The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Protein kinase B (PKB/Akt) – a key regulator of glucose transport?
Abstract
The serine/threonine kinase protein kinase B (PKB/Akt) has been shown to play a crucial role in the control of diverse and important cellular functions such as cell survival and glycogen metabolism. There is also convincing evidence that PKB plays a role in the insulin‐mediated regulation of glucose transport. Furthermore, states of cellular insulin resistance have been shown to involve impaired PKB activation, and this usually coincides with a loss of glucose transport activation. However, evidence to the contrary is also available, and the role of PKB in the control of glucose transport remains controversial. Here we provide an overview of recent findings, discuss the potential importance of PKB in the regulation of glucose transport and metabolism, and comment on future directions.
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Citations
Cites
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Cellular survival: a play in three Akts
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Tau protein kinases: Involvement in Alzheimer's disease
Martin, L., Latypova, X., Wilson, C. M., Magnaudeix, A., Perrin, M.-L., Yardin, C., & Terro, F. (2013) · Ageing Research Reviews · doi:10.1016/j.arr.2012.06.003 · Cited by 631
Amyloid beta oligomers induce impairment of neuronal insulin receptors
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M USCLE T RIGLYCERIDE AND I NSULIN R ESISTANCE
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New insights into ER stress-induced insulin resistance
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Self-citationPOWELL, D. J., TURBAN, S., GRAY, A., HAJDUCH, E., & HUNDAL, H. S. (2004) · Biochemical Journal · doi:10.1042/bj20040139 · Cited by 267
Self-citationDimopoulos, N., Watson, M., Sakamoto, K., & Hundal, H. S. (2006) · Biochemical Journal · doi:10.1042/bj20060244 · Cited by 247
Self-citationPerdomo, G., Commerford, S. R., Richard, A.-M. T., Adams, S. H., Corkey, B. E., O'Doherty, R. M., & Brown, N. F. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403566200 · Cited by 158
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Sphingolipids: agents provocateurs in the pathogenesis of insulin resistance
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Self-citationSGK1 signaling promotes glucose metabolism and survival in extracellular matrix detached cells
Mason, J. A., Cockfield, J. A., Pape, D. J., Meissner, H., Sokolowski, M. T., White, T. C., Valentín López, J. C., Liu, J., Liu, X., Martínez-Reyes, I., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.108821 · Cited by 64
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“In the muscle for example, GLUT4 is translocated from intracellular vesicles to the plasma membrane and facilitates cellular uptake and utilization of circulating glucose following insulin stimulation, which is mediated via Akt signaling [35].”
Pöllänen, E., Ronkainen, P. H. A., Horttanainen, M., Takala, T., Puolakka, J., Suominen, H., Sipilä, S., & Kovanen, V. (2010) · Growth Hormone & IGF Research · doi:10.1016/j.ghir.2010.07.003 · Cited by 54
Glucose variability aggravates cardiac fibrosis by altering Akt signalling path
Ying, C., Liu, T., Ling, H., Cheng, M., Zhou, X., Wang, S., Mao, Y., Chen, L., Zhang, R., & Li, W. (2017) · Diabetes and Vascular Disease Research · doi:10.1177/1479164117698917 · Cited by 54
Zhang, Q., Duplany, A., Moncollin, V., Mouradian, S., Goillot, E., Mazelin, L., Gauthier, K., Streichenberger, N., Angleraux, C., Chen, J., et al. (2019) · Journal of Cachexia, Sarcopenia and Muscle · doi:10.1002/jcsm.12336 · Cited by 31
“Previous studies established a major role for IRS-1/Akt2 signalling in insulin-stimulated glucose metabolism in skeletal muscle.(51,53)”
Metadata
- Authors
- Hajduch, E., Litherland, G. J., & Hundal, H. S.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2001-03-12
- Volume
- 492
- Issue
- 3
- Pages
- 199-203
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2041205764
- Cited by
- 279
- References
- 7
- FWCI
- 5.86
- Type
- journal article
- Language
- en
- Open access
- closed
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