cytochrome oxidase histochemistry. The results indicated that congenitally helpless rats had 64-71% elevated metabolism in the habenula and a 25% elevation in the related interpeduncular nucleus. In contrast, helpless rats had 28% reduced metabolism in the ventral tegmental area (VTA) and 14-16% reductions in the basal ganglia and basolateral and central amygdala. The opposite metabolic changes in the habenula and ventral tegmental area may be especially important for determining the congenitally helpless rat's global pattern of brain activity, which resembles the metabolic activity pattern produced by dopamine antagonism.
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- Authors
- Shumake, J., Edwards, E., & Gonzalez-Lima, F.
- Affiliations
- The University of Texas at Austin (US)
- University of Maryland, Baltimore (US)
- Corresponding author
- Gonzalez-Lima, F.
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 2003-02
- Volume
- 963
- Issue
- 1-2
- Pages
- 274-281
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W1999881677
- Cited by
- 232
- References
- 78
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 11 · 2023: 2 · 2022: 10 · 2021: 9 · 2020: 14 · 2019: 18 · 2018: 21 · 2017: 20 · 2016: 13 · 2015: 11 · 2014: 18 · 2013: 16 · 2012: 6
- FWCI
- 2.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (T32MH18837, T32MH018837)
- National Institute of Neurological Disorders and Stroke (R01NS037755, R01 NS-37755)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Keywords
- brain regional metabolism, habenula, ventral tegmental area, interpeduncular nucleus, amygdala, basal ganglia, depression vulnerability, stress response, dopamine antagonism, cytochrome oxidase histochemistry
- MeSH terms
- Animals, Basal Ganglia, Behavior, Animal, Electron Transport Complex IV, Histocytochemistry, Male, Phenotype, Stress, Psychological, Rats, Sprague-Dawley, Ventral Tegmental Area, Habenula, Rats
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