Cited by 89Cannabis and Cannabinoid ResearchReproductive System and PregnancyReproductive Biology and Fertility

Endocannabinoids and pregnancy.

Taylor, Anthony H., Amoako, Akwasi A., Bambang, Katerina, Karasu, Tulay, Gebeh, Alpha, Lam, Patricia M.W., Marzcylo, Timothy H., Konje, Justin C.·2010·Clinica Chimica Acta

Abstract

Acylethanolamides such as anandamide (AEA), and monoacylglycerols like 2-arachidonoylglycerol are endocannabinoids that bind to cannabinoid, vanilloid and peroxisome proliferator-activated receptors. These compounds, their various receptors, the purported membrane transporter(s), and related enzymes that synthesize and degrade them are collectively referred to as the "endocannabinoid system (ECS)". Poorly defined cellular and molecular mechanisms control the biological actions of the ECS. Over the last decade evidence has been emerging to suggest that the ECS plays a significant role in various aspects of human reproduction. In this review, we summarize our current understanding of this role especially the involvement of AEA and related ECS elements in regulating oogenesis, embryo oviductal transport, blastocyst implantation, placental development and pregnancy outcomes, and sperm survival, motility, capacitation and acrosome reaction. Additionally, the possibility that plasma and tissue AEA and other cannabinoids may represent reliable diagnostic markers of natural and assisted reproduction and pregnancy outcomes in women will be discussed.

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Crossref · 10.1016/j.cca.2010.03.012

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Authors
Taylor, A. H., Amoako, A. A., Bambang, K., Karasu, T., Gebeh, A., Lam, P. M. W., Marzcylo, T. H., & Konje, J. C.
Affiliations
University of Leicester (GB)
Corresponding author
Konje, Justin C.
Venue
Clinica Chimica Acta
Publisher
Elsevier BV
Published
2010-07
Volume
411
Issue
13-14
Pages
921-930
ISSN
0009-8981 (ISSN-L)
OpenAlex
W1969221886
Cited by
89
References
211
Citations by year
2026: 2 · 2025: 3 · 2024: 11 · 2023: 8 · 2022: 5 · 2020: 4 · 2019: 5 · 2018: 3 · 2017: 2 · 2016: 4 · 2015: 5 · 2014: 7 · 2013: 7 · 2012: 8
FWCI
1.05
Type
journal article
Language
en
Open access
closed
Locations
  • Clinica Chimica Acta (publishedVersion)
  • PubMed (publishedVersion)
  • Leicester Research Archive (University of Leicester) (submittedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
  • Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
Keywords
endocannabinoid system, anandamide, 2-arachidonoylglycerol, pregnancy, oogenesis, embryo implantation, placental development, sperm capacitation, acrosome reaction, assisted reproduction, diagnostic biomarkers, cannabinoid receptors
MeSH terms
Animals, Blastocyst, Employment, Female, Gametogenesis, Humans, Embryo Implantation, Placenta, Pregnancy, Cannabinoid Receptor Modulators, Endocannabinoids

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