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Cited by 322

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Different roles of the IGF‐I Ec peptide (MGF) and mature IGF‐I in myoblast proliferation and differentiation

Yang, Shi Yu, Goldspink, Geoffrey·2002·FEBS Letters
DOI 10.1016/s0014-5793(02)02918-6
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Abstract

The physiological function of a recently cloned splice variant of insulin‐like growth factor‐I (IGF‐I; mechano growth factor (MGF)) was studied using an in vitro cell model. Unlike mature IGF‐I, the distinct E domain of MGF inhibits terminal differentiation whilst increasing myoblast proliferation. Blocking the IGF‐I receptor with a specific antibody indicated that the function of MGF E domain is mediated via a different receptor. The results provide a basis for localized tissue adaptation and helps explain why loss of muscle mass occurs in the elderly and in dystrophic muscle in which MGF production is markedly affected.

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Metadata

Authors
Yang, S. Y., & Goldspink, G.
Venue
FEBS Letters
Publisher
Wiley
Published
2002-06-09
Volume
522
Issue
1-3
Pages
156-160
ISSN
  • 0014-5793 (ISSN-L)
  • 1873-3468
DOI
10.1016/s0014-5793(02)02918-6
OpenAlex
W2049799057
Cited by
322
References
2
FWCI
5.18
Type
journal article
Language
en
Open access
closed

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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