Identification of the membrane-type matrix metalloproteinase MT1-MMP in osteoclasts
Abstract
The osteoclasts are the cells responsible for bone resorption. Matrix metalloproteinases (MMPs) appear crucial for this process. To identify possible MMP expression in osteoclasts, we amplified osteoclast cDNA fragments having homology with MMP genes, and used them as a probe to screen a rabbit osteoclast cDNA library. We obtained a cDNA of 1,972 bp encoding a polypeptide of 582 amino acids that showed more than 92% identity to human, mouse, and rat membrane-type 1 MMP (MT1-MMP), a cell surface proteinase believed to trigger cancer cell invasion. By northern blotting, MT1-MMP was found to be highly expressed in purified osteoclasts when compared with alveolar macrophages and bone stromal cells, as well as with various tissues. In situ hybridization on bone sections showed that MT1-MMP is expressed also in osteoclasts in vivo. Antibodies recognizing MT1-MMP reacted with specific plasma membrane areas corresponding to lamellipodia and podosomes involved, respectively, in migratory and attachment activities of the osteoclasts. These observations highlight how cells might bring MT1-MMP into contact with focal points of the extracellular matrix, and are compatible with a role of MT1-MMP in migratory and attachment activities of the osteoclast.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
MMP-14 is highly expressed on osteoclast podosomes and digests interstitial collagen and other ECM molecules.
“MMP-14 is highly expressed on osteoclast podosomes,149 and it digests interstitial collagen as well as other ECM molecules.150”
From Bone remodeling: an operational process ensuring survival and bone mechanical competence (2022) · cites this paper as [149]
Cites
A comprehensive set of sequence analysis programs for the VAX
Devereux, J., Haeberli, P. E., & Smithies, O. (1984) · Nucleic Acids Research · doi:10.1093/nar/12.1part1.387 · Cited by 14,222 · see citing works
A matrix metalloproteinase expressed on the surface of invasive tumour cells
Sato, H., Takino, T., Okada, Y., Cao, J. P., Shinagawa, A., Yamamoto, E., & Seiki, M. (1994) · Nature · doi:10.1038/370061a0 · Cited by 2,534 · see citing works
Cell Biology: a Laboratory Handbook
Harris, A. (1995) · Journal of Medical Genetics · doi:10.1136/jmg.32.9.759 · Cited by 1,230 · see citing works
Cellular Mechanisms for Human Procollagenase-3 (MMP-13) Activation
Knäuper, V., Will, H., López-Otı́n, C., Smith, B., Atkinson, S. J., Stanton, H., Hembry, R. M., & Murphy, G. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.29.17124 · Cited by 747 · see citing works
92-kD type IV collagenase mediates invasion of human cytotrophoblasts.
Librach, C. L., Werb, Z., Fitzgerald, M. L., Chiu, K., Corwin, N., Esteves, R. A., Grobelny, D. W., Galardy, R. E., Damsky, C. H., & Fisher, S. J. (1991) · The Journal of Cell Biology · doi:10.1083/jcb.113.2.437 · Cited by 718 · see citing works
Proteolytic Activity of Human Osteoclast Cathepsin K
Bossard, M. J., Tomaszek, T. A., Thompson, S. K., Amegadzie, B. Y., Hanning, C. R., Jones, C. S., Kurdyla, J., McNulty, D. E., Drake, F. H., Gowen, M., et al. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.21.12517 · Cited by 500 · see citing works
Okada, A., Bellocq, J. P., Rouyer, N., Chenard, M., Rio, M., Chambon, P., & Basset, P. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.7.2730 · Cited by 499 · see citing works
Takino, T., Sato, H., Shinagawa, A., & Seiki, M. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.39.23013 · Cited by 471 · see citing works
Expression of matrix metalloproteinase-2 and -9 during early human wound healing.
Salo, T. A., Mäkelä, M., Kylmäniemi, M., Autio‐Harmainen, H., & Larjava, H. (1994) · PubMed · Cited by 406 · see citing works
Pei, D., & Weiss, S. J. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.15.9135 · Cited by 389 · see citing works
Molecular cloning of a possible cysteine proteinase predominantly expressed in osteoclasts.
Tezuka, K., Tezuka, Y., Maejima, A., Sato, T., Nemoto, K., Kamioka, H., Hakeda, Y., & Kumegawa, M. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)42227-7 · Cited by 342 · see citing works
Self-citationMarchisio, P. C., Cirillo, D. M., Naldini, L., Primavera, M. V., Teti, A. M., & Zambonin-Zallone, A. (1984) · The Journal of Cell Biology · doi:10.1083/jcb.99.5.1696 · Cited by 328 · see citing works
Molecular cloning of a novel membrane-type matrix metalloproteinase from a human breast carcinoma.
Puente, X. S., Pendás, A. M., Llano, E., Velasco, G., & López-Otı́n, C. (1996) · PubMed · Cited by 327 · see citing works
Will, H., & Hinzmann, B. (1995) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1995.0602d.x · Cited by 313 · see citing works
Okada, Y., Naka, K., Kawamura, K., Matsumoto, T., Nakanishi, I., Fujimoto, N., Sato, H., & Seiki, M. (1995) · PubMed · Cited by 303 · see citing works
The urokinase receptor is required for human monocyte chemotaxis in vitro.
Gyetko, M. R., Todd, R. F., Wilkinson, C. C., & Sitrin, R. G. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117114 · Cited by 298 · see citing works
Biology and Physiology of the Osteoclast
Rifkin, B. R. (1992) · Cited by 293 · see citing works
Everts, V. E., Delaissé, J., Korper, W., Niehof, A., Vaes, G., & Beertsen, W. (1992) · Journal of Cellular Physiology · doi:10.1002/jcp.1041500202 · Cited by 286 · see citing works
Self-citationReponen, P., Sahlberg, C., Munaut, C., Thesleff, I., & Tryggvason, K. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.124.6.1091 · Cited by 279 · see citing works
Yamamoto, M., Mohanam, S., Sawaya, R. A., Fuller, G. N., Seiki, M., Satō, H., Gokaslan, Z. L., Liotta, L. A., Nicolson, G. L., & Rao, J. S. (1996) · PubMed · Cited by 273 · see citing works
Type IV collagenases in invasive tumors
Tryggvason, K., Höyhtyä, M., & Pyke, C. (1993) · Breast Cancer Research and Treatment · doi:10.1007/bf01833261 · Cited by 251 · see citing works
Kinetics of the osteoclast cytoskeleton during the resorption cycle in vitro
Lakkakorpi, P. T., & Väänänen, K. (1991) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650060806 · Cited by 248 · see citing works
Will, H., & Hinzmann, B. (1995) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1995.tb20738.x · Cited by 245 · see citing works
Imai, K., Ohuchi, E., Aoki, T., Nomura, H., Fujii, Y., Sato, H., Seiki, M., & Okada, Y. (1996) · PubMed · Cited by 230 · see citing works
Interstitial Collagenase Is Required for Angiogenesis in Vitro
Fisher, C. L., Gilbertson-Beadling, S. K., Powers, E. A., Petzold, G. L., Poorman, R. A., & Mitchell, M. A. (1994) · Developmental Biology · doi:10.1006/dbio.1994.1104 · Cited by 227 · see citing works
Blavier, L., & Delaissé, J. M. (1995) · Journal of Cell Science · doi:10.1242/jcs.108.12.3649 · Cited by 221 · see citing works
Self-citationIdentification of osteopontin in isolated rabbit osteoclasts
Tezuka, K.-I., Sato, T., Kamioka, H., Nijweide, P. J., Tanaka, K., Matsuo, T., Ohta, M., Kurihara, N., Hakeda, Y., & Kumegawa, M. (1992) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(92)90832-6 · Cited by 209 · see citing works
Self-citationMembrane-Type Matrix Metalloproteinases (MT-MMPs) in Tumor Metastasis
Sato, H., & Seiki, M. (1996) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a021223 · Cited by 193 · see citing works
Expression of transformation-associated protease(s) that degrade fibronectin at cell contact sites.
Chen, W. T., Olden, K., Bernard, B. A., & Chu, F. F. (1984) · The Journal of Cell Biology · doi:10.1083/jcb.98.4.1546 · Cited by 185 · see citing works
Identification of matrix metalloproteinase 9 in rabbit osteoclasts.
Tezuka, K., Nemoto, K., Tezuka, Y., Sato, T., Ikeda, Y., Kobori, M., Kawashima, H., Eguchi, H., Hakeda, Y., & Kumegawa, M. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36566-3 · Cited by 167 · see citing works
Self-citationHill, P. A., Murphy, G., Docherty, A., Hembry, R. M., Millican, T. A., Reynolds, J. J., & Meikle, M. C. (1994) · Journal of Cell Science · doi:10.1242/jcs.107.11.3055 · Cited by 164 · see citing works
Kinoh, H., Sato, H., Tsunezuka, Y., Takino, T., Kawashima, A., Okada, Y., & Seiki, M. (1996) · Journal of Cell Science · doi:10.1242/jcs.109.5.953 · Cited by 157 · see citing works
Clear zone in osteoclast function: role of podosomes in regulation of bone-resorbing activity
Teti, A. M., Marchisio, P. C., & Zallone, A. Z. (1991) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1991.261.1.c1 · Cited by 144 · see citing works
Expression of 92 kD type IV collagenase/gelatinase B in human osteoclasts
Wucherpfennig, A. L., Li, Y.-P., Stetler‐Stevenson, W. G., Rosenberg, A. E., & Stashenko, P. (1994) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650090415 · Cited by 141 · see citing works
Delaissé, J., Eeckhout, Y., Neff, L., François-Gillet, C., Henriet, P., Su, Y., Vaes, G., & Baron, R. (1993) · Journal of Cell Science · doi:10.1242/jcs.106.4.1071 · Cited by 140 · see citing works
Self-citationLi, Y., Alexander, M. P., Wucherpfennig, A. L., Yelick, P. C., Chen, W., & Stashenko, P. (1995) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650100809 · Cited by 113 · see citing works
Muir, D. (1994) · Experimental Cell Research · doi:10.1006/excr.1994.1036 · Cited by 107 · see citing works
Saneshige, S., Mano, H., Tezuka, K., Kakudo, S., Mori, Y., Honda, Y., Itabashi, A., Yamada, T., Miyata, K., Hakeda, Y., et al. (1995) · Biochemical Journal · doi:10.1042/bj3090721 · Cited by 102 · see citing works
Self-citationInvadopodia promote proteolysis of a wide variety of extracellular matrix proteins
Kelly, T. J., Mueller, S. C., Yeh, Y., & Chen, W. (1994) · Journal of Cellular Physiology · doi:10.1002/jcp.1041580212 · Cited by 99 · see citing works
Kaji, H., Sugimoto, T., Kanatani, M., Fukase, M., Kumegawa, M., & Chihara, K. (1996) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650110110 · Cited by 97 · see citing works
Self-citationYamada, T., Yoshiyama, Y., Sato, H., Seiki, M., Shinagawa, A., & Takahashi, M. (1995) · Acta Neuropathologica · doi:10.1007/bf00294800 · Cited by 85 · see citing works
Tatebe, S., Ishida, M., Kasagi, N., Tsujitani, S., Kaibara, N., & Ito, H. (1996) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(19960117)65:2 · Cited by 75 · see citing works
Foda, H. D., George, S., Conner, C. E., Drews, M., Dc, T., & Zucker, S. (1996) · PubMed · Cited by 72 · see citing works
Perspectives: Osteoclast adhesion and resorption: The role of podosomes
Aubin, J. E. (1992) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650070402 · Cited by 66 · see citing works
Plasma membrane‐dependent activation of gelatinase A in human vascular endothelial cells
Lewalle, J.-M., Munaut, C., Pichot, B., Cataldo, D. D., Baramova, E. N., & Foidart, J. M. (1995) · Journal of Cellular Physiology · doi:10.1002/jcp.1041650305 · Cited by 65 · see citing works
Ailenberg, M., & Silverman, M. (1996) · Biochemical Journal · doi:10.1042/bj3130879 · Cited by 62 · see citing works
Sato, T., Hakeda, Y., Yamaguchi, Y., Mano, H., Tezuka, K., Matsumoto, K., Nakamura, T., Mori, Y., Yoshizawa, K., Sumitani, K., et al. (1995) · Journal of Cellular Physiology · doi:10.1002/jcp.1041640124 · Cited by 47 · see citing works
Self-citationCalcitonin inhibits osteopontin mRNA expression in isolated rabbit osteoclasts
Kaji, H., Sugimoto, T., Miyauchi, A., Fukase, M., Tezuka, K., Hakeda, Y., Kumegawa, M., & Chihara, K. (1994) · Endocrinology · doi:10.1210/endo.135.1.8013390 · Cited by 37 · see citing works
Self-citationBaron, R., Chakraborty, M., Chatterjee, D., Horne, W. C., Lomri, A., & Ravesloot, J. H. (1993) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-77991-6_3 · Cited by 36 · see citing works
Flagged first, then by citations
1 of the 50 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
The 'ins' and 'outs' of podosomes and invadopodia: characteristics, formation and function
Murphy, D. A., & Courtneidge, S. A. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3141 · Cited by 1,057 · see citing works
Membrane-Type 1 Matrix Metalloproteinase Cleaves Cd44 and Promotes Cell Migration
Kajita, M., Itoh, Y., Chiba, T., Mori, H., Okada, A., Kinoh, H., & Seiki, M. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.153.5.893 · Cited by 746 · see citing works
The matrix corroded: podosomes and invadopodia in extracellular matrix degradation
Linder, S. (2007) · Trends in Cell Biology · doi:10.1016/j.tcb.2007.01.002 · Cited by 640 · see citing works
Podosomes: adhesion hot-spots of invasive cells
Linder, S., & Aepfelbacher, M. (2003) · Trends in Cell Biology · doi:10.1016/s0962-8924(03)00128-4 · Cited by 615 · see citing works
Foot and mouth: podosomes, invadopodia and circular dorsal ruffles
Buccione, R., Orth, J. D., & McNiven, M. A. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1436 · Cited by 594 · see citing works
Engsig, M. T., Chen, Q.-J., Vu, T. H., Pedersen, A.-C., Therkidsen, B., Lund, L. R., Henriksen, K., Lenhard, T., Foged, N. T., Werb, Z., et al. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.151.4.879 · Cited by 596 · see citing works
Self-citationMatrix Metalloproteinases Shape the Tumor Microenvironment in Cancer Progression
Niland, S., Riscanevo, A. X., & Eble, J. A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010146 · Cited by 528 · see citing works
MT1‐MMP: A potent modifier of pericellular microenvironment
Itoh, Y., & Seiki, M. (2005) · Journal of Cellular Physiology · doi:10.1002/jcp.20431 · Cited by 499 · see citing works
Bone remodeling: an operational process ensuring survival and bone mechanical competence
Bolamperti, S., Villa, I., & Rubinacci, A. (2022) · Bone Research · doi:10.1038/s41413-022-00219-8 · Cited by 482 · see citing works
Garnero, P., Ferreras, M., Karsdal, M. A., NicAmhlaoibh, R., Risteli, J., Borel, O., Qvist, P., Delmas, P. D., Foged, N., & Delaissé, J. (2003) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2003.18.5.859 · Cited by 472 · see citing works
Self-citationMatrix remodeling during endochondral ossification
Ortéga, N., Behonick, D. J., & Werb, Z. (2004) · Trends in Cell Biology · doi:10.1016/j.tcb.2003.12.003 · Cited by 463 · see citing works
Membrane-type matrix metalloproteinases: Their functions and regulations
Itoh, Y. (2015) · Matrix Biology · doi:10.1016/j.matbio.2015.03.004 · Cited by 440 · see citing works
The role of matrix metalloproteinases in the oral environment
Hannas, A. R., Pereira, J. C., Granjeiro, J. M., & Tjäderhane, L. (2006) · Acta Odontologica Scandinavica · doi:10.1080/00016350600963640 · Cited by 411 · see citing works
Itoh, Y., Takamura, A., Ito, N., Maru, Y., Sato, H., Suenaga, N., Aoki, T., & Seiki, M. (2001) · The EMBO Journal · doi:10.1093/emboj/20.17.4782 · Cited by 399 · see citing works
Subversion of the actin cytoskeleton during viral infection
Taylor, M. P., Koyuncu, O. O., & Enquist, L. (2011) · Nature Reviews Microbiology · doi:10.1038/nrmicro2574 · Cited by 413 · see citing works
Kusano, K., Miyaura, C., Inada, M., Tamura, T., Itô, A., Nagase, H., Kamoi, K., & Suda, T. (1998) · Endocrinology · doi:10.1210/endo.139.3.5818 · Cited by 385 · see citing works
Proteolysis and cell migration: creating a path?
Murphy, G., & Gavrilović, J. (1999) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(99)00022-8 · Cited by 384 · see citing works
Degrading Devices: Invadosomes in Proteolytic Cell Invasion
Linder, S., Wiesner, C., & Himmel, M. (2011) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-092910-154216 · Cited by 363 · see citing works
Aliprantis, A. O., Ueki, Y., Sulyanto, R. M., Park, A., Sigrist, K. S., Sharma, S. M., Ostrowski, M. C., Olsen, B. R., & Glimcher, L. H. (2008) · Journal of Clinical Investigation · doi:10.1172/jci35711 · Cited by 346 · see citing works
Matrix metalloproteinases (MMP) and cathepsin K contribute differently to osteoclastic activities
Delaissé, J., Andersen, T. L., Engsig, M. T., Henriksen, K., Troen, T., & Blavier, L. (2003) · Microscopy Research and Technique · doi:10.1002/jemt.10374 · Cited by 341 · see citing works
Self-citationMori, H., Tomari, T., Koshikawa, N., Kajita, M., Itoh, Y., Sato, H., Tojo, H., Yana, I., & Seiki, M. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf411 · Cited by 336 · see citing works
Osteopenia and decreased bone formation in osteonectin-deficient mice
Delany, A. M., Amling, M., Priemel, M., Howe, C. C., Baron, R., & CANALIS, E. M. (2000) · Journal of Clinical Investigation · doi:10.1172/jci7039 · Cited by 331 · see citing works
Cox, E. A., Sastry, S. K., & Anna Huttenlocher, A. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.2.265 · Cited by 299 · see citing works
Johnson, L. L., Dyer, R. D., & HUPE, D. J. (1998) · Current Opinion in Chemical Biology · doi:10.1016/s1367-5931(98)80122-1 · Cited by 270 · see citing works
Uekita, T., Itoh, Y., Yana, I., Ohno, H., & Seiki, M. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.200108112 · Cited by 252 · see citing works
Gálvez, B. G., Matı́as-Román, S., Albar, J. P., Sánchez‐Madrid, F., & Arroyo, A. G. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104094200 · Cited by 251 · see citing works
Yu, X., Huang, Y., Collin‐Osdoby, P., & Osdoby, P. (2003) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2003.18.8.1404 · Cited by 241 · see citing works
Matrix Metalloproteinases in Bone Resorption, Remodeling, and Repair
Paiva, K. B. S., & Granjeiro, J. M. (2017) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2017.05.001 · Cited by 237 · see citing works
Proteinases in bone resorption: obvious and less obvious roles
Delaissé, J.-M., Engsig, M. T., Everts, V., del Carmen Ovejero, M., Ferreras, M., Lund, L., Vu, T. H., Werb, Z., Winding, B., Lochter, A., et al. (2000) · Clinica Chimica Acta · doi:10.1016/s0009-8981(99)00230-2 · Cited by 227 · see citing works
Self-citationMT1-MMP-Dependent Invasion Is Regulated by TI-VAMP/VAMP7
Steffen, A., Dez, G. L., Poincloux, R., Recchi, C., Nassoy, P., Rottner, K., Galli, T., & Chavrier, P. (2008) · Current Biology · doi:10.1016/j.cub.2008.05.044 · Cited by 226 · see citing works
Nemeth, J. A. (2002) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/94.1.17 · Cited by 220 · see citing works
Linder, S., & Kopp, P. (2005) · Journal of Cell Science · doi:10.1242/jcs.02390 · Cited by 217 · see citing works
Zhao, W., Byrne, M. H., Boyce, B. F., & Krane, S. M. (1999) · Journal of Clinical Investigation · doi:10.1172/jci5481 · Cited by 212 · see citing works
Steffensen, B., Häkkinen, L., & Larjava, H. (2001) · Critical Reviews in Oral Biology & Medicine · doi:10.1177/10454411010120050201 · Cited by 209 · see citing works
Bone-targeting macromolecular therapeutics
WANG, D., Miller, S. C., Kopečková, P., & Kopeček, J. (2005) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2004.12.011 · Cited by 203 · see citing works
The Great Beauty of the osteoclast
Cappariello, A., Maurizi, A., Veeriah, V., & Teti, A. M. (2014) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2014.06.017 · Cited by 203 · see citing works
Membrane type-matrix metalloproteinases (MT-MMP)
Zucker, S., Pei, D., Cao, J. P., & López-Otı́n, C. (2003) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(03)54004-2 · Cited by 197 · see citing works
Wu, X., Gan, B., Yoo, Y., & Guan, J. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.06.006 · Cited by 195 · see citing works
MT1‐MMP: A key regulator of cell migration in tissue
Itoh, Y. (2006) · IUBMB Life · doi:10.1080/15216540600962818 · Cited by 176 · see citing works
Linder, S. (2009) · Journal of Cell Science · doi:10.1242/jcs.032631 · Cited by 174 · see citing works
Everts, V. E., Korper, W., Jansen, D. C., Steinfort, J., Lammerse, I., Heera, S., Docherty, A. J. P., & Beertsen, W. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.10.1219 · Cited by 174 · see citing works
Tatin, F., Varon, C., Genot, E. M., & Moreau, V. (2006) · Journal of Cell Science · doi:10.1242/jcs.02787 · Cited by 172 · see citing works
Kiviranta, R., Morko, J. P., Alatalo, S. L., NicAmhlaoibh, R., Risteli, J., Laitala‐Leinonen, T., & VUORIO, E. I. (2004) · Bone · doi:10.1016/j.bone.2004.09.020 · Cited by 169 · see citing works
Molecular regulation of osteoclast activity
Bruzzaniti, A., & Baron, R. (2006) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-006-9009-x · Cited by 173 · see citing works
Matrix metalloproteinases and periodontal diseases
Sapna, G., Gokul, S., & Manjrekar, K. B. (2013) · Oral Diseases · doi:10.1111/odi.12159 · Cited by 170 · see citing works
Podosomes in osteoclast-like cells
Pfaff, M., & Jurdic, P. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.15.2775 · Cited by 169 · see citing works
Transforming Growth Factor β Induces Rosettes of Podosomes in Primary Aortic Endothelial Cells
Varon, C., Tatin, F., Moreau, V., Obberghen‐Schilling, E. V., Fernandez-Sauze, S., Reuzeau, E., Kramer, I. M., & Genot, E. M. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.9.3582-3594.2006 · Cited by 162 · see citing works
Mutation Analysis of Membrane Type-1 Matrix Metalloproteinase (MT1-MMP)
Rozanov, D. V., Deryugina, E. I., Ratnikov, B. I., Monosov, E., Marchenko, G. N., Quigley, J. P., & Strongin, A. Y. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m007921200 · Cited by 162 · see citing works
Henriksen, K., Karsdal, M. A., Delaissé, J., & Engsig, M. T. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m309193200 · Cited by 157 · see citing works
Self-citationHatibović‐Kofman, Š., Raimundo, L., Zheng, L., Chong, L., Friedman, M., & Andreasen, J. O. (2008) · Dental Traumatology · doi:10.1111/j.1600-9657.2007.00541.x · Cited by 148 · see citing works
Apte, S., Fukai, N., Beier, D. R., & Olsen, B. R. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.41.25511 · Cited by 148 · see citing works
Andersen, T. L., del Carmen Ovejero, M., Kirkegaard, T., Lenhard, T., Foged, N. T., & Delaissé, J.-M. (2004) · Bone · doi:10.1016/j.bone.2004.06.019 · Cited by 145 · see citing works
Self-citationUeda, J., Kajita, M., Suenaga, N., Fujii, K., & Seiki, M. (2003) · Oncogene · doi:10.1038/sj.onc.1206962 · Cited by 135 · see citing works
Nyalendo, C., Michaud, M., Beaulieu, É., Roghi, C. H., Murphy, G., Gingras, D., & Béliveau, R. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m608045200 · Cited by 133 · see citing works
Novel Proteolytic Microvesicles Released from Human Macrophages after Exposure to Tobacco Smoke
Li, C., Liu, Y., Chen, Y., Yu, D., Williams, K. J., & Liu, M. (2013) · American Journal Of Pathology · doi:10.1016/j.ajpath.2013.01.035 · Cited by 122 · see citing works
Wang, K., Yamamoto, H., Chin, J. R., Werb, Z., & Vu, T. H. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403114200 · Cited by 118 · see citing works
Matı́as-Román, S., Gálvez, B. G., Genı́s, L., Yáñez‐Mó, M., de la Rosa, G., Sánchez‐Mateos, P., Sánchez‐Madrid, F., & Arroyo, A. G. (2005) · Blood · doi:10.1182/blood-2004-06-2382 · Cited by 117 · see citing works
Owen, C. A., Hu, Z., Barrick, B., & Shapiro, S. D. (2003) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2003-0034oc · Cited by 114 · see citing works
Podosomes in adhesion, migration, mechanosensing and matrix remodeling
Schachtner, H., Calaminus, S. D. J., Thomas, S. G., & Machesky, L. M. (2013) · Cytoskeleton · doi:10.1002/cm.21119 · Cited by 112 · see citing works
Peng, H., Troen, T., Ovejero, M. D. C., Kirkegaard, T., Andersen, T. L., Byrjalsen, I., Ferreras, M., Sato, T., Shapiro, S. D., Foged, N. T., et al. (2003) · Bone · doi:10.1016/j.bone.2003.08.011 · Cited by 107 · see citing works
Self-citationTools of the trade: podosomes as multipurpose organelles of monocytic cells
Linder, S., & Wiesner, C. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1731-z · Cited by 106 · see citing works
Atley, L. M., Mort, J. S., Lalumière, M., & Eyre, D. R. (2000) · Bone · doi:10.1016/s8756-3282(99)00270-7 · Cited by 106 · see citing works
Wiesner, C., Cabec, V. L., Azzouzi, K. E., Maridonneau‐Parini, I., & Linder, S. (2014) · Cell Adhesion & Migration · doi:10.4161/cam.28116 · Cited by 102 · see citing works
Stage-Specific Secretion of HMGB1 in Cartilage Regulates Endochondral Ossification
Taniguchi, N., Yoshida, K., Ito, T., Tsuda, M., Mishima, Y., Furumatsu, T., Ronfani, L., Abeyama, K., Kawahara, K.-I., Komiya, S., et al. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00130-07 · Cited by 101 · see citing works
Chikazu, D., Hakeda, Y., Ogata, N., Nemoto, K., Itabashi, A., Takato, T., Kumegawa, M., Nakamura, K., & Kawaguchi, H. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m910132199 · Cited by 102 · see citing works
Self-citationThe role of dynamin in the assembly and function of podosomes and invadopodia
Mark, A. M. (2004) · Frontiers in bioscience · doi:10.2741/1348 · Cited by 100 · see citing works
Goicoechea, S. M., Arneman, D., Disanza, A., García‐Mata, R., Scita, G., & Otey, C. A. (2006) · Journal of Cell Science · doi:10.1242/jcs.03076 · Cited by 99 · see citing works
Sato, T., Foged, N. T., & Delaissé, J.-M. (1998) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1998.13.1.59 · Cited by 98 · see citing works
Self-citationBone targeting for the treatment of osteoporosis
Lühmann, T. C., Germershaus, O., Gröll, J., & Meinel, L. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.10.001 · Cited by 98 · see citing works
Expression of metalloproteinase-13 (collagenase-3) is induced during fracture healing in mice
Yamagiwa, H., Tokunaga, K., Hayami, T., Hatano, K., Uchida, M., Endo, N., & Takahashi, H. (1999) · Bone · doi:10.1016/s8756-3282(99)00157-x · Cited by 98 · see citing works
Henriksen, K., Sørensen, M. G., Nielsen, R. H., Gram, J., Schaller, S., Dziegiel, M. H., Everts, V. E., Bollerslev, J., & Karsdal, M. A. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.050905 · Cited by 95 · see citing works
Hyaluronan–CD44 interaction hampers migration of osteoclast-like cells by down-regulating MMP-9
Spessotto, P., Rossi, F. M., Degan, M., Francia, R. D., Perris, R., Colombatti, A., & Gattei, V. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200202120 · Cited by 95 · see citing works
Ortéga, N., Behonick, D. J., Colnot, C., Cooper, D. N. W., & Werb, Z. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-12-1119 · Cited by 96 · see citing works
Puri, P., & Sartorelli, V. (2000) · Journal of Cellular Physiology · doi:10.1002/1097-4652(200011)185:2 · Cited by 290 · see citing works
MMP14 in sarcoma: a regulator of tumor microenvironment communication in connective tissues
Gonzalez-Molina, J., Gramolelli, S., Liao, Z., Carlson, J. W., Ojala, P. M., & Lehti, K. (2019) · Cells · doi:10.3390/cells8090991 · Cited by 89 · see citing works
Starnes, T. W., Bennin, D. A., Bing, X., Eickhoff, J. C., Grahf, D. C., Bellak, J. M., Seroogy, C. M., Ferguson, P. J., & Anna Huttenlocher, A. (2014) · Blood · doi:10.1182/blood-2013-07-516948 · Cited by 89 · see citing works
Väänänen, H. K., & Zhao, H. (2008) · Elsevier eBooks · doi:10.1016/b978-0-12-373884-4.00030-6 · Cited by 89 · see citing works
Karsdal, M. A., Andersen, T., Bonewald, L. F., & Christiansen, C. (2004) · DNA and Cell Biology · doi:10.1089/104454904322964751 · Cited by 85 · see citing works
Matrix metalloproteinases and cellular motility in development and disease
VanSaun, M. N., & Matrisian, L. M. (2006) · Birth Defects Research Part C Embryo Today Reviews · doi:10.1002/bdrc.20061 · Cited by 83 · see citing works
Ouyang, M., Lu, S., Li, X.-Y., Xu, J., Seong, J., Giepmans, B. N. G., Shyy, J. Y.-J., Weiss, S. J., & Wang, Y. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m709872200 · Cited by 82 · see citing works
Ishibashi, O., Niwa, S., Kadoyama, K., & Inui, T. (2006) · Life Sciences · doi:10.1016/j.lfs.2006.05.024 · Cited by 81 · see citing works
Llavaneras, A., Ramamurthy, N. S., Heikkilä, P., Teronen, O. P., Salo, T. A., Rifkin, B. R., RYAN, M. E., Golub, L. M., & Sorsa, T. A. (2001) · Journal of Periodontology · doi:10.1902/jop.2001.72.8.1069 · Cited by 80 · see citing works
Abdelgawad, M. E., Delaisse, J.-M., Hinge, M., Jensen, P. R., Alnaimi, R. W., Rolighed, L., Engelholm, L. H., Marcussen, N., & Andersen, T. L. (2016) · Histochemistry and Cell Biology · doi:10.1007/s00418-016-1414-y · Cited by 76 · see citing works
Self-citationÁlvarez, J., Balbı́n, M., Santos, F., Fernández, M. A., Ferrando, S., & López, J. M. (2000) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2000.15.1.82 · Cited by 75 · see citing works
Cancer glycan epitopes: biosynthesis, structure and function
Pearce, O. M. T. (2018) · Glycobiology · doi:10.1093/glycob/cwy023 · Cited by 74 · see citing works
Itoh, Y., Ito, N., Nagase, H., & Seiki, M. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m709327200 · Cited by 73 · see citing works
Actin polymerization modulates CD44 surface expression, MMP‐9 activation, and osteoclast function
Samanna, V., Ma, T., Mak, T. W., Rogers, M. J., & Chellaiah, M. A. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.21137 · Cited by 71 · see citing works
Prostate Cancer-Associated Membrane Type 1-Matrix Metalloproteinase
Bonfil, R. D., Dong, Z., Filho, J. C. T., Sabbota, A. L., Osenkowski, P., Nabha, S. M., Yamamoto, H., Chinni, S. R., Zhao, H., Mobashery, S., et al. (2007) · American Journal Of Pathology · doi:10.2353/ajpath.2007.060720 · Cited by 71 · see citing works
Yang, M., & Kurkinen, M. T. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.28.17893 · Cited by 69 · see citing works
The molecular dynamics of osteoclast adhesions
Luxenburg, C., Addadi, L., & Geiger, B. (2005) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2005.11.002 · Cited by 69 · see citing works
Winding, B., NicAmhlaoibh, R., Misander, H., Høegh-Andersen, P., Andersen, T. L., Holst‐Hansen, C., Heegaard, A., Foged, N. T., Brünner, N., & Delaissé, J. (2002) · PubMed · Cited by 67 · see citing works
Self-citationWoskowicz, A., Weaver, S. A., Shitomi, Y., Ito, N., & Itoh, Y. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.496067 · Cited by 65 · see citing works
Effects of Matrix Metalloproteinase Inhibitors on Bone Resorption and Orthodontic Tooth Movement
Holliday, L. S., Vakani, A., Archer, L., & Dolce, C. (2003) · Journal of Dental Research · doi:10.1177/154405910308200906 · Cited by 63 · see citing works
Anterior Segment Dysgenesis and Early-Onset Glaucoma in nee Mice with Mutation of Sh3pxd2b
Mao, M., Hedberg‐Buenz, A., Koehn, D., John, S. W. M., & Anderson, M. G. (2011) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.10-5993 · Cited by 62 · see citing works
α‐Synuclein induces migration of BV‐2 microglial cells by up‐regulation of CD44 and MT1‐MMP
Kim, S., Cho, S., Kim, K. Y., Shin, K. Y., Kim, H., Park, C., Chang, K., Lee, S. H., Cho, D., & Suh, Y. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06075.x · Cited by 61 · see citing works
Caldesmon is an integral component of podosomes in smooth muscle cells
Eves, R. L., Webb, B. A., Zhou, S., & Mak, A. S. (2006) · Journal of Cell Science · doi:10.1242/jcs.02881 · Cited by 60 · see citing works
Nagase, H. (1998) · Elsevier eBooks · doi:10.1016/b978-012545090-4/50004-5 · Cited by 59 · see citing works
Osteocytes and Skeletal Pathophysiology
Delgado‐Calle, J., & Bellido, T. (2015) · Current Molecular Biology Reports · doi:10.1007/s40610-015-0026-y · Cited by 60 · see citing works
Shah, M. H., Huang, D., Blick, T., Connor, A., Reiter, L. A., Hardink, J. R., Lynch, C. C., Waltham, M. C., & Thompson, E. W. (2012) · PLoS ONE · doi:10.1371/journal.pone.0029615 · Cited by 57 · see citing works
Guo, C., & Piacentini, L. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m307238200 · Cited by 57 · see citing works
- Authors
- Sato, T., Ovejero, M. D. C., Hou, P., Heegaard, A.-M., Kumegawa, M., Tækker Foged, N., & Delaissé, J.-M.
- Affiliations
- Center for Clinical & Basic Research (DK)
- 1 Department of Basic Research, Center for Clinical & Basic Research, Ballerup Byvej 222, DK-2750 Ballerup, Denmark
- Meikai University (JP)
- Venue
- Journal of Cell Science
- Publisher
- The Company of Biologists
- Published
- 1997-03-01
- Volume
- 110
- Issue
- 5
- Pages
- 589-596
- ISSN
- 0021-9533 (ISSN-L)
- 1477-9137
- OpenAlex
- W2118837944
- Cited by
- 214
- References
- 50
- Citations by year
- 2025: 3 · 2024: 1 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 6 · 2018: 2 · 2017: 1 · 2016: 2 · 2015: 5 · 2014: 8 · 2013: 10 · 2012: 4
- FWCI
- 4.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Cell Science (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Rheumatology › Bone and Dental Protein Studies
- Keywords
- MT1-MMP, membrane-type matrix metalloproteinases, osteoclasts, bone resorption, cDNA cloning, gene expression, lamellipodia, podosomes, cell migration, cell attachment, extracellular matrix
- MeSH terms
- Amino Acid Sequence, Animals, Base Sequence, Humans, Immunohistochemistry, Metalloendopeptidases, Molecular Sequence Data, Osteoclasts, Rabbits, Blotting, Northern, Sequence Homology, Amino Acid, In Situ Hybridization, DNA, Complementary, Matrix Metalloproteinases, Membrane-Associated, Matrix Metalloproteinase 14
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review