The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Anatomical basis for cannabinoid-induced antinociception as revealed by intracerebral microinjections
Abstract
Cannabinoids suppress behavioral and neurophysiological responses to noxious stimuli in rodents when administered systemically. The purpose of this study was to extend previous studies of the site of cannabinoid analgesia. Rats were tested in the tail flick test before and after microinjections of the cannabinoid agonist WIN55, 212-2 (5 microg) into one of 17 different brain regions. WIN55,212-2 significantly elevated tail-flick latencies when injected into the amygdala, the lateral posterior and submedius regions of the thalamus, the superior colliculus and the noradrenergic A5 region. By contrast, pain behavior was unaffected by microinjections of the cannabinoid into the other 11 areas examined (prefrontal cortex, nucleus accumbens, lateral hypothalamus, substantia nigra, cuneiform nucleus, anterior pretectal, intralaminar, parafasicular, posterior, thalamic nuclei, as well as the ventral medial, ventral lateral nuclei in the posterior thalamus).
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“Drug concentrations were based on reports in the literature and our previous results (Martin et al, 1999;Ganon-Elazar and Akirav, 2009;Campolongo et al, 2009;Abush and Akirav, 2010;Segev and Akirav, 2011).”
From Cannabinoids prevent the development of behavioral and endocrine alterations in a rat model of intense stress (2012) · cites this paper as Martin et al, 1999
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Herkenham, M., Lynn, A., Johnson, M., Melvin, L., de Costa, B., & Rice, K. (1991) · The Journal of Neuroscience · doi:10.1523/jneurosci.11-02-00563.1991 · Cited by 2,159
Immunohistochemical distribution of cannabinoid CB1 receptors in the rat central nervous system
Tsou, K., Brown, S., Sañudo-Peña, M. C., Mackie, K., & Walker, J. M. (1998) · Neuroscience · doi:10.1016/s0306-4522(97)00436-3 · Cited by 1,586
Self-citationYaksh, T. L., Yeung, J. C., & Rudy, T. A. (1976) · Brain Research · doi:10.1016/0006-8993(76)91009-x · Cited by 610
Cannabinoids reduce hyperalgesia and inflammation via interaction with peripheral CB1 receptors
Richardson, J. D., Kilo, S., & Hargreaves, K. (1998) · Pain · doi:10.1016/s0304-3959(97)00213-3 · Cited by 501
Craig, A. D., & Burton, H. (1981) · Journal of Neurophysiology · doi:10.1152/jn.1981.45.3.443 · Cited by 288
Martin, W. J., Hohmann, A. G., & Walker, J. M. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-20-06601.1996 · Cited by 172
Self-citationAn examination of the central sites of action of cannabinoid-induced antinociception in the rat
Martin, W. J., Patrick, S. L., Coffin, P. O., Tsou, K., & Walker, J. M. (1995) · Life Sciences · doi:10.1016/0024-3205(95)00195-c · Cited by 168
Self-citationChapter 27 Pharmacologic evidence for the modulation of nociception by noradrenergic neurons
Proudfit, H. K. (1988) · Progress in brain research · doi:10.1016/s0079-6123(08)62802-2 · Cited by 149
Martin, W. J., Tsou, K., & Walker, J. M. (1998) · Neuroscience Letters · doi:10.1016/s0304-3940(98)00044-5 · Cited by 138
Self-citationHohmann, A. G., Tsou, K., & Walker, J. M. (1999) · Journal of Neurophysiology · doi:10.1152/jn.1999.81.2.575 · Cited by 127
Self-citationHohmann, A. G., Martin, W. J., Tsou, K., & Walker, J. M. (1995) · Life Sciences · doi:10.1016/0024-3205(95)00196-d · Cited by 120
Self-citationCannabinoid-induced antinociception is mediated by a spinalα2-noradrenergic mechanism
Lichtman, A. H., & Martin, B. R. (1991) · Brain Research · doi:10.1016/0006-8993(91)90017-p · Cited by 114
Tsou, K., Lowitz, K., Hohmann, A. G., Martin, W. J., Hathaway, C. B., Bereiter, D. A., & Walker, J. M. (1996) · Neuroscience · doi:10.1016/s0306-4522(96)83015-6 · Cited by 110
Self-citationHohmann, A. G., Tsou, K., & Walker, J. M. (1998) · Neuroscience Letters · doi:10.1016/s0304-3940(98)00802-7 · Cited by 108
Self-citationYaksh, T. L. (1981) · The Journal of Clinical Pharmacology · doi:10.1002/j.1552-4604.1981.tb02612.x · Cited by 103
Antinociceptive actions of cannabinoids following intraventricular administration in rats
Martin, W. J., Lai, N., Patrick, S. L., Tsou, K., & Walker, J. M. (1993) · Brain Research · doi:10.1016/0006-8993(93)91334-o · Cited by 99
Self-citationSuperior colliculus cells respond to noxious stimuli
Stein, B. E., & Dixon, J. P. (1978) · Brain Research · doi:10.1016/0006-8993(78)90006-9 · Cited by 64
Alterations in nociception following lesions of the A5 catecholamine nucleus
Sagen, J., & Proudfit, H. K. (1986) · Brain Research · doi:10.1016/0006-8993(86)91108-x · Cited by 30
Antinociceptive effect of agonists microinjected into the anterior pretectal nucleus of the rat
Prado, W. A. (1989) · Brain Research · doi:10.1016/0006-8993(89)91009-3 · Cited by 25
Chapter 7 Stimulation-produced antinociception
Dostrovsky, J. O. (1988) · Progress in brain research · doi:10.1016/s0079-6123(08)62782-x · Cited by 13
Charpentier, J. (1967) · Psychopharmacology · doi:10.1007/bf00401247 · Cited by 11
ANALGESIC EFFECT OF INTRAVENTRICULAR OR INTRACEREBRAL MICRO-INJECTION OF MORPHINE
Ang, C. (1962) · Acta Physiological Sinica · Cited by 4
Research works printed but not linked: 2
- G. Paxinos, C., Watson, The Rat Brain in Stereotaxic Coordinates, compact 3rd edn., Academic Press, San Diego, 1997.
- Tsou, 1962, Analgesic effect of intraventricular or intracerebral microinjection of morphine, Acta Physiologica Sinica, 25, 119
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Millan, M. J. (2002) · Progress in Neurobiology · doi:10.1016/s0301-0082(02)00009-6 · Cited by 3,035
The Endocannabinoid System as an Emerging Target of Pharmacotherapy
Pacher, P., Bátkai, S., & Kunos, G. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.3.2 · Cited by 2,077
The molecular logic of endocannabinoid signalling
Piomelli, D. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1247 · Cited by 1,957
Cannabinoid receptors and pain
Pertwee, R. G. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00031-9 · Cited by 741
Svendsen, K. B., Jensen, T. S., & Bach, F. W. (2004) · BMJ · doi:10.1136/bmj.38149.566979.ae · Cited by 500
Metadata
- Authors
- Martin, W. J., Coffin, P. O., Attias, E., Balinsky, M., Tsou, K., & Walker, J. M.
- Affiliations
- Brown University (US)
- Corresponding author
- Walker, J.Michael
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1999-03
- Volume
- 822
- Issue
- 1-2
- Pages
- 237-242
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2009864778
- Cited by
- 164
- References
- 22
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 2 · 2022: 5 · 2021: 2 · 2020: 3 · 2019: 8 · 2018: 2 · 2017: 9 · 2016: 5 · 2015: 6 · 2014: 8 · 2013: 7 · 2012: 7
- FWCI
- 4.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation
- National Institutes of Health (5r01ns033247-08, 5k02da000375-09, 1f31da005617-01)
- National Institute on Drug Abuse (F31DA05617, K02 DA-00375)
- National Institute of Neurological Disorders and Stroke (NS 33247)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
- Keywords
- cannabinoid analgesia, antinociception, WIN 55,212-2, intracerebral microinjection, amygdala, thalamus, superior colliculus, tail-flick test, pain behavior, cannabinoid receptor agonists
- MeSH terms
- Amygdala, Analgesics, Animals, Brain Chemistry, Cannabinoids, Male, Microinjections, Morpholines, Naphthalenes, Nociceptors, Norepinephrine, Pain, Pain Measurement, Reaction Time, Superior Colliculi, Thalamus, Rats, Sprague-Dawley, Benzoxazines, Rats
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