The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Mitochondrial ATP‐sensitive K+ channel opening decreases reactive oxygen species generation
Open accessAbstract
Mitochondrial ATP‐sensitive K+ channel (mitoK ATP) opening was shown previously to slightly increase respiration and decrease the membrane potential by stimulating K+ cycling across the inner membrane. Here we show that mitoK ATP opening reduces reactive oxygen species generation in heart, liver and brain mitochondria. Decreased H 2 O 2 release is observed when mitoK ATP is active both with respiration stimulated by oxidative phosphorylation and when ATP synthesis is inhibited. In addition, decreased H 2 O 2 release is observed when mitochondrial ΔpH is enhanced, an effect expected to occur when mitoK ATP is open. We conclude that mitoK ATP is an effective pathway to trigger mild uncoupling, preventing reactive oxygen species release.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“This might explain why a ROS-increasing effect of diazoxide has not been detected in the presence of NADH-generating substrates or when complex III was not inhibited [129,138,139].”
From Differential effects of complex II on mitochondrial ROS production and their relation to cardioprotective pre- and postconditioning (2013) · cites this paper as [138]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Korshunov, S. S., Skulachev, V. P., & Starkov, A. A. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)01159-9 · Cited by 1,727
Zhou, M., Diwu, Z. J., Panchuk-Voloshina, N., & Haugland, R. P. (1997) · Analytical Biochemistry · doi:10.1006/abio.1997.2391 · Cited by 1,400
A role for uncoupling protein‐2 as a regulator of mitochondrial hydrogen peroxide generation
Nègre‐Salvayre, A., Hirtz, C., Carrera, G., Cazenave, R., Troly, M., Salvayre, R., Pénicaud, L., & Casteilla, L. (1997) · The FASEB Journal · doi:10.1096/fasebj.11.10.9271366 · Cited by 773
Vanden Hoek, T. L., Becker, L. B., Shao, Z., Li, C., & Schumacker, P. T. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.29.18092 · Cited by 721
Skulachev, V. P. (1996) · Quarterly Reviews of Biophysics · doi:10.1017/s0033583500005795 · Cited by 703
ATP-Sensitive Potassium Channels: A Review of their Cardioprotective Pharmacology
Grover, G. J., & Garlid, K. (2000) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.2000.1111 · Cited by 396
Diazoxide-Induced Cardioprotection Requires Signaling Through a Redox-Sensitive Mechanism
Forbes, R. A., Steenbergen, C., & Murphy, E. (2001) · Circulation Research · doi:10.1161/hh0801.089342 · Cited by 395
Pauček, P., Mironova, G. D., Mahdi, F., Beavis, A. D., Woldegiorgis, G., & Garlid, K. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)35717-x · Cited by 357
Bioenergetic consequences of opening the ATP-sensitive K+channel of heart mitochondria
Kowaltowski, A. J., Seetharaman, S., Pauček, P., & Garlid, K. (2001) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2001.280.2.h649 · Cited by 351
Self-citationPreconditioning in Cardiomyocytes Protects by Attenuating Oxidant Stress at Reperfusion
Hoek, T. L. V., Becker, L. B., Shao, Z., Li, C., & Schumacker, P. T. (2000) · Circulation Research · doi:10.1161/01.res.86.5.541 · Cited by 312
Research works printed but not linked: 2
- Kowaltowski A.J. and Vercesi A.E. (2001) in: Mitochondria in Pathogenisis (Lemasters J.J. and Nieminen A.L. Eds.) pp. 281–300 Plenum Publishing Corporation New York.
- Lebuffe G. Schumacker P.T. Shao Z.H. Anderson T. Iwase H. and Vanden Hoek T.L. (2002) Am. J. Physiol. (in press) epub ahead of print: Sep 26.
Cited by
Sorted by citations
Mitochondria and reactive oxygen species
Kowaltowski, A. J., de Souza-Pinto, N. C., Castilho, R. F., & Vercesi, A. E. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.05.004 · Cited by 1,162
Self-citationCardioprotective Actions by a Water-Soluble Carbon Monoxide–Releasing Molecule
Clark, J., NAUGHTON, P. J., Shurey, S., Green, C. J., Johnson, T. R., Mann, B. E., Foresti, R., & Motterlini, R. (2003) · Circulation Research · doi:10.1161/01.res.0000084381.86567.08 · Cited by 676
Regulation of brain mitochondrial H 2 O 2 production by membrane potential and NAD(P)H redox state
Starkov, A. A., & Fiskum, G. M. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01908.x · Cited by 503
Crosstalk signaling between mitochondrial Ca2+ and ROS
Robert, F. F. (2009) · Frontiers in bioscience · doi:10.2741/3303 · Cited by 448
Mild mitochondrial uncoupling in mice affects energy metabolism, redox balance and longevity
Caldeira da Silva, C. C., Cerqueira, F. M., Barbosa, L. F., Medeiros, M. H. G., & Kowaltowski, A. J. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2008.00407.x · Cited by 306
Self-citation
Metadata
- Authors
- Ferranti, R., da Silva, M. M., & Kowaltowski, A. J.
- Affiliations
- Universidade de São Paulo (BR)
- Corresponding author
- Kowaltowski, Alicia J
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2003-01-15
- Volume
- 536
- Issue
- 1-3
- Pages
- 51-55
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2039868368
- Cited by
- 136
- References
- 25
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 3 · 2023: 4 · 2022: 1 · 2021: 4 · 2020: 3 · 2019: 1 · 2018: 4 · 2017: 2 · 2016: 2 · 2015: 6 · 2014: 5 · 2013: 8 · 2012: 6
- FWCI
- 4.25
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- FEBS Letters (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › ATP Synthase and ATPases Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Keywords
- mitochondrial ATP-sensitive potassium channel, reactive oxygen species, hydrogen peroxide release, mitochondrial uncoupling, mitochondrial membrane potential, oxidative phosphorylation, ATP synthesis inhibition, heart mitochondria, liver mitochondria, brain mitochondria, mitochondrial respiration
- MeSH terms
- Adenosine Triphosphate, Animals, Brain, Hydrogen Peroxide, Mitochondria, Mitochondria, Heart, Mitochondria, Liver, Oxidative Phosphorylation, Potassium, Potassium Channels, Ion Transport, Reactive Oxygen Species
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
