Endocannabinoid signaling in synchronizing embryo development and uterine receptivity for implantation.
Abstract
There are reports of adverse effects of cannabinoids on pregnancy outcome including retarded embryo development and pregnancy failure. Thus, discoveries of endogenous cannabinoid-like lipid mediators and cannabinoid receptors raise questions about their pathophysiological roles during normal pregnancy. We previously reported that anandamide, an endogenously produced arachidonate derivative (endocannabinoid), is synthesized in the female reproductive tracts, and it acts on cannabinoid receptors expressed on the cell surface of the embryo to regulate the preimplantation embryo development and implantation in mice. This review presents genetic, molecular, physiological and pharmacological evidence that the levels of uterine anandamide and blastocyst CB1 cannabinoid receptors are coordinately regulated to synchronize preimplantation development and uterine receptivity for implantation in mice.
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The CB1 cannabinoid receptor protein is found in the rodent uterus and blastocyst.
“The CB1 cannabinoid receptor protein (CB1) is found in the rodent uterus and blastocyst where the receptor contributes to normal fetal implantation and implantation failure [41].”
From Endocannabinoid involvement in endometriosis. (2010) · cites this paper as [41]
The CB1 receptor contributes to normal fetal implantation and implantation failure in rodents.
“The CB1 cannabinoid receptor protein (CB1) is found in the rodent uterus and blastocyst where the receptor contributes to normal fetal implantation and implantation failure [41].”
From Endocannabinoid involvement in endometriosis. (2010) · cites this paper as [41]
The endocannabinoid system is involved in reproductive function and dysfunction.
“These findings implicate involvement of the endocannabinoid system in reproductive function and dysfunction.”
From Endocannabinoid involvement in endometriosis. (2010) · cites this paper as [41]
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- Authors
- Paria, B. C., Wang, H., & Dey, S. K.
- Affiliations
- Vanderbilt University Medical Center (US)
- Corresponding author
- Paria, B.C.
- Dey, S.K.
- ORCID
- Venue
- Chemistry and Physics of Lipids
- Publisher
- Elsevier BV
- Published
- 2002-12
- Volume
- 121
- Issue
- 1-2
- Pages
- 201-210
- ISSN
- 0009-3084 (ISSN-L)
- OpenAlex
- W2020719473
- Cited by
- 47
- References
- 31
- Citations by year
- 2024: 3 · 2023: 3 · 2021: 1 · 2020: 1 · 2019: 3 · 2018: 1 · 2017: 3 · 2013: 1 · 2012: 3
- FWCI
- 0.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Chemistry and Physics of Lipids (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Drug Abuse (DA06668)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD2528, HD-33994)
- Topics
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Keywords
- endocannabinoid signaling, anandamide, CB1 receptor, embryonic development, endometrial receptivity, implantation, preimplantation embryo, blastocyst, female reproductive tract, pregnancy outcomes, cannabinoids
- MeSH terms
- Animals, Arachidonic Acids, Fatty Acids, Unsaturated, Female, Embryonic and Fetal Development, Embryo Implantation, Pregnancy, Uterus, Signal Transduction, Polyunsaturated Alkamides, Cannabinoid Receptor Modulators, Endocannabinoids
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