Opposite metabolic changes in the habenula and ventral tegmental area of a genetic model of helpless behavior

Psychopharmacology: The third generation of progress

O’Connell, R. A. (1988) · Comprehensive Psychiatry · doi:10.1016/0010-440x(88)90057-0 · Cited by 3,020

Psychopharmacology: The Third Generation of Progress.

(1988) · Annals of Internal Medicine · doi:10.7326/0003-4819-108-3-509_2 · Cited by 2,021

Limbic-cortical dysregulation: a proposed model of depression

(1997) · The Journal of Neuropsychiatry and Clinical Neurosciences · doi:10.1176/jnp.9.3.471 · Cited by 1,585

The amygdala: Neurobiological aspects of emotion, memory, and mental dysfunction.

Aggleton, J. P. (1992) · Wiley-Liss eBooks · Cited by 1,536

Neuroimaging studies of mood disorders

Drevets, W. C. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01020-9 · Cited by 1,334

The amygdala: Neurobiological aspects of emotion, memory and mental dysfunction

Scheel-Krüger, J. (1993) · Journal of Chemical Neuroanatomy · doi:10.1016/0891-0618(93)90037-5 · Cited by 1,281

Cytochrome oxidase: an endogenous metabolic marker for neuronal activity

Wong-Riley, M. T. T. (1989) · Trends in Neurosciences · doi:10.1016/0166-2236(89)90165-3 · Cited by 1,238

Neuroimaging and neuropathological studies of depression: implications for the cognitive-emotional features of mood disorders

Drevets, W. C. (2001) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00203-8 · Cited by 1,146

Associative processes in addiction and reward. The role of amygdala-ventral striatal subsystems

EVERITT, B. J., PARKINSON, J. A., OLMSTEAD, M. C., ARROYO, M., ROBLEDO, P., & ROBBINS, T. W. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb09280.x · Cited by 708

Dopamine, schizophrenia, mania, and depression: Toward a unified hypothesis of cortico-striatopallido-thalamic function

Swerdlow, N. R., & Koob, G. F. (1987) · Behavioral and Brain Sciences · doi:10.1017/s0140525x00047488 · Cited by 674

Depression, intellectual impairment, and Parkinson disease

Mayeux, R. P., Stern, Y., Rosen, J. J., & Leventhal, J. (1981) · Neurology · doi:10.1212/wnl.31.6.645 · Cited by 571

The dorsal diencephalic conduction system: A review of the anatomy and functions of the habenular complex

Sutherland, R. J. (1982) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(82)90003-3 · Cited by 537

PET measurements of brain glucose metabolism and blood flow in major depressive disorder: a critical review

Videbech, P. (2000) · Acta Psychiatrica Scandinavica · doi:10.1034/j.1600-0447.2000.101001011.x · Cited by 419

Stimulation of the lateral habenula inhibits dopamine-containing neurons in the substantia nigra and ventral tegmental area of the rat

Christoph, G., Leonzio, R., & Wilcox, K. (1986) · The Journal of Neuroscience · doi:10.1523/jneurosci.06-03-00613.1986 · Cited by 418

Physiological Evidence for Habenula as Major Link Between Forebrain and Midbrain Raphe

Wang, R. Y., & Aghajanian, G. K. (1977) · Science · doi:10.1126/science.194312 · Cited by 411

Zur Serotonin-Hypothese der Depression*

Lesch, K., & Beckmann, H. (1990) · Fortschritte der Neurologie · Psychiatrie · doi:10.1055/s-2007-1001206 · Cited by 392

Magnetic Resonance Imaging of the Caudate Nuclei in Depression: Preliminary Observations

Krishnan, K. R. R. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820070047007 · Cited by 365

Metabolic rate in the right amygdala predicts negative affect in depressed patients

Abercrombie, H. C., Schaefer, S. M., Larson, C. L., Oakes, T. R., Lindgren, K. A., Holden, J. E., Perlman, S. B., Turski, P. A., Krahn, D. D., Benca, R. M., et al. (1998) · Neuroreport · doi:10.1097/00001756-199810050-00028 · Cited by 316

Regional cerebral glucose utilization in patients with a range of severities of unipolar depression

Kimbrell, T. A., Ketter, T. A., George, M. S., Little, J. T., Benson, B. E., Willis, M. W., Herscovitch, P., & Post, R. M. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01216-1 · Cited by 303

Covariation of activity in habenula and dorsal raphe nuclei following tryptophan depletion

Morris, J. S., Smith, K. A., Cowen, P. J., Friston, K. J., & Dolan, R. J. (1999) · NeuroImage · doi:10.1006/nimg.1999.0455 · Cited by 288

Functional Magnetic Resonance Imaging of Brain Reward Circuitry in the Human

BREITER, H. C., & Rosen, B. R. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb09287.x · Cited by 233

Cerebral correlates of depressed behavior in rats, visualized using 14C- 2-deoxyglucose autoradiography

Caldecott-Hazard, S., Mazziotta, J. C., & Phelps, M. E. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-06-01951.1988 · Cited by 194

The role of the habenular complex in the elevation of dorsal raphe nucleus serotonin and the changes in the behavioral responses produced by uncontrollable stress

Amat, J., Sparks, P., Matus-Amat, P., Griggs, J., Watkins, L. R., & Maier, S. F. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02934-1 · Cited by 187

Dopaminergic abnormalities in amygdaloid nuclei in major depression: a postmortem study

Klimek, V., Schenck, J. E., Han, H., Stockmeier, C. A., & Ordway, G. A. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01383-5 · Cited by 181

Exposure to inescapable but not escapable shock increases extracellular levels of 5-HT in the dorsal raphe nucleus of the rat

Maswood, S., Barter, J. E., Watkins, L. R., & Maier, S. F. (1998) · Brain Research · doi:10.1016/s0006-8993(97)01313-9 · Cited by 173

Evidence for, and nature of, the tonic inhibitory influence of habenulointerpeduncular pathways upon cerebral dopaminergic transmission in the rat

Nishikawa, T., Fage, D., & Scatton, B. (1986) · Brain Research · doi:10.1016/0006-8993(86)90347-1 · Cited by 166

Cytochrome oxidase activity in the auditory system of the mouse: A qualitative and quantitative histochemical study

Gonzalez-Lima, F., & Cada, A. M. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90550-9 · Cited by 163

Frontostriatal deficits in unipolar major depression

Rogers, M. A., Bradshaw, J. L., Pantelis, C., & Phillips, J. G. (1998) · Brain Research Bulletin · doi:10.1016/s0361-9230(98)00126-9 · Cited by 150

Intellectual changes in patients with MPTP‐induced parkinsonism

Stern, Y., & Langston, J. W. (1985) · Neurology · doi:10.1212/wnl.35.10.1506 · Cited by 150

Possible excitatory amino acid afferents to nucleus raphe dorsalis of the rat investigated with retrograde wheat germ agglutinin and d-[3H]aspartate tracing

Kalén, P., Karlson, M., & Wiklund, L. (1985) · Brain Research · doi:10.1016/0006-8993(85)91244-2 · Cited by 148

Quantitative mapping of cytovhrome oxidase activity in the central auditory system of the gerbil: a study with calibrated activity standards and metal-intensified histochemistry

Gonzalez-Lima, F., & Jones, D. (1994) · Brain Research · doi:10.1016/0006-8993(94)90836-2 · Cited by 145

Brain Glucose Metabolism During Non—Rapid Eye Movement Sleep in Major Depression

Ho, A. P. (1996) · Archives of General Psychiatry · doi:10.1001/archpsyc.1996.01830070095014 · Cited by 131

Selective activation of the mesocortico-frontal dopaminergic neurons induced by lesion of the habenula in the rat

Lisoprawski, A., Herve, D., Blanc, G., Glowinski, J., & Tassin, J. P. (1980) · Brain Research · doi:10.1016/0006-8993(80)90135-3 · Cited by 130

Prevention of learned helplessness: In vivo correlation with cortical serotonin

Petty, F., Kramer, G. L., & Wilson, L. B. (1992) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(92)90163-a · Cited by 123

Forebrain origins and terminations of the medial forebrain bundle metabolically activated by rewarding stimulation or by reward-blocking doses of pimozide

Gallistel, C. R., Gomita, Y., Yadin, E., & Campbell, K. J. (1985) · Journal of Neuroscience · doi:10.1523/jneurosci.05-05-01246.1985 · Cited by 119

Metabolic Mapping of the Brain During Rewarding Self-Stimulation

Porrino, L. J., Esposito, R., Seeger, T., Crane, A. M., Pert, A., & Sokoloff, L. (1984) · Science · doi:10.1126/science.6710145 · Cited by 118

Cells of the rat lateral habenula respond to high-threshold somatosensory inputs

Benabid, A. L., & Jeaugey, L. (1989) · Neuroscience Letters · doi:10.1016/0304-3940(89)90393-5 · Cited by 94

Cytochrome Oxidase in Neuronal Metabolism and Alzheimer’s Disease

Gonzalez-Lima, F. (1998) · Springer eBooks · doi:10.1007/978-1-4757-9936-1 · Cited by 92

Habenula and thalamus cell transplants restore normal sleep behaviors disrupted by denervation of the interpeduncular nucleus

Haun, F., Eckenrode, T. C., & Murray, M. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-08-03282.1992 · Cited by 91

Plasticity of [14C]2-deoxy-d-glucose incorporation into neostriatum and related structures in response to dopamine neuron damage and apomorphine replacement

Kozlowski, M. R., & Marshall, J. F. (1980) · Brain Research · doi:10.1016/0006-8993(80)90442-4 · Cited by 89

The fasciculus retroflexus controls the integrity of REM sleep by supporting the generation of hippocampal theta rhythm and rapid eye movements in rats

Valjakka, A., Vartiainen, J., Tuomisto, L. M., Tuomisto, J. T., Olkkonen, H., & Airaksinen, M. M. (1998) · Brain Research Bulletin · doi:10.1016/s0361-9230(98)00006-9 · Cited by 86

Quantitative histochemistry of cytochrome oxidase in rat brain

Gonzalez-Lima, F., & Garrosa, M. (1991) · Neuroscience Letters · doi:10.1016/0304-3940(91)90943-n · Cited by 83

Self-stimulation of the habenular complex in the rat.

Sutherland, R. J., & Nakajima, S. (1981) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0077833 · Cited by 77

Ascending reticular activating system in the rat: A 2-deoxyglucose study

Gonzalez-Lima, F., & Scheich, H. (1985) · Brain Research · doi:10.1016/0006-8993(85)91190-4 · Cited by 76

Cytochrome Oxidase in Neuronal Metabolism and Alzheimer's Disease

Gonzalez-Lima, F. (2013) · Medical Entomology and Zoology · Cited by 74

Role of lateral habenula in the regulation of exploratory behavior and its relationship to stress in rats

Lee, E. H. Y., & Huang, S.-P. (1988) · Behavioural Brain Research · doi:10.1016/0166-4328(88)90169-6 · Cited by 73

Relevance of the Habenular Complex to Neuropsychiatry: A Review and Hypothesis

Sandyk, R. (1991) · International Journal of Neuroscience · doi:10.3109/00207459108990738 · Cited by 70

Haloperidol and Cerebral Metabolism in the Conscious Rat: Relation to Pharmacokinetics

Pizzolato, G., Soncrant, T. T., & Rapoport, S. I. (1984) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1984.tb12792.x · Cited by 67

Congenital helpless rats as a genetic model for cortex metabolism in depression

Shumake, J., Poremba, A., Edwards, E., & Gonzalez-Lima, F. (2000) · Neuroreport · doi:10.1097/00001756-200011270-00040 · Cited by 65

Genetic predisposition and the development of posttraumatic stress disorder in an animal model

King, J. A., Abend, S., & Edwards, E. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01071-x · Cited by 65

Neurochemical and behavioral consequences of mild, uncontrollable shock: Effects of PCPA

Edwards, E., Johnson, J., Anderson, D. C., Turano, P., & Henn, F. A. (1986) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(86)90018-3 · Cited by 58

Regional brain effects of sodium azide treatment on cytochrome oxidase activity: a quantitative histochemical study

Cada, A. M., Gonzalez-Lima, F., Rose, G. M., & Bennett, M. C. (1995) · Metabolic Brain Disease · doi:10.1007/bf02109361 · Cited by 58

Early Stress and Genetic Influences on Hypothalamic–Pituitary–Adrenal Axis Functioning in Adulthood

King, J. A., & Edwards, E. (1999) · Hormones and Behavior · doi:10.1006/hbeh.1999.1525 · Cited by 57

Further evidence for excitatory amino acid transmission in the lateral habenular projection to the rostral raphe nuclei: Lesion-induced decrease of high affinity glutamate uptake

Kalén, P., Pritzel, M., Nieoullon, A. L., & Wiklund, L. (1986) · Neuroscience Letters · doi:10.1016/0304-3940(86)90225-9 · Cited by 57

Effect of some brain lesions on intracranial self-stimulation in the rat

Boyd, E., & Gardner, L. C. (1967) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1967.213.4.1044 · Cited by 56

Quantitative Histochemistry of Cytochrome Oxidase Activity

Gonzalez-Lima, F., & Cada, A. M. (1998) · Springer eBooks · doi:10.1007/978-1-4757-9936-1_2 · Cited by 53

D1/D2 DOPAMINE RECEPTOR STIMULATION BY L-DOPA: A[14C]-2-DEOXYGLUCOSE AUTORADIOGRAPHIC STUDY

Trugman, J. M., JAMES, C. L., & Wooten, G. F. (1991) · Brain · doi:10.1093/brain/114.3.1429 · Cited by 50

Melancholia in rodents: neurobiology and pharmacology.

Henn, F. A., Johnson, J., Edwards, E., & Anderson, D. (1985) · PubMed · Cited by 49

Withdrawal following cocaine self‐administration decreases regional cerebral metabolic rate in critical brain reward regions

Hammer, R. P., Pires, W. S., Markou, A., & Koob, G. F. (1993) · Synapse · doi:10.1002/syn.890140110 · Cited by 49

Dissociation of septo-hippocampal metabolism in the congenitally helpless rat

Shumake, J., Edwards, E., & Gonzalez-Lima, F. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00297-x · Cited by 48

First and second order maternal behavior related afferents of the lateral habenula

Felton, T. M., Linton, L., Rosenblatt, J. S., & Morell, J. I. (1999) · Neuroreport · doi:10.1097/00001756-199903170-00039 · Cited by 48

Untitled work

(2001) · PubMed · Cited by 47

Hypermetabolism of paraventricular hypothalamus in the congenitally helpless rat

Shumake, J., Edwards, E., & Gonzalez-Lima, F. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(01)02142-5 · Cited by 41

Genetic Studies in Affective Disorders

PAPOLOS, DEMITRI, F., LACHMAN, & HERBERT, M. (1995) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-199509000-00014 · Cited by 38

Habenular modulation of raphe indoleamine metabolism

Speciale, S. G., Neckers, L., & Wyatt, R. J. (1980) · Life Sciences · doi:10.1016/0024-3205(80)90506-8 · Cited by 35

Alterations in glucocorticoid inducible RNAs in the limbic system of learned helpless rats

Lachman, H. M., Papolos, D. F., Boyle, A., Sheftel, G., Juthani, M., Edwards, E., & Henn, F. A. (1993) · Brain Research · doi:10.1016/0006-8993(93)90862-h · Cited by 34

Effects of reinforcement-blocking doses of pimozide on neural system driven by rewarding stimulation of the MFB: A 14C-2-deoxyglucose analysis

Gomita, Y., & Gallistel, C. R. (1982) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(82)90369-0 · Cited by 34

Action of habenular efferents on ventral tegmental area neurons studied in vitro

Matsuda, Y., & Fujimura, K. (1992) · Brain Research Bulletin · doi:10.1016/0361-9230(92)90254-u · Cited by 33

Effects of methylenedioxymethamphetamine on local cerebral glucose utilization in the rat

Wilkerson, G., & London, E. D. (1989) · Neuropharmacology · doi:10.1016/0028-3908(89)90128-7 · Cited by 33

Effect size of efficacy measures comparing divalproex, lithium and placebo in acute mania

Bowden, C. L., Davis, J. M., Morris, D. D., Swann, A. C., Calabrese, J. R., Lambert, M., & Goodnick, P. J. (1997) · Depression and Anxiety · doi:10.1002/(sici)1520-6394(1997)6:1 · Cited by 31

Network operations revealed by brain metabolic mapping in a genetic model of hyperactivity and attention deficit: the Naples high- and low-excitability rats

Gonzalez-Lima, F., & Sadile, A. G. (2000) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(99)00049-4 · Cited by 30

Lateral habenula and hippocampus: A complex interaction raphe cells-mediated

Ferraro, G., Montalbano, M. E., Sardo, P., & Grutta, V. L. (1997) · Journal of Neural Transmission · doi:10.1007/bf01291880 · Cited by 29

Habenula lesions attenuate lateral hypothalamic analgesia in the formalin test

Fuchs, P. N., & Cox, V. C. (1993) · Neuroreport · doi:10.1097/00001756-199302000-00001 · Cited by 26

Effect of some brain lesions on septal intracranial self-stimulation in the rat

Boyd, E., & Celso, M. (1970) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1970.219.3.734 · Cited by 19

Cytochrome Oxidase Atlas of Rat Brain

Gonzalez-Lima, F., & Cada, A. M. (1998) · Springer eBooks · doi:10.1007/978-1-4757-9936-1_10 · Cited by 16

Melancholia as a Neurological Disorder

Austin, M., & Mitchell, P. (1996) · Cambridge University Press eBooks · doi:10.1017/cbo9780511759024.016 · Cited by 15

Genetic Studies in Affective Disorders: Overview of Basic Methods, Current Directions, and Critical Research Issues

Dünner, D. L. (1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.6.948-a · Cited by 13

Effects of self-administered phencyclidine on regional uptake of 2-deoxy-d-[1-14C]glucose in brain

Weissman, A. D., Marquis, K. L., Moreton, J. E., & London, E. D. (1989) · Neuropharmacology · doi:10.1016/0028-3908(89)90136-6 · Cited by 10

Ketamine blocks bursting in the lateral habenula to rapidly relieve depression

Yang, Y., Cui, Y., Sang, K., Dong, Y., Ni, Z., Ma, S., & Hu, H. (2018) · Nature · doi:10.1038/nature25509 · Cited by 1,036

The habenula: from stress evasion to value-based decision-making

Hikosaka, O. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2866 · Cited by 955

Remission of major depression under deep brain stimulation of the lateral habenula in a therapy-refractory patient

Sartorius, A., Kiening, K. L., Kirsch, P., von Gall, C. C., Haberkorn, U., Unterberg, A. W., Henn, F. A., & Meyer-Lindenberg, A. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.08.027 · Cited by 611

The neurobiology of depression and antidepressant action

Willner, P., Scheel-Krüger, J., & Belzung, C. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.12.007 · Cited by 519

Reward processing by the lateral habenula in normal and depressive behaviors

Proulx, C. D., Hikosaka, O., & Malinow, R. (2014) · Nature Neuroscience · doi:10.1038/nn.3779 · Cited by 461

Hypermetabolism of paraventricular hypothalamus in the congenitally helpless rat

Shumake, J., Edwards, E., & Gonzalez-Lima, F. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(01)02142-5 · Cited by 41

Brain differences in newborn rats predisposed to helpless and depressive behavior

Shumake, J., Conejo, N. M., González‐Pardo, H., & Gonzalez-Lima, F. (2004) · Brain Research · doi:10.1016/j.brainres.2004.10.015 · Cited by 57

Dissociation of septo-hippocampal metabolism in the congenitally helpless rat

Shumake, J., Edwards, E., & Gonzalez-Lima, F. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00297-x · Cited by 48

Congenital helpless rats as a genetic model for cortex metabolism in depression

Shumake, J., Poremba, A., Edwards, E., & Gonzalez-Lima, F. (2000) · Neuroreport · doi:10.1097/00001756-200011270-00040 · Cited by 65

The functional neuroanatomy of helplessness vulnerability

Shumake, J. (2004) · Texas ScholarWorks (Texas Digital Library)