RTG1- and RTG2-dependent retrograde signaling controls mitochondrial activity and stress resistance in Saccharomyces cerevisiae
Abstract
Mitochondrial retrograde signaling is a communication pathway between the mitochondrion and the nucleus that regulates the expression of a subset of nuclear genes that codify mitochondrial proteins, mediating cell response to mitochondrial dysfunction. In Saccharomyces cerevisiae, the pathway depends on Rtg1p and Rtg3p, which together form the transcription factor that regulates gene expression, and Rtg2p, an activator of the pathway. Here, we provide novel studies aimed at assessing the functional impact of the lack of RTG-dependent signaling on mitochondrial activity. We show that mutants defective in RTG-dependent retrograde signaling present higher oxygen consumption and reduced hydrogen peroxide release in the stationary phase compared to wild-type cells. Interestingly, RTG mutants are less able to decompose hydrogen peroxide or maintain viability when challenged with hydrogen peroxide. Overall, our results indicate that RTG signaling is involved in the hormetic induction of antioxidant defenses and stress resistance.
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An earlier study proposed a hormetic induction of antioxidant defense mediated by the Rtg pathway in S. cerevisiae, which was subsequently shown to involve cooperation between the HOG and Rtg pathways.
“An earlier study (Torelli et al. 2015) proposed a hormetic induction of antioxidant defense mediated by the Rtg pathway in S. cerevisiae, that was subsequently shown to involve the cooperation between the HOG and Rtg pathways (Guaragnella et al. 2019).”
From Mitochondrial retrograde control of transcription evolves with respiratory stress, metabolic adaptation, and virulence in budding yeasts (2026) · cites this paper as Torelli et al. 2015
In S. cerevisiae, mitophagy is reduced in mutants deficient in Rtg signaling.
“Studies in S. cerevisiae also demonstrated that mitophagy is reduced in mutants deficient in Rtg signaling (Torelli et al. 2015), providing further support for the connection between these mechanisms.”
From Mitochondrial retrograde control of transcription evolves with respiratory stress, metabolic adaptation, and virulence in budding yeasts (2026) · cites this paper as Torelli et al. 2015
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- Authors
- Torelli, N. Q., Ferreira-Júnior, J. R., Kowaltowski, A. J., & da Cunha, F. M.
- Affiliations
- Universidade de São Paulo (BR)
- Venue
- Free Radical Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 2015-04
- Volume
- 81
- Pages
- 30-37
- ISSN
- 0891-5849 (ISSN-L)
- OpenAlex
- W2032892547
- Cited by
- 37
- References
- 61
- Citations by year
- 2026: 4 · 2025: 1 · 2024: 6 · 2023: 3 · 2022: 1 · 2021: 4 · 2020: 3 · 2019: 4 · 2018: 3 · 2017: 1 · 2016: 4 · 2015: 3
- FWCI
- 1.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Free Radical Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- UNIFESP Institutional Repository (Universidade Federal de São Paulo) (submittedVersion)
- Funders
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (471162/2012-4)
- Pro-Reitoria de Pesquisa, Universidade de São Paulo
- Fundação de Amparo à Pesquisa do Estado de São Paulo (2010/519016, 2012/50500-7)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- mitochondrial retrograde signaling, Saccharomyces cerevisiae, hydrogen peroxide, oxidative stress resistance, hormesis, antioxidant defense, oxygen consumption, stationary phase, mitochondrial dysfunction, mitochondrial-nuclear communication
- MeSH terms
- Adaptation, Physiological, Cell Nucleus, Hydrogen Peroxide, Mitochondria, Phosphorylation, Saccharomyces cerevisiae, Signal Transduction, Gene Expression Regulation, Fungal, Oxidative Stress, Protein Transport, Active Transport, Cell Nucleus, Saccharomyces cerevisiae Proteins, Intracellular Signaling Peptides and Proteins, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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