The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Clostridium perfringens enterotoxin binds to the second extracellular loop of claudin‐3, a tight junction integral membrane protein
Abstract
Claudins (claudin‐1 to ‐18) with four transmembrane domains and two extracellular loops constitute tight junction strands. The peptide toxin Clostridium perfringens enterotoxin (CPE) has been shown to bind to claudin‐3 and ‐4, but not to claudin‐1 or ‐2. We constructed claudin‐1/claudin‐3 chimeric molecules and found that the second extracellular loop of claudin‐3 conferred CPE sensitivity on L fibroblasts. Furthermore, overlay analyses revealed that the second extracellular loop of claudin‐3 specifically bound to CPE at the K a value of 1.0×10 8 M−1. We concluded that the second extracellular loop is the site through which claudin‐3 interacts with CPE on the cell surface.
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Cites
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JUNCTIONAL COMPLEXES IN VARIOUS EPITHELIA
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Self-citationMorita, K., Furuse, M., Fujimoto, K., & Tsukita, S. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.2.511 · Cited by 1,126
Self-citationFuruse, M., Sasaki, H., Fujimoto, K., & Tsukita, S. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.143.2.391 · Cited by 965
Self-citationTight junctions and the molecular basis for regulation of paracellular permeability
Anderson, J. M., & Van Itallie, C. M. (1995) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1995.269.4.g467 · Cited by 843
Manner of Interaction of Heterogeneous Claudin Species within and between Tight Junction Strands
Furuse, M., Sasaki, H., & Tsukita, S. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.147.4.891 · Cited by 746
Self-citationClostridium perfringens Enterotoxin Fragment Removes Specific Claudins from Tight Junction Strands
Sonoda, N., Furuse, M., Sasaki, H., Yonemura, S., Katahira, J., Horiguchi, Y., & Tsukita, S. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.147.1.195 · Cited by 610
Self-citationOccludin and claudins in tight-junction strands: leading or supporting players?
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Intestinal barrier function: molecular regulation and disease pathogenesis
Groschwitz, K. R., & Hogan, S. P. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.05.038 · Cited by 1,775
Claudins and the Modulation of Tight Junction Permeability
Günzel, D., & Yu, A. S. L. (2013) · Physiological Reviews · doi:10.1152/physrev.00019.2012 · Cited by 1,456
Structure and function of claudins
Krause, G., Winkler, L., Mueller, S. L., Haseloff, R. F., Piontek, J., & Blasig, I. E. (2008) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2007.10.018 · Cited by 829
Transmembrane proteins of tight junctions
Chiba, H., Osanai, M., Murata, M., Kojima, T., & Sawada, N. (2008) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2007.08.017 · Cited by 464
Tight junction-based epithelial microenvironment and cell proliferation
Tsukita, S., Yamazaki, Y., Katsuno, T., Tamura, A., & Tsukita, S. (2008) · Oncogene · doi:10.1038/onc.2008.344 · Cited by 375
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Metadata
- Authors
- Fujita, K., Katahira, J., Horiguchi, Y., Sonoda, N., Furuse, M., & Tsukita, S.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2000-07-03
- Volume
- 476
- Issue
- 3
- Pages
- 258-261
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W1979308263
- Cited by
- 283
- References
- 16
- FWCI
- 3.88
- Type
- journal article
- Language
- en
- Open access
- closed
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- Fujita, K., Katahira, J., Horiguchi, Y., Sonoda, N., Furuse, M., & Tsukita, S. (2000). Clostridium perfringens enterotoxin binds to the second extracellular loop of claudin‐3, a tight junction integral membrane protein. FEBS Letters. https://doi.org/10.1016/s0014-5793(00)01744-0
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