The physiological role of dehydroascorbic acid
Open accessAbstract
Dehydroascorbic acid (DHA) is abundant in the human diet and also is generated from vitamin C (ascorbic acid, AA) in the lumen of the gastrointestinal tract. DHA is absorbed from the lumen of the small intestine and reduced to AA, which subsequently circulates in the blood. Utilization of AA as an antioxidant and enzyme cofactor causes its oxidation to DHA in extracellular fluid and cells. DHA has an important role in many cell types because it can be used to regenerate AA. Both physiological (e.g. insulin, insulin‐like growth factor I, cyclic AMP) and pathological (e.g. oxidative stress, diabetes, sepsis) factors alter the transport and metabolic mechanisms responsible for this DHA recycling.
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Cancer cells with high GLUT1, rather than sodium-dependent vitamin C transporters, take up ascorbate only as DHA in culture and in animals.
“cancer cells with high GLUT1 but not sodium-dependent vitamin C transporters exclusively take up ascorbate in the form of DHA both in vitro or in vivo6,8,47,53.”
From Targeting cancer vulnerabilities with high-dose vitamin C (2019) · cites this paper as [8]
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- Authors
- Wilson, J. X.
- Affiliations
- Western University (CA)
- Corresponding author
- Wilson, John X
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2002-08-14
- Volume
- 527
- Issue
- 1-3
- Pages
- 5-9
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2147271521
- Cited by
- 218
- References
- 54
- Citations by year
- 2026: 7 · 2025: 6 · 2024: 8 · 2023: 7 · 2022: 13 · 2021: 6 · 2020: 12 · 2019: 17 · 2018: 12 · 2017: 6 · 2016: 8 · 2015: 11 · 2014: 7 · 2013: 15 · 2012: 6
- FWCI
- 1.64
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- FEBS Letters (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Natural Sciences and Engineering Research Council of Canada
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial metabolism and enzyme function
- Keywords
- dehydroascorbic acid, vitamin C, ascorbate recycling, oxidative stress, antioxidants, enzyme cofactors, insulin, insulin-like growth factor I, cyclic AMP, diabetes mellitus, sepsis, gastrointestinal absorption, small intestine
- MeSH terms
- Animals, Ascorbic Acid, Biological Transport, Dehydroascorbic Acid, Diabetes Mellitus, Humans, Inflammation, Oxidation-Reduction, Reperfusion Injury, Sepsis
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