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Mild mitochondrial uncoupling in mice affects energy metabolism, redox balance and longevity
Abstract
Summary: Caloric restriction is the most effective non‐genetic intervention to enhance lifespan known to date. A major research interest has been the development of therapeutic strategies capable of promoting the beneficial results of this dietary regimen. In this sense, we propose that compounds that decrease the efficiency of energy conversion, such as mitochondrial uncouplers, can be caloric restriction mimetics. Treatment of mice with low doses of the protonophore 2,4‐dinitrophenol promotes enhanced tissue respiratory rates, improved serological glucose, triglyceride and insulin levels, decrease of reactive oxygen species levels and tissue DNA and protein oxidation, as well as reduced body weight. Importantly, 2,4‐dinitrophenol‐treated animals also presented enhanced longevity. Our results demonstrate that mild mitochondrial uncoupling is a highly effective in vivo antioxidant strategy, and describe the first therapeutic intervention capable of effectively reproducing the physiological, metabolic and lifespan effects of caloric restriction in healthy mammals.
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“mitochondrial uncoupling, either genetically through the overexpression of the uncoupling protein UCP1 or by administration of the chemical uncoupler 2-4-dinitrophenol can increase lifespan in flies and mice”
From The Hallmarks of Aging (2013) · cites this paper as Caldeira da Silva et al., 2008
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Cites
Mitochondrial formation of reactive oxygen species
Turrens, J. F. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.049478 · Cited by 5,084
Resveratrol improves health and survival of mice on a high-calorie diet
Baur, J. A., Pearson, K. J., Price, N. L., Jamieson, H. A., Lerin, C., Kalra, A., Prabhu, V. V., Allard, J. S., Lopez-Lluch, G., Lewis, K., et al. (2006) · Nature · doi:10.1038/nature05354 · Cited by 4,290
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
Howitz, K. T., Bitterman, K. J., Cohen, H. Y., Lamming, D. W., Lavu, S., Wood, J. G., Zipkin, R. E., Chung, P., Kisielewski, A., Zhang, L.-L., et al. (2003) · Nature · doi:10.1038/nature01960 · Cited by 3,796
Lin, S.-J., Defossez, P.-A., & Guarente, L. (2000) · Science · doi:10.1126/science.289.5487.2126 · Cited by 1,775
Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS
Nisoli, E., Tonello, C., Cardile, A., Cozzi, V., Bracale, R., Tedesco, L., Falcone, S., Valerio, A., Cantoni, O., Clementi, E., et al. (2005) · Science · doi:10.1126/science.1117728 · Cited by 1,107 · cited 6×
“Lower insulin levels in calorie-restricted animals may induce nitric oxide synthase (Nisoli et al., 2005) and increase uncoupling protein expression (Nisoli et al., 2003).”
BackgroundInfluentialCalorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration
Lin, S.-J., Kaeberlein, M., Andalis, A. A., Sturtz, L. A., Defossez, P.-A., Culotta, V. C., Fink, G. R., & Guarente, L. (2002) · Nature · doi:10.1038/nature00829 · Cited by 1,057
Skulachev, V. P. (1996) · Quarterly Reviews of Biophysics · doi:10.1017/s0033583500005795 · Cited by 703
Two neurons mediate diet-restriction-induced longevity in C. elegans
Bishop, N. A., & Guarente, L. (2007) · Nature · doi:10.1038/nature05904 · Cited by 643
Mitochondria—A Nexus for Aging, Calorie Restriction, and Sirtuins?
Guarente, L. (2008) · Cell · doi:10.1016/j.cell.2008.01.007 · Cited by 513
Mitochondrial uncoupling as a target for drug development for the treatment of obesity.
Harper, J. A., Dickinson, K., & Brand, M. D. (2001) · Obesity Reviews · doi:10.1046/j.1467-789x.2001.00043.x · Cited by 250
Flagged first, then by citations
Research works printed but not linked: 53
- 10.1038/82565 · DOI
- 10.1016/j.cell.2005.02.001 · DOI · Paper page
- 10.1074/jbc.M408918200 · DOI
- 10.1111/j.1474-9728.2004.00097.x · DOI · Paper page
- 10.1016/j.cmet.2007.02.009 · DOI · Paper page
- 10.1016/S0531-5565(00)00135-2 · DOI · Paper page
- 10.1016/j.molmed.2006.12.004 · DOI
- 10.1080/15216540600702198 · DOI
- 10.1016/j.cell.2005.08.042 · DOI
- Fiala ES, 1989, Oxidative DNA and RNA damage in the livers of Sprague‐Dawley rats treated with the hepatocarcinogen 2‐nitropropane, Cancer Res, 49, 5518
- 10.1016/j.cmet.2005.01.005 · DOI
- 10.1074/jbc.M910177199 · DOI
- 10.1080/15216540600702198 · DOI
- 10.1016/S0145-305X(02)00103-9 · DOI
- 10.1046/j.1467-789X.2001.00043.x · DOI · Paper page
- 10.1080/10408390600550299 · DOI
- 10.1111/j.1474-9726.2006.00202.x · DOI
- 10.1111/j.1471-4159.2007.04516.x · DOI
- 10.1074/jbc.M500655200 · DOI · Paper page
- 10.1016/S0014-5793(97)01159-9 · DOI · Paper page
- 10.1152/ajpheart.2001.280.2.H649 · DOI
- 10.1111/j.1474-9726.2006.00202.x · DOI
- 10.1093/gerona/60.2.175 · DOI
- 10.1016/j.exger.2003.12.009 · DOI
- 10.1016/S0047-6374(98)00027-X · DOI
- 10.1042/BJ20070606 · DOI · Paper page
- Masoro EJ, 1992, Dietary restriction alters characteristics of glucose fuel use, J. Gerontol, 47, B202, 10.1093/geronj/47.6.B202 · DOI
- 10.2337/diabetes.54.8.2343 · DOI · Paper page
- 10.1046/j.1474-9728.2003.00074.x · DOI
- 10.1016/j.freeradbiomed.2006.04.001 · DOI
- 10.1096/fasebj.11.10.9271366 · DOI
- 10.1126/science.1079368 · DOI · Paper page
- 10.1007/BF01874175 · DOI
- 10.1038/nrg753 · DOI
- 10.1042/bj3450161 · DOI
- 10.1126/science.1102541 · DOI
- 10.1126/science.1106653 · DOI · Paper page
- 10.1016/0891-5849(94)90169-4 · DOI
- 10.1016/S0005-2728(97)00091-1 · DOI · Paper page
- 10.1134/S0006297907120139 · DOI
- 10.1126/science.273.5271.59 · DOI
- 10.1111/j.1474-9728.2004.00097.x · DOI · Paper page
- 10.1523/JNEUROSCI.1899-04.2004 · DOI
- 10.1016/j.freeradbiomed.2004.12.003 · DOI
- 10.1016/S0014-5793(03)00007-3 · DOI · Paper page
- 10.1038/ng2004 · DOI
- Tretter L, 2004, Generation of reactive oxygen species in the reaction catalyzed by α‐ketoglutarate dehydrogenase, J. Neurosci, 24, 7771, 10.1523/JNEUROSCI.1842-04.2004 · DOI
- 10.1111/j.1469-7793.2003.00335.x · DOI · Paper page
- Van Zant G, 1999, Genetic control of lifespan: studies from animal models, Expert Rev. Mol. Med, 1999, 1, 10.1017/S1462399499001441 · DOI
- 10.1093/gerona/57.6.B211 · DOI
- Wang L, 1994, Purification of genomic DNA from human whole blood by isopropanol‐fractionation with concentrated NaI and SDS, Nucleic Acids Res, 22, 1774, 10.1093/nar/22.9.1774 · DOI
- 10.1111/j.1471-4159.2007.04516.x · DOI
- 10.1006/abio.1997.2391 · DOI
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López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982
Mitochondrial Reactive Oxygen Species (ROS) and ROS-Induced ROS Release
Zorov, D. B., Juhaszova, M., & Sollott, S. J. (2014) · Physiological Reviews · doi:10.1152/physrev.00026.2013 · Cited by 5,383
Feldmann, H. M., Golozoubova, V., Cannon, B., & Nedergaard, J. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2008.12.014 · Cited by 1,318
Mitochondria and reactive oxygen species
Kowaltowski, A. J., de Souza-Pinto, N. C., Castilho, R. F., & Vercesi, A. E. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.05.004 · Cited by 1,162
Self-citationMitochondrial and metabolic dysfunction in ageing and age-related diseases
Amorim, J. A., Coppotelli, G., Rolo, A. P., Palmeira, C. M., Ross, J. M., & Sinclair, D. A. (2022) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00626-7 · Cited by 990
Metadata
- Authors
- Caldeira da Silva, C. C., Cerqueira, F. M., Barbosa, L. F., Medeiros, M. H. G., & Kowaltowski, A. J.
- Venue
- Aging Cell
- Publisher
- Wiley
- Published
- 2008-07-10
- Volume
- 7
- Issue
- 4
- Pages
- 552-560
- ISSN
- 1474-9718
- 1474-9726
- Cited by
- 306
- References
- 11
- Language
- en
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