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The p38 MAP kinase signaling pathway in Alzheimer's disease
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“neuroinflammation is increasingly linked to pathogenesis of Alzheimer disease (29, 30)”
From An Unbiased Approach to Identifying Tau Kinases That Phosphorylate Tau at Sites Associated with Alzheimer Disease (2013) · cites this paper as [29]
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“Moreover, neuroinflammation is increasingly linked to pathogenesis of Alzheimer disease (29, 30); thus; inhibition of the p38 pathway may slow AD progression through anti-inflammatory mechanisms.”
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“Significantly, recent findings have provided strong evidence that the p38 MAPK signaling cascade is overactivated in AD (Zhu et al., 2001; Johnson and Bailey, 2003; Sun et al., 2003).”
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Augé, C. (2004) · edoc (University of Basel) · doi:10.5451/unibas-003617456
Anti‐Inflammatory/Analgesics: An In‐Depth Look at p 38 MAP Kinases
Brown, K. L. (2011) · Wiley eBooks · doi:10.1002/9780470571224.pse446
Metadata
- Authors
- Johnson, G.
- Affiliations
- University of Alabama at Birmingham (US)
- Corresponding author
- Johnson, G
- ORCID
- Johnson, G
- Venue
- Experimental Neurology
- Publisher
- Elsevier BV
- Published
- 2003-10
- Volume
- 183
- Issue
- 2
- Pages
- 263-268
- ISSN
- 0014-4886 (ISSN-L)
- OpenAlex
- W1994973104
- Cited by
- 106
- References
- 60
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 5 · 2023: 5 · 2022: 2 · 2021: 6 · 2020: 2 · 2019: 4 · 2018: 5 · 2017: 1 · 2016: 2 · 2015: 3 · 2014: 2 · 2013: 8 · 2012: 5
- FWCI
- 3.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Experimental Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- p38 MAPK, Alzheimer's disease, CD68, scavenger receptors, atherosclerosis, macrophages, oxidized LDL, macrophage apoptosis, reactive oxygen species, MAPK signaling, necrotic core, ApoE-deficient mice, coronary artery disease
- MeSH terms
- Alzheimer Disease, Animals, Humans, Substrate Specificity, Signal Transduction, tau Proteins, Mitogen-Activated Protein Kinases, p38 Mitogen-Activated Protein Kinases
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