The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Different roles of the IGF‐I Ec peptide (MGF) and mature IGF‐I in myoblast proliferation and differentiation
Abstract
The physiological function of a recently cloned splice variant of insulin‐like growth factor‐I (IGF‐I; mechano growth factor (MGF)) was studied using an in vitro cell model. Unlike mature IGF‐I, the distinct E domain of MGF inhibits terminal differentiation whilst increasing myoblast proliferation. Blocking the IGF‐I receptor with a specific antibody indicated that the function of MGF E domain is mediated via a different receptor. The results provide a basis for localized tissue adaptation and helps explain why loss of muscle mass occurs in the elderly and in dystrophic muscle in which MGF production is markedly affected.
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Musarò, A., McCullagh, K., Paul, A., Houghton, L., Dobrowolny, G., Molinaro, M., Barton, E. R., L Sweeney, H., & Rosenthal, N. (2001) · Nature Genetics · doi:10.1038/84839 · Cited by 1,137
Exon duplication and divergence in the human preproglucagon gene
Bell, G. I., Sanchez-Pescador, R., Laybourn, P. J., & Najarian, R. C. (1983) · Nature · doi:10.1038/304368a0 · Cited by 593
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Metadata
- Authors
- Yang, S. Y., & Goldspink, G.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2002-06-09
- Volume
- 522
- Issue
- 1-3
- Pages
- 156-160
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2049799057
- Cited by
- 322
- References
- 2
- FWCI
- 5.18
- Type
- journal article
- Language
- en
- Open access
- closed
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- Yang, S. Y., & Goldspink, G. (2002). Different roles of the IGF‐I Ec peptide (MGF) and mature IGF‐I in myoblast proliferation and differentiation. FEBS Letters. https://doi.org/10.1016/s0014-5793(02)02918-6
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
