RAGE mediates Aβ accumulation in a mouse model of Alzheimer’s disease via modulation of β- and γ-secretase activity
Open accessAbstract
Receptor for Advanced Glycation End products (RAGE) has been implicated in amyloid β-peptide (Aβ)-induced perturbation relevant to the pathogenesis of Alzheimer's disease (AD). However, whether and how RAGE regulates Aβ metabolism remains largely unknown. Aβ formation arises from aberrant cleavage of amyloid pre-cursor protein (APP) by β- and γ-secretase. To investigate whether RAGE modulates β- and γ-secretase activity potentiating Aβ formation, we generated mAPP mice with genetic deletion of RAGE (mAPP/RO). These mice displayed reduced cerebral amyloid pathology, inhibited aberrant APP-Aβ metabolism by reducing β- and γ-secretases activity, and attenuated impairment of learning and memory compared with mAPP mice. Similarly, RAGE signal transduction deficient mAPP mice (mAPP/DN-RAGE) exhibited the reduction in Aβ40 and Aβ42 production and decreased β-and γ-secretase activity compared with mAPP mice. Furthermore, RAGE-deficient mAPP brain revealed suppression of activation of p38 MAP kinase and glycogen synthase kinase 3β (GSK3β). Finally, RAGE siRNA-mediated gene silencing or DN-RAGE-mediated signaling deficiency in the enriched human APP neuronal cells demonstrated suppression of activation of GSK3β, accompanied with reduction in Aβ levels and decrease in β- and γ-secretases activity. Our findings highlight that RAGE-dependent signaling pathway regulates β- and γ-secretase cleavage of APP to generate Aβ, at least in part through activation of GSK3β and p38 MAP kinase. RAGE is a potential therapeutic target to limit aberrant APP-Aβ metabolism in halting progression of AD.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Higher levels of RAGE expression are found in neuronal, microglial, and endothelial cells in Alzheimer's disease patients compared with age-matched non-demented controls.
“AGEs and the receptor for advanced glycation end-products (RAGE) can play an important role in AD pathogenesis as higher levels of RAGE expression in neuronal, microglial, and endothelial cells in patients with AD compared with age-matched, non- demented controls are found [43,44,45,46].”
From Role of Oxidative Damage in Alzheimer’s Disease and Neurodegeneration: From Pathogenic Mechanisms to Biomarker Discovery (2021) · cites this paper as [43]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
1 retracted
Ma, H., Li, S., Xu, P., Babcock, S. A., Dolence, E. K., Brownlee, M., Li, J., & Ren, J. T. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00547.x · Cited by 155 · see citing works
RetractedAnalysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860 · see citing works
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837 · see citing works
Pathological roles of MAPK signaling pathways in human diseases
Kim, E. K., & Choi, E.-J. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2009.12.009 · Cited by 2,472 · see citing works
Amyloid Precursor Protein Processing and Alzheimer's Disease
O'Brien, R. J., & Wong, P. C. (2011) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-061010-113613 · Cited by 2,061 · see citing works
RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease
Yan, S. D., Chen, X., Fu, J., Chen, M., Zhu, H., Roher, A., Slattery, T., Zhao, L., Nagashima, M., Morser, J., et al. (1996) · Nature · doi:10.1038/382685a0 · Cited by 2,012 · see citing works
Self-citationMucke, L., Masliah, E., Yu, G.-Q., Mallory, M., Rockenstein, E. M., Tatsuno, G., Hu, K., Kholodenko, D., Johnson-Wood, K., & McConlogue, L. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-11-04050.2000 · Cited by 1,856 · see citing works
Translating cell biology into therapeutic advances in Alzheimer's disease
Selkoe, D. J. (1999) · Nature · doi:10.1038/399a023 · Cited by 1,588 · see citing works
Neeper, M. P., Schmidt, A. M., Brett, J., Yan, S. D., Wang, F., Pan, Y., Elliston, K. O., Stern, D., & SHAW, A. R. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42138-2 · Cited by 1,542 · see citing works
Molecular cloning and expression of glycogen synthase kinase‐3/factor A.
Woodgett, J. R. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb07419.x · Cited by 1,362 · see citing works
Understanding RAGE, the receptor for advanced glycation end products
Bierhaus, A., Humpert, P. M., Morcos, M., Wendt, T., Chavakis, T., Arnold, B., Stern, D. M., & Nawroth, P. P. (2005) · Journal of Molecular Medicine · doi:10.1007/s00109-005-0688-7 · Cited by 1,297 · see citing works
The multiligand receptor RAGE as a progression factor amplifying immune and inflammatory responses
Schmidt, A. M., Yan, S. D., Yan, S. F., & Stern, D. M. (2001) · Journal of Clinical Investigation · doi:10.1172/jci14002 · Cited by 1,256 · see citing works
A Phase 3 Trial of Semagacestat for Treatment of Alzheimer's Disease
Doody, R. S., Raman, R., Farlow, M., Iwatsubo, T., Vellas, B., Joffe, S., Kieburtz, K., He, F., Sun, X., Thomas, R. G., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1210951 · Cited by 1,224 · see citing works
The multiligand receptor RAGE as a progression factor amplifying immune and inflammatory responses
Schmidt, A. M., Yan, S. D., Yan, S. F., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci200114002 · Cited by 1,039 · see citing works
Self-citationLuo, Y., Bolon, B., Kahn, S., Bennett, B. D., Babu-Khan, S., Denis, P., Fan, W., Kha, H., Zhang, J., Gong, Y., et al. (2001) · Nature Neuroscience · doi:10.1038/85059 · Cited by 1,001 · see citing works
Du, H., Guo, L., Fang, F., Chen, D., Sosunov, A. A., McKhann, G. M., Yan, Y., Wang, C., Zhang, H., Molkentin, J. D., et al. (2008) · Nature Medicine · doi:10.1038/nm.1868 · Cited by 935 · see citing works
Functional gamma‐secretase inhibitors reduce beta‐amyloid peptide levels in brain
Dovey, H. F., John, V., Anderson, J. P., Chen, L. Z., Andrieu, P. D. S. I., Fang, L. Y., Freedman, S. B., Folmer, B., Goldbach, E. G., Holsztynska, E. J., et al. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00012.x · Cited by 870 · see citing works
Schmidt, A. M., Vianna, M., Gerlach, M. L., Brett, J., Ryan, J., Kao, J. J., Esposito, C., Hegarty, H. M., Hurley, W. L., & Clauss, M. A. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42137-0 · Cited by 833 · see citing works
The secretases: enzymes with therapeutic potential in Alzheimer disease
De Strooper, B., Vassar, R., & Golde, T. (2010) · Nature Reviews Neurology · doi:10.1038/nrneurol.2009.218 · Cited by 799 · see citing works
BACE1 is the major β-secretase for generation of Aβ peptides by neurons
Cai, H., Wang, Y.-S., McCarthy, D., Wen, H., Borchelt, D., Price, D. L., & Wong, P. (2001) · Nature Neuroscience · doi:10.1038/85064 · Cited by 791 · see citing works
Mitochondrial Aβ: a potential focal point for neuronal metabolic dysfunction in Alzheimer's disease
Caspersen, C., Wang, N., Yao, J., Sosunov, A., Chen, X., Lustbader, J. W., Xu, H. W., Stern, D., McKhann, G., & Du Yan, S. (2005) · The FASEB Journal · doi:10.1096/fj.05-3735fje · Cited by 738 · see citing works
Wong, G. T., Manfra, D. J., Poulet, F. M., Zhang, Q., Josien, H. B., Bara, T. A., Engstrom, L., Pinzon-Ortiz, M. C., Fine, J. S., Lee, H.-J. J., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311652200 · Cited by 715 · see citing works
Roberds, S. L. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.12.1317 · Cited by 705 · see citing works
Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model
Du, H., Guo, L., Yan, S., Sosunov, A. A., McKhann, G. M., & ShiDu Yan, S. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1006586107 · Cited by 704 · see citing works
Mitogen inactivation of glycogen synthase kinase-3β in intact cells via serine 9 phosphorylation
Stambolic, V., & Woodgett, J. R. (1994) · Biochemical Journal · doi:10.1042/bj3030701 · Cited by 581 · see citing works
Geling, A., Steiner, H., Willem, M., Bally‐Cuif, L., & Haass, C. (2002) · The EMBO Reports · doi:10.1093/embo-reports/kvf124 · Cited by 497 · see citing works
Proteases and Proteolysis in Alzheimer Disease: A Multifactorial View on the Disease Process
De Strooper, B. (2010) · Physiological Reviews · doi:10.1152/physrev.00023.2009 · Cited by 455 · see citing works
Lue, L.-F., Walker, D. G., Brachova, L., Beach, T. G., Rogers, J., Schmidt, A. M., Stern, D. M., & Yan, S. D. (2001) · Experimental Neurology · doi:10.1006/exnr.2001.7732 · Cited by 439 · see citing works
Regulation of Akt and glycogen synthase kinase-3β phosphorylation by sodium valproate and lithium
Sarno, P. D., Li, X., & Jope, R. S. (2002) · Neuropharmacology · doi:10.1016/s0028-3908(02)00215-0 · Cited by 433 · see citing works
Yan, S. D., Yan, S. F., Chen, X., Fu, J., Chen, M., Kuppusamy, P., Smith, M. A., Perry, G., Godman, G. C., Nawroth, P., et al. (1995) · Nature Medicine · doi:10.1038/nm0795-693 · Cited by 406 · see citing works
BACE1 inhibitor drugs in clinical trials for Alzheimer’s disease
Vassar, R. (2014) · Alzheimer's Research & Therapy · doi:10.1186/s13195-014-0089-7 · Cited by 393 · see citing works
p38 Kinase Is Activated in the Alzheimer's Disease Brain
Hensley, K., Floyd, R. A., Zheng, N., Nael, R., Robinson, K. A., Nguyen, X., Pye, Q. N., Stewart, C. A., Geddes, J., Markesbery, W. R., et al. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0722053.x · Cited by 373 · see citing works
Central role of RAGE-dependent neointimal expansion in arterial restenosis
Sakaguchi, T., Yan, S. F., Yan, S. D., Belov, D., Rong, L., Sousa, M. M., Andrassy, M., Marso, S. P., Duda, S., Arnold, B., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17115 · Cited by 370 · see citing works
Deficiency in neuronal TGF-β signaling promotes neurodegeneration and Alzheimer’s pathology
Tesseur, I., Zou, K., Esposito, L., Bard, F., Berber, E., Can, J. V., Lin, A. H., Crews, L., Tremblay, P., Mathews, P., et al. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27341 · Cited by 355 · see citing works
Fang, F., Lue, L.-F., Yan, S., Xu, H., Luddy, J. S., Chen, D., Walker, D. G., Stern, D. M., Yan, S., Schmidt, A. M., et al. (2010) · The FASEB Journal · doi:10.1096/fj.09-139634 · Cited by 335 · see citing works
Self-citationRAGE potentiates Aβ‐induced perturbation of neuronal function in transgenic mice
Arancio, O., Zhang, H. P., Chen, X., Lin, C., Trinchese, F., Puzzo, D., Liu, S., Hegde, A. N., Yan, S. F., Stern, A., et al. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600415 · Cited by 328 · see citing works
A γ‐secretase inhibitor decreases amyloid‐β production in the central nervous system
Bateman, R. J., Siemers, E. R., Mawuenyega, K. G., Wen, G., Browning, K. R., Sigurdson, W. C., Yarasheski, K. E., Friedrich, S. W., DeMattos, R. B., May, P. C., et al. (2009) · Annals of Neurology · doi:10.1002/ana.21623 · Cited by 322 · see citing works
Central role of RAGE-dependent neointimal expansion in arterial restenosis
Sakaguchi, T., Yan, S. F., Yan, S. D., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200317115 · Cited by 313 · see citing works
Self-citationPINK1 signalling rescues amyloid pathology and mitochondrial dysfunction in Alzheimer’s disease
Du, F., Yu, Q., Yan, S., Hu, G., Lue, L., Walker, D., Wu, L., Yan, S. F., Tieu, K., & Yan, S. S. (2017) · Brain · doi:10.1093/brain/awx258 · Cited by 306 · see citing works
Glycogen Synthase Kinase-3β Facilitates Staurosporine- and Heat Shock-induced Apoptosis
Bijur, G. N., Sarno, P. D., & Jope, R. S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.11.7583 · Cited by 302 · see citing works
Vassar, R. J., & Citron, M. (2000) · Neuron · doi:10.1016/s0896-6273(00)00051-9 · Cited by 299 · see citing works
Yuan, S., Ryder, J. W., Li, B., Wu, X., Fox, N. W., Solenberg, P., Brune, K. A., Paul, S. M., Zhou, Y., Liu, F., et al. (2004) · Biochemistry · doi:10.1021/bi035627j · Cited by 295 · see citing works
RAGE-mediated signaling contributes to intraneuronal transport of amyloid-β and neuronal dysfunction
Takuma, K., Fang, F., Zhang, W., Yan, S., Fukuzaki, E., Du, H., Sosunov, A., McKhann, G., Funatsu, Y., Nakamichi, N., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0905686106 · Cited by 290 · see citing works
Self-citationLessons from a failed γ-secretase Alzheimer trial
De Strooper, B. (2014) · Cell · doi:10.1016/j.cell.2014.10.016 · Cited by 277 · see citing works
Sasaki, N., Toki, S., Chowei, H., Saito, T., Nakano, N., Hayashi, Y., Takeuchi, M., & Makita, Z. (2001) · Brain Research · doi:10.1016/s0006-8993(00)03075-4 · Cited by 253 · see citing works
Developmental expression and localization of glycogen synthase kinase-3β in rat brain
Leroy, K., & Brion, J. (1999) · Journal of Chemical Neuroanatomy · doi:10.1016/s0891-0618(99)00012-5 · Cited by 241 · see citing works
Du, H., Guo, L., Zhang, W., Rydzewska, M., & Yan, S.-D. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.03.003 · Cited by 230 · see citing works
Munoz, L., Ranaivo, H. R., Roy, S. M., Hu, W., Craft, J. M., McNamara, L. K., Chico, L. W., Van Eldik, L. J., & Watterson, D. M. (2007) · Journal of Neuroinflammation · doi:10.1186/1742-2094-4-21 · Cited by 224 · see citing works
Pyo, H., Jou, I., Jung, S., Hong, S., & Joe, E.-H. (1998) · Neuroreport · doi:10.1097/00001756-199803300-00020 · Cited by 217 · see citing works
Comery, T., Martone, R., Aschmies, S., Atchison, K., Diamantidis, G., Gong, X.-H., Zhou, H., Kreft, A., Pangalos, M., Sonnenberg-Reines, J., et al. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.2693-05.2005 · Cited by 204 · see citing works
Origlia, N., Righi, M., Capsoni, S., Cattaneo, A., Fang, F., Stern, D. M., Chen, J. X., Schmidt, A. M., Arancio, O., Yan, S. D., et al. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0204-08.2008 · Cited by 200 · see citing works
Hippocampal RAGE immunoreactivity in early and advanced Alzheimer’s disease
Miller, M. C., Tavares, R., Johanson, C. E., Hovanesian, V., Donahue, J. E., Gonzalez, L., Silverberg, G. D., & Stopa, E. G. (2008) · Brain Research · doi:10.1016/j.brainres.2008.06.124 · Cited by 194 · see citing works
RAGE and Alzheimer's Disease: A Progression Factor for Amyloid-β-Induced Cellular Perturbation?
Yan, S. D., Bierhaus, A., Nawroth, P. P., & Stern, D. M. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-1030 · Cited by 179 · see citing works
BACE1 Deficiency Causes Altered Neuronal Activity and Neurodegeneration
Hu, X., Zhou, X., He, W., Yang, J., Xiong, W., Wong, P., Wilson, C. G., & Yan, R. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.1334-10.2010 · Cited by 162 · see citing works
γ‐Secretase/presenilin inhibitors for Alzheimer's disease phenocopy Notch mutations in Drosophila
Micchelli, C. A., Esler, W. P., Kimberly, W. T., Jack, C. E., Berezovska, O., Kornilova, A. Y., Hyman, B. T., Perrimon, N., & Wolfe, M. S. (2002) · The FASEB Journal · doi:10.1096/fj.02-0394fje · Cited by 142 · see citing works
β-secretase inhibitor; a promising novel therapeutic drug in Alzheimer’s disease
Menting, K. W., & Claassen, J. A. H. R. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00165 · Cited by 139 · see citing works
Nunan, J., Shearman, M. S., Checler, F., Cappai, R., Evin, G. M., Beyreuther, K., Masters, C. L., & Small, D. H. (2001) · European Journal of Biochemistry · doi:10.1046/j.0014-2956.2001.02465.x · Cited by 127 · see citing works
Amyloid-beta-induced neurotoxicity is reduced by inhibition of glycogen synthase kinase-3
Koh, S., Noh, M., & Kim, S. H. (2007) · Brain Research · doi:10.1016/j.brainres.2007.10.064 · Cited by 126 · see citing works
RAGE is a key cellular target for A -induced perturbation in Alzheimer s disease
Yan, S. S. (2011) · Frontiers in Bioscience-Scholar · doi:10.2741/265 · Cited by 108 · see citing works
The p38 MAP kinase signaling pathway in Alzheimer's disease
Johnson, G. (2003) · Experimental Neurology · doi:10.1016/s0014-4886(03)00268-1 · Cited by 106 · see citing works
RAGE is a key cellular target for A -induced perturbation in Alzheimer s disease
Yan, S. S. (2012) · Frontiers in Bioscience-Scholar · doi:10.2741/s265 · Cited by 97 · see citing works
Lee, K., Koh, S., Noh, M., Park, K. W., Lee, Y. J., & Kim, S. H. (2006) · Brain Research · doi:10.1016/j.brainres.2006.10.055 · Cited by 88 · see citing works
Du, F., Wang, Y., Zhang, Z., Du, H., Yan, S., Sun, Q., Zhong, C., Wu, L., Vangavaragu, J. R., Yan, S., et al. (2015) · Human Molecular Genetics · doi:10.1093/hmg/ddv241 · Cited by 86 · see citing works
Chang, Y., Tesco, G., Jeong, W. J., Lindsley, L., Eckman, E. A., Eckman, C. B., Tanzi, R. E., & Guénette, S. Y. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m309561200 · Cited by 80 · see citing works
Criscuolo, C., Fontebasso, V., Middei, S., Stazi, M., Ammassari‐Teule, M., Yan, S. S., & Origlia, N. (2017) · Scientific Reports · doi:10.1038/srep42370 · Cited by 75 · see citing works
Methylglyoxal Induces Tau Hyperphosphorylation via Promoting AGEs Formation
Li, X., Xie, J., Jiang, X., Lv, B.-L., Cheng, X., Du, L., Zhang, J. Y., Wang, J., & Zhou, X. (2012) · NeuroMolecular Medicine · doi:10.1007/s12017-012-8191-0 · Cited by 72 · see citing works
Origlia, N., Criscuolo, C., Arancio, O., Yan, S., & Domenici, L. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.0141-14.2014 · Cited by 56 · see citing works
Advances in the identification of γ-secretase inhibitors for the treatment of Alzheimer's disease
D’Onofrio, G., Panza, F., Frisardi, V., Solfrizzi, V., Imbimbo, B. P., Paroni, G., Cascavilla, L., Seripa, D., & Pilotto, A. (2011) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2012.645534 · Cited by 50 · see citing works
Du, F., Zhang, Z., Li, H., Yu, Q., Douglas, J. T., Bratasz, A., Kuppusamy, P., & Yan, S. S. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-150917 · Cited by 48 · see citing works
P38 Activation Mediates Amyloid-β Cytotoxicity
Zhu, X., Mei, M. G., Lee, H., Wang, Y., Han, J., Perry, G. L., & Smith, M. A. (2005) · Neurochemical Research · doi:10.1007/s11064-005-6872-x · Cited by 43 · see citing works
Molecular Rationale for the Pharmacological Treatment of Alzheimer??s Disease
Zimmermann, M., Gardoni, F., & Luca, M. D. (2005) · Drugs & Aging · doi:10.2165/00002512-200522001-00003 · Cited by 41 · see citing works
Genetic deficiency of neuronal RAGE protects against AGE-induced synaptic injury
Zhang, H., Wang, Y., Yan, S., Wu, L., Wu, L., Yan, S. S. D., & Yan, S. S. D. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.248 · Cited by 39 · see citing works
Jack, C. E., Berezovska, O., Wolfe, M. S., & Hyman, B. T. (2001) · Molecular Brain Research · doi:10.1016/s0169-328x(01)00010-9 · Cited by 26 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Hypertension, Neurovascular Dysfunction, and Cognitive Impairment
Santisteban, M. M., Iadecola, C., & Carnevale, D. (2022) · Hypertension · doi:10.1161/hypertensionaha.122.18085 · Cited by 291 · see citing works
Paudel, Y. N., Angelopoulou, E., Piperi, C., Othman, I., Aamir, K., & Shaikh, M. F. (2020) · Cells · doi:10.3390/cells9020383 · Cited by 257 · see citing works
Pathophysiology of RAGE in inflammatory diseases
Dong, H., Zhang, Y., Huang, Y., & Deng, H. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.931473 · Cited by 245 · see citing works
Involvement of p38 MAPK in Synaptic Function and Dysfunction
Falcicchia, C., Tozzi, F., Arancio, O., Watterson, D. M., & Origlia, N. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21165624 · Cited by 243 · see citing works
Amyloidosis in Alzheimer’s Disease: Pathogeny, Etiology, and Related Therapeutic Directions
Ma, C., Hong, F., & Yang, S. (2022) · Molecules · doi:10.3390/molecules27041210 · Cited by 243 · see citing works
Role of p38/MAPKs in Alzheimer's Disease: Implications for Amyloid Beta Toxicity Targeted Therapy
Kheiri, G., Dolatshahi, M., Rahmani, F., & Rezaei, N. (2018) · Reviews in the Neurosciences · doi:10.1515/revneuro-2018-0008 · Cited by 211 · see citing works
Relationship Between Amyloid-β Deposition and Blood–Brain Barrier Dysfunction in Alzheimer’s Disease
Wang, D., Chen, F., Han, Z., Yin, Z., Ge, X., & Lei, P. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.695479 · Cited by 201 · see citing works
Buccellato, F. R., D’Anca, M., Fenoglio, C., Scarpini, E., & Galimberti, D. (2021) · Antioxidants · doi:10.3390/antiox10091353 · Cited by 179 · see citing works
Innate immune activation in neurodegenerative diseases
Castro‐Gomez, S., & Heneka, M. T. (2024) · Immunity · doi:10.1016/j.immuni.2024.03.010 · Cited by 167 · see citing works
Hypertension, Neurodegeneration, and Cognitive Decline
Pacholko, A. G., & Iadecola, C. (2024) · Hypertension · doi:10.1161/hypertensionaha.123.21356 · Cited by 150 · see citing works
Sekino, N., Selim, M. H., & Shehadah, A. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02464-4 · Cited by 141 · see citing works
Microglial activation states and their implications for Alzheimer's Disease
Valiukas, Z., Tangalakis, K., Apostolopoulos, V., & Feehan, J. (2025) · The Journal of Prevention of Alzheimer s Disease · doi:10.1016/j.tjpad.2024.100013 · Cited by 155 · see citing works
Rivera, S., García‐González, L., Khrestchatisky, M., & Baranger, K. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03178-2 · Cited by 112 · see citing works
Guan, L., Mao, Z., Yang, S., Wu, G., Chen, Y., Yin, L., Qi, Y., Han, L., & Xu, L. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113248 · Cited by 101 · see citing works
GSK3: A potential target and pending issues for treatment of Alzheimer's disease
Zhao, J., Wei, M., Guo, M., Wang, M., Niu, H., Xu, T., & Zhou, Y. (2024) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14818 · Cited by 100 · see citing works
The relationship between amyloid-beta and brain capillary endothelial cells in Alzheimer’s disease
Su, Q., Guo, J.-H., Zhang, Y.-L., Wang, J., & Zhang, Z.-N. (2022) · Neural Regeneration Research · doi:10.4103/1673-5374.335829 · Cited by 91 · see citing works
Akhter, F., Chen, D., Akhter, A., Yan, S. F., & Yan, S. S. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.12.021 · Cited by 77 · see citing works
The Effects of Dietary Advanced Glycation End-Products on Neurocognitive and Mental Disorders
D'Cunha, N. M., Sergi, D., Lane, M. M., Naumovski, N., Gamage, E., Rajendran, A., Kouvari, M., Gauci, S., Dissanayaka, T. D., Marx, W., et al. (2022) · Nutrients · doi:10.3390/nu14122421 · Cited by 80 · see citing works
Kong, Y., Wang, F., Wang, J., Liu, C., Zhou, Y., Xu, Z., Zhang, C., Sun, B., & Guan, Y. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.00217 · Cited by 74 · see citing works
Danger-Sensing/Patten Recognition Receptors and Neuroinflammation in Alzheimer’s Disease
Chiarini, A., Armato, U., Hu, P., & Prà, I. D. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21239036 · Cited by 75 · see citing works
Beura, S. K., Dhapola, R., Panigrahi, A. R., Yadav, P., HariKrishnaReddy, D., & Singh, S. K. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.120855 · Cited by 64 · see citing works
Liu, J., Ye, T., Zhang, Y., Zhang, R., Kong, Y., Zhang, Y., & Sun, J. (2021) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.1c05038 · Cited by 61 · see citing works
Progress of RAGE Molecular Imaging in Alzheimer’s Disease
Kong, Y., Liu, C., Zhou, Y., Qi, J., Zhang, C., Sun, B., Wang, J., & Guan, Y. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.00227 · Cited by 61 · see citing works
High Dietary Advanced Glycation End Products Impair Mitochondrial and Cognitive Function
Akhter, F., Chen, D., Akhter, A., Sosunov, A. A., Chen, A., McKhann, G. M., Yan, S. F., & Yan, S. S. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-191236 · Cited by 59 · see citing works
Glycans and glycosaminoglycans in neurobiology: key regulators of neuronal cell function and fate
Hayes, A. J., & Melrose, J. (2018) · Biochemical Journal · doi:10.1042/bcj20180283 · Cited by 58 · see citing works
Khattab, M. N. M., Mansour, H. M., Fawzy, H. M., & El-Khatib, A. S. (2021) · Neural Regeneration Research · doi:10.4103/1673-5374.332132 · Cited by 53 · see citing works
Li, W., Chen, Q., Peng, C., Yang, D., Liu, S., Lv, Y., Jiang, L., Xu, S., & Li-hua, H. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26010403 · Cited by 53 · see citing works
Ullah, R., & Lee, E. J. (2023) · Experimental Neurobiology · doi:10.5607/en23014 · Cited by 49 · see citing works
Hong, Y., Dong, X., Chang, L., Xie, C., Chang, M., Aguilar, J. S., Lin, J., Lin, J., & Li, Q. Q. (2023) · iScience · doi:10.1016/j.isci.2023.106267 · Cited by 46 · see citing works
Zhou, R., Chen, L., Yang, H., Li, L., Liu, J., Chen, L., Hong, W., Wang, C., Ma, J., Huang, J., et al. (2021) · Current Alzheimer Research · doi:10.2174/1567205018666210906092940 · Cited by 44 · see citing works
Bhargavan, B., Woollard, S. M., Mcmillan, J. E. M., & Kanmogne, G. D. (2021) · Molecular Neurodegeneration · doi:10.1186/s13024-021-00500-0 · Cited by 43 · see citing works
Neurochemical effects of sepsis on the brain
Barichello, T., Giridharan, V. V., Catalão, C. H. R., Ritter, C., & Dal‐Pizzol, F. (2023) · Clinical Science · doi:10.1042/cs20220549 · Cited by 41 · see citing works
Unveiling the impact of aging on BBB and Alzheimer's disease: Factors and therapeutic implications
Jha, N. K., Jha, N. K., Nuli, M. V., Gupta, S. K., Kanna, S., Gahtani, R. M., Hani, U., Singh, A. K., Abomughaid, M. M., Abomughayedh, A. M., et al. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102224 · Cited by 42 · see citing works
Koerich, S., Parreira, G. M., de Almeida, D. L., Vieira, R. P., & de Oliveira, A. C. P. (2022) · Current Neuropharmacology · doi:10.2174/1570159x20666220922153903 · Cited by 40 · see citing works
Immune Regulatory Functions of Macrophages and Microglia in Central Nervous System Diseases
Poppell, M., Hammel, G., & Ren, Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065925 · Cited by 38 · see citing works
Detka, J., Płachtij, N., Strzelec, M., Manik, A., & Sałat, K. (2024) · Molecules · doi:10.3390/molecules29184354 · Cited by 38 · see citing works
An, F.-M., Bai, Y., Xuan, X., Bian, M., Zhang, G., & Wei, C. (2022) · Molecules · doi:10.3390/molecules27123913 · Cited by 36 · see citing works
Neurodegenerative diseases have genetic hallmarks of autoinflammatory disease
Richards, R. I., Robertson, S. A., & Kastner, D. L. (2018) · Human Molecular Genetics · doi:10.1093/hmg/ddy139 · Cited by 27 · see citing works
Giridharan, V. V., Generoso, J. S., Collodel, A., Dominguini, D., Faller, C. J., Tardin, F., Bhatti, G. S., Petronilho, F. C., Dal‐Pizzol, F., & Barichello, T. (2020) · Neurotherapeutics · doi:10.1007/s13311-020-00917-3 · Cited by 26 · see citing works
Pilat, D., Paumier, J.-M., García-González, L., Louis, L., Stephan, D., Manrique, C., Khrestchatisky, M., Pasquale, E. D., Baranger, K., & Rivera, S. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02407-z · Cited by 21 · see citing works
Manipulation of the diet–microbiota–brain axis in Alzheimer’s disease
Lee, D. D., Lee, V. M. ‐., & Hur, S. K. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.1042865 · Cited by 32 · see citing works
Gasparotto, J., Somensi, N., Girardi, C. S., Bittencourt, R. R., de Oliveira, L. M., Hoefel, L. P. L., Scheibel, I. M., Peixoto, D. O., Moreira, J. C. F., Outeiro, T. F., et al. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.15890 · Cited by 26 · see citing works
Therapeutic Strategies Targeting Amyloid-β Receptors and Transporters in Alzheimer’s Disease
Lao, K., Zhang, R., Luan, J., Zhang, Y., & Gou, X. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-200851 · Cited by 25 · see citing works
Liu, Y.-C., Chen, S.-Y., Chen, Y.-Y., Chang, H., Chiang, I., & Yen, G. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.133898 · Cited by 24 · see citing works
Advanced Glycation End Products in Neurodegenerative Diseases
Raghavan, C. T. (2024) · Journal of Molecular Neuroscience · doi:10.1007/s12031-024-02297-1 · Cited by 23 · see citing works
Zhao, J., Ren, T., Li, X., Guo, T.-L., Liu, C., & Wang, X. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.831977 · Cited by 21 · see citing works
Intravenous Delivery of Lung‐Targeted Nanofibers for Pulmonary Hypertension in Mice
Marulanda, K., Mercel, A. I., Gillis, D. C., Sun, K., Gambarian, M., Roark, J., Weiss, J. M., Tsihlis, N. D., Karver, M. R., Centeno, S. R., et al. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202100302 · Cited by 21 · see citing works
Ayoub, S., Arabi, M., Al-Najjar, Y. A., Laswi, I., Outeiro, T. F., & Châari, A. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05051-9 · Cited by 21 · see citing works
The Hidden Role of Non-Canonical Amyloid β Isoforms in Alzheimer’s Disease
Busch, L., Eggert, S., Endres, K., & Bufe, B. (2022) · Cells · doi:10.3390/cells11213421 · Cited by 19 · see citing works
Lian, W., Wang, Z., Zhou, F., Yuan, X., Xia, C., Wang, W., Yu, Y., Cheng, Y., Yang, H., Xu, J., et al. (2024) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-024-10120-2 · Cited by 19 · see citing works
Effects of the age/rage axis in the platelet activation
Recabarren-Leiva, D., Burgos, C. F., Hernández, B., García‐García, F. J., Castro, R. I., Guzmán, L., Eduardo Fuentes, Q., Palomo, I. F., & Alarcón, M. A. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.10.270 · Cited by 19 · see citing works
The Role of Astrocytes and Blood–Brain Barrier Disruption in Alzheimer’s Disease
Cruz, J. V. R., Batista, C., Diniz, L., & Mendes, F. (2023) · Neuroglia · doi:10.3390/neuroglia4030015 · Cited by 15 · see citing works
Pluta, R. M., Kocki, J., Bogucki, J., Bogucka‐Kocka, A., & Czuczwar, S. J. (2023) · Cells · doi:10.3390/cells12232763 · Cited by 19 · see citing works
Role and Therapeutic Potential of RAGE Signaling in Neurodegeneration
Pehar, M., & Kinscherf, N. A. (2022) · Current Drug Targets · doi:10.2174/1389450123666220610171005 · Cited by 17 · see citing works
Modulation of Innate Immunity by Amyloidogenic Peptides
Westwell-Roper, C. Y., & Verchere, C. B. (2019) · Trends in Immunology · doi:10.1016/j.it.2019.06.005 · Cited by 17 · see citing works
Li, Z., Yang, P., & Feng, B. (2020) · Molecular Biology Reports · doi:10.1007/s11033-020-05998-z · Cited by 16 · see citing works
Philippens, I., & Langermans, J. (2021) · Vaccines · doi:10.3390/vaccines9040388 · Cited by 18 · see citing works
Li, T., Li, D., Wei, Q., Shi, M., Xiang, J., Gao, R., Chen, C., & Xu, Z. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106114 · Cited by 17 · see citing works
Lee, H., Jeong, H.-R., Park, J.-H., & Hoe, H. (2021) · Biology · doi:10.3390/biology10090938 · Cited by 15 · see citing works
Nikolaeva, N. S., Yandulova, E. Y., Aleksandrova, Y. R., Starikov, A. S., & Неганова, М. Е. (2022) · Acta Naturae · doi:10.32607/actanaturae.11723 · Cited by 14 · see citing works
Pradhan, S. P., Sahu, P. K., & Behera, A. (2023) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-023-04696-1 · Cited by 12 · see citing works
Fu, C.-X., Dai, L., Yuan, X.-Y., & Xu, Y. (2020) · Biological Trace Element Research · doi:10.1007/s12011-020-02280-y · Cited by 11 · see citing works
Saaoud, F., Liu, L., Xu, K., Lu, Y., Shao, Y., Issa, M., Jiang, X., Wang, X., Liu, X., Autieri, M. V., et al. (2025) · Journal of Alzheimer s Disease · doi:10.1177/13872877251329583 · Cited by 11 · see citing works
He, M. T., Kim, J.-H., Kim, J. H., Park, C. H., & Cho, E. J. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2020.104048 · Cited by 10 · see citing works
Płoska, A., Cieślik, P., Siekierzycka, A., Kalinowski, L., & Wierońska, J. M. (2021) · Brain Research · doi:10.1016/j.brainres.2021.147577 · Cited by 10 · see citing works
Is pseudoexfoliation glaucoma a neurodegenerative disorder?
Padhy, B., & Alone, D. P. (2021) · Journal of Biosciences · doi:10.1007/s12038-021-00217-8 · Cited by 9 · see citing works
Verma, A., Sharma, M., Alam, O., & Anwer, T. (2025) · European Journal of Neuroscience · doi:10.1111/ejn.70364 · Cited by 8 · see citing works
Erim, B., & Binici, H. İ. (2024) · Nutrire · doi:10.1186/s41110-024-00298-z · Cited by 8 · see citing works
Li, D., Yang, H., Lyu, M., Zhou, L., Zhang, Y., Kang, C., Wang, J., & Wang, Y. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105207 · Cited by 7 · see citing works
Immune signaling and function in neurodegeneration
Latour, Y. L., & McGavern, D. B. (2026) · Journal of Clinical Investigation · doi:10.1172/jci199850 · Cited by 7 · see citing works
Qrareya, A. N., Wise, N. S., Hodges, E. R., Mahdi, F., Stewart, J. A., & Paris, J. J. (2022) · Viruses · doi:10.3390/v14102191 · Cited by 6 · see citing works
From Better Diagnostics to Earlier Treatment: The Rapidly Evolving Alzheimer’s Disease Landscape
Bougea, A. M., Debasa‐Mouce, M., Gulkarov, S., Castro‐Mosquera, M., Reiss, A. B., & Ouro, A. (2025) · Medicina · doi:10.3390/medicina61081462 · Cited by 5 · see citing works
Li, Q., Shang, Y., Huang, H., Dai, X., & Lao, F. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05329-y · Cited by 5 · see citing works
Salminen, A. (2026) · Neurochemistry International · doi:10.1016/j.neuint.2026.106115 · Cited by 5 · see citing works
γ-Secretase fanning the fire of innate immunity
Liu, C., Nikain, C., & Li, Y.-M. (2023) · Biochemical Society Transactions · doi:10.1042/bst20221445 · Cited by 4 · see citing works
Sani, N. F. A., Hamzah, A. I. Z. A., Bakar, Z. H. A., Yusof, Y. A. M., Makpol, S., Ngah, W. Z. W., & Damanhuri, H. A. (2021) · Cells · doi:10.3390/cells10071611 · Cited by 4 · see citing works
Takei, S., Ochi, M., Shiraoka, A., Matsumoto, S., Fujishita, S., Okada, Y., Miura, S., Ochi, H., Igase, M., & Ohyagi, Y. (2024) · Archives of Gerontology and Geriatrics Plus · doi:10.1016/j.aggp.2024.100071 · Cited by 3 · see citing works
Wu, R., Guo, J., Liu, Y., Huang, S., Wu, P., & Liu, W. (2025) · Journal of Alzheimer s Disease · doi:10.1177/13872877251338687 · Cited by 3 · see citing works
A novel hybrid protein promotes Aβ clearance and reduces inflammatory response through MerTKPreprint
Samentar, L., Salazar, A., Pan, P., Etebar, K., Choy, K., Uddin, D., Eliseeff, P., Bugayong, A. M., Garrido, J. A. M. G., Emini, A., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.11.03.467048 · Cited by 2 · see citing works
The Role of Periodontitis in Increasing Cognitive Decline in Alzheimer\'s Disease
Freitas, C. M. T., Patil, S., Klonaris, N., & Murcia, J. D. G. (2025) · The Journal of Contemporary Dental Practice · doi:10.5005/jp-journals-10024-3847 · Cited by 2 · see citing works
HMGB1 signalling in Alzheimer’s disease: pathogenic roles and therapeutic prospects
Tyagi, P., Kumari, S., Sharma, P., Dhapola, R., Paidlewar, M., Medhi, B., & HariKrishnaReddy, D. (2026) · International Immunopharmacology · doi:10.1016/j.intimp.2026.117204 · Cited by 2 · see citing works
Differential expression of SLC30A10 and RAGE in mouse pups by early life lead exposure
Li, N., Wen, L., Shen, Y., Li, T., Wang, T., Qiao, M., Song, L., & Huang, X. (2023) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2023.127233 · Cited by 2 · see citing works
Mahayana, N. P. K., Yadmika, N. P. W. P., Aryaweda, M. D. W., Mahardana, M. D. P., Mamangdean, C. T., Dewi, N. N. A., Wirawan, C., & Laksmidewi, A. A. A. P. (2024) · The Egyptian Journal of Neurology Psychiatry and Neurosurgery · doi:10.1186/s41983-024-00870-4 · Cited by 2 · see citing works
Bhargavan, B., Annadurai, N., & Kanmogne, G. D. (2025) · Acta Neuropathologica Communications · doi:10.1186/s40478-025-02197-4 · Cited by 1 · see citing works
Kumar, R., Shinn, G., Lin, J., Li, Q. Q., & Hong, Y. (2026) · Organoids · doi:10.3390/organoids5020012 · Cited by 1 · see citing works
Mitochondrial oxidative stress promotes the accumulation of advanced glycation end products
Akhter, F., Samanta, S., Sosunov, A. A., Wu, H., Tieu, E. K., Yan, S. F., & Yan, S. S. (2026) · PLoS ONE · doi:10.1371/journal.pone.0352355 · Cited by 1 · see citing works
Knight in Splicing Armor: Alternative Splicing as a Neuroprotective Mechanism
Park, J., Tao, X., & Zhai, R. G. (2020) · OBM Genetics · doi:10.21926/obm.genet.2001106
Bagle, S., Muke, S., Peshattiwar, V., Kaikini, A. A., Dighe, V. D., & Sathaye, S. S. (2025) · Exploration of Neuroprotective Therapy · doi:10.37349/ent.2025.1004128
Ojo, T. O., Adelusi, T. I., Bolaji, O. Q., Quainoo, B., Cudjoe, J., Faloyo, M. O., Osalaye, O. O., Elegbeleye, O. E., Boyenle, I. D., Oyedele, A.-Q. K., et al. (2025) · In Silico Research in Biomedicine · doi:10.1016/j.insi.2025.100078
Mikhailov, I. G., Mikhailova, M. S., Baklashov, A. D., Ponamareva, P. S., Shumilova, S. N., Shuvaev, А. N., Belozor, О. S., & Shuvaev, А. N. (2026) · Biomedicines · doi:10.3390/biomedicines14040779
Molecular mechanisms of action of MT-MMPs involved in the pathogenesis of Alzheimer’s disease
García‐González, L. (2020) · theses.fr (ABES) · doi:10.70675/a04672c0z1f4az472ezbcd5zbea446eac50c
An RNA interference strategy for the treatment of Alzheimer's disease
Liu, X. (2021) · theses.fr (ABES) · doi:10.70675/35211b03z3b19z478czb3e2z8d35ab2170d6
Bhargavan, B., Annadurai, N., & Kanmogne, G. D. (2026) · Fluids and Barriers of the CNS · doi:10.1186/s12987-026-00807-4
Li, L., Yan, X., Cui, M. A., Yuting, W., Dou, T., & Xie, W. (2026) · Journal of Acupuncture and Tuina Science · doi:10.1007/s11726-026-1567-8
Otaegui, L., Lehoux, J., Bégu, S., Moujellil-Legagneur, T., Zussy, C., Vitalis, M., Mathias, M., Beau, A., Durand, T., Givalois, L., et al. (2026) · Drug Delivery and Translational Research · doi:10.1007/s13346-026-02142-5
Jia, M., Mei, J., Guan, Y., Wang, Z., & Ai, H. (2026) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.6c00207
Insulin-linked synaptic modulation in Alzheimer's pathology: Emerging potential of nanofibers
Sellers, P. R., Pokharel, B., Arnipalli, S. R., & Ziouzenkova, O. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-30263-3.00031-2
Thakur, A., Sharma, R. R., Kumari, S., Prakash, D., & Devi, A. S. (2026) · Inflammopharmacology · doi:10.1007/s10787-026-02371-7
Li, Z., Zhang, N., Dai, L., Meng, X., Huang, J., Hei, Q., Mei, Z., & Xiong, H. (2026) · Phytomedicine · doi:10.1016/j.phymed.2026.158822
- Authors
- Fang, F., Yu, Q., Arancio, O., Chen, D., Gore, S. S., Yan, S. S., & Yan, S. F.
- Affiliations
- University of Kansas (US)
- Columbia University (US)
- Corresponding author
- Yan, Shirley ShiDu
- Yan, Shi Fang
- Venue
- Human Molecular Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 2018-01-10
- Volume
- 27
- Issue
- 6
- Pages
- 1002-1014
- ISSN
- 0964-6906 (ISSN-L)
- 1460-2083
- PMC
- PMC6075512
- OpenAlex
- W2782715813
- Cited by
- 103
- References
- 72
- Citations by year
- 2026: 16 · 2025: 12 · 2024: 11 · 2023: 12 · 2022: 17 · 2021: 17 · 2020: 13 · 2019: 2 · 2018: 3
- FWCI
- 6.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Human Molecular Genetics (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Health (R37AG037319, R01AG044793, R01AG053041, R01NS089116)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- receptor for advanced glycation end products, Alzheimer's disease, amyloid-beta deposition, beta-secretase, gamma-secretase, amyloid precursor protein, GSK3β, p38 MAPK, APP processing, learning and memory impairment, therapeutic target
- MeSH terms
- Receptor for Advanced Glycation End Products, Glycogen Synthase Kinase 3 beta, Alzheimer Disease, Animals, Brain, Disease Models, Animal, Humans, Memory, Mice, Transgenic, Neurons, Signal Transduction, Amyloid beta-Peptides, Amyloid beta-Protein Precursor, p38 Mitogen-Activated Protein Kinases, Mice, Amyloid Precursor Protein Secretases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
