Cited by 136Mitochondrial Function and PathologyATP Synthase and ATPases ResearchIon channel regulation and function

Mitochondrial ATP‐sensitive K+ channel opening decreases reactive oxygen species generation

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Ferranti, Renato, da Silva, Mirian M, Kowaltowski, Alicia J·2003·FEBS Letters

Abstract

Mitochondrial ATP‐sensitive K+ channel (mitoK ATP) opening was shown previously to slightly increase respiration and decrease the membrane potential by stimulating K+ cycling across the inner membrane. Here we show that mitoK ATP opening reduces reactive oxygen species generation in heart, liver and brain mitochondria. Decreased H 2 O 2 release is observed when mitoK ATP is active both with respiration stimulated by oxidative phosphorylation and when ATP synthesis is inhibited. In addition, decreased H 2 O 2 release is observed when mitochondrial ΔpH is enhanced, an effect expected to occur when mitoK ATP is open. We conclude that mitoK ATP is an effective pathway to trigger mild uncoupling, preventing reactive oxygen species release.

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Research works printed but not linked: 2

  1. Kowaltowski, A.J. and Vercesi, A.E. (2001) in: Mitochondria in Pathogenisis (Lemasters, J.J. and Nieminen, A.L., Eds.), pp. 281^ 300, Plenum Publishing Corporation, New York.
  2. Lebu¡e, G., Schumacker, P.T., Shao, Z.H., Anderson, T., Iwase, H. and Vanden Hoek, T.L. (2002) Am. J. Physiol. (in press) epub ahead of print: Sep 26.

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Authors
Ferranti, R., da Silva, M. M., & Kowaltowski, A. J.
Affiliations
Universidade de São Paulo (BR)
Corresponding author
Kowaltowski, Alicia J
Venue
FEBS Letters
Publisher
Wiley
Published
2003-01-15
Volume
536
Issue
1-3
Pages
51-55
ISSN
  • 0014-5793 (ISSN-L)
  • 1873-3468
OpenAlex
W2039868368
Cited by
136
References
25
Citations by year
2026: 2 · 2025: 4 · 2024: 3 · 2023: 4 · 2022: 1 · 2021: 4 · 2020: 3 · 2019: 1 · 2018: 4 · 2017: 2 · 2016: 2 · 2015: 6 · 2014: 5 · 2013: 8 · 2012: 6
FWCI
4.25
Type
journal article
Language
en
Open access
Locations
  • FEBS Letters (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Fundação de Amparo à Pesquisa do Estado de São Paulo
  • Conselho Nacional de Desenvolvimento Científico e Tecnológico
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › ATP Synthase and ATPases Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
Keywords
mitochondrial ATP-sensitive potassium channel, reactive oxygen species, hydrogen peroxide release, mitochondrial uncoupling, mitochondrial membrane potential, oxidative phosphorylation, ATP synthesis inhibition, heart mitochondria, liver mitochondria, brain mitochondria, mitochondrial respiration
MeSH terms
Adenosine Triphosphate, Animals, Brain, Hydrogen Peroxide, Mitochondria, Mitochondria, Heart, Mitochondria, Liver, Oxidative Phosphorylation, Potassium, Potassium Channels, Ion Transport, Reactive Oxygen Species

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