Cited by 136Mitochondrial Function and PathologyATP Synthase and ATPases ResearchIon channel regulation and function

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Mitochondrial ATP‐sensitive K+ channel opening decreases reactive oxygen species generation

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Ferranti, Renato, da Silva, Mirian M, Kowaltowski, Alicia J·2003·FEBS Letters

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Abstract

Mitochondrial ATP‐sensitive K+ channel (mitoK ATP) opening was shown previously to slightly increase respiration and decrease the membrane potential by stimulating K+ cycling across the inner membrane. Here we show that mitoK ATP opening reduces reactive oxygen species generation in heart, liver and brain mitochondria. Decreased H 2 O 2 release is observed when mitoK ATP is active both with respiration stimulated by oxidative phosphorylation and when ATP synthesis is inhibited. In addition, decreased H 2 O 2 release is observed when mitochondrial ΔpH is enhanced, an effect expected to occur when mitoK ATP is open. We conclude that mitoK ATP is an effective pathway to trigger mild uncoupling, preventing reactive oxygen species release.

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Research works printed but not linked: 2

Kowaltowski A.J. and Vercesi A.E. (2001) in: Mitochondria in Pathogenisis (Lemasters J.J. and Nieminen A.L. Eds.) pp. 281–300 Plenum Publishing Corporation New York.
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Authors: Ferranti, R., da Silva, M. M., & Kowaltowski, A. J.
Affiliations: Universidade de São Paulo (BR)
Corresponding author: Kowaltowski, Alicia J
ORCID: Ferranti, Renato
Kowaltowski, Alicia J
Venue: FEBS Letters
Publisher: Wiley
Published: 2003-01-15
Volume: 536
Issue: 1-3
Pages: 51-55
ISSN: 0014-5793 (ISSN-L)
1873-3468
DOI: 10.1016/s0014-5793(03)00007-3
OpenAlex: W2039868368
Cited by: 136
References: 25
Citations by year: 2026: 2 · 2025: 4 · 2024: 3 · 2023: 4 · 2022: 1 · 2021: 4 · 2020: 3 · 2019: 1 · 2018: 4 · 2017: 2 · 2016: 2 · 2015: 6 · 2014: 5 · 2013: 8 · 2012: 6
FWCI: 4.25
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: FEBS Letters (publishedVersion)
PubMed (publishedVersion)
Funders: Fundação de Amparo à Pesquisa do Estado de São Paulo
Conselho Nacional de Desenvolvimento Científico e Tecnológico
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › ATP Synthase and ATPases Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
Keywords: mitochondrial ATP-sensitive potassium channel, reactive oxygen species, hydrogen peroxide release, mitochondrial uncoupling, mitochondrial membrane potential, oxidative phosphorylation, ATP synthesis inhibition, heart mitochondria, liver mitochondria, brain mitochondria, mitochondrial respiration
MeSH terms: Adenosine Triphosphate, Animals, Brain, Hydrogen Peroxide, Mitochondria, Mitochondria, Heart, Mitochondria, Liver, Oxidative Phosphorylation, Potassium, Potassium Channels, Ion Transport, Reactive Oxygen Species

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Mitochondrial ATP‐sensitive K+ channel opening decreases reactive oxygen species generation

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