Amyloid beta oligomers induce impairment of neuronal insulin receptors

Alzheimer's Disease Is a Synaptic Failure

Selkoe, D. J. (2002) · Science · doi:10.1126/science.1074069 · Cited by 4,420 · see citing works

Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo

Walsh, D. M., Klyubin, I., Fadeeva, J. V., Cullen, W. K., Anwyl, R., Wolfe, M. S., Rowan, M. J., & Selkoe, D. J. (2002) · Nature · doi:10.1038/416535a · Cited by 4,291 · see citing works

Diffusible, nonfibrillar ligands derived from Aβ _1–42 are potent central nervous system neurotoxins

Lambert, M. P., Barlow, A. K., Chromy, B. A., Edwards, C., Freed, R., Liosatos, M., Morgan, T. E., Rozovsky, I., Trommer, B., Viola, K. L., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.11.6448 · Cited by 3,506 · see citing works

Pathways towards and Away from Alzheimer’s Disease

Mattson, M. P. (2004) · Nature · doi:10.1038/nature02621 · Cited by 3,052 · see citing works

Critical nodes in signalling pathways: insights into insulin action

Taniguchi, C. M., Emanuelli, B., & Kahn, C. R. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1837 · Cited by 2,760 · see citing works

AMPA Receptor Trafficking and Synaptic Plasticity

Malinow, R., & Malenka, R. C. (2002) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.25.112701.142758 · Cited by 2,588 · see citing works

Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease – is this type 3 diabetes?

Steen, E., Terry, B. M., J. Rivera, E., Cannon, J. L., Neely, T. R., Tavares, R., Xu, X. J., Wands, J. R., & de la Monte, S. M. (2005) · Journal of Alzheimer's Disease · doi:10.3233/jad-2005-7107 · Cited by 1,703 · see citing works

Natural oligomers of the amyloid-β protein specifically disrupt cognitive function

Cleary, J. P., Walsh, D. M., Hofmeister, J. J., Shankar, G. M., Kuskowski, M. A., Selkoe, D. J., & Ashe, K. H. (2004) · Nature Neuroscience · doi:10.1038/nn1372 · Cited by 1,677 · see citing works

Regulation of NMDA receptor trafficking by amyloid-β

Snyder, E. M., Nong, Y., Almeida, C. G., Paul, S., Moran, T., Choi, E. Y., Nairn, A. C., Salter, M. W., Lombroso, P. J., Gouras, G. K., et al. (2005) · Nature Neuroscience · doi:10.1038/nn1503 · Cited by 1,561 · cited 3× · see citing works

Deciphering the Molecular Basis of Memory Failure in Alzheimer's Disease

Walsh, D. M., & Selkoe, D. J. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.010 · Cited by 1,207 · see citing works

Aβ Oligomer-Induced Aberrations in Synapse Composition, Shape, and Density Provide a Molecular Basis for Loss of Connectivity in Alzheimer's Disease

Lacor, P. N., Buniel, M. C., Furlow, P. W., Sanz Clemente, A., Velasco, P. T., Wood, M., Viola, K. L., & Klein, W. L. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.3501-06.2007 · Cited by 1,188 · see citing works

Alzheimer's disease-affected brain: Presence of oligomeric Aβ ligands (ADDLs) suggests a molecular basis for reversible memory loss

Gong, Y., Chang, L., Viola, K. L., Lacor, P. N., Lambert, M. P., Finch, C. E., Krafft, G. A., & Klein, W. L. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1834302100 · Cited by 1,061 · see citing works

Receptor trafficking and synaptic plasticity

Collingridge, G. L., Isaac, J. T. R., & Wang, Y. T. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1556 · Cited by 1,046 · see citing works

AMPAR Removal Underlies Aβ-Induced Synaptic Depression and Dendritic Spine Loss

Hsieh, H., Boehm, J., Sato, C., Iwatsubo, T., Tomita, T., Sisodia, S., & Malinow, R. (2006) · Neuron · doi:10.1016/j.neuron.2006.10.035 · Cited by 1,042 · see citing works

Calcium Dysregulation and Membrane Disruption as a Ubiquitous Neurotoxic Mechanism of Soluble Amyloid Oligomers*♦

Demuro, A., Mina, E. W., Kayed, R., Milton, S. C. F., Parker, I., & Glabe, C. G. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500997200 · Cited by 1,038 · see citing works

Phosphorylation of Ser307 in Insulin Receptor Substrate-1 Blocks Interactions with the Insulin Receptor and Inhibits Insulin Action

Aguirre, V., Werner, E. D., Giraud, J., Lee, Y. H., Shoelson, S. E., & White, M. F. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m101521200 · Cited by 1,010 · see citing works

Targeting small Aβ oligomers: the solution to an Alzheimer's disease conundrum?

Klein, W. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01749-5 · Cited by 989 · see citing works

Synaptic Targeting by Alzheimer's-Related Amyloid β Oligomers

Lacor, P. N., Buniel, M. C., Chang, L., Fernandez, S. J., Gong, Y., Viola, K. L., Lambert, M. P., Velasco, P. T., Bigio, E. H., Finch, C. E., et al. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.3432-04.2004 · Cited by 954 · see citing works

Signaling pathways in insulin action: molecular targets of insulin resistance

Pessin, J. E., & Saltiel, A. R. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10582 · Cited by 939 · see citing works

Paradigm shift in neuroprotection by NMDA receptor blockade: memantine and beyond

Lipton, S. A. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd1958 · Cited by 909 · see citing works

Aβ Oligomers Induce Neuronal Oxidative Stress through an N-Methyl-D-aspartate Receptor-dependent Mechanism That Is Blocked by the Alzheimer Drug Memantine

De Felice, F. G., Velasco, P. T., Lambert, M. P., Viola, K., Fernandez, S. J., Ferreira, S. T., & Klein, W. L. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m607483200 · Cited by 882 · see citing works

Nanoparticle-based detection in cerebral spinal fluid of a soluble pathogenic biomarker for Alzheimer’s disease

Georganopoulou, D. G., Chang, L., Nam, J.-M., Thaxton, C. S., Mufson, E. J., Klein, W. L., & Mirkin, C. A. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409336102 · Cited by 835 · see citing works

Insulin and neurodegenerative disease: shared and specific mechanisms

Craft, S., & Stennis Watson, G. (2004) · The Lancet Neurology · doi:10.1016/s1474-4422(04)00681-7 · Cited by 830 · see citing works

Arc/Arg3.1 interacts with the endocytic machinery to regulate AMPA receptor trafficking

Chowdhury, S., Shepherd, J. D., Okuno, H., Lyford, G., Petralia, R. S., Plath, N., Kuhl, D., Huganir, R. L., & Worley, P. F. (2006) · Neuron · doi:10.1016/j.neuron.2006.08.033 · Cited by 792 · see citing works

Inflammatory pathways and insulin action

Hotamisligil, G. S. (2003) · International Journal of Obesity · doi:10.1038/sj.ijo.0802502 · Cited by 717 · see citing works

FROM MICE TO MEN: Insights into the Insulin Resistance Syndromes

Biddinger, S. B., & Kahn, C. R. (2005) · Annual Review of Physiology · doi:10.1146/annurev.physiol.68.040104.124723 · Cited by 700 · see citing works

Hyperinsulinemia and risk of Alzheimer disease

Luchsinger, J. A., Tang, M.-X., Shea, S., & Mayeux, R. (2004) · Neurology · doi:10.1212/01.wnl.0000140292.04932.87 · Cited by 683 · see citing works

Open-channel block of N-methyl-D-aspartate (NMDA) responses by memantine: therapeutic advantage against NMDA receptor-mediated neurotoxicity

Chen, H., Pellegrini, J. W., Aggarwal, S., Lei, S., Warach, S. J., Jensen, F., & Lipton, S. A. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-11-04427.1992 · Cited by 630 · see citing works

Effects of secreted oligomers of amyloid β‐protein on hippocampal synaptic plasticity: a potent role for trimers

Townsend, M., Shankar, G. M., Mehta, T., Walsh, D. M., & Selkoe, D. J. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2005.103754 · Cited by 619 · see citing works

Insulin/IGF-1 and TNF-α stimulate phosphorylation of IRS-1 at inhibitory Ser307 via distinct pathways

Rui, L., Aguirre, V., Kim, J. K., Shulman, G. I., Lee, A., Corbould, A. M., Dunaif, A. E., & White, M. F. (2001) · Journal of Clinical Investigation · doi:10.1172/jci10934 · Cited by 600 · see citing works

Distinct molecular mechanisms and divergent endocytotic pathways of AMPA receptor internalization

Lin, J., Ju, W. H., Foster, K. A., Lee, S. H., Ahmadian, G., Wyszynski, M. W., Wang, Y. T., & Sheng, M. (2000) · Nature Neuroscience · doi:10.1038/81814 · Cited by 557 · see citing works

Alzheimer's β-Amyloid Peptides Compete for Insulin Binding to the Insulin Receptor

Xie, L., Helmerhorst, E., Taddei, K., Plewright, B., van Bronswijk, W., & Martins, R. N. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-10-j0001.2002 · Cited by 542 · see citing works

Recruitment of functional GABAA receptors to postsynaptic domains by insulin

Wan, Q., Xiong, Z., Man, H., Ackerley, C., Braunton, J., Lu, W. Y., Becker, L. E., MacDonald, J. F., & Wang, Y. T. (1997) · Nature · doi:10.1038/41792 · Cited by 537 · see citing works

Brain Insulin Receptors and Spatial Memory

Zhao, W., Chen, H., Xu, H., Moore, E., Meiri, N., Quon, M. J., & Alkon, D. L. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.49.34893 · Cited by 535 · see citing works

Soluble oligomers of β amyloid (1-42) inhibit long-term potentiation but not long-term depression in rat dentate gyrus

Wang, H.-W., Pasternak, J. F., Kuo, H., Ristic, H., Lambert, M. P., Chromy, B., Viola, K. L., Klein, W. L., Stine, W. B., Krafft, G. A., et al. (2002) · Brain Research · doi:10.1016/s0006-8993(01)03058-x · Cited by 527 · see citing works

Role of insulin and insulin receptor in learning and memory

Zhao, W., & Alkon, D. L. (2001) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(01)00455-5 · Cited by 492 · see citing works

Activation of Akt/PKB, increased phosphorylation of Akt substrates and loss and altered distribution of Akt and PTEN are features of Alzheimer’s disease pathology

Griffin, R. J., Moloney, A., Kelliher, M., Johnston, J. A., Ravid, R., Dockery, P., O'Connor, R., & O'Neill, C. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02949.x · Cited by 459 · see citing works

Oligomerization of Alzheimer's β-Amyloid within Processes and Synapses of Cultured Neurons and Brain

Takahashi, R. H., Almeida, C. G., Kearney, P. F., Yu, F., Lin, M. T., Milner, T. A., & Gouras, G. K. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.5167-03.2004 · Cited by 445 · see citing works

Alzheimer's disease-type neuronal tau hyperphosphorylation induced by Aβ oligomers

De Felice, F. G., Wu, D., Lambert, M. P., Fernandez, S. J., Velasco, P. T., Lacor, P. N., Bigio, E. H., Jerecic, J., Acton, P. J., Shughrue, P. J., et al. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.02.029 · Cited by 432 · see citing works

Place Learning and Hippocampal Synaptic Plasticity in Streptozotocin-Induced Diabetic Rats

Biessels, G. J., Kamal, A., Ramakers, G. M. J., Urban, I. J. A., Spruijt, B. M., Erkelens, D. W., & Gispen, W. H. (1996) · Diabetes · doi:10.2337/diab.45.9.1259 · Cited by 413 · see citing works

Inflammatory status and insulin resistance

Grimble, R. F. (2002) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/00075197-200209000-00015 · Cited by 410 · see citing works

Beta-amyloid accumulation in APP mutant neurons reduces PSD-95 and GluR1 in synapses

Almeida, C. G., Tampellini, D., Takahashi, R. H., Greengard, P., Lin, M. T., Snyder, E. M., & Gouras, G. K. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.02.008 · Cited by 397 · see citing works

Temporal Profile of Amyloid-β (Aβ) Oligomerization in an in Vivo Model of Alzheimer Disease

Oddo, S., Caccamo, A., Tran, L., Lambert, M. P., Glabe, C. G., Klein, W. L., & LaFerla, F. M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m507892200 · Cited by 379 · see citing works

Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B

Anderson, K. E., Coadwell, J., Stephens, L., & Hawkins, P. T. (1998) · Current Biology · doi:10.1016/s0960-9822(98)70274-x · Cited by 360 · see citing works

Role for neuronal insulin resistance in neurodegenerative diseases

Schubert, M., Gautam, D., Surjo, D., Ueki, K., Baudler, S., Schubert, D., Kondo, T., Alber, J., Galldiks, N., Kustermann, E., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308724101 · Cited by 339 · see citing works

Recent Advances in Our Understanding of Insulin Action and Insulin Resistance

Roith, D. L., & Zick, Y. (2001) · Diabetes Care · doi:10.2337/diacare.24.3.588 · Cited by 337 · see citing works

Therapeutic rescue of neurodegeneration in experimental type 3 diabetes: Relevance to Alzheimer's disease

de la Monte, S. M., Tong, M., Lester-Coll, N. H., Plater, M. E., & Wands, J. R. (2006) · Journal of Alzheimer s Disease · doi:10.3233/jad-2006-10113 · Cited by 324 · see citing works

Rosiglitazone attenuates learning and memory deficits in Tg2576 Alzheimer mice

Pedersen, W. A., McMillan, P. J., Kulstad, J. J., Leverenz, J. B., Craft, S., & Haynatzki, G. R. (2006) · Experimental Neurology · doi:10.1016/j.expneurol.2006.01.018 · Cited by 321 · see citing works

Monoclonal antibodies that target pathological assemblies of Aβ

Lambert, M. P., Velasco, P. T., Chang, L., Viola, K. L., Fernandez, S., Lacor, P. N., Khuon, D., Gong, Y., Bigio, E. H., Shaw, P., et al. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04157.x · Cited by 314 · see citing works

Modulation of memory by insulin and glucose: Neuropsychological observations in Alzheimer’s disease

Watson, G. S., & Craft, S. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.02.048 · Cited by 307 · see citing works

Therapy insight, type 2 diabetes mellitus and the risk of late-onset Alzheimer's disease

Haan, M. N. (2006) · Nature Clinical Practice Neurology · doi:10.1038/ncpneuro0124 · Cited by 284 · see citing works

Protein kinase B (PKB/Akt) – a key regulator of glucose transport?

Hajduch, É., Litherland, G. J., & Hundal, H. S. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)02242-6 · Cited by 277 · see citing works

Cognitive effects of insulin in the central nervous system

Park, C. R. (2001) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(01)00016-1 · Cited by 270 · see citing works

Structural differences between insulin receptors in the brain and peripheral target tissues.

Heidenreich, K. A., Zahniser, N. R., Berhanu, P., Brandenburg, D., & Olefsky, J. M. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)32085-4 · Cited by 265 · see citing works

Role of tyrosine kinase activity in signal transduction by the insulin-like growth factor-I (IGF-I) receptor. Characterization of kinase-deficient IGF-I receptors and the action of an IGF-I-mimetic antibody (alpha IR-3).

Kato, H., Faria, T. N., STANNARD, B. S., Roberts, C. T., & LeRoith, D. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53824-2 · Cited by 244 · see citing works

Contribution of cytoskeleton to the internalization of AMPA receptors

Zhou, Q., Xiao, M., & Nicoll, R. A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.3.1261 · Cited by 229 · see citing works

Learning and Memory in Transgenic Mice Modeling Alzheimer's Disease

Ashe, K. H. (2001) · Learning & Memory · doi:10.1101/lm.43701 · Cited by 224 · see citing works

Protein Kinase C-ζ Phosphorylates Insulin Receptor Substrate-1 and Impairs Its Ability to Activate Phosphatidylinositol 3-Kinase in Response to Insulin

Ravichandran, L. V., Esposito, D. L., Chen, J. Y. ‐., & Quon, M. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m007231200 · Cited by 217 · see citing works

Insulin receptor signaling in long-term memory consolidation following spatial learningPreprint

Dou, J., Chen, M., Dufour, F., Alkon, D. L., & Zhao, W. (2005) · Learning & Memory · doi:10.1101/lm.88005 · Cited by 217 · see citing works

Phosphatidylinositol 3‐kinase is a central mediator of NMDA receptor signalling to MAP kinase (Erk1/2), Akt/PKB and CREB in striatal neurones

Perkinton, M. S., Ip, J. E., Wood, G. L., Crossthwaite, A. J., & Williams, R. J. (2002) · Journal of Neurochemistry · doi:10.1046/j.0022-3042.2001.00699.x · Cited by 210 · see citing works

Akt and PI 3-Kinase Signaling in Cardiomyocyte Hypertrophy and Survival

Matsui, T., Nagoshi, T., & Rosenzweig, A. (2003) · Cell Cycle · doi:10.4161/cc.2.3.381 · Cited by 191 · see citing works

Effects of hyperglycemia on memory and hormone levels in dementia of the Alzheimer type: A longitudinal study.

Craft, S., Dagogo-Jack, S. E., Wiethop, B. V., Murphy, C., Nevins, R. T., Fleischman, S., Rice, V., Newcomer, J. W., & Cryer, P. E. (1993) · Behavioral Neuroscience · doi:10.1037//0735-7044.107.6.926 · Cited by 191 · see citing works

Effects of hyperglycemia on memory and hormone levels in dementia of the Alzheimer type: A longitudinal study.

Craft, S., Dagogo-Jack, S. E., Wiethop, B. V., Murphy, C., Nevins, R. T., Fleischman, S., Rice, V., Newcomer, J. W., & Cryer, P. E. (1993) · Behavioral Neuroscience · doi:10.1037/0735-7044.107.6.926 · Cited by 191 · see citing works

Preparation of Amyloid β‐Protein for Structural and Functional Studies

Teplow, D. B. (2006) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(06)13002-5 · Cited by 187 · see citing works

Akt: Versatile Mediator of Cell Survival and Beyond

Kim, D., & Chung, J. (2002) · BMB Reports · doi:10.5483/bmbrep.2002.35.1.106 · Cited by 182 · see citing works

Solution State Characterization of Amyloid β-Derived Diffusible Ligands

Hepler, R. W., Grimm, K. M., Nahas, D. D., Breese, R., Chen-Dodson, E., Acton, P. J., Keller, P. M., Yeager, M. D., Wang, H., Shughrue, P. J., et al. (2006) · Biochemistry · doi:10.1021/bi061850f · Cited by 181 · see citing works

Brain glucose and energy metabolism abnormalities in sporadic Alzheimer disease. Causes and consequences: an update

Hoyer, S. (2000) · Experimental Gerontology · doi:10.1016/s0531-5565(00)00156-x · Cited by 174 · see citing works

How to build a central synapse: clues from cell culture

Craig, A. M., Graf, E. R., & Linhoff, M. W. (2005) · Trends in Neurosciences · doi:10.1016/j.tins.2005.11.002 · Cited by 168 · see citing works

Insulin Resistance Syndrome and Alzheimer Disease: Pathophysiologic Mechanisms and Therapeutic Implications

Craft, S. (2006) · Alzheimer Disease & Associated Disorders · doi:10.1097/01.wad.0000213866.86934.7e · Cited by 167 · see citing works

Akt activity in Alzheimer’s disease and other neurodegenerative disorders

Rickle, A., Bogdanović, N., Volkmann, I., Winblad, B. G., Ravid, R., & Cowburn, R. F. (2004) · Neuroreport · doi:10.1097/00001756-200404290-00005 · Cited by 166 · see citing works

A Disturbance in the Neuronal Insulin Receptor Signal Transduction in Sporadic Alzheimer's Disease

Frölich, L., Blum-Degen, D., Riederer, P. F., & Hoyer, S. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb07839.x · Cited by 160 · see citing works

Chronic Activation of Protein Kinase C in Soleus Muscles and Other Tissues of Insulin-Resistant Type II diabetic Goto-Kakizaki (GK), Obese/Aged, and Obese/Zucker Rats: A Mechanism For Inhibiting Glycogen Synthesis

Avignon, A., Yamada, K., Zhou, X., Spencer, B. A., Cardona, O., Saba-Siddique, S., Galloway, L. C., Standaert, M. L., & Farese, R. V. (1996) · Diabetes · doi:10.2337/diab.45.10.1396 · Cited by 143 · see citing works

Oxidative Stress, Perturbed Calcium Homeostasis, and Immune Dysfunction in Alzheimer's Disease

Mattson, M. P. (2002) · Journal of NeuroVirology · doi:10.1080/13550280290100978 · Cited by 142 · see citing works

Protein kinase C is increased in the liver of humans and rats with non-insulin-dependent diabetes mellitus: an alteration not due to hyperglycemia.

Considine, R. V., Nyce, M. R., Allen, L. E., Morales, L. M., Triester, S., Serrano, J., Colberg, J., Lanza-Jacoby, S., & Caro, J. F. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118001 · Cited by 141 · see citing works

Akt Mediates the Cross-Talk Between β-Adrenergic and Insulin Receptors in Neonatal Cardiomyocytes

Morisco, C., Condorelli, G., Trimarco, V., Bellis, A., Marrone, C., Condorelli, G., Sadoshima, J., & Trimarco, B. (2005) · Circulation Research · doi:10.1161/01.res.0000152968.71868.c3 · Cited by 141 · see citing works

Enhanced Akt Signaling Is an Early Pro-survival Response That Reflects N-Methyl-D-aspartate Receptor Activation in Huntington's Disease Knock-in Striatal Cells

Ginés, S., Ivanova, E. V., Seong, I., Saura, C. A., & MacDonald, M. E. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m309348200 · Cited by 136 · see citing works

Insulin receptor substrate proteins and diabetes

Lee, Y. H., & White, M. F. (2004) · Archives of Pharmacal Research · doi:10.1007/bf02980074 · Cited by 135 · see citing works

β-Amyloid-induced Dynamin 1 Depletion in Hippocampal Neurons

Kelly, B. L., Vassar, R. J., & Ferreira, A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m503259200 · Cited by 127 · see citing works

Insulin resistance and non-insulin-dependent diabetes mellitus: cellular and molecular mechanisms

Olefsky, J. M., & Nolan, J. J. (1995) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/61.4.980s · Cited by 123 · see citing works

Mechanism of Insulin Resistance Induced by Sustained Levels of Cytosolic Free Calcium in Rat Adipocytes*

Draznin, B., LEWIS, D., Houlder, N., SHERMAN, N., Adamo, M. L., Garvey, W. T., LeRoith, D., & Sussman, K. E. (1989) · Endocrinology · doi:10.1210/endo-125-5-2341 · Cited by 115 · see citing works

Identification of Enhanced Serine Kinase Activity in Insulin Resistance

Qiao, L. Y., Goldberg, J. L., Russell, J. C., & Sun, X. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.15.10625 · Cited by 111 · see citing works

Insulin resistance contributes to aberrant stress responses in the Tg2576 mouse model of Alzheimer's disease

PEDERSEN, W., & FLYNN, E. (2004) · Neurobiology of Disease · doi:10.1016/j.nbd.2004.08.003 · Cited by 108 · see citing works

Synaptic targeting by Aβ oligomers (ADDLS) as a basis for memory loss in early Alzheimer's disease

Klein, W. L. (2006) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2005.11.003 · Cited by 107 · see citing works

Plasma levels of amyloid β-protein 42 are increased in women with mild cognitive impairment

Assini, A., Cammarata, S., Vitali, A., Colucci, M. E. W., Giliberto, L., Borghi, R., Inglese, M. L., Volpe, S., Ratto, S., Dagna-Bricarelli, F., et al. (2004) · Neurology · doi:10.1212/01.wnl.0000137040.64252.ed · Cited by 104 · see citing works

Unique Features of the Insulin Receptor in Rat Brain

Hendricks, S. A., Agardh, C., Taylor, S. I., & Roth, J. (1984) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1984.tb05387.x · Cited by 95 · see citing works

Diabetes, Alzheimer's disease and apolipoprotein genotype

Messier, C. (2003) · Experimental Gerontology · doi:10.1016/s0531-5565(03)00153-0 · Cited by 92 · see citing works

Protein kinase C isoforms β 1 and β 2 inhibit the tyrosine kinase activity of the insulin receptor

Bossenmaier, B., Mosthaf, L., Mischak, H., Ullrich, A., & Häring, H. (1997) · Diabetologia · doi:10.1007/s001250050761 · Cited by 91 · see citing works

Insulin exerts neuroprotection by counteracting the decrease in cell‐surface GABAA receptors following oxygen–glucose deprivation in cultured cortical neurons

Mielke, J. G., & Wang, Y. T. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02841.x · Cited by 87 · see citing works

Diabetes and brain aging: Epidemiologic evidence

Launer, L. J. (2005) · Current Diabetes Reports · doi:10.1007/s11892-005-0069-1 · Cited by 85 · see citing works

Differential effects of IRS1 phosphorylated on Ser307 or Ser632 in the induction of insulin resistance by oxidative stress

Bloch-Damti, A., Potashnik, R., Gual, P., MARCHAND‐BRUSTEL, Y. L., Tanti, J., Rudich, A., & Bashan, N. (2006) · Diabetologia · doi:10.1007/s00125-006-0349-6 · Cited by 85 · see citing works

Non‐fibrillar β‐amyloid abates spike‐timing‐dependent synaptic potentiation at excitatory synapses in layer 2/3 of the neocortex by targeting postsynaptic AMPA receptors

Shemer, I., Holmgren, C. D., Min, R., Fülöp, L., Zilberter, M. Y., Sousa, K. M., Farkas, T., Härtig, W., Penke, B., Burnashev, N., et al. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04733.x · Cited by 82 · see citing works

Alterations in Glucose Metabolism in Patients with Alzheimer's Disease

Meneilly, G. S., & Hill, A. (1993) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1993.tb07458.x · Cited by 79 · see citing works

Insulin Receptors from Guinea Pig Liver and Brain:Structural and Functional Studies

Lowe, W. L., & LeRoith, D. (1986) · Endocrinology · doi:10.1210/endo-118-4-1669 · Cited by 45 · see citing works

PGH2‐derived levuglandin adducts increase the neurotoxicity of amyloid β1–42

Boutaud, O. G., Montine, T. J., Chang, L., Klein, W. L., & Oates, J. A. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03586.x · Cited by 44 · see citing works

Chronic activation of protein kinase C in soleus muscles and other tissues of insulin-resistant type II diabetic Goto-Kakizaki (GK), obese/aged, and obese/Zucker rats. A mechanism for inhibiting glycogen synthesis

Avignon, A., Yamada, K., Zhou, X., et al. (1996) · Diabetes · doi:10.2337/diabetes.45.10.1396 · Cited by 37 · see citing works

Amyloid β protein activates PKC-δ and induces translocation of myristoylated alanine-rich C kinase substrate (MARCKS) in microglia

Nakai, M., Tanimukai, S., Yagi, K., Saito, N., Taniguchi, T., Terashima, A., Kawamata, T., Yamamoto, H., Fukunaga, K., Miyamoto, E., et al. (2001) · Neurochemistry International · doi:10.1016/s0197-0186(00)00126-1 · Cited by 36 · see citing works

Another Role for the Celebrity

Tian, R. (2005) · Circulation Research · doi:10.1161/01.res.0000156076.17807.1f · Cited by 35 · see citing works

Deregulation of the Phosphatidylinositol-3 Kinase Signaling Cascade Is Associated with Neurodegeneration in Npc1−/− Mouse Brain

Bi, X., Liu, J., Yao, Y., Baudry, M., & LYNCH, G. S. (2005) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)61197-2 · Cited by 32 · see citing works

Specific localization of the annexin II heterotetramer in brain lipid raft fractions and its changes in spatial learning

Zhao, W., Waisman, D. M., & GRIMALDI, M. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02509.x · Cited by 32 · see citing works

Postbinding characterization of five naturally occurring mutations in the human insulin receptor gene: impaired insulin-stimulated c-jun expression and thymidine incorporation despite normal receptor autophosphorylation

Quon, M. J., Cama, A., & Taylor, S. I. (1992) · Biochemistry · doi:10.1021/bi00156a013 · Cited by 25 · see citing works

Molecules that Disrupt Memory Circuits in Alzheimer’s Disease: The Attack on Synapses by Aβ Oligomers (ADDLs)

Klein, W. L., Lacor, P. N., Felice, F. G. D., & Ferreira, S. T. (2007) · Research and perspectives in neurosciences · doi:10.1007/978-3-540-45702-2_11 · Cited by 23 · see citing works

Specific Binding of Insulin to Membranes from Dendrodendritic Synaptosomes of Rat Olfactory Bulb

Matsumoto, H., & Rhoads, D. E. (1990) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1990.tb13321.x · Cited by 23 · see citing works

Modulation of Insulin Receptor Signaling: Potential Mechanisms of a Cross Talk Between Bradykinin and the Insulin Receptor

Häring, H., Tippmer, S., Kellerer, M., Mosthaf, L., Kroder, G., Bossenmaier, B., & Berti, L. (1996) · Diabetes · doi:10.2337/diab.45.1.s115 · Cited by 23 · see citing works

Plasma levels of insulin and amyloid β42 are correlated in patients with amnestic Mild Cognitive Impairment

Odetti, P. R., Piccini, A., Giliberto, L., Borghi, R., Natale, A., Monacelli, F., Marchese, M., Assini, A., Colucci, M., Cammarata, S., et al. (2005) · Journal of Alzheimer s Disease · doi:10.3233/jad-2005-8303 · Cited by 19 · see citing works

Different cellular localization, translocation, and insulin‐induced phosphorylation of PKBα in HepG2 cells and hepatocytes

Syed, N., Horner, K. N., Misra, V., & Khandelwal, R. L. (2002) · Journal of Cellular Biochemistry · doi:10.1002/jcb.10189 · Cited by 17 · see citing works

TPA inhibits insulin stimulated PIP hydrolysis in fat cell membranes: Evidence for modulation of insulin dependent phospholipase C by proteinkinase C

Kellerer, M., Seffer, E., Mushack, J., Obermaier-Kusser, B., & Häring, H. (1990) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(90)90693-h · Cited by 16 · see citing works

Genetic determinants of type 2 diabetes mellitus: lessons learned from family studies.

Froguel, P., Velho, G., Passa, P., & Cohen, D. (1993) · PubMed · Cited by 14 · see citing works

Nanomolar amyloid β protein activates a specific PKC isoform mediating phosphorylation of MARCKS in Neuro2A cells

Tanimukai, S., Hasegawa, H., Nakai, M., Yagi, K., Hirai, M., Saito, N., Taniguchi, T., Terashima, A., Yasuda, M., Kawamata, T., et al. (2002) · Neuroreport · doi:10.1097/00001756-200203250-00037 · Cited by 9 · see citing works

Peptide mapping on Northern blot analyses of insulin receptors in brain and adipocytes

Heidenreich, K. A., Gilmore, P. R., Brandenburg, D., & Hatada, E. N. (1988) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(88)90068-8 · Cited by 8 · see citing works

Insulin, diabetes mellitus, Alzheimer's disease, and apolipoprotein E

Gambassi, G., & Bernabei, R. (1998) · Neurology · doi:10.1212/wnl.51.3.925-b · Cited by 4 · see citing works

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

Talbot, K., Wang, H.-Y., Kazi, H., Han, L.-Y., Bakshi, K. P., Stucky, A., Fuino, R. L., Kawaguchi, K. R., Samoyedny, A. J., Wilson, R. S., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59903 · Cited by 1,871 · see citing works

The Amyloid-β Oligomer Hypothesis: Beginning of the Third Decade

Cline, E. N., Bicca, M. A., Viola, K. L., & Klein, W. L. (2018) · Journal of Alzheimer's Disease · doi:10.3233/jad-179941 · Cited by 870 · see citing works

An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease–associated Aβ oligomers

Bomfim, T. R., Forny‐Germano, L., Sathler, L. B., Brito‐Moreira, J., Houzel, J., Decker, H., Silverman, M. A., Kazi, H., Melo, H. M., McClean, P. L., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci57256 · Cited by 830 · see citing works

Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer’s disease indicate possible resistance to IGF-1 and insulin signalling

Moloney, A. M., Griffin, R. J., Timmons, S., O’Connor, R., Ravid, R., & O’Neill, C. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.04.002 · Cited by 764 · see citing works

Decoding Alzheimer's disease from perturbed cerebral glucose metabolism: Implications for diagnostic and therapeutic strategies

Chen, Z., & Zhong, C. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.06.004 · Cited by 671 · see citing works

Protection of synapses against Alzheimer's-linked toxins: Insulin signaling prevents the pathogenic binding of Aβ oligomers

De Felice, F. G., Vieira, M. N. N., Bomfim, T. R., Decker, H., Velasco, P. T., Lambert, M. P., Viola, K. L., Zhao, W.-Q., Ferreira, S. T., & Klein, W. L. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809158106 · Cited by 657 · see citing works

Inflammation, Defective Insulin Signaling, and Mitochondrial Dysfunction as Common Molecular Denominators Connecting Type 2 Diabetes to Alzheimer Disease

Felice, F. G. D., & Ferreira, S. T. (2014) · Diabetes · doi:10.2337/db13-1954 · Cited by 647 · see citing works

Is Alzheimer’s disease a type 3 diabetes? A critical appraisal

Kandimalla, R., Thirumala, V., & Reddy, P. H. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.08.018 · Cited by 621 · see citing works

Nose-to-brain drug delivery: An update on clinical challenges and progress towards approval of anti-Alzheimer drugs

Agrawal, M., Saraf, S., Saraf, S., Antimisiaris, S. G., Chougule, M. B., Shoyele, S. A., & Alexander, A. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.05.011 · Cited by 630 · see citing works

Brain Insulin Resistance at the Crossroads of Metabolic and Cognitive Disorders in Humans

Kullmann, S., Heni, M., Hallschmid, M., Fritsche, A., Preissl, H. T., & Häring, H. (2016) · Physiological Reviews · doi:10.1152/physrev.00032.2015 · Cited by 632 · see citing works

Amyloid β oligomers in Alzheimer’s disease pathogenesis, treatment, and diagnosis

Viola, K. L., & Klein, W. L. (2015) · Acta Neuropathologica · doi:10.1007/s00401-015-1386-3 · Cited by 628 · see citing works

Amyloid oligomers: formation and toxicity of Aβ oligomers

Sakono, M., & Zako, T. (2010) · FEBS Journal · doi:10.1111/j.1742-4658.2010.07568.x · Cited by 602 · see citing works

Hippocampal insulin resistance and cognitive dysfunction

Biessels, G. J., & Reagan, L. P. (2015) · Nature reviews. Neuroscience · doi:10.1038/nrn4019 · Cited by 536 · see citing works

-Amyloid Oligomers Induce Phosphorylation of Tau and Inactivation of Insulin Receptor Substrate via c-Jun N-Terminal Kinase Signaling: Suppression by Omega-3 Fatty Acids and Curcumin

Ma, Q.-L., Yang, F., Rosario, E. R., Ubeda, O. J., Beech, W., Gant, D. J., Chen, P. P., Hudspeth, B., Chen, C., Zhao, Y., et al. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1071-09.2009 · Cited by 536 · see citing works

Estrogen: A master regulator of bioenergetic systems in the brain and body

Rettberg, J. R., Yao, J., & Brinton, R. D. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2013.08.001 · Cited by 534 · see citing works

Synaptic degeneration in Alzheimer disease

Tzioras, M., McGeachan, R. I., Durrant, C. S., & Spires-Jones, T. L. (2023) · Nature Reviews Neurology · doi:10.1038/s41582-022-00749-z · Cited by 504 · see citing works

Alzheimer's disease: synaptic dysfunction and Aβ

Shankar, G. M., & Walsh, D. M. (2009) · Molecular Neurodegeneration · doi:10.1186/1750-1326-4-48 · Cited by 522 · see citing works

Diabetes-accelerated memory dysfunction via cerebrovascular inflammation and Aβ deposition in an Alzheimer mouse model with diabetes

Takeda, S., Sato, N., Uchio‐Yamada, K., Sawada, K., Kunieda, T., Takeuchi, D., Kurinami, H., Shinohara, M., Rakugi, H., & Morishita, R. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000645107 · Cited by 506 · see citing works

Alzheimer's disease, β‐amyloid, glutamate, NMDA receptors and memantine – searching for the connections

Danysz, W., & Parsons, C. G. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2012.02057.x · Cited by 500 · see citing works

Inflammation and Oxidative Stress: The Molecular Connectivity between Insulin Resistance, Obesity, and Alzheimer’s Disease

Verdile, G., Keane, K. N., Cruzat, V. F., Medic, S., Sabale, M., Rowles, J., Wijesekara, N., Martins, R. N., Fraser, P. E., & Newsholme, P. (2015) · Mediators of Inflammation · doi:10.1155/2015/105828 · Cited by 501 · see citing works

Intranasal Insulin as a Treatment for Alzheimer’s Disease: A Review of Basic Research and Clinical Evidence

Freiherr, J., Hallschmid, M., Frey, W. H., Brünner, Y. F., Chapman, C. D., Hölscher, C., Craft, S., Felice, F. G. D., & Benedict, C. (2013) · CNS Drugs · doi:10.1007/s40263-013-0076-8 · Cited by 470 · see citing works

The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer’s disease

Ferreira, S. T., & Klein, W. L. (2011) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2011.08.003 · Cited by 442 · see citing works

TNF-α Mediates PKR-Dependent Memory Impairment and Brain IRS-1 Inhibition Induced by Alzheimer’s β-Amyloid Oligomers in Mice and Monkeys

Lourenco, M. V., Clarke, J. R., Frozza, R. L., Bomfim, T. R., Forny‐Germano, L., Batista, A. F., Sathler, L. B., Brito‐Moreira, J., Amaral, O. B., Silva, C. A., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.11.002 · Cited by 415 · see citing works

Molecular Mechanisms of Amyloid Oligomers Toxicity

Kayed, R., & Lasagna‐Reeves, C. A. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-129001 · Cited by 417 · see citing works

Elevated risk of type 2 diabetes for development of Alzheimer disease: A key role for oxidative stress in brain

Butterfield, D. A., Di Domenico, F., & Barone, E. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.06.010 · Cited by 402 · see citing works

Antidiabetic drug metformin (Glucophage ^R ) increases biogenesis of Alzheimer's amyloid peptides via up-regulating <i>BACE1</i> transcription

Chen, Y., Zhou, K., Wang, R., Liu, Y., Kwak, Y.-D., Ma, T., Thompson, R. C., Zhao, Y., Smith, L., Gasparini, L., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0807991106 · Cited by 390 · see citing works

The chemistry of Alzheimer’s disease

Rauk, A. (2009) · Chemical Society Reviews · doi:10.1039/b807980n · Cited by 417 · see citing works

Soluble amyloid-β oligomers as synaptotoxins leading to cognitive impairment in Alzheimer’s disease

Ferreira, S. T., Lourenco, M. V., Oliveira, M. M., & De Felice, F. G. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00191 · Cited by 373 · see citing works

Liraglutide can reverse memory impairment, synaptic loss and reduce plaque load in aged APP/PS1 mice, a model of Alzheimer's disease

McClean, P. L., & Hölscher, C. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.08.005 · Cited by 359 · see citing works

Inflammation, defective insulin signaling, and neuronal dysfunction in Alzheimer's disease

Ferreira, S. T., Clarke, J. R., Bomfim, T. R., & Felice, F. G. D. (2014) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2013.12.010 · Cited by 354 · see citing works

Microglia-Mediated Synapse Loss in Alzheimer's Disease

Rajendran, L., & Paolicelli, R. C. (2018) · The Journal of Neuroscience · doi:10.1523/jneurosci.1136-17.2017 · Cited by 355 · see citing works

Alteration of mTOR signaling occurs early in the progression of Alzheimer disease (AD): analysis of brain from subjects with pre‐clinical AD, amnestic mild cognitive impairment and late‐stage AD

Tramutola, A., Triplett, J. C., Di Domenico, F., Niedowicz, D. M., Murphy, M. P., Coccia, R., Perluigi, M., & Butterfield, D. A. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13037 · Cited by 347 · see citing works

Insulin resistance and amyloidogenesis as common molecular foundation for type 2 diabetes and Alzheimer's disease

Zhao, W., & Townsend, M. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2008.10.014 · Cited by 353 · see citing works

Scaling of Brain Metabolism with a Fixed Energy Budget per Neuron: Implications for Neuronal Activity, Plasticity and Evolution

Herculano-Houzel, S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017514 · Cited by 343 · see citing works

How does brain insulin resistance develop in Alzheimer's disease?

De Felice, F. G., Lourenco, M. V., & Ferreira, S. T. (2014) · Alzheimer's &amp; Dementia · doi:10.1016/j.jalz.2013.12.004 · Cited by 337 · see citing works

Alzheimer’s disease and insulin resistance: translating basic science into clinical applications

Felice, F. G. D. (2013) · Journal of Clinical Investigation · doi:10.1172/jci64595 · Cited by 328 · see citing works

Insulin in Central Nervous System: More than Just a Peripheral Hormone

Duarte, A. I., Moreira, P. I., & Oliveira, C. R. (2012) · Journal of Aging Research · doi:10.1155/2012/384017 · Cited by 324 · see citing works

mTOR signaling in aging and neurodegeneration: at the crossroad between metabolism dysfunction and impairment of autophagy

Perluigi, M., Di Domenico, F., & Butterfield, D. A. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.03.014 · Cited by 339 · see citing works

Mammalian/mechanistic target of rapamycin (mTOR) complexes in neurodegeneration

Querfurth, H., & Lee, H.-K. (2021) · Molecular Neurodegeneration · doi:10.1186/s13024-021-00428-5 · Cited by 288 · see citing works

Synaptic changes in Alzheimer’s disease and its models

Pozueta, J., Lefort, R., & Shelanski, M. L. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.05.050 · Cited by 305 · see citing works

Peripheral insulin-sensitizer drug metformin ameliorates neuronal insulin resistance and Alzheimer’s-like changes

Gupta, A., Bisht, B., & Dey, C. S. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.01.033 · Cited by 302 · see citing works

Beta amyloid oligomers and fibrils stimulate differential activation of primary microglia

Sondag, C. M., Dhawan, G., & Combs, C. K. (2009) · Journal of Neuroinflammation · doi:10.1186/1742-2094-6-1 · Cited by 295 · see citing works

Link between type 2 diabetes and Alzheimer’s disease: from epidemiology to mechanism and treatment

Li, X., Leng, S. X., & Song, D. (2015) · Clinical Interventions in Aging · doi:10.2147/cia.s74042 · Cited by 294 · see citing works

Aberrant insulin signaling in Alzheimer's disease: current knowledge

Bedse, G., Domenico, F. D., Serviddio, G., & Cassano, T. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00204 · Cited by 294 · see citing works

PI3-kinase/Akt/mTOR signaling: Impaired on/off switches in aging, cognitive decline and Alzheimer's disease

Neill, C. O. (2013) · Experimental Gerontology · doi:10.1016/j.exger.2013.02.025 · Cited by 292 · see citing works

The role of type 2 diabetes in neurodegeneration

Verdile, G., Fuller, S. J., & Martins, R. N. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.04.008 · Cited by 276 · see citing works

Role of the Blood-Brain Barrier in Central Nervous System Insulin Resistance

Rhea, E. M., & Banks, W. A. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00521 · Cited by 263 · see citing works

The brain as an insulin-sensitive metabolic organ

Milstein, J. L., & Ferris, H. A. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2021.101234 · Cited by 269 · see citing works

Amyloid-β Receptors: The Good, the Bad, and the Prion Protein

Jarosz-Griffiths, H. H., Noble, E., Rushworth, J. V., & Hooper, N. M. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.r115.702704 · Cited by 256 · see citing works

Type 2 Diabetes Mellitus and Alzheimer’s Disease: Role of Insulin Signalling and Therapeutic Implications

Tumminia, A., Vinciguerra, F., Parisi, M., & Frittitta, L. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19113306 · Cited by 252 · see citing works

The neuroprotective effects of glucagon-like peptide 1 in Alzheimer’s and Parkinson’s disease: An in-depth review

Reich, N., & Hölscher, C. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.970925 · Cited by 248 · see citing works

The relationship between Alzheimer's disease and diabetes: Type 3 diabetes?

Kroner, Z. (2009) · PubMed · Cited by 246 · see citing works

The diabetes drug liraglutide reverses cognitive impairment in mice and attenuates insulin receptor and synaptic pathology in a non‐human primate model of Alzheimer's disease

Batista, A. F., Forny‐Germano, L., Clarke, J. R., Silva, N. M. L. E., Brito‐Moreira, J., Boehnke, S. E., Winterborn, A., Coe, B. C., Lablans, A., Vital, J. F. S., et al. (2018) · The Journal of Pathology · doi:10.1002/path.5056 · Cited by 246 · see citing works

Neuronal cell death mechanisms in Alzheimer’s disease: An insight

Goel, P., Chakrabarti, S., Goel, K., Bhutani, K., Chopra, T., & Bali, S. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.937133 · Cited by 235 · see citing works

Review: Astrocytes in Alzheimer's disease and other age‐associated dementias: a supporting player with a central role

Garwood, C. J., Ratcliffe, L. E., Simpson, J. E., Heath, P. R., Ince, P. G., & Wharton, S. B. (2017) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12338 · Cited by 233 · see citing works

A Role for Synaptic Zinc in Activity-Dependent Aβ Oligomer Formation and Accumulation at Excitatory Synapses

Deshpande, A., Kawai, H., Metherate, R., Glabe, C. G., & Busciglio, J. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.5980-08.2009 · Cited by 232 · see citing works

Brain insulin signaling: A key component of cognitive processes and a potential basis for cognitive impairment in type 2 diabetes

McNay, E. C., & Recknagel, A. K. (2011) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2011.08.005 · Cited by 229 · see citing works

Insulin Resistance and Diabetes Mellitus in Alzheimer’s Disease

Burillo, J., Marqués, P., Jiménez, B., González-Blanco, C., Benito, M., & Guillén, C. (2021) · Cells · doi:10.3390/cells10051236 · Cited by 235 · see citing works

The PI3K/Akt signaling axis in Alzheimer’s disease: a valuable target to stimulate or suppress?

Razani, E., Pourbagheri‐Sigaroodi, A., Safaroghli‐Azar, A., Zoghi, A., Bavarsad, M. S., & Bashash, D. (2021) · Cell Stress and Chaperones · doi:10.1007/s12192-021-01231-3 · Cited by 229 · see citing works

Lipid Rafts: Linking Alzheimer′s Amyloid‐βProduction, Aggregation, and Toxicity at Neuronal Membranes

Rushworth, J. V., & Hooper, N. M. (2010) · International Journal of Alzheimer s Disease · doi:10.4061/2011/603052 · Cited by 218 · see citing works

Insulin receptor signaling in the development of neuronal structure and function

Chiu, S., & Cline, H. T. (2010) · Neural Development · doi:10.1186/1749-8104-5-7 · Cited by 217 · see citing works

Alzheimer‐associated Aβ oligomers impact the central nervous system to induce peripheral metabolic deregulation

Clarke, J. R., Lyra e Silva, N. M., Figueiredo, C. P., Frozza, R. L., Ledo, J. H., Beckman, D., Katashima, C. K., Razolli, D., Carvalho, B. M., Frazão, R., et al. (2015) · EMBO Molecular Medicine · doi:10.15252/emmm.201404183 · Cited by 214 · see citing works

Tau deletion promotes brain insulin resistance

Marciniak, E., Leboucher, A., Caron, E., Ahmed, T., Tailleux, A., Dumont, J., Issad, T., Gerhardt, E., Pagesy, P., Vileno, M., et al. (2017) · Journal of Experimental Medicine · doi:10.1084/jem.20161731 · Cited by 205 · see citing works

The Insulin/Akt Signaling Pathway Is Targeted by Intracellular β-Amyloid

Lee, H., Kumar, P., Fu, Q., Rosen, K. M., & Querfurth, H. W. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-07-0777 · Cited by 205 · see citing works

The Link between Type 2 Diabetes and Neurodegeneration: Roles for Amyloid-β, Amylin, and Tau Proteins

Bharadwaj, P., Wijesekara, N., Liyanapathirana, M., Newsholme, P., Ittner, L. M., Fraser, P. E., & Verdile, G. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-161192 · Cited by 203 · see citing works

Changes in insulin and insulin signaling in Alzheimer’s disease: cause or consequence?

Stanley, M., Macauley, S. L., & Holtzman, D. M. (2016) · The Journal of Experimental Medicine · doi:10.1084/jem.20160493 · Cited by 199 · see citing works

Age-dependent Accumulation of Soluble Amyloid β (Aβ) Oligomers Reverses the Neuroprotective Effect of Soluble Amyloid Precursor Protein-α (sAPPα) by Modulating Phosphatidylinositol 3-Kinase (PI3K)/Akt-GSK-3β Pathway in Alzheimer Mouse Model

Jiménez, S., Torres, M., Vizuete, M., Sanchez-Varo, R. M., Sánchez‐Mejías, E., Trujillo‐Estrada, L., Carmona‐Cuenca, I., Caballero, C., Ruano, D., Gutiérrez, A., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.209718 · Cited by 190 · see citing works

Inhibition of Calcineurin-mediated Endocytosis and α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors Prevents Amyloid β Oligomer-induced Synaptic Disruption

Zhao, W.-Q., Santini, F., Breese, R., Ross, D., Zhang, X. D., Stone, D. J., Ferrer, M., Townsend, M., Wolfe, A. L., Seager, M. A., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.057182 · Cited by 188 · see citing works

Amyloid Beta: Multiple Mechanisms of Toxicity and Only Some Protective Effects?

Carrillo‐Mora, P., Luna, R., & Colín-Barenque, L. (2014) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2014/795375 · Cited by 184 · see citing works

Hypothalamic Alterations in Neurodegenerative Diseases and Their Relation to Abnormal Energy Metabolism

Vercruysse, P., Vieau, D., Blum, D., Petersén, Å., & Dupuis, L. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00002 · Cited by 172 · see citing works

Impaired insulin signalling and allostatic load in Alzheimer disease

Felice, F. G. D., Gonçalves, R. A., & Ferreira, S. T. (2022) · Nature reviews. Neuroscience · doi:10.1038/s41583-022-00558-9 · Cited by 180 · see citing works

Insulin in the nervous system and the mind: Functions in metabolism, memory, and mood

Lee, S.-H., Zabolotny, J. M., Huang, H., Lee, H., & Kim, Y.-B. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2016.06.011 · Cited by 176 · see citing works

Astrocyte Transforming Growth Factor Beta 1 Protects Synapses against Aβ Oligomers in Alzheimer's Disease Model

Pereira Diniz, L., Tortelli, V., Matias, I., Morgado, J., Bérgamo Araujo, A. P., Melo, H. M., Seixas da Silva, G. S., Alves-Leon, S. V., de Souza, J. M., Ferreira, S. T., et al. (2017) · The Journal of Neuroscience · doi:10.1523/jneurosci.3351-16.2017 · Cited by 171 · see citing works

Inflammation and NF-κB in Alzheimer's Disease and Diabetes

Granic, I., Dolga, A. M., Nijholt, I. M., van Dijk, G., & Eisel, U. L. M. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-0976 · Cited by 174 · see citing works

Naturally Secreted Amyloid-β Increases Mammalian Target of Rapamycin (mTOR) Activity via a PRAS40-mediated Mechanism

Caccamo, A., Maldonado, M. A., Majumder, S., Medina, D. X., Holbein, W. W., Magrì, A., & Oddo, S. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.180638 · Cited by 174 · see citing works

Isolation and Characterization of Patient-derived, Toxic, High Mass Amyloid β-Protein (Aβ) Assembly from Alzheimer Disease Brains

Noguchi, A., Matsumura, S., Dezawa, M., Tada, M., Yanazawa, M., Ito, A., Akioka, M., Kikuchi, S., Sato, M., Ideno, S., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.000208 · Cited by 172 · see citing works

The Interplay Among Oxidative Stress, Brain Insulin Resistance and AMPK Dysfunction Contribute to Neurodegeneration in Type 2 Diabetes and Alzheimer Disease

Barone, E., Domenico, F. D., Perluigi, M., & Butterfield, D. (2021) · Free Radical Biology & Medicine · doi:10.1016/j.freeradbiomed.2021.09.006 · Cited by 155 · see citing works

Cytoskeletal pathologies of Alzheimer disease

Bamburg, J. R., & Bloom, G. S. (2009) · Cell Motility and the Cytoskeleton · doi:10.1002/cm.20388 · Cited by 168 · see citing works

N ‐Methyl‐ d ‐aspartate receptors are required for synaptic targeting of Alzheimer’s toxic amyloid‐β peptide oligomers

Decker, H., Jürgensen, S., Adrover, M. F., Brito‐Moreira, J., Bomfim, T. R., Klein, W. L., Epstein, A. L., Felice, F. G. D., Jerusalinsky, D. A., & Ferreira, S. T. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.07058.x · Cited by 164 · see citing works

Stimulation of Neurogenesis and Synaptogenesis by Bilobalide and Quercetin via Common Final Pathway in Hippocampal Neurons

Tchantchou, F., Lacor, P. N., Cao, Z., Lao, L., Hou, Y., Cui, C., Klein, W. L., & Luo, Y. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-1189 · Cited by 163 · see citing works

Type 2 Diabetes Mellitus and Alzheimer’s Disease: Shared Molecular Mechanisms and Potential Common Therapeutic Targets

Hamzé, R., Delangre, E., Tolu, S., Moreau, M., Janel, N., Bailbé, D., & Movassat, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232315287 · Cited by 163 · see citing works

Insulin in combination with other diabetes medication is associated with less Alzheimer neuropathology

Beeri, M. S., Schmeidler, J., Silverman, J. M., Gandy, S., Wysocki, M., Hannigan, C. M., Purohit, D. P., Lesser, G., Grossman, H. T., & Haroutunian, V. (2008) · Neurology · doi:10.1212/01.wnl.0000324925.95210.6d · Cited by 157 · see citing works

Neuropathological role of PI3K/Akt/mTOR axis in Down syndrome brain

Perluigi, M., Pupo, G., Tramutola, A., Cini, C., Coccia, R., Barone, E., Head, E., Butterfield, D. A., & Di Domenico, F. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.04.007 · Cited by 155 · see citing works

Aβ Oligomer-Induced Synapse Degeneration in Alzheimer’s Disease

Wilcox, K. C., Lacor, P. N., Pitt, J. E., & Klein, W. L. (2011) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-011-9691-4 · Cited by 156 · see citing works

The Diabetes Drug Liraglutide Ameliorates Aberrant Insulin Receptor Localisation and Signalling in Parallel with Decreasing Both Amyloid-β Plaque and Glial Pathology in a Mouse Model of Alzheimer’s Disease

Long-Smith, C. M., Manning, S., McClean, P. L., Coakley, M. F., O’Halloran, D., Hölscher, C., & O’Neill, C. (2012) · NeuroMolecular Medicine · doi:10.1007/s12017-012-8199-5 · Cited by 156 · see citing works

Shared links between type 2 diabetes mellitus and Alzheimer's disease: A review

Mittal, K., & Katare, D. P. (2016) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2016.01.021 · Cited by 154 · see citing works

Insulin Receptor Dysfunction Impairs Cellular Clearance of Neurotoxic Oligomeric Aβ

Zhao, W.-Q., Lacor, P. N., Chen, H., Lambert, M. P., Quon, M. J., Krafft, G. A., & Klein, W. L. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.011015 · Cited by 154 · see citing works

Mechanisms Underlying Insulin Deficiency-Induced Acceleration of β-Amyloidosis in a Mouse Model of Alzheimer's Disease

Devi, L., Alldred, M. J., Ginsberg, S. D., & Ohno, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032792 · Cited by 155 · see citing works

GLP-1 agonists facilitate hippocampal LTP and reverse the impairment of LTP induced by beta-amyloid

Gault, V. A., & Hölscher, C. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.03.025 · Cited by 155 · see citing works

The Toxicity of Amyloid ß Oligomers

Zhao, L. N., Leong, H., Mu, Y., & Chew, L. Y. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms13067303 · Cited by 154 · see citing works

GluT4: A central player in hippocampal memory and brain insulin resistance

McNay, E. C., & Pearson-Leary, J. (2019) · Experimental Neurology · doi:10.1016/j.expneurol.2019.113076 · Cited by 156 · see citing works

Neuroprotective properties of GLP-1: theoretical and practical applications

Holst, J. J., Burcelin, R., & Nathanson, E. (2011) · Current Medical Research and Opinion · doi:10.1185/03007995.2010.549466 · Cited by 152 · see citing works

The PI3K-Akt-mTOR pathway regulates Aβ oligomer induced neuronal cell cycle events

Bhaskar, K., Miller, M., Chludzinski, A., Herrup, K., Zagorski, M., & Lamb, B. T. (2009) · Molecular Neurodegeneration · doi:10.1186/1750-1326-4-14 · Cited by 177 · see citing works

Cross-interactions between the Alzheimer Disease Amyloid-β Peptide and Other Amyloid Proteins: A Further Aspect of the Amyloid Cascade Hypothesis

Luo, J., Wärmländer, S. K. T. S., Gräslund, A., & Abrahams, J. P. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.r116.714576 · Cited by 142 · see citing works

Synaptotoxic Amyloid-β Oligomers: A Molecular Basis for the Cause, Diagnosis, and Treatment of Alzheimer's Disease?

Klein, W. L. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-129039 · Cited by 141 · see citing works

Metabolism-Centric Overview of the Pathogenesis of Alzheimer's Disease

Kang, S., Lee, Y., & Lee, J. E. (2017) · Yonsei Medical Journal · doi:10.3349/ymj.2017.58.3.479 · Cited by 143 · see citing works

Insulin and IGF-1 signalling: longevity, protein homoeostasis and Alzheimer's disease

O’Neill, C., Kiely, A. P., Coakley, M. F., Manning, S., & Long-Smith, C. M. (2012) · Biochemical Society Transactions · doi:10.1042/bst20120080 · Cited by 138 · see citing works

Aβ Oligomers Induce Neuronal Cell Cycle Events in Alzheimer's Disease

Varvel, N. H., Bhaskar, K., Patil, A. R., Pimplikar, S. W., Herrup, K., & Lamb, B. T. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.2441-08.2008 · Cited by 138 · see citing works

The Neurovascular Unit Dysfunction in Alzheimer’s Disease

Soto-Rojas, L. O., Pacheco‐Herrero, M., Martínez-Gómez, P. A., Campa-Córdoba, B. B., Apátiga-Pérez, R., Villegas-Rojas, M. M., Harrington, C. R., de la Cruz, F., Garcés‐Ramírez, L., & Luna‐Muñoz, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22042022 · Cited by 140 · see citing works

P4‐263: Insulin prevents the pathological impact of soluble Abeta oligomers on neuronal insulin receptors

Felice, F. G. D., Vieira, M. N. N., Bonfim, T. J. S., Viola, K. L., Velasco, P. T., Lambert, M. P., Ferreira, S. T., & Klein, W. L. (2008) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2008.05.2332

P2‐327: Aβ oligomers impair neuronal insulin signaling

Felice, F. G. D., Bonfim, T. J. S., Klein, W. L., & Ferreira, S. T. (2010) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2010.05.1378

Amyloid Beta-Derived Diffusible Ligands (ADDLs) Induce Abnormal Expression of Insulin Receptors in Rat Hippocampal Neurons

Liu, X., Teng, Z., Cui, C., Wang, R., Liu, M., & Zhang, Y. (2014) · Journal of Molecular Neuroscience · doi:10.1007/s12031-013-0216-0 · Cited by 14 · see citing works

Insulin Receptor Dysfunction Impairs Cellular Clearance of Neurotoxic Oligomeric Aβ

Zhao, W.-Q., Lacor, P. N., Chen, H., Lambert, M. P., Quon, M. J., Krafft, G. A., & Klein, W. L. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.011015 · Cited by 154 · see citing works

Protection of synapses against Alzheimer's-linked toxins: Insulin signaling prevents the pathogenic binding of Aβ oligomers

De Felice, F. G., Vieira, M. N. N., Bomfim, T. R., Decker, H., Velasco, P. T., Lambert, M. P., Viola, K. L., Zhao, W.-Q., Ferreira, S. T., & Klein, W. L. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809158106 · Cited by 657 · see citing works