Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetes

Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus

The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus* (2002) · Diabetes Care · doi:10.2337/diacare.25.2007.s5 · Cited by 10,320 · see citing works

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

Cross, D. A. E., Alessi, D. R., Cohen, P., Andjelkovich, M., & Hemmings, B. A. (1995) · Nature · doi:10.1038/378785a0 · Cited by 5,244 · see citing works

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha.

Alessi, D., James, S., Downes, C., Holmes, A. B., Gaffney, P., Reese, C., & Cohen, P. (1997) · Current Biology · doi:10.1016/s0960-9822(06)00122-9 · Cited by 3,047 · see citing works

Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus

The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus (2003) · Diabetes Care · doi:10.2337/diacare.26.2007.s5 · Cited by 2,689 · see citing works

Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

Stambolic, V., Suzuki, A., de la Pompa, J. L., Brothers, G. M., Mirtsos, C., Sasaki, T., Ruland, J., Penninger, J. M., Siderovski, D. P., & Mak, T. W. (1998) · Cell · doi:10.1016/s0092-8674(00)81780-8 · Cited by 2,551 · see citing works

Pathogenesis of NIDDM. A balanced overview.

DeFronzo, R. A., Bonadonna, R. C., & Ferrannini, E. (1992) · Diabetes Care · doi:10.2337/diacare.15.3.318 · Cited by 2,085 · see citing works

Disruption of IRS-2 causes type 2 diabetes in mice

Withers, D., Gutiérrez, J., Towery, H., Burks, D., Ren, J.-M., Previs, S., Zhang, Y., Bernal, D., Pons, S., Shulman, G., et al. (1998) · Nature · doi:10.1038/36116 · Cited by 1,850 · see citing works

PI3K: Downstream AKTion Blocks Apoptosis

Franke, T. F., Kaplan, D. R., & Cantley, L. C. (1997) · Cell · doi:10.1016/s0092-8674(00)81883-8 · Cited by 1,692 · see citing works

Phosphatidylinositol 3-Kinase Activation Is Required for Insulin Stimulation of pp70 S6 Kinase, DNA Synthesis, and Glucose Transporter Translocation

Cheatham, B., Vlahos, C. J., Cheatham, L. A., Wang, L., Blenis, J., & Kahn, C. R. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.7.4902-4911.1994 · Cited by 1,067 · see citing works

A Retroviral Oncogene, akt , Encoding a Serine-Threonine Kinase Containing an SH2-Like Region

Bellacosa, A., Testa, J. R., Staal, S. P., & Tsichlis, P. N. (1991) · Science · doi:10.1126/science.1833819 · Cited by 939 · see citing works

Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. Studies with a selective inhibitor wortmannin.

Okada, T., Kawano, Y., Sakakibara, T., Hazeki, O., & Ui, M. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)41901-6 · Cited by 917 · see citing works

Insulin Action and the Insulin Signaling Network*

Cheatham, B., & Kahn, C. R. (1995) · Endocrine Reviews · doi:10.1210/edrv-16-2-117 · Cited by 878 · see citing works

Mechanism of activation and function of protein kinase B

Alessi, D. R., & Cohen, P. (1998) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(98)80062-2 · Cited by 743 · see citing works

Calcium promotes cell survival through CaM-K kinase activation of the protein-kinase-B pathway

Yano, S., Tokumitsu, H., & Soderling, T. R. (1998) · Nature · doi:10.1038/25147 · Cited by 617 · see citing works

Protein Kinase B/Akt Participates in GLUT4 Translocation by Insulin in L6 Myoblasts

Wang, Q., Somwar, R., Bilan, P. J., Liu, Z., Jin, J., Woodgett, J. R., & Klip, A. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.6.4008 · Cited by 590 · see citing works

The insulin signalling system and the IRS proteins

White, M. F. (1997) · Diabetologia · doi:10.1007/s001250051387 · Cited by 581 · see citing works

Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation, and phosphatidylinositol 3-kinase activity are decreased in intact skeletal muscle strips from obese subjects.

Goodyear, L. J., Giorgino, F., Sherman, L., Carey, J., Smith, R. J., & Dohm, G. L. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117909 · Cited by 525 · see citing works

Akt, a Pleckstrin Homology Domain Containing Kinase, Is Activated Primarily by Phosphorylation

Kohn, A. D., Takeuchi, F., & Roth, R. A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.36.21920 · Cited by 476 · see citing works

1-Phosphatidylinositol 3-kinase activity is required for insulin-stimulated glucose transport but not for RAS activation in CHO cells.

Hara, K., Yonezawa, K., Sakaue, H., Ando, A., Kotani, K., Kitamura, T., Kitamura, Y., Ueda, H., Stephens, L., & Jackson, T. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.16.7415 · Cited by 433 · see citing works

Type 2 Diabetes: When Insulin Secretion Fails to Compensate for Insulin Resistance

Kahn, B. B. (1998) · Cell · doi:10.1016/s0092-8674(00)81125-3 · Cited by 426 · see citing works

Insulin action on glucose transport and plasma membrane GLUT4 content in skeletal muscle from patients with NIDDM

Zierath, J. R., He, L., Gumà, A., Wahlström, E. O., Klip, A., & Wallberg-Henriksson, H. (1996) · Diabetologia · doi:10.1007/bf02658504 · Cited by 402 · see citing works

Physiological Role of Akt in Insulin-Stimulated Translocation of GLUT4 in Transfected Rat Adipose Cells

Cong, L.-N., Chen, H., Li, Y., Zhou, L., McGibbon, M. A., Taylor, S. I., & Quon, M. J. (1997) · Molecular Endocrinology · doi:10.1210/mend.11.13.0027 · Cited by 383 · see citing works

A Novel 160-kDa Phosphotyrosine Protein in Insulin-treated Embryonic Kidney Cells Is a New Member of the Insulin Receptor Substrate Family

Lavan, B. E., Fantin, V. R., Chang, E. T., Lane, W. S., Keller, S. R., & Lienhard, G. E. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.34.21403 · Cited by 381 · see citing works

The role of protein phosphorylation in the hormonal control of enzyme activity

Cohen, P. (1985) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1985.tb09121.x · Cited by 379 · see citing works

A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region

Bellacosa, A., Testa, Staal, S., et al. (1991) · Science · doi:10.1126/science.254.5029.274 · Cited by 365 · see citing works

Insulin Receptor Substrate-1 Phosphorylation and Phosphatidylinositol 3-Kinase Activity in Skeletal Muscle From NIDDM Subjects After In Vivo Insulin Stimulation

Björnholm, M., Kawano, Y., Lehtihet, M., & Zierath, J. R. (1997) · Diabetes · doi:10.2337/diab.46.3.524 · Cited by 358 · see citing works

Potential Role of Protein Kinase B in Insulin-induced Glucose Transport, Glycogen Synthesis, and Protein Synthesis

Ueki, K., Yamamoto‐Honda, R., Kaburagi, Y., Yamauchi, T., Tobe, K., Burgering, B. M. T., Coffer, P. J., Komuro, I., Akanuma, Y., Yazaki, Y., et al. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.9.5315 · Cited by 356 · see citing works

Insulin stimulates the kinase activity of RAC‐PK, a pleckstrin homology domain containing ser/thr kinase.

Kohn, A. D., Kovacina, K. S., & Roth, R. A. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb00103.x · Cited by 355 · see citing works

The 60-kDa Phosphotyrosine Protein in Insulin-treated Adipocytes Is a New Member of the Insulin Receptor Substrate Family

Lavan, B. E., Lane, W. S., & Lienhard, G. E. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.17.11439 · Cited by 353 · see citing works

Constitutive activation of protein kinase B alpha by membrane targeting promotes glucose and system A amino acid transport, protein synthesis, and inactivation of glycogen synthase kinase 3 in L6 muscle cells.

Hajduch, E., Alessi, D. R., Hemmings, B. A., & Hundal, H. S. (1998) · Diabetes · doi:10.2337/diabetes.47.7.1006 · Cited by 335 · cited 1× · see citing works

Insulin Signal Transduction and the IRS Proteins

Myers, M. G., & White, M. F. (1996) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.36.040196.003151 · Cited by 333 · see citing works

Requirement for Activation of the Serine-Threonine Kinase Akt (Protein Kinase B) in Insulin Stimulation of Protein Synthesis but Not of Glucose Transport

Kitamura, T., Ogawa, W., Sakaue, H., Hino, Y., Kuroda, S., Takata, M., Matsumoto, M., Maeda, T., Konishi, H., Kikkawa, U., et al. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.7.3708 · Cited by 329 · see citing works

Insulin-Stimulated Akt Kinase Activity Is Reduced in Skeletal Muscle From NIDDM Subjects

Krook, A., Roth, R. A., Jiang, X. J., Zierath, J. R., & Wallberg‐Henriksson, H. (1998) · Diabetes · doi:10.2337/diab.47.8.1281 · Cited by 309 · see citing works

Differential regulation of insulin receptor substrates-1 and -2 (IRS-1 and IRS-2) and phosphatidylinositol 3-kinase isoforms in liver and muscle of the obese diabetic (ob/ob) mouse.

Kerouz, N., Hörsch, D., Pons, S., & Kahn, C. R. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119872 · Cited by 301 · see citing works

Contrasting Effects of IRS-1 Versus IRS-2 Gene Disruption on Carbohydrate and Lipid Metabolism in Vivo

Previs, S. F., Withers, D. J., Ren, J.-M., White, M. F., & Shulman, G. I. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m006490200 · Cited by 291 · see citing works

Activation of protein kinase B β and γ isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B α

Walker, K. S., Deák, M., PATERSON, A., Hudson, K., Cohen, P., & Alessi, D. R. (1998) · Biochemical Journal · doi:10.1042/bj3310299 · Cited by 279 · see citing works

Insulin stimulation of glycogen synthesis and glycogen synthase activity is blocked by wortmannin and rapamycin in 3T3-L1 adipocytes: evidence for the involvement of phosphoinositide 3-kinase and p70 ribosomal protein-S6 kinase

Shepherd, P. R., Navé, B. T., & Siddle, K. (1995) · Biochemical Journal · doi:10.1042/bj3050025 · Cited by 277 · see citing works

Potential Role of Protein Kinase B in Glucose Transporter 4 Translocation in Adipocytes

Tanti, J., Grillo, S., Grémeaux, T., Coffer, P. J., OBBERGHEN, E. V., & MARCHAND‐BRUSTEL, Y. L. (1997) · Endocrinology · doi:10.1210/endo.138.5.5136 · Cited by 261 · see citing works

Regulation of Protein Kinase B and Glycogen Synthase Kinase-3 by Insulin and β-Adrenergic Agonists in Rat Epididymal Fat Cells

MOULE, S. K., Welsh, G. I., EDGELL, N. J., Foulstone, E. J., Proud, C. G., & Denton, R. M. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.12.7713 · Cited by 242 · see citing works

Insulin Action and Glucose Metabolism in Nondiabetic Control and NIDDM Subjects: Comparison Using Human Skeletal Muscle Cell Cultures

Henry, R. R., Abrams, L., Nikoulina, S., & Ciaraldi, T. P. (1995) · Diabetes · doi:10.2337/diab.44.8.936 · Cited by 233 · see citing works

Insulin activates protein kinase B, inhibits glycogen synthase kinase‐3 and activates glycogen synthase by rapamycin‐insensitive pathways in skeletal muscle and adipose tissue

Cross, D. A. E., Watt, P., Shaw, M., KAAY, J. V. D., Downes, C. P., Holder, J. C., & Cohen, P. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)00240-8 · Cited by 220 · see citing works

Stimulation of Protein Synthesis, Eukaryotic Translation Initiation Factor 4E Phosphorylation, and PHAS-I Phosphorylation by Insulin Requires Insulin Receptor Substrate 1 and Phosphatidylinositol 3-Kinase

Méndez, R., Myers, M. G., White, M. F., & Rhoads, R. E. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.6.2857 · Cited by 218 · see citing works

From receptor to transporter: insulin signalling to glucose transport

Holman, G. D., & Kasuga, M. (1997) · Diabetologia · doi:10.1007/s001250050780 · Cited by 216 · see citing works

Inhibition of Clathrin-Mediated Endocytosis Selectively Attenuates Specific Insulin Receptor Signal Transduction Pathways

Ceresa, B. P., Kao, A. W., Santeler, S. R., & Pessin, J. E. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.7.3862 · Cited by 214 · see citing works

Reduced glycogen synthase activity in skeletal muscle from obese patients with and without Type 2 (non-insulin-dependent) diabetes mellitus

Damsbo, P., Vaag, A., Hother-Nielsen, O., & Beck-Nielsen, H. (1991) · Diabetologia · doi:10.1007/bf00405082 · Cited by 203 · see citing works

Phosphoinositide 3-kinase activity is required for insulin-stimulated glucose transport but not for ras activation in CHO cells

Hara, K. (1994) · Medical Entomology and Zoology · Cited by 197 · see citing works

Activation of RAC-protein kinase by heat shock and hyperosmolarity stress through a pathway independent of phosphatidylinositol 3-kinase.

Konishi, H., Matsuzaki, H., Tanaka, M., Ono, Y., Tokunaga, C., Kuroda, S., & Kikkawa, U. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.15.7639 · Cited by 192 · see citing works

Intracellular glucose oxidation and glycogen synthase activity are reduced in non-insulin-dependent (type II) diabetes independent of impaired glucose uptake.

Thorburn, A. W., Gumbiner, B., Bulacan, F., Wallace, P., & Henry, R. R. (1990) · Journal of Clinical Investigation · doi:10.1172/jci114468 · Cited by 185 · see citing works

Differential Effects of Constitutively Active Phosphatidylinositol 3-Kinase on Glucose Transport, Glycogen Synthase Activity, and DNA Synthesis in 3T3-L1 Adipocytes

Frevert, E. U., & Kahn, B. B. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.1.190 · Cited by 178 · see citing works

Overexpression of a Constitutively Active Form of Phosphatidylinositol 3-Kinase Is Sufficient to Promote Glut 4 Translocation in Adipocytes

Tanti, J., Grémeaux, T., Grillo, S., Calleja, V., Klippel, A., Williams, L. T., OBBERGHEN, E. V., & MARCHAND‐BRUSTEL, Y. L. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.41.25227 · Cited by 156 · see citing works

Multiple defects in muscle glycogen synthase activity contribute to reduced glycogen synthesis in non-insulin dependent diabetes mellitus.

Thorburn, A. W., Gumbiner, B., Bulacan, F., Brechtel, G., & Henry, R. R. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115022 · Cited by 152 · see citing works

Improved Glucose Tolerance Restores Insulin-Stimulated Akt Kinase Activity and Glucose Transport in Skeletal Muscle From Diabetic Goto-Kakizaki Rats

Krook, A., Kawano, Y., Song, X. M., Efendić, S., Roth, R. A., Wallberg‐Henriksson, H., & Zierath, J. R. (1997) · Diabetes · doi:10.2337/diab.46.12.2110 · Cited by 143 · see citing works

Localization of Rate-Limiting Defect for Glucose Disposal in Skeletal Muscle of Insulin-Resistant Type I Diabetic Patients

Yki-Järvinen, H., Sahlin, K., Ren, J. M., & Koivisto, V. A. (1990) · Diabetes · doi:10.2337/diab.39.2.157 · Cited by 131 · cited 1× · see citing works

Phosphoinositide 3-Kinase Is Required for Insulin-Induced but Not for Growth Hormone- or Hyperosmolarity-Induced Glucose Uptake in 3T3-L1 Adipocytes

Sakaue, H., Ogawa, W., Takata, M., Kuroda, S., Kotani, K., Matsumoto, M., Sakaue, M., Nishio, S., Ueno, H., & Kasuga, M. (1997) · Molecular Endocrinology · doi:10.1210/mend.11.10.9986 · Cited by 125 · see citing works

Defect in skeletal muscle phosphatidylinositol-3-kinase in obese insulin-resistant mice.

Heydrick, S. J., Jullien, D., Gautier, N., Tanti, J., Giorgetti‐Peraldi, S., OBBERGHEN, E. V., & MARCHAND‐BRUSTEL, Y. L. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116337 · Cited by 114 · see citing works

Covalent phosphorylation in the regulation of glycogen synthase activity

Roach, P. J., & Larner, J. (1977) · Molecular and Cellular Biochemistry · doi:10.1007/bf01734108 · Cited by 94 · see citing works

Glucosamine infusion in rats rapidly impairs insulin stimulation of phosphoinositide 3-kinase but does not alter activation of Akt/protein kinase B in skeletal muscle.

Kim, Y. B., Zhu, J. S., Zierath, J. R., Shen, H., Baron, A., & Kahn, B. B. (1999) · Diabetes · doi:10.2337/diabetes.48.2.310 · Cited by 89 · see citing works

Wortmannin inhibits the action of insulin but not that of okadaic acid in skeletal muscle: comparison with fat cells

MARCHAND‐BRUSTEL, Y. L., Gautier, N., Cormont, M., & OBBERGHEN, E. V. (1995) · Endocrinology · doi:10.1210/endo.136.8.7628394 · Cited by 84 · see citing works

Interaction of carbohydrate and fat fuels in human skeletal muscle: impact of obesity and NIDDM

Mandarino, L. J., Consoli, A., Jain, A., & Kelley, D. E. (1996) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1996.270.3.e463 · Cited by 83 · see citing works

Muscle fiber type-specific defects in insulin signal transduction to glucose transport in diabetic GK rats.

Song, X., Kawano, Y., Krook, A., Ryder, J. W., Efendić, S., Roth, R. A., Wallberg‐Henriksson, H., & Zierath, J. R. (1999) · Diabetes · doi:10.2337/diabetes.48.3.664 · Cited by 76 · see citing works

Activation of the Ras Mitogen-activated Protein Kinase-Ribosomal Protein Kinase Pathway Is Not Required for the Repression of Phosphoenolpyruvate Carboxykinase Gene Transcription by Insulin

Sutherland, C. D., Waltner-Law, M. E., Gnudi, L., et al. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.6.3198 · Cited by 54 · see citing works

The SH2-like Akt homology (AH) domain of c-akt is present in multiple copies in the genome of vertebrate and invertebrate eucaryotes. Cloning and characterization of the Drosophila melanogaster c-akt homolog Dakt1.

Franke, T. F., Tartof, K. D., & Tsichlis, P. N. (1994) · PubMed · Cited by 52 · see citing works

Okadaic Acid, Vanadate, and Phenylarsine Oxide Stimulate 2-Deoxyglucose Transport in Insulin-Resistant Human Skeletal Muscle

Carey, J. O., Azevedo, J. L., Morris, P. G., et al. (1995) · Diabetes · doi:10.2337/diab.44.6.682 · Cited by 47 · see citing works

Impaired activation of skeletal muscle glycogen synthase in non-insulin-dependent diabetes mellitus is unrelated to the degree of obesity

Johnson, A. B., Argyraki, M., Thow, J. C., Jones, I. R., Broughton, D., Miller, M. A., & Taylor, R. (1991) · Metabolism · doi:10.1016/0026-0495(91)90106-7 · Cited by 43 · see citing works

Insulin action on metabolism

Heesom, K., Harbeck, M. C., Kahn, C. R., & Denton, R. M. (1997) · Diabetologia · doi:10.1007/bf03168179 · Cited by 20 · see citing works

Glucose transporters and diabetes

Zierath, J. R., Houseknecht, K. L., & Kahn, B. B. (1996) · Seminars in Cell and Developmental Biology · doi:10.1006/scdb.1996.0038 · Cited by 18 · see citing works

Insulin activation of phosphatidylinositol 3-kinase in human skeletal muscle in vivo

Hickey, M. S., Tanner, C. J., O’Neill, D. S., Morgan, L. J., Dohm, G. L., & Houmard, J. A. (1997) · Journal of Applied Physiology · doi:10.1152/jappl.1997.83.3.718 · Cited by 17 · see citing works

Effect of IGF-I on Phosphatidylinositol 3-Kinase in Soleus Muscle of Lean and Insulin-Resistant Obese Mice

Jullien, D., Heydrick, S. J., Gautier, N., OBBERGHEN, E. V., & MARCHAND‐BRUSTEL, Y. L. (1996) · Diabetes · doi:10.2337/diab.45.7.869 · Cited by 16 · see citing works

Skeletal Muscle Insulin Resistance Is the Primary Defect in Type 2 Diabetes

DeFronzo, R. A., & Tripathy, D. (2009) · Diabetes Care · doi:10.2337/dc09-s302 · Cited by 2,102 · see citing works

Insulin Resistance and the Polycystic Ovary Syndrome Revisited: An Update on Mechanisms and Implications

Diamanti-Kandarakis, E., & Dunaif, A. (2012) · Endocrine Reviews · doi:10.1210/er.2011-1034 · Cited by 1,947 · see citing works

Banting Lecture 2001

McGarry, J. D. (2002) · Diabetes · doi:10.2337/diabetes.51.1.7 · Cited by 1,435 · see citing works

Pathogenesis of type 2 diabetes mellitus

DeFronzo, R. A. (2004) · Medical Clinics of North America · doi:10.1016/j.mcna.2004.04.013 · Cited by 1,342 · see citing works

The integrative biology of type 2 diabetes

Roden, M., & Shulman, G. I. (2019) · Nature · doi:10.1038/s41586-019-1797-8 · Cited by 1,167 · see citing works

Insulin resistance: review of the underlying molecular mechanisms

Yaribeygi, H., Farrokhi, F. R., Butler, A. E., & Sahebkar, A. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.27603 · Cited by 929 · see citing works

Signaling pathways in insulin action: molecular targets of insulin resistance

Pessin, J. E., & Saltiel, A. R. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10582 · Cited by 939 · see citing works

Biochemical and cellular properties of insulin receptor signalling

Haeusler, R. A., McGraw, T. E., & Accili, D. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.89 · Cited by 739 · see citing works

Pathogenesis of insulin resistance in skeletal muscle

Abdul-Ghani, M. A., & DeFronzo, R. A. (2010) · Journal of Biomedicine and Biotechnology · doi:10.1155/2010/476279 · Cited by 670 · see citing works

Strength training increases insulin-mediated glucose uptake, GLUT4 content, and insulin signaling in skeletal muscle in patients with type 2 diabetes

Holten, M. K., Zacho, M., Gaster, M., Juel, C., Wojtaszewski, J. F. P., & Dela, F. (2004) · Diabetes · doi:10.2337/diabetes.53.2.294 · Cited by 615 · see citing works

Invited Review: Effects of acute exercise and exercise training on insulin resistance

Henriksen, E. J. (2002) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01219.2001 · Cited by 535 · see citing works

The Role of Skeletal Muscle Glycogen Breakdown for Regulation of Insulin Sensitivity by Exercise

Jensen, J., Rustad, P. I., Kolnes, A. J., & Lai, Y.-C. (2011) · Frontiers in Physiology · doi:10.3389/fphys.2011.00112 · Cited by 412 · see citing works

Overactivation of S6 Kinase 1 as a Cause of Human Insulin Resistance During Increased Amino Acid Availability

Tremblay, F., Krebs, M., Dombrowski, L., Brehm, A., Bernroider, E., Roth, E., Nowotny, P., Waldhäusl, W., Marette, A., & Roden, M. (2005) · Diabetes · doi:10.2337/diabetes.54.9.2674 · Cited by 370 · see citing works

Insulin action and insulin resistance in human skeletal muscle

Zierath, J. R., Krook, A., & Wallberg-Henriksson, H. (2000) · Diabetologia · doi:10.1007/s001250051457 · Cited by 367 · see citing works

The many actions of insulin in skeletal muscle, the paramount tissue determining glycemia

Sylow, L., Tokarz, V. L., Richter, E. A., & Klip, A. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.03.020 · Cited by 366 · see citing works

Exercise as a therapeutic intervention for the prevention and treatment of insulin resistance

Hawley, J. A. (2004) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.505 · Cited by 344 · see citing works

Skeletal muscle lipid deposition and insulin resistance: effect of dietary fatty acids and exercise

Corcoran, M. P., Lamon-Fava, S., & Fielding, R. A. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.3.662 · Cited by 341 · see citing works

Defects in insulin receptor signaling in vivo in the polycystic ovary syndrome (PCOS)

Dunaif, A., Wu, X., Lee, A., & Diamanti-Kandarakis, E. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.281.2.e392 · Cited by 337 · see citing works

Reduced activation of phosphatidylinositol-3 kinase and increased serine 636 phosphorylation of insulin receptor substrate-1 in primary culture of skeletal muscle cells from patients with type 2 diabetes

Bouzakri, K., Roques, M., Gual, P., Espinosa, S., Guebre-Egziabher, F., Riou, J.-P., Laville, M., Le Marchand-Brustel, Y., Tanti, J.-F., & Vidal, H. (2003) · Diabetes · doi:10.2337/diabetes.52.6.1319 · Cited by 305 · see citing works

Skeletal muscle insulin resistance: role of mitochondria and other ROS sources

Di Meo, S., Iossa, S., & Venditti, P. (2017) · Journal of Endocrinology · doi:10.1530/joe-16-0598 · Cited by 282 · see citing works

Insulin resistance in the skeletal muscle of women with PCOS involves intrinsic and acquired defects in insulin signaling

Corbould, A., Kim, Y.-B., Youngren, J. F., Pender, C., Kahn, B. B., Lee, A., & Dunaif, A. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00361.2004 · Cited by 283 · see citing works

5′-AMP-activated Protein Kinase Phosphorylates IRS-1 on Ser-789 in Mouse C2C12 Myotubes in Response to 5-Aminoimidazole-4-carboxamide Riboside

Jakobsen, S. N., Hardie, D. G., Morrice, N., & Tornqvist, H. E. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c100483200 · Cited by 238 · see citing works

Exercise training increases insulin-stimulated glucose disposal and GLUT4 (SLC2A4) protein content in patients with type 2 diabetes

O’Gorman, D. J., Karlsson, H. K. R., McQuaid, S., Yousif, O., Rahman, Y., Gasparro, D., Glund, S., Chibalin, A. V., Zierath, J. R., & Nolan, J. J. (2006) · Diabetologia · doi:10.1007/s00125-006-0457-3 · Cited by 226 · see citing works

Increased p85/55/50 Expression and Decreased Phosphotidylinositol 3-Kinase Activity in Insulin-Resistant Human Skeletal Muscle

Bandyopadhyay, G. K., Yu, J. G., Ofrecio, J., & Olefsky, J. M. (2005) · Diabetes · doi:10.2337/diabetes.54.8.2351 · Cited by 210 · see citing works

Exercise training increases glycogen synthase activity and GLUT4 expression but not insulin signaling in overweight nondiabetic and type 2 diabetic subjects

Christ-Roberts, C. Y., Pratipanawatr, T., Pratipanawatr, W., Berria, R., Belfort, R., Kashyap, S., & Mandarino, L. J. (2004) · Metabolism · doi:10.1016/j.metabol.2004.03.022 · Cited by 210 · see citing works

Insulin in the nervous system and the mind: Functions in metabolism, memory, and mood

Lee, S.-H., Zabolotny, J. M., Huang, H., Lee, H., & Kim, Y.-B. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2016.06.011 · Cited by 176 · see citing works

Insulin signaling and glucose transport in insulin resistant human skeletal muscle

Karlsson, H. K. R., & Zierath, J. R. (2007) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-007-0030-9 · Cited by 159 · see citing works

Elevated Muscle TLR4 Expression and Metabolic Endotoxemia in Human Aging

Ghosh, S., Lertwattanarak, R., Garduno, J. D. J., Galeana, J. J., Li, J., Zamarripa, F., Lancaster, J. L., Mohan, S., Hussey, S., & Musi, N. (2015) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glu067 · Cited by 150 · see citing works

Adipose triglyceride lipase deficiency causes tissue-specific changes in insulin signaling

Kienesberger, P. C., Lee, D., Pulinilkunnil, T., Brenner, D. S., Cai, L., Magnes, C., Koefeler, H. C., Streith, I. E., Rechberger, G. N., Haemmerle, G., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.047787 · Cited by 120 · see citing works

Fat Oxidation, Fitness and Skeletal Muscle Expression of Oxidative/Lipid Metabolism Genes in South Asians: Implications for Insulin Resistance?

Hall, L. M. L., Moran, C. N., Milne, G. R., Wilson, J., MacFarlane, N. G., Forouhi, N. G., Hariharan, N., Salt, I. P., Sattar, N., & Gill, J. M. R. (2010) · PLoS ONE · doi:10.1371/journal.pone.0014197 · Cited by 106 · see citing works

Food additive carrageenan: Part I: A critical review of carrageenan<i>in vitro</i>studies, potential pitfalls, and implications for human health and safety

McKim, J. M. (2014) · Critical Reviews in Toxicology · doi:10.3109/10408444.2013.861797 · Cited by 108 · see citing works

Muscle-Specific Vascular Endothelial Growth Factor Deletion Induces Muscle Capillary Rarefaction Creating Muscle Insulin Resistance

Bonner, J. S., Lantier, L., Hasenour, C. M., James, F. D., Bracy, D. P., & Wasserman, D. H. (2013) · Diabetes · doi:10.2337/db12-0354 · Cited by 107 · see citing works

Chronic high fat feeding attenuates load‐induced hypertrophy in mice

Sitnick, M., Bodine, S. C., & Rutledge, J. C. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.180174 · Cited by 104 · see citing works

Increased Skeletal Muscle Tumor Necrosis Factor-α and Impaired Insulin Signaling Persist in Obese Women With Gestational Diabetes Mellitus 1 Year Postpartum

Friedman, J. E., Kirwan, J. P., Jing, M., Presley, L., & Catalano, P. M. (2008) · Diabetes · doi:10.2337/db07-1356 · Cited by 98 · see citing works

Muscle glucose transport and phosphorylation in type 2 diabetic, obese nondiabetic, and genetically predisposed individuals

Pendergrass, M., Bertoldo, A., Bonadonna, R., Nucci, G., Mandarino, L., Cobelli, C., & DeFronzo, R. A. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00617.2005 · Cited by 87 · see citing works

Effects of fasting on insulin action and glucose kinetics in lean and obese men and women

Bergman, B. C., Cornier, M.-A., Horton, T. J., & Bessesen, D. H. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00613.2006 · Cited by 87 · see citing works

High-Intensity Interval Training Improves Markers of Oxidative Metabolism in Skeletal Muscle of Individuals With Obesity and Insulin Resistance

Matos, M. A. D., Vieira, D. V., Pinhal, K. C., Lopes, J. F., Dias-Peixoto, M. F., Pauli, J. R., Castro Magalhães, F. D., Little, J. P., Rocha-Vieira, E., & Amorim, F. T. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01451 · Cited by 75 · see citing works

Skeletal muscle and insulin sensitivity: pathophysiological alterations

Ryder, J. (2001) · Frontiers in bioscience · doi:10.2741/ryder · Cited by 73 · see citing works

Altered Response of Skeletal Muscle to IL-6 in Type 2 Diabetic Patients

Jiang, L. Q., Duque-Guimaraes, D. E., Machado, U. F., Zierath, J. R., & Krook, A. (2013) · Diabetes · doi:10.2337/db11-1790 · Cited by 65 · see citing works

Exercise training and calorie restriction increase SREBP-1 expression and intramuscular triglyceride in skeletal muscle

Nadeau, K. J., Ehlers, L. B., Aguirre, L. E., Moore, R. L., Jew, K. N., Ortmeyer, H. K., Hansen, B. C., Reusch, J. E. B., & Draznin, B. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00543.2005 · Cited by 57 · see citing works

Long-chain n-3 polyunsaturated fatty acids dissociate phosphorylation of Akt from phosphatidylinositol 3’-kinase activity in rats

Le Foll, C., Corporeau, C., Le Guen, V., Gouygou, J.-P., Bergé, J.-P., & Delarue, J. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00446.2006 · Cited by 45 · see citing works

Insulin signal transduction and glucose transport in human adipocytes: effects of obesity and low calorie diet

M., B., L., A.-K., A., D., E., N., S., R., J., Z., & P., A. (2002) · Diabetologia · doi:10.1007/s00125-002-0875-9 · Cited by 28 · see citing works

Liraglutide and Exercise Synergistically Attenuate Vascular Inflammation and Enhance Metabolic Insulin Action in Early Diet-Induced Obesity

Liu, J., Aylor, K. W., & Liu, Z. (2023) · Diabetes · doi:10.2337/db22-0745 · Cited by 30 · see citing works

Clinical value of isoform-specific detection and targeting of AKT1, AKT2 and AKT3 in breast cancer

Pérez‐Tenorio, G., Karlsson, E. A., & Stål, O. (2014) · Breast Cancer Management · doi:10.2217/bmt.14.35 · Cited by 4 · see citing works

AKT2 is the Predominant Akt Isoform Expressed in Human Skeletal Muscle

Geddis, A. V., Abdalla, M. N., Leandry, L. A., McClung, H. L., Pasiakos, S. M., & Matheny, R. W. (2017) · The FASEB Journal · doi:10.1096/fasebj.31.1_supplement.lb144 · Cited by 3 · see citing works

Development and characterization of protein kinase B/AKT isoform-specific nanobodies

Merckaert, T., Zwaenepoel, O., Gevaert, K., & Gettemans, J. (2020) · PLoS ONE · doi:10.1371/journal.pone.0240554 · Cited by 10 · see citing works

Development and characterization of Protein Kinase B/AKT isoform-specific NanobodiesPreprint

Merckaert, T., Zwaenepoel, O., Gevaert, K., et al. (2020) · Research Square · doi:10.21203/rs.3.rs-18280/v1 · Cited by 3 · see citing works

The study on the role of different isoforms of Akt in the regulation of apoptosis

Shen, F. (2005) · Tumori