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Cited by 178Intestinal and Peritoneal AdhesionsSurgical Sutures and AdhesivesHernia repair and management

Prevention of Post-Operative Adhesions: A Comprehensive Review of Present and Emerging Strategies

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Fatehi Hassanabad, Ali, Zarzycki, Anna N., Jeon, Kristina, Dundas, Jameson A., Vasanthan, Vishnu, Deniset, Justin F., Fedak, Paul W. M.·2021·Biomolecules
DOI 10.3390/biom11071027PMC PMC8301806
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Abstract

Post-operative adhesions affect patients undergoing all types of surgeries. They are associated with serious complications, including higher risk of morbidity and mortality. Given increased hospitalization, longer operative times, and longer length of hospital stay, post-surgical adhesions also pose a great financial burden. Although our knowledge of some of the underlying mechanisms driving adhesion formation has significantly improved over the past two decades, literature has yet to fully explain the pathogenesis and etiology of post-surgical adhesions. As a result, finding an ideal preventative strategy and leveraging appropriate tissue engineering strategies has proven to be difficult. Different products have been developed and enjoyed various levels of success along the translational tissue engineering research spectrum, but their clinical translation has been limited. Herein, we comprehensively review the agents and products that have been developed to mitigate post-operative adhesion formation. We also assess emerging strategies that aid in facilitating precision and personalized medicine to improve outcomes for patients and our healthcare system.

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  • In hernia repairs, ePTFE serves as a physical barrier that prevents post-surgical adhesions between organs and surrounding tissues, reducing complications such as bowel obstruction or chronic pain.

    “For instance, in hernia repairs, ePTFE serves as a physical barrier that prevents post-surgical adhesions between organs and surrounding tissues, thereby reducing complications such as bowel obstruction or chronic pain [241].”

    From Biomaterials in Postoperative Adhesion Barriers and Uterine Tissue Engineering (2025) · cites this paper as [241]

    Section 4.1 describes ePTFE as a permanent physical barrier that can prevent adhesion formation, and the Introduction identifies chronic pain as a complication of adhesions. The copy does not establish that ePTFE prevents adhesions specifically in hernia repairs or that its use reduces bowel obstruction or chronic pain in those patients; the ePTFE evidence discussed concerns other surgical settings. (LLM, conf=0.88)

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Authors
Fatehi Hassanabad, A., Zarzycki, A. N., Jeon, K., Dundas, J. A., Vasanthan, V., Deniset, J. F., & Fedak, P. W. M.
Affiliations
  • Section of Cardiac Surgery, Department of Cardiac Sciences, Libin Cardiovascular Institute, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 2N9, Canada
  • University of Calgary (CA)
  • University of Alberta (CA)
Corresponding author
Fedak, Paul W. M.
ORCID
Venue
Biomolecules
Publisher
MDPI AG
Published
2021-07-14
Volume
11
Issue
7
Pages
1027
ISSN
2218-273X (ISSN-L)
DOI
10.3390/biom11071027
PMC
PMC8301806
OpenAlex
W3177926842
Cited by
178
References
6
Citations by year
2026: 40 · 2025: 49 · 2024: 47 · 2023: 27 · 2022: 11 · 2021: 4
FWCI
5.28
Type
journal article
Language
en
Open access
Licence
Locations
  • Biomolecules (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Medicine › Surgery › Intestinal and Peritoneal Adhesions
  • Health Sciences › Medicine › Surgery › Surgical Sutures and Adhesives
  • Health Sciences › Medicine › Surgery › Hernia repair and management
Keywords
postoperative adhesions, adhesion prevention, tissue engineering, clinical translation, personalized medicine, surgical complications
MeSH terms
Acetylcysteine, Tissue Adhesions, Anti-Inflammatory Agents, Non-Steroidal, Biocompatible Materials, Humans, Materials Testing, Polymers, Postoperative Complications, Receptors, Angiotensin, Surgical Mesh, Genetic Therapy, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Nanoparticles, Molecular Targeted Therapy

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