Cited by 306Endoplasmic Reticulum Stress and DiseaseAdipokines, Inflammation, and Metabolic DiseasesMetabolism, Diabetes, and Cancer

New insights into ER stress-induced insulin resistance

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Flamment, Mélissa, Hajduch, Eric, Ferré, Pascal, Foufelle, Fabienne·2012·Trends in Endocrinology & Metabolism

Abstract

Insulin resistance is a major characteristic of obesity and type 2 diabetes (T2DM). During the last decade, endoplasmic reticulum (ER) stress has emerged as a new player in this field and a considerable number of recent studies have pointed out its role in the onset of insulin resistance (IR). ER stress appears to act directly as a negative modulator of the insulin signaling pathway but also indirectly by promoting lipid accumulation. This review aims to summarize and decipher the abundant new literature concerning the emerging and multifaceted involvement of ER stress in the development of metabolic dysfunctions in insulin target tissues.

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Crossref · 10.1016/j.tem.2012.06.003

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Authors
Flamment, M., Hajduch, E., Ferré, P., & Foufelle, F.
Affiliations
Inserm (FR)
Corresponding author
Foufelle, Fabienne
Venue
Trends in Endocrinology & Metabolism
Publisher
Elsevier BV
Published
2012-08
Volume
23
Issue
8
Pages
381-390
ISSN
1043-2760 (ISSN-L)
OpenAlex
W1974719515
Cited by
306
References
100
Citations by year
2026: 7 · 2025: 21 · 2024: 11 · 2023: 18 · 2022: 20 · 2021: 34 · 2020: 23 · 2019: 21 · 2018: 26 · 2017: 29 · 2016: 23 · 2015: 20 · 2014: 29 · 2013: 23 · 2012: 1
FWCI
2.08
Type
journal article
Language
en
Open access
Locations
  • Trends in Endocrinology and Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
  • Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, other-oa)
Funders
  • European Commission
  • Institut National de la Santé et de la Recherche Médicale
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Endoplasmic Reticulum Stress and Disease
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords
endoplasmic reticulum stress, insulin resistance, type 2 diabetes, obesity, insulin signaling pathway, lipid accumulation, insulin target tissues, metabolic dysfunction
MeSH terms
Adipose Tissue, Diabetes Mellitus, Type 2, Humans, Insulin Resistance, Liver, Obesity, Transcription Factors, Signal Transduction, Muscle, Skeletal, Lipid Metabolism, Unfolded Protein Response, Endoplasmic Reticulum Stress

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