The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Angiotensin II, adhesion, and cardiac fibrosis
Abstract
Angiotensin II (AII) plays a critical role in cardiac remodeling. This peptide promotes cardiac myocyte hypertrophy and cardiac fibroblast interstitial fibrotic changes associated with left ventricular hypertrophy, post myocardial infarction remodeling and congestive heart failure. AII mediates cardiac myocyte hypertrophy directly via induction of immediate early genes through a MAP kinase dependent pathway. In addition, it mediates cardiac hypertrophy indirectly by stimulating release of norepinephrine from cardiac nerve endings and endothelin from endothelial cells. AII also has multiple effects on cardiac fibroblasts: it induces cardiac fibroblast proliferation, synthesis and secretion of adhesion molecules and extracellular matrix proteins, and expression of integrin adhesion receptors. In addition it stimulates cardiac fibroblasts to adhere more vigorously to defined matrixes. This review will discuss the molecular pathways that have been implicated in these AII induced effects in the cardiac fibroblast.
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Cited by
Cardiac Fibrosis: The Fibroblast Awakens
Travers, J. G., Kamal, F. A., Robbins, J., Yutzey, K. E., & Blaxall, B. C. (2016) · Circulation Research · doi:10.1161/circresaha.115.306565 · Cited by 1,596
Gene Expression in Fibroblasts and Fibrosis: Involvement in Cardiac Hypertrophy
Manabe, I., Shindo, T., & Nagai, R. (2002) · Circulation Research · doi:10.1161/01.res.0000046452.67724.b8 · Cited by 512
Ross, R. S., & Borg, T. K. (2001) · Circulation Research · doi:10.1161/hh1101.091862 · Cited by 451
Getting to the Heart of the Matter: New Insights Into Cardiac Fibrosis
Leask, A. (2015) · Circulation Research · doi:10.1161/circresaha.116.305381 · Cited by 340
Prevention of Post-Operative Adhesions: A Comprehensive Review of Present and Emerging Strategies
Fatehi Hassanabad, A., Zarzycki, A. N., Jeon, K., Dundas, J. A., Vasanthan, V., Deniset, J. F., & Fedak, P. W. M. (2021) · Biomolecules · doi:10.3390/biom11071027 · Cited by 178
Metadata
- Authors
- Schnee, J.
- Venue
- Cardiovascular Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-05
- Volume
- 46
- Issue
- 2
- Pages
- 264-268
- ISSN
- 0008-6363 (ISSN-L)
- OpenAlex
- W2044427990
- Cited by
- 254
- References
- 41
- FWCI
- 8.70
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
