The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Inhibition of angiotensin converting enzyme (ACE) activity by flavan‐3‐ols and procyanidins
Abstract
It was determined that flavan‐3‐ols and procyanidins have an inhibitory effect on angiotensin I converting enzyme (ACE) activity, and the effect was dependent on the number of epicatechin units forming the procyanidin. The inhibition by flavan‐3‐ols and procyanidins was competitive with the two substrates assayed: N‐hippuryl‐L‐histidyl‐L‐leucine (HHL) and N‐[3‐(2‐furyl)acryloyl]‐L‐phenylalanylglycylglycine (FAPGG). Tetramer and hexamer fractions were the more potent inhibitors, showing Ki of 5.6 and 4.7 μM, respectively. As ACE is a membrane protein, the interaction of flavanols and procyanidins with the enzyme could be related to the number of hydroxyl groups on the procyanidins, which determine their capacity to be adsorbed on the membrane surface.
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Citations
Cites
Procyanidin content and variation in some commonly consumed foods
Hammerstone, J. F., Lazarus, S. A., & Schmitz, H. H. (2000) · The Journal of Nutrition · doi:10.1093/jn/130.8.2086s · Cited by 356
Cited by
Masella, R., Di Benedetto, R., Varì, R., Filesi, C., & Giovannini, C. (2005) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2005.05.013 · Cited by 1,107
Dietary polyphenols and their biological significance
Han, X., Shen, T., & Lou, H. (2007) · International Journal of Molecular Sciences · doi:10.3390/i8090950 · Cited by 1,081
Halliwell, B., Rafter, J., & Jenner, A. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.1.268s · Cited by 711
Hooper, L., Kay, C., Abdelhamid, A., Kroon, P. A., Cohn, J. S., Rimm, E. B., & Cassidy, A. (2012) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.023457 · Cited by 610
Cocoa and Chocolate in Human Health and Disease
Katz, D. L., Doughty, K., & Ali, A. (2011) · Antioxidants & Redox Signaling · doi:10.1089/ars.2010.3697 · Cited by 441
Metadata
- Authors
- Actis-Goretta, L., Ottaviani, J. I., Keen, C. L., & Fraga, C. G.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2003-11-27
- Volume
- 555
- Issue
- 3
- Pages
- 597-600
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2099682888
- Cited by
- 241
- References
- 1
- FWCI
- 5.34
- Type
- journal article
- Language
- en
- Open access
- closed
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- Actis-Goretta, L., Ottaviani, J. I., Keen, C. L., & Fraga, C. G. (2003). Inhibition of angiotensin converting enzyme (ACE) activity by flavan‐3‐ols and procyanidins. FEBS Letters. https://doi.org/10.1016/s0014-5793(03)01355-3
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
