Enhancement of neuronal protection from oxidative stress by glutamic acid decarboxylase delivery with a defective herpes simplex virus vector

Lamigeon, C; Prod'Hon, C; De Frias, V; Michoudet, C; Jacquemont, B

doi:10.1016/s0014-4886(03)00400-x

Cited by 13Virus-based gene therapy researchNeuroscience and Neuropharmacology ResearchHerpesvirus Infections and Treatments

Enhancement of neuronal protection from oxidative stress by glutamic acid decarboxylase delivery with a defective herpes simplex virus vector

Lamigeon, C, Prod'Hon, C, De Frias, V, Michoudet, C, Jacquemont, B·2003·Experimental Neurology

DOI 10.1016/s0014-4886(03)00400-x

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Abstract

We have developed defective herpes simplex virus 1 (HSV-1) vectors, based on amplicon plasmids with a replication-deficient mutant, as helper for the transfer of the glutamic acid decarboxylase (GAD67) or beta-galactosidase (beta-gal) gene as control directed by HCMV promoter into neuronal-like cells (PC12) and primary neurons. GAD67 protein was detected immunochemically, while GAD67 activity in virus-producing and nonproducing cell lines was detected enzymatically or by GABA release. Infection with GAD67-expressing amplicon vectors enhanced the resistance of PC12 cells to H(2)O(2). This protection was related to increased energy metabolism, as shown by MTT reduction and ATP level, and involved the GABA shunt, as shown by the reduction in ATP level seen in the presence of gamma-vinyl GABA (GVG), a specific GABA transaminase inhibitor. Level of glutathione (GSH), which requires ATP for its synthesis, was increased by the GAD67 transgene. The activity of glucose-6-phosphate dehydrogenase involved in the maintenance of the NADPH that can be used for the regeneration of the GSH pool, was increased by infection with amplicon vectors. Thus, replication-deficient HSV-1 and the GAD67 transgene have complementary neuroprotective effects and infection with GAD67-expressing amplicon vectors was able to protect nondifferentiated cortical neurons from glutamate toxicity mediated by oxidative stress. Such defective GAD67-expressing HSV-1, as neurotropic vector, should be helpful in neurodegenerative diseases implicating alterations of energy metabolism and oxidative stress in neuronal cells expressing GABA transaminase.

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Several reports showed that enhanced GAD2 activity may contribute to neuronal protection from oxidative stress in vitro neuronal tissue cultures.
“In this way, several reports showed that enhanced GAD2 activity may contribute to neuronal protection from oxidative stress in vitro neuronal tissue cultures [238, 239].”
From Oxidative Stress Implications in the Affective Disorders: Main Biomarkers, Animal Models Relevance, Genetic Perspectives, and Antioxidant Approaches (2016) · cites this paper as [238]

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“In this way, several reports showed that enhanced GAD2 activity may contribute to neuronal protection from oxidative stress in vitro neuronal tissue cultures [238, 239].”
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Authors: Lamigeon, C., Prod'Hon, C., De Frias, V, Michoudet, C., & Jacquemont, B.
Affiliations: Inserm (FR)
Corresponding author: Jacquemont, B
Venue: Experimental Neurology
Publisher: Elsevier BV
Published: 2003-11
Volume: 184
Issue: 1
Pages: 381-392
ISSN: 0014-4886 (ISSN-L)
DOI: 10.1016/s0014-4886(03)00400-x
OpenAlex: W2002735515
Cited by: 13
References: 76
Citations by year: 2025: 1 · 2020: 1 · 2018: 1 · 2016: 1 · 2013: 2
FWCI: 0.53
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Experimental Neurology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Health Sciences › Medicine › Epidemiology › Herpesvirus Infections and Treatments
Keywords: glutamic acid decarboxylase 67, neuroprotection, oxidative stress, glutamate excitotoxicity, GABA shunt, glutathione, energy metabolism, vigabatrin, glucose-6-phosphate dehydrogenase, NADPH regeneration, PC12 cells, cortical neurons, viral gene delivery
MeSH terms: Adenosine Triphosphate, Animals, beta-Galactosidase, Cell Survival, gamma-Aminobutyric Acid, Glutamate Decarboxylase, Glutathione, Heterozygote, Hydrogen Peroxide, Isoenzymes, Neurons, Plasmids, PC12 Cells, Genes, Reporter, Gene Transfer Techniques, Herpesvirus 1, Human, Oxidative Stress, Glutamic Acid, Transgenes, Rats

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Enhancement of neuronal protection from oxidative stress by glutamic acid decarboxylase delivery with a defective herpes simplex virus vector

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