Effects of p38 MAPK Inhibition on Early Stages of Diabetic Retinopathy and Sensory Nerve Function

Mammalian Mitogen-Activated Protein Kinase Signal Transduction Pathways Activated by Stress and Inflammation

Kyriakis, J. M., & Avruch, J. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.807 · Cited by 3,369 · see citing works

A central role for inflammation in the pathogenesis of diabetic retinopathy

Joussen, A. M., Poulaki, V., Le, M. L., Koizumi, K., Esser, C., Janicki, H., Schraermeyer, U., Kociok, N., Fauser, S., Kirchhof, B., et al. (2004) · The FASEB Journal · doi:10.1096/fj.03-1476fje · Cited by 1,178 · see citing works

p38 Mitogen-Activated Protein Kinase Is Activated after a Spinal Nerve Ligation in Spinal Cord Microglia and Dorsal Root Ganglion Neurons and Contributes to the Generation of Neuropathic Pain

Jin, S., Zhuang, Z.-Y., Woolf, C. J., & Ji, R. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-10-04017.2003 · Cited by 854 · see citing works

Regulation of Hsp27 Oligomerization, Chaperone Function, and Protective Activity against Oxidative Stress/Tumor Necrosis Factor α by Phosphorylation

Rogalla, T., Ehrnsperger, M., Préville, X., Kotlyarov, A., Lutsch, G., Ducasse, C., Paul, C., Wieske, M., Arrigo, A., Büchner, J., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.27.18947 · Cited by 742 · see citing works

p38-dependent marking of inflammatory genes for increased NF-κB recruitment

Saccani, S., Pantano, S., & Natoli, G. (2001) · Nature Immunology · doi:10.1038/ni748 · Cited by 694 · see citing works

Contributions of Inflammatory Processes to the Development of the Early Stages of Diabetic Retinopathy

Kern, T. S. (2007) · Journal of Diabetes Research · doi:10.1155/2007/95103 · Cited by 615 · see citing works

Nonsteroidal anti‐inflammatory drugs prevent early diabetic retinopathy via TNF‐α suppression

Joussen, A. M., Poulaki, V., Mitsiades, N., Kirchhof, B., Koizumi, K., Doehmen, S., & Adamis, A. P. (2002) · The FASEB Journal · doi:10.1096/fj.01-0707fje · Cited by 566 · see citing works

Tumor Necrosis Factor-α Induces Mechanical Allodynia after Spinal Nerve Ligation by Activation of p38 MAPK in Primary Sensory Neurons

Schäfers, M., Svensson, C. I., Sommer, C., & Sorkin, L. S. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-07-02517.2003 · Cited by 519 · see citing works

MSK2 and MSK1 mediate the mitogen‐ and stress‐induced phosphorylation of histone H3 and HMG‐14

Soloaga, A., Thomson, S., Wiggin, G. R., Rampersaud, N., Dyson, M. H., Hazzalin, C. A., Mahadevan, L. C., & Arthur, J. S. C. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg273 · Cited by 508 · see citing works

The p38 MAP kinase pathway as a therapeutic target in inflammatory disease

Saklatvala, J. (2004) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2004.03.009 · Cited by 408 · see citing works

Glucose or diabetes activates p38 mitogen-activated protein kinase via different pathways

Igarashi, M., Wakasaki, H., Takahara, N., Ishii, H., Jiang, Z.-Y., Yamauchi, T., Kuboki, K., Meier, M., Rhodes, C. J., & King, G. L. (1999) · Journal of Clinical Investigation · doi:10.1172/jci3326 · Cited by 386 · see citing works

Hyperglycemia increases mitochondrial superoxide in retina and retinal cells

Du, Y., Miller, C. M., & Kern, T. S. (2003) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2003.08.018 · Cited by 355 · see citing works

Immunological mechanisms in the pathogenesis of diabetic retinopathy

Adamis, A. P., & Berman, A. J. (2008) · Seminars in Immunopathology · doi:10.1007/s00281-008-0111-x · Cited by 323 · see citing works

Glial proinflammatory cytokines mediate exaggerated pain states: implications for clinical pain.

Watkins, L. R., Milligan, E. D., & Maier, S. F. (2003) · PubMed · Cited by 314 · see citing works

Pharmacological Inhibition of Diabetic Retinopathy

Kern, T. S., & Engerman, R. L. (2001) · Diabetes · doi:10.2337/diabetes.50.7.1636 · Cited by 277 · see citing works

Induction of Cyclooxygenase-2 by the Activated MEKK1 → SEK1/MKK4 → p38 Mitogen-activated Protein Kinase Pathway

Guan, Z., Buckman, S. Y., Pentland, A. P., Templeton, D. J., & Morrison, A. R. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.21.12901 · Cited by 271 · see citing works

Response of capillary cell death to aminoguanidine predicts the development of retinopathy: comparison of diabetes and galactosemia.

Kern, T. S., Tang, J., Mizutani, M., Kowluru, A., Nagaraj, R. H., Romeo, G. R., Podestà, F., & Lorenzi, M. (2000) · PubMed · Cited by 253 · see citing works

Role of p38 Mitogen-Activated Protein Kinase in a Murine Model of Pulmonary Inflammation

Nick, J. A., Young, S. K., Brown, K. K., Briones, N. J., Arndt, P. G., Suratt, B. T., Janes, M. S., Henson, P. M., & Worthen, G. S. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.4.2151 · Cited by 242 · see citing works

Involvement of p38 mitogen‐activated protein kinase in lipopolysaccharide‐induced iNOS and COX‐2 expression in J774 macrophages

CHEN, CHEN, & Lin, W. (1999) · Immunology · doi:10.1046/j.1365-2567.1999.00747.x · Cited by 240 · see citing works

Poly(ADP-Ribose) Polymerase Is Involved in the Development of Diabetic Retinopathy via Regulation of Nuclear Factor-κB

Zheng, L., Szabó, C., & Kern, T. S. (2004) · Diabetes · doi:10.2337/diabetes.53.11.2960 · Cited by 238 · see citing works

Tactile allodynia and formalin hyperalgesia in streptozotocin-diabetic rats: effects of insulin, aldose reductase inhibition and lidocaine

Calcutt, N. A., Jorge, M. C., Yaksh, T. L., & Chaplan, S. R. (1996) · Pain · doi:10.1016/s0304-3959(96)03201-0 · Cited by 226 · see citing works

Estrogen Prevents Cardiomyocyte Apoptosis through Inhibition of Reactive Oxygen Species and Differential Regulation of p38 Kinase Isoforms

Kim, J. K., Pedram, A., Razandi, M., & Levin, E. R. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m511024200 · Cited by 220 · see citing works

Inhibition of p38 MAP kinase‐and RICK/NF‐κB‐signaling suppresses inflammatory bowel disease

Hollenbach, E., Neumann, M., Vieth, M. W., Roessner, A., Malfertheiner, P., & Naumann, M. (2004) · The FASEB Journal · doi:10.1096/fj.04-1642fje · Cited by 212 · see citing works

Abnormal p38 mitogen-activated protein kinase signalling in human and experimental diabetic nephropathy

Adhikary, L. P., Chow, F. C. C., Nikolic‐Paterson, D. J., Stambe, C., Dowling, J. P., Atkins, R. C., & Tesch, G. H. (2004) · Diabetologia · doi:10.1007/s00125-004-1437-0 · Cited by 197 · see citing works

Hyperoxia-induced NAD(P)H oxidase activation and regulation by MAP kinases in human lung endothelial cells

Parinandi, N. L., Kleinberg, M. A., Usatyuk, P. V., Cummings, R. J., Pennathur, A., Cardounel, A. J., Zweier, J. L., Garcia, J. G. N., & Natarajan, V. (2003) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00123.2002 · Cited by 190 · see citing works

The p38/Reactivating Kinase Mitogen-activated Protein Kinase Cascade Mediates the Activation of the Transcription Factor Insulin Upstream Factor 1 and Insulin Gene Transcription by High Glucose in Pancreatic β-Cells

Macfarlane, W. M., Smith, S. B., James, R. F. L., Clifton, A. D., Doza, Y. N., Cohen, P., & Docherty, K. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.33.20936 · Cited by 176 · see citing works

Salicylate-Based Anti-Inflammatory Drugs Inhibit the Early Lesion of Diabetic Retinopathy

Zheng, L., Howell, S. J., Hatala, D. A., Huang, K., & Kern, T. S. (2007) · Diabetes · doi:10.2337/db06-0789 · Cited by 176 · see citing works

Interaction between NO and COX pathways in retinal cells exposed to elevated glucose and retina of diabetic rats

Du, Y., Sarthy, V. P., & Kern, T. S. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00080.2003 · Cited by 169 · see citing works

Roles of p38 MAPK, PKC and PI3‐K in the signaling pathways of NADPH oxidase activation and phagocytosis in bovine polymorphonuclear leukocytes

Yamamori, T., Inanami, O., Nagahata, H., Cui, Y.-D., & Kuwabara, M. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)01167-4 · Cited by 151 · see citing works

CXCL12 and C5a trigger cell migration via a PAK1/2-p38α MAPK-MAPKAP-K2-HSP27 pathway

Rousseau, S., Dolado, I., Beardmore, V. A., Shpiro, N., Márquez, R., Nebreda, Á. R., Arthur, J. S. C., Case, L. C., Tessier‐Lavigne, M., Gaestel, M., et al. (2006) · Cellular Signalling · doi:10.1016/j.cellsig.2006.02.006 · Cited by 126 · see citing works

Mitogen-Activated Protein Kinases and Retinal Ischemia

Roth, S., Shaikh, A. R., Hennelly, M. M., Li, Q., Bindokas, V., & Graham, C. E. (2003) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.03-0451 · Cited by 117 · see citing works

RIG-I-mediated Activation of p38 MAPK Is Essential for Viral Induction of Interferon and Activation of Dendritic Cells

Mikkelsen, S. S., Jensen, S. B., Chiliveru, S., Melchjorsen, J., Julkunen, I., Gaestel, M., Arthur, J. S. C., Flavell, R. A., Ghosh, S., & Paludan, S. R. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m807272200 · Cited by 115 · see citing works

Chronic exposure of human mesangial cells to high glucose environments activates the p38 MAPK pathway

Wilmer, W. A., Dixon, C. L., & Hebert, C. L. (2001) · Kidney International · doi:10.1046/j.1523-1755.2001.060003858.x · Cited by 107 · see citing works

The p38 MAP kinase signaling pathway in Alzheimer's disease

Johnson, G. (2003) · Experimental Neurology · doi:10.1016/s0014-4886(03)00268-1 · Cited by 106 · see citing works

Pain phenomena and possible mechanisms in patients with painful polyneuropathy

Otto, M., Bak, S., Bach, F. W., Jensen, T. S., & Sindrup, S. H. (2002) · Pain · doi:10.1016/s0304-3959(02)00313-5 · Cited by 103 · see citing works

Effects of p38 MAPK Inhibitor on Angiotensin II-Dependent Hypertension, Organ Damage, and Superoxide Anion Production

Bao, W., Behm, D. J., Nerurkar, S. S., Ao, Z., Bentley, R. G., Mirabile, R. C., Johns, D. G., Woods, T. N., Doe, C. P. A., Coatney, R. W., et al. (2007) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0b013e318046f34a · Cited by 99 · see citing works

Prevention of MKK6-Dependent Activation by Binding to p38α MAP Kinase

Sullivan, J. E., Holdgate, G. A., Campbell, D., Timms, D. A., Gerhardt, S., Breed, J., Breeze, A. L., Bermingham, A., Pauptit, R. A., Norman, R. A., et al. (2005) · Biochemistry · doi:10.1021/bi051714v · Cited by 90 · see citing works

Role of p38 MAP kinase in LPS‐induced airway inflammation in the rat

Haddad, E., Birrell, M. A., McCluskie, K., Ling, A. L. H., Webber, S. E., Foster, M. L., & Belvisi, M. G. (2001) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704022 · Cited by 88 · see citing works

Experimental models of painful diabetic neuropathy

Calcutt, N. A. (2004) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2004.03.015 · Cited by 76 · see citing works

Duration of streptozotocin-induced diabetes differentially affects p38-mitogen-activated protein kinase (MAPK) phosphorylation in renal and vascular dysfunction

Chen, H., Brahmbhatt, S., Gupta, A., & Sharma, A. C. (2005) · Cardiovascular Diabetology · doi:10.1186/1475-2840-4-3 · Cited by 72 · see citing works

Activation of the Neutrophil NADPH Oxidase Is Inhibited by SB 203580, a Specific Inhibitor of SAPK2/p38

LAL, A. S., Clifton, A. D., Rouse, J. W., Segal, A. W., & Cohen, P. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.0759 · Cited by 66 · see citing works

p38MAPK and ERK promote nitric oxide production in cultured human retinal pigmented epithelial cells induced by high concentration glucose

Yuan, Z., Feng, W., Hong, J. H., Zheng, Q., Shuai, J., & Ge, Y. (2008) · Nitric Oxide · doi:10.1016/j.niox.2008.09.001 · Cited by 64 · see citing works

Inhibition of interleukin-1 beta production by SKF86002: evidence of two sites of in vitro activity and of a time and system dependence.

Perregaux, D. G., Dean, D. F., Cronan, M. R., Connelly, P. W., & Gabel, C. A. (1995) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)10491-4 · Cited by 61 · see citing works

Human Keratinocytes Respond to Osmotic Stress by p38 Map Kinase Regulated Induction of HSP70 and HSP27

Garmyn, M., Pupe, A., Mammone, T., Gan, D., Declercq, L., & Maes, D. H. (2001) · Journal of Investigative Dermatology · doi:10.1046/j.0022-202x.2001.01553.x · Cited by 61 · see citing works

Differential effects of SB 242235, a selective p38 mitogen-activated protein kinase inhibitor, on IL-1 treated bovine and human cartilage/chondrocyte cultures

Badger, A. M., Roshak, A., Cook, M., Newman‐Tarr, T., Swift, B. A., Carlson, K. L., Connor, J. R., Lee, J. C., Gowen, M., Lark, M. W., et al. (2000) · Osteoarthritis and Cartilage · doi:10.1053/joca.1999.0319 · Cited by 50 · see citing works

Renal p38 MAP kinase activity in experimental diabetes

Komers, R., Lindsley, J. N., Oyama, T., Cohen, D., & Anderson, S. (2007) · Laboratory Investigation · doi:10.1038/labinvest.3700549 · Cited by 48 · see citing works

Ultraviolet B-Mediated Phosphorylation of the Small Heat Shock Protein HSP27 in Human Keratinocytes

Wong, J. W., Shi, B., Farboud, B., McClaren, M., Shibamoto, T., Cross, C. E., & Isseroff, R. R. (2000) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2000.00077.x · Cited by 47 · see citing works

Activation of p38 MAPK induced peroxynitrite generation in LPS plus IFN-γ-stimulated rat primary astrocytes via activation of iNOS and NADPH oxidase

Yoo, B. K., Choi, J. W., Shin, C. Y., Jeon, S. J., Park, S. J., Cheong, J. H., Han, S., Ryu, J. R., Song, M. R., & Ko, K. H. (2007) · Neurochemistry International · doi:10.1016/j.neuint.2007.12.009 · Cited by 47 · see citing works

Association of 14-3-3γ and Phosphorylated Bad Attenuates Injury in Ischemic Astrocytes

Chen, X., Fung, Y. W., & Yu, A. C. H. (2005) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600032 · Cited by 46 · see citing works

SD0006: A Potent, Selective and Orally Available Inhibitor of p38 Kinase

Burnette, B., Selness, S., Devraj, R., Jungbluth, G., Kurumbail, R., Stillwell, L., Anderson, G., Mnich, S., Hirsch, J., Compton, R., et al. (2009) · Pharmacology · doi:10.1159/000227286 · Cited by 38 · see citing works

Inhibition of p38 MAP Kinase Corrects Biochemical and Neurological Deficits in Experimental Diabetic Neuropathy

Agthong, S., & Tomlinson, D. R. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04665.x · Cited by 35 · see citing works

Sulfasalazine Blocks the Development of Tactile Allodynia in Diabetic Rats

Berti‐Mattera, L. N., Kern, T. S., Siegel, R. E., Nemet, I., & Mitchell, R. D. (2008) · Diabetes · doi:10.2337/db07-1274 · Cited by 34 · see citing works

Characterization of Activation of MAP Kinase Superfamily in Vasculature from Diabetic Rats

Igarashi, M., Hirata, A., Yamaguchi, H., Sugae, N., Kadomoto, Y., Nozaki, H., Jimbu, Y., & Tominaga, M. (2007) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.e514 · Cited by 14 · see citing works

Regulation of Cyclooxygenase-2 by the Activated p38 Mapk Signaling Pathway

Guan, Z., Buckman, S. Y., Springer, L. D., & Morrison, A. R. (1999) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-4793-8_2 · Cited by 8 · see citing works

Mechanisms of Diabetic Complications

Forbes, J. M., & Cooper, M. E. (2013) · Physiological Reviews · doi:10.1152/physrev.00045.2011 · Cited by 2,890 · see citing works

Inflammation in diabetic retinopathy

Tang, J. C. O., & Kern, T. S. (2011) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2011.05.002 · Cited by 1,118 · see citing works

Mechanism of diabetic neuropathy: Where are we now and where to go?

Yagihashi, S., Mizukami, H., & Sugimoto, K. (2011) · Journal of Diabetes Investigation · doi:10.1111/j.2040-1124.2010.00070.x · Cited by 488 · see citing works

NF-κβ: A Potential Target in the Management of Vascular Complications of Diabetes

Suryavanshi, S. V., & Kulkarni, Y. A. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00798 · Cited by 353 · see citing works

Photoreceptor cells are major contributors to diabetes-induced oxidative stress and local inflammation in the retina

Du, Y., Veenstra, A. A., Palczewski, K., & Kern, T. S. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1314575110 · Cited by 338 · see citing works

Diabetic retinopathy pathogenesis and the ameliorating effects of melatonin; involvement of autophagy, inflammation and oxidative stress

Dehdashtian, E., Mehrzadi, S., Yousefi, B., Hosseinzadeh, A., Reiter, R. J., Safa, M., Ghaznavi, H., & Naseripour, M. (2017) · Life Sciences · doi:10.1016/j.lfs.2017.12.001 · Cited by 265 · see citing works

Regulation of blood-retinal barrier cell-junctions in diabetic retinopathy

Rudraraju, M., Narayanan, S. P., & Somanath, P. R. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105115 · Cited by 217 · see citing works

Animal Models of Diabetic Retinopathy: Summary and Comparison

Lai, A. K. W., & Lo, A. (2013) · Journal of Diabetes Research · doi:10.1155/2013/106594 · Cited by 219 · see citing works

Protein kinases: mechanisms and downstream targets in inflammation-mediated obesity and insulin resistance

Nandipati, K. C., Subramanian, S., & Agrawal, D. K. (2016) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-016-2878-8 · Cited by 210 · see citing works

Mechanistic Insights into Pathological Changes in the Diabetic Retina

Roy, S., Kern, T. S., Song, B. J., & Stuebe, C. M. (2016) · American Journal Of Pathology · doi:10.1016/j.ajpath.2016.08.022 · Cited by 206 · see citing works

The Relevance of Oxidative Stress in the Pathogenesis and Therapy of Retinal Dystrophies

Domènech, E. B., & Marfany, G. (2020) · Antioxidants · doi:10.3390/antiox9040347 · Cited by 169 · see citing works

Defective axonal transport: A common pathological mechanism in inherited and acquired peripheral neuropathies

Prior, R. C., Helleputte, L. V., Benoy, V., & Bosch, L. V. D. (2017) · Neurobiology of Disease · doi:10.1016/j.nbd.2017.02.009 · Cited by 118 · see citing works

Regenerative Therapeutic Potential of Adipose Stromal Cells in Early Stage Diabetic Retinopathy

Gangaraju, R., Ramadan, A., Abburi, C., Callaghan, B., Traktuev, D. O., Evans‐Molina, C., Maturi, R. K., Harris, A., Kern, T. S., & March, K. L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0084671 · Cited by 117 · see citing works

Low-Intensity Far-Red Light Inhibits Early Lesions That Contribute to Diabetic Retinopathy: In Vivo and In Vitro

Tang, J. C. O., Du, Y., Lee, C. A., Talahalli, R. R., Eells, J. T., & Kern, T. S. (2013) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.12-11018 · Cited by 112 · see citing works

Baicalein alleviates diabetic peripheral neuropathy through inhibition of oxidative–nitrosative stress and p38 MAPK activation

Stavniichuk, R., Drel, V. R., Shevalye, H., Maksimchyk, Y., Kuchmerovska, T. M., Nadler, J. L., & Obrosova, I. G. (2011) · Experimental Neurology · doi:10.1016/j.expneurol.2011.04.002 · Cited by 105 · see citing works

Potential of Dietary Non-Provitamin A Carotenoids in the Prevention and Treatment of Diabetic Microvascular Complications

Murillo, A. G., & Fernández, M. L. (2016) · Advances in Nutrition · doi:10.3945/an.115.009803 · Cited by 94 · see citing works

Reactive Oxygen Species-Mediated Damage of Retinal Neurons: Drug Development Targets for Therapies of Chronic Neurodegeneration of the Retina

Rohowetz, L. J., Kraus, J. G., & Koulen, P. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19113362 · Cited by 89 · see citing works

PARP inhibition alleviates diabetes-induced systemic oxidative stress and neural tissue 4-hydroxynonenal adduct accumulation: Correlation with peripheral nerve function

Lupachyk, S., Shevalye, H., Maksimchyk, Y., Drel, V. R., & Obrosova, I. G. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.01.037 · Cited by 82 · see citing works

Heat Shock Proteins in Vascular Diabetic Complications: Review and Future Perspective

Bellini, S., Barutta, F., Mastrocola, R., Imperatore, L., Bruno, G., & Gruden, G. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18122709 · Cited by 83 · see citing works

Photoreceptor Cells Produce Inflammatory Mediators That Contribute to Endothelial Cell Death in Diabetes

Tonade, D., Liu, H., & Kern, T. S. (2016) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.16-19859 · Cited by 81 · see citing works

Diabetic retinopathy and signaling mechanism for activation of matrix metalloproteinase‐9

Mohammad, G., & Kowluru, R. A. (2011) · Journal of Cellular Physiology · doi:10.1002/jcp.22822 · Cited by 80 · see citing works

Photobiomodulation Inhibits Long-term Structural and Functional Lesions of Diabetic Retinopathy

Cheng, Y., Du, Y., Liu, H., Tang, J., Veenstra, A., & Kern, T. S. (2017) · Diabetes · doi:10.2337/db17-0803 · Cited by 75 · see citing works

Atypical p38 Signaling, Activation, and Implications for Disease

Burton, J. C., Antoniades, W., Okáľová, J., Roos, M., & Grimsey, N. J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22084183 · Cited by 71 · see citing works

Gallic acid ameliorates renal functions by inhibiting the activation of p38 MAPK in experimentally induced type 2 diabetic rats and cultured rat proximal tubular epithelial cells

Ahad, A., Ahsan, H., Mujeeb, M., & Siddiqui, W. A. (2015) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2015.08.026 · Cited by 69 · see citing works

Photoreceptor Cells Influence Retinal Vascular Degeneration in Mouse Models of Retinal Degeneration and Diabetes

Liu, H., Tang, J., Du, Y., Saadane, A., Tonade, D., Samuels, I. S., Veenstra, A., Palczewski, K., & Kern, T. S. (2016) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.16-19415 · Cited by 64 · see citing works

MAPK Pathways in Ocular Pathophysiology: Potential Therapeutic Drugs and Challenges

Moustardas, P., Aberdam, D., & Lagali, N. (2023) · Cells · doi:10.3390/cells12040617 · Cited by 63 · see citing works

Noncoding RNAs involved in DNA methylation and histone methylation, and acetylation in diabetic vascular complications

Lu, J., Huang, Y., Zhang, X., Xu, Y., & Nie, S. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105520 · Cited by 64 · see citing works

Diabetic corneal neuropathy as a surrogate marker for diabetic peripheral neuropathy

So, W. Z., Wong, N. S. Q., Tan, H. C., Lin, M. T. Y., Lee, I. X. Y., Mehta, J. S., & Liu, Y. (2022) · Neural Regeneration Research · doi:10.4103/1673-5374.327364 · Cited by 60 · see citing works

Diabetic neuropathic pain development in type 2 diabetic mouse model and the prophylactic and therapeutic effects of coenzyme Q10

Zhang, Y. P., Song, C. Y., Yuan, Y., Eber, A. E., Rodriguez, Y. F., Levitt, R. C., Takács, P., Yang, Z., Goldberg, R. B., & Candiotti, K. A. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.05.003 · Cited by 57 · see citing works

Curcumin Metabolite Tetrahydrocurcumin in the Treatment of Eye Diseases

Kao, Y.-W., Hsu, S., Chen, J. Y., Lin, I., Chen, K., Lee, P., Ng, H. S., Chiu, C., & Cheng, K. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms22010212 · Cited by 55 · see citing works

Retinylamine Benefits Early Diabetic Retinopathy in Mice

Liu, H., Tang, J., Du, Y., Lee, C. A., Golczak, M., Muthusamy, A., Antonetti, D. A., Veenstra, A. A., Amengual, J., Lintig, J. V., et al. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.655555 · Cited by 55 · see citing works

Deletion of Aldose Reductase from Mice Inhibits Diabetes-Induced Retinal Capillary Degeneration and Superoxide Generation

Tang, J., Du, Y., Petrash, J. M., Sheibani, N., & Kern, T. S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062081 · Cited by 54 · see citing works

Transcriptome analysis using next generation sequencing reveals molecular signatures of diabetic retinopathy and efficacy of candidate drugs.

Kandpal, R. P., Rajasimha, H. K., Brooks, M. J., Nellissery, J. K., Wan, J., Qian, J. X., Kern, T. S., & Swaroop, A. (2012) · Europe PMC (PubMed Central) · Cited by 54 · see citing works

DNA Methylomes Reveal Biological Networks Involved in Human Eye Development, Functions and Associated Disorders

Berdasco, M., Gómez, A., Rubio, M., Mora, J. C., Zanón‐Moreno, V., López, M., Hernández, C., Yoshida, S., Nakama, T., Ishikawa, K., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-12084-1 · Cited by 54 · see citing works

Understanding the Signaling Pathways Related to the Mechanism and Treatment of Diabetic Peripheral Neuropathy

Tang, H.-Y., Jiang, A., Ma, J., Wang, F., & Shen, G.-M. (2019) · Endocrinology · doi:10.1210/en.2019-00311 · Cited by 53 · see citing works

MyD88-Dependent Pathways in Leukocytes Affect the Retina in Diabetes

Tang, J., Lee, C. A., Du, Y., Sun, Y., Pearlman, E. M., Sheibani, N., & Kern, T. S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0068871 · Cited by 53 · see citing works

Activated Rho Kinase Mediates Diabetes-Induced Elevation of Vascular Arginase Activation and Contributes to Impaired Corpora Cavernosa Relaxation: Possible Involvement of p38 MAPK Activation

Toque, H. A., Nunes, K. P., Yao, L., Liao, J. K., Webb, R. C., Caldwell, R. B., & Caldwell, R. W. (2013) · The Journal of Sexual Medicine · doi:10.1111/jsm.12134 · Cited by 52 · see citing works

Tiam1-Rac1 Axis Promotes Activation of p38 MAP Kinase in the Development of Diabetic Retinopathy: Evidence for a Requisite Role for Protein Palmitoylation

Veluthakal, R., Kumar, B., Mohammad, G., Kowluru, A., & Kowluru, R. A. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000374065 · Cited by 52 · see citing works

Response of Small Heat Shock Proteins in Diabetic Rat Retina

Reddy, V., Ganugula, R., Reddy, S. S., Pasupulati, A. K., Suryanarayana, P., & Reddy, G. B. (2013) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.13-12715 · Cited by 51 · see citing works

Adrenergic and serotonin receptors affect retinal superoxide generation in diabetic mice: relationship to capillary degeneration and permeability

Du, Y., Cramer, M. L., Lee, C. A., Tang, J., Muthusamy, A., Antonetti, D. A., Jin, H., Palczewski, K., & Kern, T. S. (2015) · The FASEB Journal · doi:10.1096/fj.14-269431 · Cited by 49 · see citing works

The MAPK signaling pathway mediates the GPR91-dependent release of VEGF from RGC-5 cells

HU, J., LI, T., DU, S., CHEN, Y., WANG, S., XIONG, F., & WU, Q. (2015) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2015.2195 · Cited by 48 · see citing works

Diabetic Retinopathy, lncRNAs, and Inflammation: A Dynamic, Interconnected Network

Biswas, S., Sarabusky, M. A., & Chakrabarti, S. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8071033 · Cited by 47 · see citing works

Decorin Prevents Retinal Pigment Epithelial Barrier Breakdown Under Diabetic Conditions by Suppressing p38 MAPK Activation

Wang, S., Du, S., Wu, Q., Hu, J., & Li, T. (2015) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.14-15874 · Cited by 44 · see citing works

Pro-inflammatory cytokines downregulate Hsp27 and cause apoptosis of human retinal capillary endothelial cells

Nahomi, R. B., Palmer, A., Green, K. M., Fort, P. E., & Nagaraj, R. H. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.11.011 · Cited by 46 · see citing works

Molecular Mechanisms Mediating Diabetic Retinal Neurodegeneration: Potential Research Avenues and Therapeutic Targets

Chakravarthy, H., & Devanathan, V. (2018) · Journal of Molecular Neuroscience · doi:10.1007/s12031-018-1188-x · Cited by 46 · see citing works

Diabetes-Induced Impairment in Visual Function in Mice: Contributions of p38 MAPK, RAGE, Leukocytes, and Aldose Reductase

Lee, C. A., Li, G., Patel, M. D., Petrash, J. M., Benetz, B. A., Veenstra, A., Amengual, J., Lintig, J. V., Burant, C. J., Tang, J. C. O., et al. (2013) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.13-11659 · Cited by 45 · see citing works

Pro‐inflammatory angiogenesis is mediated by p38 MAP kinase

Gangaraju, R., Kamocka, M. M., Marin, A., Suckow, M. A., Wolter, W. R., Badve, S., Sanjeevaiah, A. R., Pumiglia, K. M., Rosen, E. D., & Clauss, M. A. (2010) · Journal of Cellular Physiology · doi:10.1002/jcp.22404 · Cited by 45 · see citing works

Comparison of three strains of diabetic rats with respect to the rate at which retinopathy and tactile allodynia develop.

Kern, T. S., Miller, C. M., Tang, J., Du, Y., Ball, S. L., & Berti‐Mattera, L. N. (2010) · PubMed Central · Cited by 44 · see citing works

Discovery of CC-99677, a selective targeted covalent MAPKAPK2 (MK2) inhibitor for autoimmune disorders

Malona, J., Chuaqui, C. E., Seletsky, B. M., Beebe, L., Cantin, S. M., van Kalken, D., Fahnoe, K. C., WANG, Z., Browning, B., Szabo, H., et al. (2022) · Translational research · doi:10.1016/j.trsl.2022.06.005 · Cited by 43 · see citing works

Degeneration of retinal ganglion cells in diabetic dogs and mice: relationship to glycemic control and retinal capillary degeneration.

Howell, S. J., Mekhail, M. N., Azem, R., Ward, N. L., & Kern, T. S. (2013) · Europe PMC (PubMed Central) · Cited by 42 · see citing works

Prothymosin‐alpha preconditioning activates TLR 4– TRIF signaling to induce protection of ischemic retina

Halder, S. K., Matsunaga, H., Ishii, K. J., & Ueda, H. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13356 · Cited by 41 · see citing works

Pathophysiology of Diabetic Retinopathy: Contribution and Limitations of Laboratory Research

Kern, T. S., Antonetti, D. A., & Smith, L. E. H. (2019) · Ophthalmic Research · doi:10.1159/000500026 · Cited by 40 · see citing works

Targeting receptors of advanced glycation end products (RAGE): Preventing diabetes induced cancer and diabetic complications

Chhipa, A. S., Borse, S., Baksi, R., Lalotra, S., & Nivsarkar, M. (2019) · Pathology - Research and Practice · doi:10.1016/j.prp.2019.152643 · Cited by 40 · see citing works

Curcumolide reduces diabetic retinal vascular leukostasis and leakage partly via inhibition of the p38MAPK/NF-κ B signaling

Cai, Y., Li, W., Tu, H., Chen, N., Zhong, Z., Yan, P., & Dong, J. (2017) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2017.02.045 · Cited by 35 · see citing works

Retinoprotective effect of agmatine in streptozotocin-induced diabetic rat model: avenues for vascular and neuronal protection

Gheit, R. E. A. E., Soliman, N. A., Badawi, G. A., Madi, N. M., El‐Saka, M. H., Badr, S. M., & Emam, M. N. (2021) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-021-00799-9 · Cited by 33 · see citing works

Diabetic retinopathy: could the alpha-1 antitrypsin be a therapeutic option?

Ortiz, G., Salica, J. P., Chuluyán, E., & Gallo, J. E. (2014) · Biological Research · doi:10.1186/0717-6287-47-58 · Cited by 31 · see citing works

Systemic Retinaldehyde Treatment Corrects Retinal Oxidative Stress, Rod Dysfunction, and Impaired Visual Performance in Diabetic Mice

Berkowitz, B. A., Kern, T. S., Bissig, D., Patel, P., Bhatia, A., Kefalov, V. J., & Roberts, R. (2015) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.15-16990 · Cited by 30 · see citing works

Metanx and Early Stages of Diabetic Retinopathy

Liu, H., Tang, J. C. O., Lee, C. A., & Kern, T. S. (2015) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.14-15220 · Cited by 29 · see citing works

Anti-hyperalgesic effects of photobiomodulation therapy (904 nm) on streptozotocin-induced diabetic neuropathy imply MAPK pathway and calcium dynamics modulation

Vieira, W. F., Malange, K. F., de Magalhães, S. F., Lemes, J. B. P., dos Santos, G. G., Nishijima, C. M., de Oliveira, A. L. R., da Cruz‐Höfling, M. A., Tambeli, C. H., & Parada, C. A. (2022) · Scientific Reports · doi:10.1038/s41598-022-19947-2 · Cited by 28 · see citing works

Pentosan polysulfate ameliorates apoptosis and inflammation by suppressing activation of the p38 MAPK pathway in high glucose‑treated HK‑2 cells

Chen, P., Yuan, Y., Zhang, T., Xu, B., Gao, Q., & Guan, T. (2017) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2017.3290 · Cited by 28 · see citing works

The Increased Transforming Growth Factor-β Signaling Induced by Diabetes Protects Retinal Vessels

Dagher, Z., Gerhardinger, C., Vaz, J., Goodridge, M., Tecilazich, F., & Lorenzi, M. (2017) · American Journal Of Pathology · doi:10.1016/j.ajpath.2016.11.007 · Cited by 27 · see citing works

Taxifolin Shows Anticataractogenesis and Attenuates Diabetic Retinopathy in STZ-Diabetic Rats<i>via</i>Suppression of Aldose Reductase, Oxidative Stress, and MAPK Signaling Pathway

Liu, F., Ma, Y., & Xu, Y. (2020) · Endocrine, Metabolic &amp; Immune Disorders - Drug Targets · doi:10.2174/1871530319666191018122821 · Cited by 26 · see citing works

Painful neuropathy

Lee-Kubli, C. A., & Calcutt, N. A. (2014) · Handbook of clinical neurology · doi:10.1016/b978-0-444-53480-4.00034-5 · Cited by 25 · see citing works

Acute and Chronic Hyperglycemia Elicit JIP1/JNK-Mediated Endothelial Vasodilator Dysfunction of Retinal Arterioles

Hein, T. W., Xu, W., Xu, X., & Kuo, L. (2016) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.16-19990 · Cited by 24 · see citing works

Trigonelline promotes auditory function through nerve growth factor signaling on diabetic animal models

Castañeda-Miranda, R., Rodríguez, I., Nam, Y. H., Hong, B. N., & Kang, T. H. (2017) · Phytomedicine · doi:10.1016/j.phymed.2017.09.023 · Cited by 25 · see citing works

Tonicity-responsive enhancer binding protein regulates the expression of aldose reductase and protein kinase C δ in a mouse model of diabetic retinopathy

Park, J., Kim, H., Park, S. Y., Lim, S. W., Kim, Y. S., Lee, D. H., Roh, G. S., Kim, H. J., Kang, S. S., Cho, G. J., et al. (2014) · Experimental Eye Research · doi:10.1016/j.exer.2014.03.001 · Cited by 23 · see citing works

Therapeutic Potential of Complementary and Alternative Medicines in Peripheral Nerve Regeneration: A Systematic Review

Yow, Y., Goh, T.-K., Nyiew, K.-Y., Lim, L. W., Phang, S., Lim, S., Ratnayeke, S., & Wong, K.-H. (2021) · Cells · doi:10.3390/cells10092194 · Cited by 21 · see citing works

CPSF1 mediates retinal vascular dysfunction in diabetes mellitus via the MAPK/ERK pathway

Zhang, J., Zhang, X., Zou, Y., & Han, F. (2020) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2020.1722704 · Cited by 20 · see citing works

Bone Morphogenetic Protein-2 Induces Non-Canonical Inflammatory and Oxidative Pathways in Human Retinal Endothelial Cells

Al‐Shabrawey, M., Hussein, K. A., Wang, F., Wan, M., Elmasry, K., Elsherbiny, N. M., Saleh, H., Yu, P. B., Tawfik, A. M., & Ibrahim, A. S. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.568795 · Cited by 20 · see citing works

12/15-Lipoxygenase inhibition counteracts MAPK phosphorylation in mouse and cell culture models of diabetic peripheral neuropathy

Stavniichuk, R., Obrosov, A. A., Drel, V. R., Nadler, J. L., Obrosova, I. G., & Yorek, M. A. (2013) · Journal of Diabetes Mellitus · doi:10.4236/jdm.2013.33015 · Cited by 20 · see citing works

Blocking CXCR3 with AMG487 ameliorates the blood-retinal barrier disruption in diabetic mice through anti-oxidative

Wang, H., Li, J., Zhong, P., Wang, S., Zhang, L., Yang, R., Wu, D., Chen, M., Ji, A., Li, Y., et al. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.04.016 · Cited by 19 · see citing works

Therapeutic stratagems for vascular degenerative disorders of the posterior eye

Jain, G. K., Warsi, M. H., Nirmal, J., Garg, V., Pathan, S. A., Ahmad, F. J., & Khar, R. K. (2012) · Drug Discovery Today · doi:10.1016/j.drudis.2012.03.006 · Cited by 19 · see citing works

Na+/H+-exchanger-1 inhibition counteracts diabetic cataract formation and retinal oxidative-nitrative stress and apoptosis

Obrosova, I. G. (2012) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2012.933 · Cited by 19 · see citing works

Histamine causes an imbalance between pro-angiogenic and anti-angiogenic factors in the retinal pigment epithelium of diabetic retina via H4 receptor/p38 MAPK axis

Lee, B. J., Byeon, H.-E., Cho, C. S., Kim, Y. H., Kim, J. H., Che, J., Seok, S. H., Kwon, J.-W., Kim, J. H., & Lee, K. (2020) · BMJ Open Diabetes Research & Care · doi:10.1136/bmjdrc-2020-001710 · Cited by 18 · see citing works

Emerging role of protein kinases in diabetes mellitus: From mechanism to therapy

Gupta, P., Taiyab, A., & Hassan, M. I. (2020) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2020.11.001 · Cited by 18 · see citing works

Regulation of Adrenergic, Serotonin, and Dopamine Receptors to Inhibit Diabetic Retinopathy: Monotherapies versus Combination Therapies

Kern, T. S., Du, Y., Tang, J., Lee, C. A., Liu, H., Dreffs, A. A., Leinonen, H., Antonetti, D. A., & Palczewski, K. (2021) · Molecular Pharmacology · doi:10.1124/molpharm.121.000278 · Cited by 18 · see citing works

Amelioration of hyperglycemia-induced oxidative damage in ARPE-19 cells by myricetin derivatives isolated from Syzygium malaccense

Arumugam, B., Palanisamy, U. D., Chua, K. H., & Kuppusamy, U. R. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2020.103844 · Cited by 17 · see citing works

The Role of Immune Cells and Signaling Pathways in Diabetic Eye Disease: A Comprehensive Review

Barone, V., Surico, P. L., Cutrupi, F., Mori, T., Afflitto, G. G., Zazzo, A. D., & Coassin, M. (2024) · Biomedicines · doi:10.3390/biomedicines12102346 · Cited by 17 · see citing works

The role of Raf-1 kinase in diabetic retinopathy

Mohammad, G., & Kowluru, R. A. (2011) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2011.553604 · Cited by 17 · see citing works

Yiqi Tongluo Fang could preventive and delayed development and formation of diabetic retinopathy through antioxidant and anti-inflammatory effects

Di, S., An, X., Pang, B., Wang, T., Wu, H., Wang, J., & Li, M. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112254 · Cited by 16 · see citing works

Role of Histone Deacetylase Inhibitor in Diabetic Painful Neuropathy

Thakur, V., Gonzalez, M. A., Parada, M., Martinez, R. D., & Chattopadhyay, M. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03701-4 · Cited by 16 · see citing works

Caspase-14: a novel caspase in the retina with a potential role in diabetic retinopathy.

Al‐Shabrawey, M., Ahmad, S., Megyerdi, S., Othman, A., Baban, B., Palenski, T. L., Shin, E. S., Gürel, Z., Hsu, S., & Sheibani, N. (2012) · Europe PMC (PubMed Central) · Cited by 15 · see citing works

Naloxone Inhibition of Lipopolysaccharide-Induced Activation of Retinal Microglia is Partly Mediated via the p38 Mitogen Activated Protein Kinase Signalling Pathway

Xu, Y., Fu, L., Jiang, C., Qin, Y., Ni, Y., & Fan, J. (2012) · Journal of International Medical Research · doi:10.1177/147323001204000422 · Cited by 14 · see citing works

Common and rare exonic MUC5B variants associated with type 2 diabetes in Han Chinese

Chen, G., Zhang, Z., Adebamowo, S. N., Liu, G., Adeyemo, A., Zhou, Y., Doumatey, A. P., Wang, C., Zhou, J., Yan, W., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0173784 · Cited by 11 · see citing works

Anticataractogenesis and Antiretinopathy Effects of the Novel Protective Agent Containing the Combined Extract of Mango and Vietnamese Coriander in STZ‐Diabetic Rats

Wattanathorn, J., Thiraphatthanavong, P., Thukham-mee, W., Muchimapura, S., Wannanond, P., & Tong-un, T. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/5290161 · Cited by 11 · see citing works

Finding Needles in a Haystack: Application of Network Analysis and Target Enrichment Studies for the Identification of Potential Anti-Diabetic Phytochemicals

Fayaz, S. M., Kumar, V. S. S., & Rajanikant, G. K. (2014) · PLoS ONE · doi:10.1371/journal.pone.0112911 · Cited by 11 · see citing works

Effect of Phosphorylated-Extracellular Regulated Kinase 1/2 Inhibitor on Retina from Light-induced Photoreceptor Degeneration

Ding, X.-Y., Gu, R.-P., Tang, W.-Y., Shu, Q.-M., Xu, G.-Z., & Zhang, M. (2018) · Chinese Medical Journal · doi:10.4103/0366-6999.246064 · Cited by 10 · see citing works

Pro‐apoptotic effects of micro‐ribonucleic acid‐365 on retinal neurons by targeting insulin‐like growth factor‐1 in diabetic rats: An in vivo and in vitro study

Zheng, K., Wang, N., Shen, Y., Zhang, Z., Gu, Q., Xu, X., Qin, Q., & Liu, Y. (2018) · Journal of Diabetes Investigation · doi:10.1111/jdi.12815 · Cited by 9 · see citing works

MAP3K1 May be a Promising Susceptibility Gene for Type 2 Diabetes Mellitus in an Iranian Population.

Torkamandi, S., Bastami, M., Ghaedi, H., moghadam, F., Mirfakhraie, R., & Omrani, M. D. (2016) · Europe PMC (PubMed Central) · Cited by 8 · see citing works

SiRNA silencing of VEGF, IGFs, and their receptors in human retinal microvascular endothelial cells.

Nicolau, Y., Bany-Mohammed, F., Cai, C. L., Aranda, J. V., & Beharry, K. D. A. (2018) · Europe PMC (PubMed Central) · Cited by 8 · see citing works

Phosphorylation of alphaB-crystallin in epiretinal membrane of human proliferative diabetic retinopathy

Dong, Y., Dong, Z., Kase, S., Andõ, R., Fukuhara, J., Kinoshita, S., Inafuku, S., Tagawa, Y., Ishizuka, E. T., Saito, W., et al. (2016) · International Journal of Ophthalmology · doi:10.18240/ijo.2016.08.03 · Cited by 8 · see citing works

Lentiviral-mediated RNAi targeting p38MAPK ameliorates high glucose-induced apoptosis in osteoblast MC3T3-E1 cell line.

Feng, Z., Deng, H., Du, J., Chen, D., Jiang, R., & Liang, X. (2011) · PubMed · Cited by 7 · see citing works

Environmental Exposures and Oxidative Stress in Retinal and Optic Nerve Diseases: Mechanisms, Consequences, and Therapeutic Opportunities

Roberson, J., Bauer, A. N., Lopez-Ramirez, A., Jenness, D. B., Zayas, S. C., Bailey, J. N. C., & Woodlief, T. (2026) · Antioxidants · doi:10.3390/antiox15030281 · Cited by 6 · see citing works

Role of apigenin in high glucose-induced retinal microvascular endothelial cell dysfunction via regulating NOX4/p38 MAPK pathway in vitro

Liu, L.-L. (2023) · International Journal of Ophthalmology · doi:10.18240/ijo.2023.04.04 · Cited by 6 · see citing works

Exploration of potential novel drug targets for diabetic retinopathy by plasma proteome screening

Yuan, W., Xu, W., Xu, X., Qu, B., & Zhao, F. (2024) · Scientific Reports · doi:10.1038/s41598-024-62069-0 · Cited by 6 · see citing works

A Sesame Seeds-Based Breakfast Could Attenuate Sub-Clinical Inflammation in Type 2 Diabetic Patients: A Randomized Controlled Trial

Bahadoran, Z. (2015) · International Journal of Nutrition and Food Sciences · doi:10.11648/j.ijnfs.s.2015040201.11 · Cited by 6 · see citing works

p38α MAPK-Mediated Redox Regulation of Transglutaminase 2 Drives Microvascular Leakage in Diabetic Retinas

Koh, T.-Y., Lee, A.-J., Moon, C., Cho, W. R., Yoon, J.-S., Kim, M., & Ha, K. (2026) · Antioxidants · doi:10.3390/antiox15020192 · Cited by 5 · see citing works

Retinal Vein Occlusion Induced by a MEK Inhibitor - Impact of Oxidative Stress on the Blood-Retinal Barrier

Amy, H., & Huang, W. (2012) · InTech eBooks · doi:10.5772/36114 · Cited by 5 · see citing works

Inhibition of P38 Mapk Inhibits Early Stages of Diabetic Retinopathy

Kern, T. S., Du, Y., Tang, J., Li, G., Lee, C. A., Bartkowski, D. M., Gale, D. C., Monahan, J., Niesman, M. R., & Alton, G. (2010) · Investigative Ophthalmology & Visual Science · Cited by 1 · see citing works

Luo Tong formula attenuates retinal inflammation in diabetic rats via inhibition of the p38MAPK/NF-κB pathway

Pang, B., Li, M., Song, J., Li, Q., Wang, J., Di, S., Tong, X., & Ni, Q. (2020) · Chinese Medicine · doi:10.1186/s13020-019-0284-3 · Cited by 25 · see citing works

Inhibition of p38 MAP Kinase Corrects Biochemical and Neurological Deficits in Experimental Diabetic Neuropathy

Agthong, S., & Tomlinson, D. R. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04665.x · Cited by 35 · see citing works

Protective effect ofblocking the signal path of p38 mitogen-activated protein kinase on blood-retinal barrierand retinal ganglion cells in early diabetic rats

Li, Y., & Lin (2010) · Zhonghua yandibing zazhi · doi:10.3760/cma.j.issn.1005-1015.2010.02.11

Expression of p38MAPK and TGF#beta#_(2)in retina of experimental diabetic hamster

Peng, H., Su-ling, H., Yongxian, T., Yan, P., & Jiang, R. (2007) · Di-san junyi daxue xuebao · Cited by 1 · see citing works